Antibodies to the desmoglein 1 precursor proprotein but not to the mature cell surface protein cloned from individuals without pemphigus

Journal of Immunology

Volumn 183, Issue 9, 2009, Pages 5615-5621

  Yamagami, Jun ^a   Kacir, Stephen ^a   Ishii, Ken ^a   Payne, Aimee S ^a   Siegel, Don L ^a   Stanley, John R ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CELL SURFACE PROTEIN; COMPLEMENTARY DNA; DESMOGLEIN 1 ANTIBODY; MONOCLONAL ANTIBODY; PROTEIN PRECURSOR;

ARTICLE; AUTOIMMUNITY; CELL CLONING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN TISSUE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; KERATINOCYTE; PEMPHIGUS; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SKIN CULTURE; SOMATIC HYPERMUTATION; THROMBOTIC THROMBOCYTOPENIC PURPURA;

ANTIBODIES, MONOCLONAL; ANTIBODY SPECIFICITY; AUTOANTIBODIES; CLONING, MOLECULAR; DESMOGLEIN 1; HUMANS; IMMUNE TOLERANCE; MEMBRANE PROTEINS; PEMPHIGUS; PROTEIN PRECURSORS; PURPURA, THROMBOTIC THROMBOCYTOPENIC;

EID: 77649212308     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901691     Document Type: Article

References (35)

1. Stanley, J. R., and M. Amagai. 2006. Pemphigus, bullous impetigo, and staphylococcal scalded skin syndrome. N. Engl. J. Med. 355: 1800-1810.
2. Eyre, R. W., and J. R. Stanley. 1987. Human autoantibodies against a desmosomal protein complex with a calcium-sensitive epitope are characteristic of pemphigus foliaceus patients. J. Exp. Med. 165: 1719-1724.
3. Koulu, L., A. Kusumi, M. S. Steinberg, V. Klaus Kovtun, and J. R. Stanley. 1984. Human autoantibodies against a desmosomal core protein in pemphigus foliaceus. J. Exp. Med. 160: 1509-1518.
4. Posthaus, H., C. M. Dubois, and E. Muller. 2003. Novel insights into cadherin processing by subtilisin-like convertases. FEBS Lett. 536: 203-208.
5. Wahl, J. K., III, Y. J. Kim, J. M. Cullen, K. R. Johnson, and M. J. Wheelock. 2003. N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J. Biol. Chem. 278: 17269-17276.
6. Hashimoto, K., K. M. Shafran, P. S. Webber, G. S. Lazarus, and K. H. Singer. 1983. Anti-cell surface pemphigus autoantibody stimulates plasminogen activator activity of human epidermal cells. J. Exp. Med. 157: 259-272.
7. Roscoe, J. T., L. Diaz, S. A. Sampaio, R. M. Castro, R. S. Labib, Y. Takahashi, H. Patel, and G. J. Anhalt. 1985. Brazilian pemphigus foliaceus autoantibodies are pathogenic to BALB/c mice by passive transfer. J. Invest. Dermatol. 85: 538-541.
8. Rock, B., C. R. Martins, A. N. Theofilopoulos, R. S. Balderas, G. J. Anhalt, R. S. Labib, S. Futamura, E. A. Rivitti, and L. A. Diaz. 1989. The pathogenic effect of IgG4 autoantibodies in endemic pemphigus foliaceus (fogo selvagem). N. Engl. J. Med. 320: 1463-1469.
9. Ishii, K., C. Lin, D. L. Siegel, and J. R. Stanley. 2008. Isolation of pathogenic monoclonal anti-desmoglein 1 human antibodies by phage display of pemphigus foliaceus autoantibodies. J. Invest. Dermatol. 128: 939-948.
10. Yokouchi, M., M. A. Saleh, K. Kuroda, T. Hachiya, J. R. Stanley, M. Amagai, and K. Ishii. 2009. Pathogenic epitopes of autoantibodies in pemphigus reside in the amino-terminal adhesive region of desmogleins which are unmasked by proteolytic processing of prosequence. J. Invest. Dermatol. 129: 2156-2166.
11. Hanakawa, Y., N. Schechter, C. Lin, L. Garza, H. Li, T. Yamaguchi, Y. Fudaba, K. Nishifuji, M. Sugai, M. Amagai, and J. R. Stanley. 2002. Molecular mechanisms of blister formation in bullous impetigo and staphylococcal scalded skin syndrome. J. Clin. Invest. 110: 53-60.
12. Barbas, C. F. I., D. R. Burton, J. K. Scott, and G. J. Silverman. 2001. Phage Display: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
13. Payne, A. S., K. Ishii, S. Kacir, C. Lin, H. Li, Y. Hanakawa, K. Tsunoda, M. Amagai, J. R. Stanley, and D. L. Siegel. 2005. Genetic and functional characterization of human pemphigus vulgaris monoclonal autoantibodies isolated by phage display. J. Clin. Invest. 115: 888-899.
14. Ishii, K., M. Amagai, R. P. Hall, T. Hashimoto, A. Takayanagi, S. Gamou, N. Shimizu, and T. Nishikawa. 1997. Characterization of autoantibodies in pemphigus using antigen-specific enzyme-linked immunosorbent assays with baculovirus-expressed recombinant desmogleins. J. Immunol. 159: 2010-2017.
15. Payne, A. S., D. L. Siegel, and J. R. Stanley. 2007. Targeting pemphigus autoantibodies through their heavy-chain variable region genes. J. Invest. Dermatol. 127: 1681-1691.
16. Basu, U., J. Chaudhuri, C. Alpert, S. Dutt, S. Ranganath, G. Li, J. P. Schrum, J. P. Manis, and F. W. Alt. 2005. The AID antibody diversification enzyme is regulated by protein kinase A phosphorylation. Nature 438: 508-511.
17. Baumgarth, N., O. C. Herman, G. C. Jager, L. Brown, L. A. Herzenberg, and L. A. Herzenberg. 1999. Innate and acquired humoral immunities to influenza virus are mediated by distinct arms of the immune system. Proc. Natl. Acad. Sci. USA 96: 2250-2255.
18. McKean, D., K. Huppi, M. Bell, L. Staudt, W. Gerhard, and M. Weigert. 1984. Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin. Proc. Natl. Acad. Sci. USA 81: 3180-3184. (Pubitemid 14110702)
19. HH by mutational hotspot randomization. J. Immunol. Methods 297: 213-224.
20. Chang, T. Y., and D. L. Siegel. 1998. Genetic and immunological properties of phage-displayed human anti-Rh(D) antibodies: implications for Rh(D) epitope topology. Blood 91: 3066-3078.
21. Roark, J. H., J. B. Bussel, D. B. Cines, and D. L. Siegel. 2002. Genetic analysis of autoantibodies in idiopathic thrombocytopenic purpura reveals evidence of clonal expansion and somatic mutation. Blood 100: 1388-1398.
22. Lacroix-Desmazes, S., S. V. Kaveri, L. Mouthon, A. Ayouba, E. Malanchere, A. Coutinho, and M. D. Kazatchkine. 1998. Self-reactive antibodies (natural autoantibodies) in healthy individuals. J. Immunol. Methods 216: 117-137.
23. Mouthon, L., A. Nobrega, N. Nicolas, S. V. Kaveri, C. Barreau, A. Coutinho, and M. D. Kazatchkine. 1995. Invariance and restriction toward a limited set of self-antigens characterize neonatal IgM antibody repertoires and prevail in autoreactive repertoires of healthy adults. Proc. Natl. Acad. Sci. USA 92: 3839-3843.
24. Avrameas, S., T. Ternynck, I. A. Tsonis, and P. Lymberi. 2007. Naturally occurring B-cell autoreactivity: a critical overview. J. Autoimmun. 29: 213-218.
25. Wardemann, H., S. Yurasov, A. Schaefer, J. W. Young, E. Meffre, and M. C. Nussenzweig. 2003. Predominant autoantibody production by early human B cell precursors. Science 301: 1374-1377.
26. Goodnow, C. C., J. Sprent, B. Fazekas de St. Groth, and C. G. Vinuesa. 2005. Cellular and genetic mechanisms of self tolerance and autoimmunity. Nature 435: 590-597.
27. Julien, S., P. Soulas, J. C. Garaud, T. Martin, and J. L. Pasquali. 2002. B cell positive selection by soluble self-antigen. J. Immunol. 169: 4198-4204.
28. Soulas, P., A. Woods, B. Jaulhac, A. M. Knapp, J. L. Pasquali, T. Martin, and A. S. Korganow. 2005. Autoantigen, innate immunity, and T cells cooperate to break B cell tolerance during bacterial infection. J. Clin. Invest. 115: 2257-2267.
29. Mo, J. A., and R. Holmdahl. 1996. The B cell response to autologous type II collagen: biased V gene repertoire with V gene sharing and epitope shift. J. Immunol. 157: 2440-2448.
30. Mukherjee, J., G. Nussbaum, M. D. Scharff, and A. Casadevall. 1995. Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell. J. Exp. Med. 181: 405-409.
31. Shlomchik, M. J., J. E. Craft, and M. J. Mamula. 2001. From T to B and back again: positive feedback in systemic autoimmune disease. Nat. Rev. Immunol. 1: 147-153.
32. Panigrahi, A. K., N. G. Goodman, R. A. Eisenberg, M. R. Rickels, A. Naji, and E. T. Luning Prak. 2008. RS rearrangement frequency as a marker of receptor editing in lupus and type 1 diabetes. J. Exp. Med. 205: 2985-2994.
33. Veldman, C. M., K. L. Gebhard, W. Uter, R. Wassmuth, J. Grotzinger, E. Schultz, and M. Hertl. 2004. T cell recognition of desmoglein 3 peptides in patients with pemphigus vulgaris and healthy individuals. J. Immunol. 172: 3883-3892.
34. Hertl, M., R. Eming, and C. Veldman. 2006. T cell control in autoimmune bullous skin disorders. J. Clin. Invest. 116: 1159-1166.
35. Mouquet, H., S. Farci, P. Joly, B. Maillere, J. Leblond, L. Drouot, J. Leprince, M. C. Tonon, P. Loiseau, D. Charron, et al. 2006. A truncated alternative spliced isoform of human desmoglein 1 contains a specific T cell epitope binding to the pemphigus foliaceus-associated HLA class II DRβ1*0102 molecule. J. Immunol. 177: 6517-6526.