Antiproliferative activity of brown cuban propolis extract on human breast cancer cells

Natural Product Communications

Volumn 4, Issue 12, 2009, Pages 1711-1716

  Popolo, Ada ^a   Piccinelli, Lisa Anna ^a   Morello, Silvana ^b   Cuesta Rubio, Osmany ^a   Sorrentino, Rosalinda ^a   Rastrelli, Luca ^a   Pinto, Aldo ^a  

^a UNIVERSITY OF SALERNO   (Italy)

^b INSTITUTO DE FARMACIA Y ALIMENTOS   (Cuba)

Author keywords

Breast cancer; Brown cuban propolis; Cytotoxicity; MCF 7

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ALCOHOL; BROWN CUBAN PROPOLIS EXTRACT; ESTRADIOL; ESTROGEN RECEPTOR; PLANT EXTRACT; PROPOLIS; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; DRUG DERIVATIVE; FULVESTRANT;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CANCER GROWTH; CANCER INHIBITION; CELL CYCLE G1 PHASE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GROWTH INHIBITION; HUMAN; HUMAN CELL; BREAST TUMOR; CHEMISTRY; CLUSIA; CUBA; DRUG EFFECT; FEMALE; FLOW CYTOMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MITOSIS; TUMOR CELL LINE;

CUBAN PROPOLIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CLUSIA; CUBA; ESTRADIOL; FEMALE; FLOW CYTOMETRY; HUMANS; MITOSIS; PROPOLIS;

EID: 77649267260     PISSN: 1934578X     EISSN: 15559475     Source Type: Journal    
DOI: 10.1177/1934578x0900401221     Document Type: Article

References (26)

1. Burdock GA. (1998) Review of the biological properties and toxicity of bee propolis (propolis). Food and Chemical Toxicology, 36, 347-363.
2. Banskota AH, Tezuka Y, Kadota S. (2001) Recent progress in pharmacological research of propolis. Phytotherapy Research, 15, 561-571.
3. Bankova VS, Popova M, Trusheva B. (2006) Plant sources of propolis: an update from a chemist's point of view. Natural Product Communications, 1, 1023-1028.
4. Kumazawa S, Hamasaka T, Nakayama T. (2004) Antioxidant activity of propolis of various geographic origins. Food Chemistry, 84, 329-339.
5. Russo A, Cardile V, Sanchez F, Troncoso N, Vanella A, Garbarino JA. (2004) Chilean propolis: antioxidant action in human tumor cell lines. Life Sciences, 76, 545-558.
6. Ahn MR, Kunimasa K, Ohta T, Kumazawa S, Kamihira M, Kaji K, Uto Y, Hori H, Nagasawa H, Nakayama T. (2007) Suppression of tumor-induced angiogenesis by Brazilian propolis: Major component artepillin C inhibits in vitro tube formation and endothelial cell proliferation. Cancer Letters, 252, 235-243.
7. Cuesta-Rubio O, Piccinelli AL, Fernandez MC, Hernández IM, Rosado A, Rastrelli L. (2007) Chemical characterization of Cuban propolis by HPLC-PDA, HPLC-MS, and NMR: the brown, red, and yellow Cuban varieties of propolis. Journal of Agricultural and Food Chemistry, 55, 7502-7509.
8. Cuesta-Rubio O, Cuellar Cuellar A, Rojas N, Velez Castro H, Rastrelli L, Aquino R. (1999) A polyisoprenylated benzophenone from Cuban propolis. Journal of Natural Products, 62, 1013-1015.
9. Cuesta-Rubio O, Frontana-Uribe BA, Ramirez-Apan T, Cárdenas J. (2002) Polyisoprenylated benzophenones in Cuban propolis; biological activity of nemorosone. Zeitschrift fuer Naturforschung, 57C, 372-378. (Pubitemid 34489938)
10. Marquez Hernandez I, Campo Fernandez M, Cuesta-Rubio O, Piccinelli AL, Rastrelli L. (2005) Polyprenylated benzophenone derivatives from Cuban propolis. Journal of Natural Products, 68, 931-934.
11. Piccinelli AL, Campo Fernandez M, Cuesta-Rubio O, Marquez Hernandez I, De Simone F, Rastrelli L. (2005) Isoflavonoids isolated from Cuban propolis. Journal of Agricultural and Food Chemistry, 53, 9010-9016.
12. Cuesta-Rubio O, Velez-Castro H, Frontana-Uribe BA, Cardenas J. (2001) Nemorosone, the major constituent of floral resins of Clusia rosea. Phytochemistry, 57, 279-283.
13. Barnes S. (1998) Phytoestrogens and breast cancer. Bailliere's Clinical Endocrinology and Metabolism, 12, 559-579.
14. Padmavathi R, Senthilnathan P, Chodon D, Sakthisekaran D. (2006) Therapeutic effect of paclitaxel and propolis on lipid peroxidation and antioxidant system in 7,12 dimethyl benz(a)anthracene-induced breast cancer in female Sprague Dawley rats. Life Sciences, 78, 2820-2825.
15. Song YS, Jin C, Jung KJ, Park EH. (2002) Estrogenic effects of ethanol and ether extract of propolis. Journal of Ethnopharmacology, 82, 89-95.
16. Green LM, Reade JL, Ware CFR. (1984) Rapid colormetric assay for cell viability: Application to the quantitation of cytotoxic and growth inhibitory lymphokines. Journal of Immunological Methods, 70, 257-268.
17. Renoir JM, Bouclier C, Seguin A, Marsaud FV, Sola B. (2008) Antiestrogen-mediated cell cycle arrest and apoptosis induction in breast cancer and multiple myeloma cells. Journal of Molecular Endocrinology, 40, 101-112.
18. Bankova V, Popova M, Bogdanov S, Sabatini AG. (2002) Chemical composition of European propolis: expected and unexpected results. Zeitschrift fuer Naturforschung, 57C, 530-533. (Pubitemid 34775948)
19. Park YK, Alencar SM, Aguiar CL. (2002) Botanical origin and chemical composition of Brazilian propolis. Journal of Agricultural and Food Chemistry, 50, 2502-2509.
20. Jamerson MH, Johnson MD, Dickson RB. (2004) Of mice and Myc: c-Myc and mammary tumorigenesis. Journal of Mammary Gland Biology and Neoplasia, 9, 27-37.
21. Diel P, Smolnikar K, Michna H. (1999) In vitro test systems for the evaluation of the estrogenic activity of natural products. Planta Medica, 65, 197-203.
22. Jordan VC. (1997) Tamoxifen: the herald of a new era of preventive therapeutics. Journal of the National Cancer Institute, 89, 747-749. (Pubitemid 27242274)
23. Santell RC, Chang YC, Nair MG, Halferich WG. (1997) Dietary genistein exerts estrogenic effects upon the uterus, mammary gland and hypothalamic/pituitary axis in rats. Journal of Nutrition, 127, 263-269.
24. Díaz-Carballo D, Malak S, Bardenheuer W, Freistuehler M, Reusch HP. (2008) Cytotoxic activity of nemorosone in neuroblastoma cells. International Journal of Clinical Pharmacology Therapy, 46, 428-439.
25. So FV, Guthrie N, Chambers AF, Carroll KK. (1997) Inhibition of proliferation of estrogen receptor-positive MCF-7 human breast cancer cells by flavonoids in the presence and absence of excess estrogen. Cancer Letters, 112, 127-133. (Pubitemid 27104286)
26. Das JR, Fryar-Tita EB, Zhou Y, Green S, Southerland WM, Bowen D. (2007) Sequence-dependent administration of 5-fluorouracil maintains methotrexate antineoplastic activity in human estrogen-negative breast cancer and protects against methotrexate cytotoxicity in human bone marrow. Anticancer Research, 27, 3791-3799.