Neuroimmunomodulation of natural killer (NK) cells by ergot alkaloid derivatives

Physiological Research

Volumn 46, Issue 2, 1997, Pages 119-125

  Fiserova A ^a   Kovaru H ^c   Hajduova Z ^c   Mares V ^b   Starec, M ^c   Kren V ^a   Flieger, M ^a   Pospisil M ^a  

^a INSTITUTE OF MICROBIOLOGY   (Czech Republic)

^b INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Ergot alkaloids; Natural killer cells; Neuroimmunomodulation

Indexed keywords

ADENYLATE CYCLASE; AGROCLAVINE; ELYMOCLAVINE; ERGOT ALKALOID; GLYCOSIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 2; LIPOSOME; MEMBRANE RECEPTOR; PHYTOHEMAGGLUTININ; PROTEIN SUBUNIT;

ANIMAL CELL; ASTROCYTE; CELLULAR IMMUNITY; CONFERENCE PAPER; CONTROLLED STUDY; CYTOTOXICITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; IMMUNOMODULATION; LYMPHOCYTE PROLIFERATION; NATURAL KILLER CELL; NONHUMAN; RAT; SIGNAL TRANSDUCTION; TUMOR REGRESSION;

ANIMALS; CELL DIVISION; CELLS, CULTURED; CLAVICEPS; CYTOTOXICITY, IMMUNOLOGIC; DRUG DELIVERY SYSTEMS; ERGOLINES; ERGOT ALKALOIDS; HUMANS; KILLER CELLS, NATURAL; LIPOSOMES; MICE; MONOCYTES; NEUROIMMUNOMODULATION; OLIGOSACCHARIDES; RATS; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0030986594     PISSN: 08628408     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (28)

1. AARONS R.D., NIES A.S., GERBER J.G., MOLINOFF P.B.: Decreased β-adrenergic receptor density on human lymphocytes after chronic treatment with agonists. J. Pharmacol. Exp. Ther. 224: 1-6, 1983.
2. BEZOUŠKA K., VLAHAS G., HORVÁTH O., JINOCHOVÁ G., FIŠEROVÁ A., GIORDA R., CHAMBERS W.H., FEIZI T., POSPÍŠIL M.: Rat natural killer cell antigen, NKR-P1, related to C-type animal lectins is a carbohydrate-binding protein. J. Biol. Chem. 269: 16945-16952, 1994a.
3. BEZOUŠKA K., YUEN C.T., O'BRIEN J., CHILDS R.A., CHAI W., LAWSON A.M., DRBAL K., FIŠEROVÁ A., POSPÍŠIL M., FEIZI T.: Oligosaccharide ligands for NKR-P1 protein activate NK cells and cytotoxicity. Nature 372: 150-157, 1994b.
4. CHELMICKA-SCHORR E., ARNASON B.G.: Nervous system-immune system interactions. In: Immunologic Mechanisms in Neurologic and Psychiatric Disease, Vol. 68, B.H. WAKSMAN (ed.), 1990, pp. 67-90.
5. DAVIS J.R.E., BIDEY P., TOMLINSON S.: Signal transduction in endocrine tissue. Clin. Endocrinol. 36: 437-449, 1992.
6. DELEPLAQUE B., VITIELO S., LE-MOAL M., NEVEN P.J.: Modulation of immune reactivity by unilateral striatal and mesolimbic dopaminergic lesions. Neurosci. Lett. 166: 216-220, 1994.
7. EICH E., PERTZ H.: Ergot alkaloids as lead structures for differential receptor systems. Pharmazie 49:867-877, 1994.
8. 3H]-dopamine to human lymphocytes: possible relationship to neurotransmitter uptake sites. Pharmacology 42: 135-141, 1991.
9. FIŠEROVÁ A., KOVÁŘŮ H., HAJDUOVÁ Z., MAREŠ V., KŘEN V., FLIEGER M., POSPÍŠIL M.: Neuroimmunomodulation of natural killer (NK) cells by ergot alkaloid derivatives. Physiol. Res. 45: 2P, 1996.
10. FIŠEROVÁ A., TRINCHIERI G., CHAN S., BEZOUŠKA K., FLIEGER M., POSPÍŠIL M.: Ergot alkaloids induced cell proliferation, cytotoxicity and lymphokine production. Adv. Exp. Med. Biol. 371A: 163-166, 1995a.
11. FIŠEROVÁ A., KŘEN V., AUGÉ C., ŠÍMA P., POSPÍŠIL M.: Ergot alkaloid derivatives with immunomodulatory activities. Proc. Int. Conf. on Experimental, Therapeutic and Toxic Manipulation of Host Defence System, Hradec Králové, 1995b, p. 67-73.
12. GOLDSMITH P., GIERSCHIK P., MILLIGAN G., UNSON C.G., VINITSKY R., MALECH H.L., SPIEGEL A.M.: Antibodies directed against synthetic peptides distinguish between GTP-binding proteins in neutrophiles and brain. J. Biol. Chem. 262: 14683-14688, 1987.
13. HADDEN J.W.: Neuroendocrine modulation of the thymus-dependent immune system. Agonists and mechanisms. Ann. N.Y. Acad. Sci. 49: 39-48, 1987.
14. HELLSTRAND K., HERMODSSON S.: An immunopharmacological analysis of adrenaline-induced suppression of human natural killer cell cytotoxicity. Int. Arch. Allergy Appl. Immunol. 89: 334-341, 1989.
15. 1A receptors. Cell. Immunol. 127: 199-214, 1990
16. HELLSTRAND K., ASEA A., HERMODSSON S.: Role of histamine in natural killer cell-mediated resistance against tumor cells. J. Immunol. 145: 4365-4370, 1990.
17. KOVÁŘŮ H., FIŠEROVÁ A., LISÁ V., KOVÁŘŮ F., FIŠAR Z., ŽIŽKOVSKÝ V., MALBOHAN L., DOBROVSKÝ K.: Antidepressant effects on expression of G-protein alpha-subunits in C-6 glioma cells and natural killer (NK) lymphocytes. Physiol Res. 45: 3P, 1996.
18. KŘEN V., ŠČIGELOVÁ M., PŘIKRYLOVÁ V., HAVLÍČEK V., SEDMERA P.: Enzymatic preparation of β-N-acetyl hexosaminides of ergot alkaloids. Biocatalysis 10: 181-193, 1994.
19. KŘEN V., FIŠEROVÁ A., AUGÉ C., SEDMERA P., HAVLÍČEK V., ŠÍMA P.: Ergot alkaloid glycosides with immunomodulatory activities. Bioorg. Med. Chem. 4: 869-876, 1996.
20. MARX J.: Two major signal pathway linked. Science 262: 12, 988-999, 1993.
21. MULLER-SCHWEINITZER E., WEIDMANN H.: Basic pharmacological properties. B. BERDE, H.O. SCHILD (eds), In: Ergot Alkaloids and Related Compounds. Handbook of Experimental Pharmacology, Vol. 49, Springer, Berlin, 1987, pp. 87-139.
22. PERUSSIA B., RAMONI C., ANEGON I., CUTURI M.C., FAUST J., TRINCHIERI G.: Preferential proliferation of natural killer cells among peripheral blood mononuclear cells cocultured with B lymphoblastoid cell lines. Nat. Immun. Cell Growth Regul. 6: 171-188, 1987.
23. RANSNÄS L.A., INSEL P.A.: Quantitation of a guanine nucleotide binding regulatory protein by an enzyme-linked immunosorbent competition assay. Anal. Biochem. 176: 185-190, 1989.
24. 2-adrenergic receptor to the inhibitory G-protein G(i) and adenylate cyclase in HT29 cells. Biochem. J. 292: 283-288, 1993.
25. SINGH U.: Lymphopoiesis in the nude fetal thymus following sympathectomy. Cell. Immunol. 93: 222-228, 1985.
26. SINGH U., FATANI J.A., MOHAJIR A.M.: Ontogeny of cholinergic innervation of thymus in mouse. Dev. Comp. Immunol. 11: 627-635, 1987.
27. TRINCHIERI G.: Biology of natural killer cells. Adv. Immunol. 47: 187-376, 1989.
28. VAAGE J., MAYHEW E., LASIC D., MARTIN F.: Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes. Int. J. Cancer 51: 942-894, 1992.