Additive interaction between peripheral and central mechanisms involved in the antinociceptive effect of diclofenac in the formalin test in rats

Pharmacology Biochemistry and Behavior

Volumn 91, Issue 1, 2008, Pages 32-37

  Ortiz, Mario I ^a   Lozano Cuenca, Jair ^b   Granados Soto, Vinicio ^b   Castañeda Hernández, Gilberto ^b  

^a UNIVERSIDAD AUTÓNOMA DEL ESTADO DE HIDALGO   (Mexico)

^b DEPARTAMENTO DE FÍSICA   (Mexico)

Author keywords

Additive interaction; Antinociception; Diclofenac; Formalin test; Isobolographic analysis; Mechanism of action

Indexed keywords

DICLOFENAC; FORMALDEHYDE; GLIBENCLAMIDE; N(G) NITROARGININE METHYL ESTER; NITRIC OXIDE; POTASSIUM;

ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DRUG ADMINISTRATION ROUTE; DRUG EFFECT; DRUG MECHANISM; FEMALE; NONHUMAN; PAIN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; AREA UNDER CURVE; CENTRAL NERVOUS SYSTEM; DICLOFENAC; ENZYME INHIBITORS; FEMALE; FORMALDEHYDE; NG-NITROARGININE METHYL ESTER; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; PAIN MEASUREMENT; PERIPHERAL NERVOUS SYSTEM; POTASSIUM CHANNELS; RATS; RATS, WISTAR; SPINAL CORD;

RATTUS;

EID: 50349089097     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2008.06.008     Document Type: Article

References (32)

1. + channels activation. Life Sci 74 (2004) 2577-2591
2. Bhat A.S., Tandan S.K., Kumar D., Krishna V., and Prakash V.R. Interaction between inhibitors of inducible nitric oxide synthase and cyclooxygenase in adjuvant-induced arthritis in female albino rats: an isobolographic study. Eur J Pharmacol 556 (2007) 190-199
3. Björkman R. Central antinociceptive effects of non-steroidal anti-inflammatory drugs and paracetamol. Experimental studies in the rat. Acta Anaesthesiol Scand Suppl 103 (1995) 1-44
4. Burian M., Tegeder I., Seegel M., and Geisslinger G. Peripheral and central antihyperalgesic effects of diclofenac in a model of human inflammatory pain. Clin Pharmacol Ther 74 (2003) 113-120
5. Capone F., and Aloisi A.M. Refinement of pain evaluation techniques. The formalin test. Ann Ist Super Sanita 40 (2004) 223-229
6. Davies N.M., and Anderson K.E. Clinical pharmacokinetics of diclofenac. Clin Pharmacokinet 33 (1997) 184-213
7. + channels. Annu Rev Pharmacol Toxicol 33 (1993) 597-637
8. Fowler P.D., Shadforth M.F., Crook P.R., and John V.A. Plasma and synovial fluid concentrations of diclofenac sodium and its major hydroxylated metabolites during long-term treatment of rheumatoid arthritis. Eur J Clin Pharmacol 25 (1983) 389-394
9. Granados-Soto V., and Argüelles C.F. Synergic antinociceptive interaction between tramadol and gabapentin after local, spinal and systemic administration. Pharmacology 74 (2005) 200-208
10. Jiménez-Andrade J.M., Ortiz M.I., Pérez-Urizar J., Aguirre-Bañuelos P., Granados-Soto V., and Castañeda-Hernández G. Synergistic effects between codeine and diclofenac after local, spinal and systemic administration. Pharmacol Biochem Behav 76 (2003) 463-471
11. Lozano-Cuenca J., Castañeda-Hernández G., and Granados-Soto V. Peripheral and spinal mechanisms of antinociceptive action of lumiracoxib. Eur J Pharmacol 513 (2005) 81-91
12. Miranda H.F., Lopez J., Sierralta F., Correa A., and Pinardi G. NSAID antinociception measured in a chemical and a thermal assay in mice. Pain Res Manag 6 (2001) 190-196
13. + channel pathway participates in the antiallodynic effect of spinal gabapentin. Eur J Pharmacol 531 (2006) 87-95
14. Mysler E. Lumiracoxib (Prexige): a new selective COX-2 inhibitor. Int J Clin Pract 58 (2004) 606-611
15. Oliw E., Lundén I., and Angäard E. In vivo inhibition of prostaglandin synthesis in rabbit kidney by non-steroidal anti-inflammatory drugs. Acta Pharmacol Toxicol (Copenh) 42 (1978) 179-184
16. + channels by diclofenac. Eur J Pharmacol 438 (2002) 85-91
17. + channel pathway participates in the antinociceptive effect of diclofenac, but not of indomethacin. Pharmacol Biochem Behav 76 (2003) 187-195
18. Ossipov M.H., Lozito R., Messineo E., Green J., Harris S., and Lloyd P. Spinal antinociceptive synergy between clonidine and morphine, U69593, and DPDPE: isobolographic analysis. Life Sci 47 (1990) PL71-PL76
19. Picazo A., Castañeda-Hernández G., and Ortiz M.I. Examination of the interaction between peripheral diclofenac and gabapentin on the 5% formalin test in rats. Life Sci 79 (2006) 2283-2287
20. Rees D.D., Palmer R.M.S., Schulz R., Hodson H.F., and Moncada S. Characterization of three inhibitors of endothelial nitric oxide synthase in vitro and in vivo. Br J Pharmacol 101 (1990) 746-752
21. Sacerdote P., Monza G., Mantegazza P., and Panerai A.E. Diclofenac and pirprofen modify pituitary and hypothalamic beta-endorphin concentrations. Pharmacol Res Commun 17 (1985) 679-684
22. Tallarida R.J. Statistical analysis of drugs combinations for synergism. Pain 49 (1992) 93-97
23. Tallarida R.J. Drug synergism and dose-effect data analysis. 1st. Ed. (2000), Chapman & Hall/CRC, New York 1-72
24. Tallarida R.J. The interaction index: a measure of drug synergism. Pain 98 (2002) 163-168
25. Tallarida R.J., Stone D.J., McCarty J.D., and Raffa R.B. Response surface analysis of synergism between morphine and clonidine. J Pharm Exp Ther 289 (1999) 8-13
26. Todd P.A., and Sorkin E.M. Diclofenac sodium. A reappraisal of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy. Drugs 35 (1988) 244-285
27. Tonussi C.R., and Ferreira S.H. Mechanism of diclofenac analgesia: direct blockade of inflammatory sensitization. Eur J Pharmacol 251 (1994) 173-179
28. Torres-López J.E., López-Muñoz F.J., Castañeda-Hernández G., Flores-Murrieta F.J., and Granados-Soto V. Pharmacokinetic-pharmacodynamic modeling of the antinociceptive effect of diclofenac in the rat. J Pharmacol Exp Ther 282 (1997) 685-690
29. Torres-López J.E., Ortiz M.I., Castañeda-Hernández G., Alonso-López R., Asomoza-Espinosa R., and Granados-Soto V. Comparison of the antinociceptive effect of celecoxib, diclofenac and resveratrol in the formalin test. Life Sci 70 (2002) 1669-1676
30. Vanegas H. Bases for a spinal analgesic action of cyclooxygenase inhibitors. Proc West Pharmacol Soc 45 (2002) 225-227
31. Zecca L., Ferrario P., and Costi P. Determination of diclofenac and its metabolites in plasma and cerebrospinal fluid by high-performance liquid chromatography with electrochemical detection. J Chromatogr 567 (1991) 425-432
32. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110