Transcriptional activation of DNA-dependent protein kinase catalytic subunit gene expression by oestrogen receptor-α

EMBO Reports

Volumn 11, Issue 3, 2010, Pages 208-213

  Medunjanin, Senad ^a   Weinert, Sönke ^a   Poitz, David ^a   Schmeisser, Alexander ^b   Strasser, Ruth H ^a   Braun Dullaeus, Ruediger C ^b  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; DNA DEPENDENT PROTEIN KINASE CATALYTIC SUBUNIT; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CONTROLLED STUDY; DNA REPAIR; DNA REPLICATION; DOUBLE STRANDED DNA BREAK; ESTROGEN BINDING; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMOTER REGION; TRANSACTIVATION; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; UPREGULATION;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CELL LINE, TUMOR; CERCOPITHECUS AETHIOPS; COS CELLS; DNA-ACTIVATED PROTEIN KINASE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; HUMANS; MODELS, BIOLOGICAL; RADIATION, IONIZING; RNA, SMALL INTERFERING; TRANSCRIPTIONAL ACTIVATION;

MAMMALIA;

EID: 77649274595     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2009.279     Document Type: Article

References (27)

1. Anderson CW, Lees-Miller SP (1992) The nuclear serine/threonine protein kinase DNA-PK. Crit Rev Eukaryot Gene Expr 2: 283-314
2. Boulay F, Perdiz D (2005) 17b-estradiol modulates UVB-induced cellular responses in estrogen receptors positive human breast cancer cells. J Photochem Photobiol B 81: 143-153
3. Collis SJ, DeWeese TL, Jeggo PA, Parker AR (2005) The life and death of DNA-PK. Oncogene 24: 949-961
4. Connelly MA, Zhang H, Kieleczawa J, Anderson CW (1998) The promoters for human DNA-PKcs (PRKDC) and MCM4: divergently transcribed genes located at chromosome 8 band q11. Genomics 47: 71-83
5. Deroo BJ, Korach KS (2006) Estrogen receptors and human disease. J Clin Invest 116: 561-570
6. Errami A, Overkamp WJ, He DM, Friedl AA, Gell DA, Eckardt-Schupp F, Jackson SP, Hendrickson EA, Lohman PH, Zdzienicka MZ (2000) A new X-ray sensitive CHO cell mutant of ionizing radiation group 7,XR-C2, that is defective in DSB repair but has only a mild defect in V(D)J recombination. Mutat Res 461: 59-69
7. Fisher B et al (2002) Tamoxifen, radiation therapy, or both for prevention of ipsilateral breast tumor recurrence after lumpectomy in women with invasive breast cancers of one centimeter or less. J Clin Oncol 20: 4141-4149
8. Gadal F et al (2005) Integrative analysis of gene expression patterns predicts specific modulations of defined cell functions by estrogen and tamoxifen in MCF7 breast cancer cells. J Mol Endocrinol 34: 61-75
9. Grisouard J, Medunjanin S, Hermani A, Shukla A, Mayer D (2007) Glycogen synthase kinase-3 protects estrogen receptor alpha from proteasomal degradation and is required for full transcriptional activity of the receptor. Mol Endocrinol 21: 2427-2439
10. Hah YS, Lee JH, Kim DR (2007) DNA-dependent protein kinase mediates V(D)J recombination via RAG2 phosphorylation. J Biochem Mol Biol 40: 432-438
11. Klein-Hitpass L, Ryffel GU, Heitlinger E, Cato AC (1988) A 13bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor. Nucleic Acids Res 16: 647-663
12. Kysela B, Chovanec M, Jeggo PA (2005) Phosphorylation of linker histones by DNA-dependent protein kinase is required for DNA ligase IV-dependent ligation in the presence of histone H1. Proc Natl Acad Sci USA 102: 1877-1882
13. Lees-Miller SP (1996) The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight. Biochem Cell Biol 74: 503-512
14. Li J, Stern DF (2005) Regulation of CHK2 by DNA-dependent protein kinase. J Biol Chem 280: 12041-12050
15. Martinez E, Wahli W (1989) Cooperative binding of estrogen receptor to imperfect estrogen-responsive DNA elements correlates with their synergistic hormone-dependent enhancer activity. EMBO J 8: 3781-3791
16. Matsuoka S, Rotman G, Ogawa A, Shiloh Y, Tamai K, Elledge SJ (2000) Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro. Proc Natl Acad Sci USA 97: 10389-10394
17. Medunjanin S, Hermani A, De SB, Grisouard J, Rincke G, Mayer D (2005) Glycogen synthase kinase-3 interacts with and phosphorylates estrogen receptor-a and is involved in the regulation of receptor activity. J Biol Chem 280: 33006-33014
18. Norbury CJ, Hickson ID (2001) Cellular responses to DNA damage. Annu Rev Pharmacol Toxicol 41: 367-401
19. Rothkamm K, Lobrich M (2003) Evidence for a lack of DNA double-strand break repair in human cells exposed to very low X-ray doses. Proc Natl Acad Sci USA 100: 5057-5062
20. Ruiz C et al (2006) Tissue microarrays for comparing molecular features with proliferation activity in breast cancer. Int J Cancer 118: 2190-2194
21. Sedelnikova OA, Rogakou EP, Panyutin IG, Bonner WM (2002) Quantitative detection of (125)IdU-induced DNA double-strand breaks with g-H2AX antibody. Radiat Res 158: 486-492
22. Shen H, Schultz M, Kruh GD, Tew KD (1998) Increased expression of DNA-dependent protein kinase confers resistance to adriamycin. Biochim Biophys Acta 1381: 131-138
23. Smith GC, Jackson SP (1999) The DNA-dependent protein kinase. Genes Dev 13: 916-934
24. Wang XQ, Redpath JL, Fan ST, Stanbridge EJ (2006) ATR dependent activation of Chk2. J Cell Physiol 208: 613-619
25. Wazer DE, Tercilla OF, Lin PS, Schmidt-Ullrich R (1989) Modulation in the radiosensitivity of MCF-7 human breast carcinoma cells by 17b-estradiol and tamoxifen. Br J Radiol 62: 1079-1083
26. Wei X, Xu H, Kufe D (2006) MUC1 oncoprotein stabilizes and activates estrogen receptor-a. Mol Cell 21: 295-305
27. Woods T, Wang W, Convery E, Errami A, Zdzienicka MZ, Meek K (2002) A single amino acid substitution in DNA-PKcs explains the novel phenotype of the CHO mutant, XR-C2. Nucleic Acids Res 30: 5120-5128