Dynamics of ECT normalization of low G protein function and immunoreactivity in mononuclear leukocytes of patients with major depression

American Journal of Psychiatry

Volumn 155, Issue 5, 1998, Pages 666-671

  Avissar, Sofia ^a   Nechamkin, Yakov ^a   Roitman, Gregori ^a   Schreiber, Gabriel ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ADRENERGIC RECEPTOR STIMULATING AGENT; GUANINE NUCLEOTIDE BINDING PROTEIN; MUSCARINIC AGENT; POLYCLONAL ANTIBODY;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; ELECTROCONVULSIVE THERAPY; FEMALE; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MALE; MONOCYTE; PRIORITY JOURNAL;

EID: 0031968939     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.155.5.666     Document Type: Article

References (44)

1. Schatzberg AF, Schildkraut JJ: Recent studies on norepinephrine systems in mood disorders, in Psychopharmacology: The Fourth Generation of Progress. Edited by Bloom FE, Kupfer DJ. New York, Raven Press, 1995, pp 911-920
2. Janowsky DS, Overstreet DH: The role of acetylcholine mechanisms in mood disorders. Ibid, pp 945-956
3. Gilman AG: G proteins: transducers of receptor-generated signals. Annu Rev Biochem 1987; 56:615-649
4. Hepler JR, Gilman AG: G proteins. Trends Biochem Sci 1992; 17:383-387
5. Schreiber G, Avissar S, Danon A, Belmaker RH: Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol Psychiatry 1991; 29:273-280
6. Avissar S, Nechamkin Y, Barki-Harrington L, Roitman G, Schreiber G: Differential G protein measures in mononuclear leukocytes of patients with bipolar mood disorder are state dependent. J Affect Disord 1997; 43:85-93
7. s protein function and Gsα immunoreactivity in mononuclear leukocytes of patients with depression. Biol Psychiatry 1996; 39:755-760
8. Avissar S, Nechamkin Y, Roitman G, Schreiber G: Reduced G protein functions and immunoreactive levels in mononuclear leukocytes of patients with depression. Am J Psychiatry 1997; 154:211-217
9. Karege F, Bovier P, Stepanian R, Gaillard J-M: Change in platelet GTP-binding protein in drug-free depressed patients. Human Psychopharmacology 1996; 11:115-121
10. Friedman E, Wang HY: Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects. J Neurochem 1996; 67:1145-1152
11. sα subunit levels are elevated in bipolar affective disorder. Brain Res 1991; 553:323-326
12. s protein levels and forskolin-stimulated cyclic AMP formation are increased in bipolar affective disorder. J Neurochem 1993; 61:890-898
13. Avissar S, Schreiber G, Danon A, Belmaker RH: Lithium inhibits adrenergic and cholinergic increases in GTP binding in rat cortex. Nature 1988; 331:440-442
14. Avissar S, Schreiber G: Muscarinic receptor subclassification and G-proteins: significance for lithium action in affective disorders and for the treatment of the extrapyramidal side effects of neuroleptics. Biol Psychiatry 1989; 26:113-130
15. Avissar S, Murphy DL, Schreiber G: Magnesium reverses lithium inhibition of beta adrenergic and muscarinic receptor coupling to G proteins. Biochem Pharmacol 1991; 41:171-175
16. s protein function. Neuropharmacology 1990; 29:1067-1071
17. Avissar S, Schreiber G, Aulakh CS, Murphy DL: Carbamazepine and electroconvulsive shock attenuate beta-adrenoceptor and muscarinic cholinoceptor coupling to G proteins in rat cortex. Eur J Pharmacol (Mol Pharmacol) 1990; 100:99-103
18. Avissar S, Schreiber G: The involvement of G proteins in the pathogenesis and treatment of affective disorders. Biol Psychiatry 1992; 31:435-459
19. Avissar S, Schreiber G: Interaction of antibipolar and antidepressant treatments with receptor-coupled G proteins. Pharmacopsychiatry 1992; 25:44-50
20. Meyniel G, Doly M, Gaillard G: [Inhibition of transducin by lithium: electrophysiological demonstration using the isolated retina]. C R Acad Sci (III) 1989; 309:289-294 (French)
21. Mork A, Geisler A: Effects of GTP on hormone-stimulated adenylate cyclase activity in cerebral cortex, striatum and hippocampus from rats treated chronically with lithium. Biol Psychiatry 1989; 26:279-288
22. Newman ME, Shapira B, Lerer B: Effects of lithium and desipramine on second messenger responses in rat hippocampus: relation to G protein effects. Neuropharmacology 1991; 30:1297-1310
23. Manji HK, Bitran J, Masana M, Chen G, Hsiao JK, Risby ED, Rudorfer MW, Potter WZ: Signal transduction modulation by lithium: cell culture, cerebral microdialysis and human studies. Psychopharmacol Bull 1991; 27:199-208
24. Song L, Jope RS: Chronic lithium treatment impairs phosphatidylinositol hydrolysis in membranes from rat brain regions. J Neurochem 1992; 58:2200-2206
25. i-2 α subunit mRNA levels in rat cortex. Eur J Pharmacol (Mol Pharmacol) 1991; 206:165-166
26. iα protein in rat brain. Eur J Pharmacol (Mol Pharmacol) 1991; 207:355-359
27. Lerer B: Neurochemical and other neurobiological consequences of ECT: implications for the pathogenesis and treatment of affective disorders, in Psychopharmacology: The Third Generation of Progress. Edited by Meltzer HY. New York, Raven Press, 1987, pp 577-588
28. Sackeim HA, Devanand DP, Nobler MS: Electroconvulsive therapy, in Psychopharmacology: The Fourth Generation of Progress. Edited by Bloom FE, Kupfer DJ. New York, Raven Press, 1995, pp 1123-1141
29. Dubovsky SL: Electroconvulsive therapy, in Comprehensive Textbook of Psychiatry, 6th ed, vol 2. Edited by Kaplan HI, Sadock BJ. Baltimore, Williams & Wilkins, 1995, pp 2129-2140
30. McGowen S, Eastwood SL, Mead A, Burnet PWJ, Smith C, Flanigan TP, Harrison PJ: Hippocampal and cortical G protein (Gsα, Goα and Gi2α) mRNA expression after electroconvulsive shock or lithium carbonate treatment. Eur J Pharmacol 1996; 306:249-255
31. s to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs. J Neurochem 1991; 56:330-338
32. Newman ME, Solomon H, Lerer B: Electroconvulsive shock and cyclic AMP signal transduction: effects distal to the receptor. J Neurochem 1986; 46:1667-1669
33. Avissar S, Schreiber G: Measurement of early events in signal transduction beyond receptors involving G proteins function in mononuclear leukocytes. J Neuroimmunol 1996; 70:81-86
34. Roszman TL, Brooks WH: Neural modulation of immune function. J Neuroimmunol 1985; 10:59-69
35. Livnat S, Felten SY, Carlson SL, Bellinger DL, Felten DL: Involvement of peripheral and central catecholamine systems in neural immune interactions. J Neuroimmunol 1985; 10:5-30
36. Paraskevas F, Foerster J: The lymphocytes, in Wintrobe's Clinical Hematology, 9th ed, vol 1. Edited by Lee GR, Bithell TC, Foerster J, Athens JW, Lukens JN. London, Lea & Febiger, 1993, pp 354-430
37. Avissar S, Schreiber G: Antidepressant and antibipolar treatments effects on receptor-coupled G proteins measures in lymphocytes of patients with mood disorders (abstract). Neuropsychopharmacology 1994; 10(suppl):170S
38. Barki-Harrington L, Nechamkin Y, Schreiber G, Avissar S: Functional and quantitative measures of receptor-coupled G proteins in human mononuclear leukocytes: no change with age. Exp Gerontol 1996; 31:351-363
39. Pandey GN, Dysken MW, Garver DL, Davis JM: Beta-adrenergic receptor function in affective illness. Am J Psychiatry 1979; 136:675-678
40. Extein I, Tallman J, Smith CC, Goodwin FK: Changes in lymphocyte beta-adrenergic receptors in depression and mania. Psychiatry Res 1979; 1:191-197
41. Mann JJ, Brown RP, Halper JP, Sweeney JA, Kocsis JH, Stokes PE, Bilezikian JP: Reduced sensitivity of lymphocyte beta-adrenergic receptors in patients with endogenous depression and psychomotor agitation. N Engl J Med 1985; 313:715-720
42. Halper JP, Brown RP, Sweeney JA, Kocsis JH, Peters A, Mann JJ: Blunted β-adrenoceptor responsivity of peripheral blood mononuclear cells in endogenous depression: isoproterenol dose-response studies. Arch Gen Psychiatry 1988; 45:241-244
43. Ebstein RP, Lerer B, Shapira B, Shemesh Z, Moscovich DG, Kindler S: Cyclic AMP second-messenger signal amplification in depression. Br J Psychiatry 1988; 152:665-669
44. Ram A, Guedj F, Cravchik A, Weinstein L, Cao Q, Badner JA, Goldin LR, Grisaru N, Manji HK, Belmaker RH, Gershon ES, Gejman PV: No abnormality in the gene for the G protein stimulatory alpha subunit in patients with bipolar disorder. Arch Gen Psychiatry 1997; 54:44-48