Synthesis, radiofluorination, and hypoxia-selective studies of FRAZ: A configurational and positional analogue of the clinical hypoxia marker, [18F]-FAZA

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 6, 2010, Pages 2255-2264

  Kumar, Piyush ^a   Naimi, Ebrahim ^a   McEwan, Alexander J ^a   Wiebe, Leonard I ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Azomycin nucleoside based radiosensitizer; FRAZ; Positron emission tomography (PET); Tumor hypoxia

Indexed keywords

1 ALPHA DEXTRO (2 DEOXY 2 FLUORORIBOFURANOSYL) 2 NITROIMIDAZOLE F 18; RADIOPHARMACEUTICAL AGENT; RADIOSENSITIZING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CANCER SCINTISCANNING; CARBON NUCLEAR MAGNETIC RESONANCE; CELL HYPOXIA; COLORECTAL CANCER; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; FLUORINATION; FLUORINE NUCLEAR MAGNETIC RESONANCE; HUMAN; HUMAN CELL; ISOTOPE LABELING; MOUSE; NONHUMAN; PARTITION COEFFICIENT; POSITRON EMISSION TOMOGRAPHY; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS;

ANOXIA; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DRUG SCREENING ASSAYS, ANTITUMOR; FLUORINE RADIOISOTOPES; HUMANS; ISOTOPE LABELING; NITROIMIDAZOLES; POSITRON-EMISSION TOMOGRAPHY; RIBOSE; TUMOR MARKERS, BIOLOGICAL;

EID: 77649231321     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.064     Document Type: Article

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