Synthesis and kinetic analysis of some phosphonate analogs of cyclophostin as inhibitors of human acetylcholinesterase

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2265-2274

  Dutta, Supratik ^a   Malla, Raj K ^b   Bandyopadhyay, Saibal ^b   Spilling, Christopher D ^b   Dupureur, Cynthia M ^a  

^a UNIVERSITY OF MISSOURI ST LOUIS   (United States)

^b UNIVERSITY OF MISSOURI ST LOUIS   (United States)

Author keywords

Acetylcholinesterase; Cyclic phosphonate; Inhibitor

Indexed keywords

ACETYLCHOLINESTERASE; CHOLINESTERASE INHIBITOR; CYCLOPHOSTIN; CYCLOPHOSTIN DERIVATIVE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; PARAOXON; PHOSPHONIC ACID DERIVATIVE; PRALIDOXIME; SOMAN; TABUN; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; ENZYME INHIBITOR INTERACTION; HUMAN; IC 50; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; BINDING SITES; CHOLINESTERASE INHIBITORS; HUMANS; KINETICS; MASS SPECTROMETRY; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; PHOSPHONIC ACIDS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77649231880     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.063     Document Type: Article

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