Radiosynthesis and biodistribution in mice of a 18F-labeled analog of O-1302 for use in cerebral CB1 cannabinoid receptor imaging

Biological and Pharmaceutical Bulletin

Volumn 31, Issue 6, 2008, Pages 1274-1278

  Nojiri, Yumiko ^a   Ishiwata, Kiichi ^b   Qinggeletu, ^b   Tobiishi, Shintaro ^a   Sasada, Toru ^b   Yamamoto, Fumihiko ^a   Mukai, Takahiro ^a   Maeda, Minoru ^a  

^a KYUSHU UNIVERSITY   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Brain distribution; CB1 cannabinoid ligand; Fluorine 18; Radiopharmaceutical

Indexed keywords

ACETONITRILE; CANNABINOID 1 RECEPTOR; CYCLOSPORIN A; FLUORINE 18; GLYCOPROTEIN P; N (PIPERIDIN 1 YL) 1 (2,4 DICHLOROPHENYL) 4 METHYL 5 [4' (5 4 TOLUENESULFONYLOXYPENTYL)PHENYL] 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; N (PIPERIDIN 1 YL) 1 (2,4 DICHLOROPHENYL) 4 METHYL 5 [4' (5 FLUOROPENTYL)PHENYL] 1H PYRAZOLE 3 CARBOXAMIDE F 18; N (PIPERIDIN 1 YL) 1 (2,4 DICHLOROPHENYL) 5 [4' (5 FLUOROPENTYL)PHENYL] 4 METHYL 1H PYRAZOLE 3 CARBOXAMIDE; O 1302; RIMONABANT; TRACER;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD BRAIN BARRIER; BRAIN REGION; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BINDING; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG UPTAKE; LIPOPHILICITY; MALE; MOUSE; NEUROIMAGING; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PROTEIN FUNCTION; TISSUE DISTRIBUTION;

ANIMALS; BIOTRANSFORMATION; BRAIN; CHROMATOGRAPHY, THIN LAYER; CYCLOSPORINE; FLUORINE RADIOISOTOPES; IMMUNOSUPPRESSIVE AGENTS; INDICATORS AND REAGENTS; INJECTIONS, INTRAVENOUS; ISOTOPE LABELING; MALE; MICE; PIPERIDINES; PYRAZOLES; RADIOPHARMACEUTICALS; RECEPTOR, CANNABINOID, CB1; TISSUE DISTRIBUTION;

EID: 45749083409     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.31.1274     Document Type: Article

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