메뉴 건너뛰기




Volumn 51, Issue 3, 2010, Pages 362-370

Improved seizure control by alternating therapy of levetiracetam and valproate in epileptic rats

Author keywords

Antiepileptic drug; Pharmacoresistance; Status epilepticus; Temporal lobe epilepsy; Tolerance

Indexed keywords

ETIRACETAM; VALPROIC ACID;

EID: 77749239703     PISSN: 00139580     EISSN: 15281167     Source Type: Journal    
DOI: 10.1111/j.1528-1167.2009.02261.x     Document Type: Article
Times cited : (14)

References (38)
  • 1
    • 33845866924 scopus 로고    scopus 로고
    • Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays
    • Baltes S, Fedrowitz M, Tortos CL, Potschka H, Loscher W. (2007) Valproic acid is not a substrate for P-glycoprotein or multidrug resistance proteins 1 and 2 in a number of in vitro and in vivo transport assays. J Pharmacol Exp Ther 320:331-343.
    • (2007) J Pharmacol Exp Ther , vol.320 , pp. 331-343
    • Baltes, S.1    Fedrowitz, M.2    Tortos, C.L.3    Potschka, H.4    Loscher, W.5
  • 2
    • 33847125762 scopus 로고    scopus 로고
    • Plasticity of antiepileptic drug targets
    • Beck H. (2007) Plasticity of antiepileptic drug targets. Epilepsia 48(suppl 1):14-18.
    • (2007) Epilepsia , vol.48 , Issue.SUPPL. 1 , pp. 14-18
    • Beck, H.1
  • 3
    • 33748792802 scopus 로고    scopus 로고
    • The multidrug transporter hypothesis of drug resistance in epilepsy: Proof-of-principle in a rat model of temporal lobe epilepsy
    • Brandt C, Bethmann K, Gastens AM, Loscher W. (2006) The multidrug transporter hypothesis of drug resistance in epilepsy: proof-of-principle in a rat model of temporal lobe epilepsy. Neurobiol Dis 24:202-211.
    • (2006) Neurobiol Dis , vol.24 , pp. 202-211
    • Brandt, C.1    Bethmann, K.2    Gastens, A.M.3    Loscher, W.4
  • 4
    • 1642550928 scopus 로고    scopus 로고
    • Pharmacological outcomes in newly diagnosed epilepsy
    • Brodie MJ, Mohanraj R. (2003) Pharmacological outcomes in newly diagnosed epilepsy. Epilepsia 44:84.
    • (2003) Epilepsia , vol.44 , pp. 84
    • Brodie, M.J.1    Mohanraj, R.2
  • 5
    • 0020659302 scopus 로고
    • Valproic acid therapy for complex partial seizures. Its efficacy and toxic effects
    • Bruni J, Albright P. (1983) Valproic acid therapy for complex partial seizures. Its efficacy and toxic effects. Arch Neurol 40:135-137.
    • (1983) Arch Neurol , vol.40 , pp. 135-137
    • Bruni, J.1    Albright, P.2
  • 6
    • 34248136001 scopus 로고    scopus 로고
    • Levetiracetam: Part II, the clinical profile of a novel anticonvulsant drug
    • De Smedt T, Raedt R, Vonck K, Boon P. (2007) Levetiracetam: part II, the clinical profile of a novel anticonvulsant drug. CNS Drug Rev 13:57-78.
    • (2007) CNS Drug Rev , vol.13 , pp. 57-78
    • De Smedt, T.1    Raedt, R.2    Vonck, K.3    Boon, P.4
  • 7
    • 0020596948 scopus 로고
    • Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: Study of long-term efficacy and tolerance]
    • Feuerstein J, Revol M, Roger J, Sallou C, Truelle JL, Vercelletto P, Weber M. (1983) [Monotherapy with sodium valproate in generalized primary epilepsy. 2d phase: study of long-term efficacy and tolerance]. Sem Hop 59:1263-1274.
    • (1983) Sem Hop , vol.59 , pp. 1263-1274
    • Feuerstein, J.1    Revol, M.2    Roger, J.3    Sallou, C.4    Truelle, J.L.5    Vercelletto, P.6    Weber, M.7
  • 8
    • 33645015647 scopus 로고    scopus 로고
    • Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures
    • Friedman D, French JA. (2006) Effects of intermittent levetiracetam dosing in a patient with refractory daily seizures. Neurology 66:590-591.
    • (2006) Neurology , vol.66 , pp. 590-591
    • Friedman, D.1    French, J.A.2
  • 9
    • 0035118635 scopus 로고    scopus 로고
    • Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons
    • Gorter JA, van Vliet EA, Aronica E, Lopes daSilva FH. (2001) Progression of spontaneous seizures after status epilepticus is associated with mossy fibre sprouting and extensive bilateral loss of hilar parvalbumin and somatostatin-immunoreactive neurons. Eur J Neurosci 13:657-669.
    • (2001) Eur J Neurosci , vol.13 , pp. 657-669
    • Gorter, J.A.1    van Vliet, E.A.2    Aronica, E.3    Lopes daSilva, F.H.4
  • 11
    • 0034257051 scopus 로고    scopus 로고
    • Mechanisms of action of valproate: A commentary
    • Johannessen CU. (2000) Mechanisms of action of valproate: a commentary. Neurochem Int 37:103-110.
    • (2000) Neurochem Int , vol.37 , pp. 103-110
    • Johannessen, C.U.1
  • 12
    • 0018959587 scopus 로고
    • Valproic acid in childhood epilepsy: Anticonvulsive efficacy in relation to its plasma levels
    • Klotz U, Schweizer C. (1980) Valproic acid in childhood epilepsy: anticonvulsive efficacy in relation to its plasma levels. Int J Clin Pharmacol Ther Toxicol 18:461-465.
    • (1980) Int J Clin Pharmacol Ther Toxicol , vol.18 , pp. 461-465
    • Klotz, U.1    Schweizer, C.2
  • 13
    • 0034598762 scopus 로고    scopus 로고
    • Early identification of refractory epilepsy
    • Kwan P, Brodie MJ. (2000) Early identification of refractory epilepsy. N Engl J Med 342:314-319.
    • (2000) N Engl J Med , vol.342 , pp. 314-319
    • Kwan, P.1    Brodie, M.J.2
  • 14
    • 0034935392 scopus 로고    scopus 로고
    • The mechanisms of action of commonly used antiepileptic drugs
    • Kwan P, Sills GJ, Brodie MJ. (2001) The mechanisms of action of commonly used antiepileptic drugs. Pharmacol Ther 90:21-34.
    • (2001) Pharmacol Ther , vol.90 , pp. 21-34
    • Kwan, P.1    Sills, G.J.2    Brodie, M.J.3
  • 15
    • 0028836283 scopus 로고
    • Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats
    • Leite JP, Cavalheiro EA. (1995) Effects of conventional antiepileptic drugs in a model of spontaneous recurrent seizures in rats. Epilepsy Res 20:93-104.
    • (1995) Epilepsy Res , vol.20 , pp. 93-104
    • Leite, J.P.1    Cavalheiro, E.A.2
  • 16
    • 0020610769 scopus 로고
    • Distribution of valproic acid and its metabolites in various brain areas of dogs and rats after acute and prolonged treatment
    • Loscher W, Nau H. (1983) Distribution of valproic acid and its metabolites in various brain areas of dogs and rats after acute and prolonged treatment. J Pharmacol Exp Ther 226:845-854.
    • (1983) J Pharmacol Exp Ther , vol.226 , pp. 845-854
    • Loscher, W.1    Nau, H.2
  • 17
    • 0022921723 scopus 로고
    • Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils
    • Loscher W. (1986) Development of tolerance to the anticonvulsant effect of GABAmimetic drugs in genetically epilepsy-prone gerbils. Pharmacol Biochem Behav 24:1007-1013.
    • (1986) Pharmacol Biochem Behav , vol.24 , pp. 1007-1013
    • Loscher, W.1
  • 18
    • 0023897574 scopus 로고
    • Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations
    • Loscher W, Schmidt D. (1988) Which animal models should be used in the search for new antiepileptic drugs? A proposal based on experimental and clinical considerations Epilepsy Res 2:145-181.
    • (1988) Epilepsy Res , vol.2 , pp. 145-181
    • Loscher, W.1    Schmidt, D.2
  • 19
    • 0024448128 scopus 로고
    • Valproic acid in amygdala-kindled rats: Alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment
    • Loscher W, Fisher JE, Nau H, Honack D. (1989) Valproic acid in amygdala-kindled rats: alterations in anticonvulsant efficacy, adverse effects and drug and metabolite levels in various brain regions during chronic treatment. J Pharmacol Exp Ther 250:1067-1078.
    • (1989) J Pharmacol Exp Ther , vol.250 , pp. 1067-1078
    • Loscher, W.1    Fisher, J.E.2    Nau, H.3    Honack, D.4
  • 20
    • 8444232772 scopus 로고    scopus 로고
    • New horizons in the development of antiepileptic drugs: The search for new targets
    • Loscher W, Schmidt D. (2004) New horizons in the development of antiepileptic drugs: the search for new targets. Epilepsy Res 60:77-150.
    • (2004) Epilepsy Res , vol.60 , pp. 77-150
    • Loscher, W.1    Schmidt, D.2
  • 21
    • 33746887419 scopus 로고    scopus 로고
    • Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs
    • Loscher W, Schmidt D. (2006) Experimental and clinical evidence for loss of effect (tolerance) during prolonged treatment with antiepileptic drugs. Epilepsia 47:1253-1284.
    • (2006) Epilepsia , vol.47 , pp. 1253-1284
    • Loscher, W.1    Schmidt, D.2
  • 22
    • 34447341436 scopus 로고    scopus 로고
    • The pharmacokinetics of antiepileptic drugs in rats: Consequences for maintaining effective drug levels during prolonged drug administration in rat models of epilepsy
    • Loscher W. (2007) The pharmacokinetics of antiepileptic drugs in rats: consequences for maintaining effective drug levels during prolonged drug administration in rat models of epilepsy. Epilepsia 48:1245-1258.
    • (2007) Epilepsia , vol.48 , pp. 1245-1258
    • Loscher, W.1
  • 24
    • 0026564734 scopus 로고
    • Tolerance to the anticonvulsant effects of carbamazepine, diazepam, and sodium valproate in kindled rats
    • Mana MJ, Kim CK, Pinel JP. (1992a) Tolerance to the anticonvulsant effects of carbamazepine, diazepam, and sodium valproate in kindled rats. Pharmacol Biochem Behav 41:109-113.
    • (1992) Pharmacol Biochem Behav , vol.41 , pp. 109-113
    • Mana, M.J.1    Kim, C.K.2    Pinel, J.P.3
  • 25
    • 0026540937 scopus 로고
    • Contingent tolerance to the anticonvulsant effects of carbamazepine, diazepam, and sodium valproate in kindled rats
    • Mana MJ, Kim CK, Pinel JP, Jones CH. (1992b) Contingent tolerance to the anticonvulsant effects of carbamazepine, diazepam, and sodium valproate in kindled rats. Pharmacol Biochem Behav 41:121-126.
    • (1992) Pharmacol Biochem Behav , vol.41 , pp. 121-126
    • Mana, M.J.1    Kim, C.K.2    Pinel, J.P.3    Jones, C.H.4
  • 26
    • 33645305420 scopus 로고    scopus 로고
    • Diagnosing refractory epilepsy: Response to sequential treatment schedules
    • Mohanraj R, Brodie MJ. (2006) Diagnosing refractory epilepsy: response to sequential treatment schedules. Eur J Neurol 13:277-282.
    • (2006) Eur J Neurol , vol.13 , pp. 277-282
    • Mohanraj, R.1    Brodie, M.J.2
  • 28
    • 33847278982 scopus 로고    scopus 로고
    • Effect of antiepileptic drugs on spontaneous seizures in epileptic rats
    • Nissinen J, Pitkanen A. (2007) Effect of antiepileptic drugs on spontaneous seizures in epileptic rats. Epilepsy Res 73:181-191.
    • (2007) Epilepsy Res , vol.73 , pp. 181-191
    • Nissinen, J.1    Pitkanen, A.2
  • 29
    • 45749150011 scopus 로고    scopus 로고
    • Antiepileptic drugs - best practice guidelines for therapeutic drug monitoring: A position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies
    • Patsalos PN, Berry DJ, Bourgeois BF, Cloyd JC, Glauser TA, Johannessen SI, Leppik IE, Tomson T, Perucca E. (2008) Antiepileptic drugs - best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies. Epilepsia 49:1239-1276.
    • (2008) Epilepsia , vol.49 , pp. 1239-1276
    • Patsalos, P.N.1    Berry, D.J.2    Bourgeois, B.F.3    Cloyd, J.C.4    Glauser, T.A.5    Johannessen, S.I.6    Leppik, I.E.7    Tomson, T.8    Perucca, E.9
  • 30
    • 0032918385 scopus 로고    scopus 로고
    • Clinical aspects and biological bases of drug-resistant epilepsies
    • Regesta G, Tanganelli P. (1999) Clinical aspects and biological bases of drug-resistant epilepsies. Epilepsy Res 34:109-122.
    • (1999) Epilepsy Res , vol.34 , pp. 109-122
    • Regesta, G.1    Tanganelli, P.2
  • 31
    • 3042798891 scopus 로고    scopus 로고
    • The neurobiology of antiepileptic drugs
    • Rogawski MA, Loscher W. (2004) The neurobiology of antiepileptic drugs. Nat Rev Neurosci 5:553-564.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 553-564
    • Rogawski, M.A.1    Loscher, W.2
  • 32
    • 20544475805 scopus 로고    scopus 로고
    • Drug resistance in epilepsy: Putative neurobiologic and clinical mechanisms
    • Schmidt D, Loscher W. (2005) Drug resistance in epilepsy: putative neurobiologic and clinical mechanisms. Epilepsia 46:858-877.
    • (2005) Epilepsia , vol.46 , pp. 858-877
    • Schmidt, D.1    Loscher, W.2
  • 33
    • 0037399407 scopus 로고    scopus 로고
    • Mechanisms of antiepileptic drug resistance
    • Sisodiya SM. (2003) Mechanisms of antiepileptic drug resistance. Curr Opin Neurol 16:197-201.
    • (2003) Curr Opin Neurol , vol.16 , pp. 197-201
    • Sisodiya, S.M.1
  • 34
    • 2342612627 scopus 로고    scopus 로고
    • Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation
    • Van Vliet EA, Aronica E, Tolner EA, Lopes daSilva FH, Gorter JA. (2004) Progression of temporal lobe epilepsy in the rat is associated with immunocytochemical changes in inhibitory interneurons in specific regions of the hippocampal formation. Exp Neurol 187:367-379.
    • (2004) Exp Neurol , vol.187 , pp. 367-379
    • Van Vliet, E.A.1    Aronica, E.2    Tolner, E.A.3    Lopes daSilva, F.H.4    Gorter, J.A.5
  • 37
    • 0032168788 scopus 로고    scopus 로고
    • Effect of valproic acid on sodium currents in cortical neurons from patients with pharmaco-resistant temporal lobe epilepsy
    • Vreugdenhil M, van Veelen CW, van Rijen PC, Lopes daSilva FH, Wadman WJ. (1998) Effect of valproic acid on sodium currents in cortical neurons from patients with pharmaco-resistant temporal lobe epilepsy. Epilepsy Res 32:309-320.
    • (1998) Epilepsy Res , vol.32 , pp. 309-320
    • Vreugdenhil, M.1    van Veelen, C.W.2    van Rijen, P.C.3    Lopes daSilva, F.H.4    Wadman, W.J.5
  • 38
    • 0025279779 scopus 로고
    • Development of tolerance to the anticonvulsant effect of valproate but not to ethosuximide in a rat model of absence epilepsy
    • Wahle H, Frey HH. (1990) Development of tolerance to the anticonvulsant effect of valproate but not to ethosuximide in a rat model of absence epilepsy. Eur J Pharmacol 181:1-8.
    • (1990) Eur J Pharmacol , vol.181 , pp. 1-8
    • Wahle, H.1    Frey, H.H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.