Photorhabdus luminescens toxins adp-ribosylate actin and rhoa to force actin clustering

Science

Volumn 327, Issue 5969, 2010, Pages 1139-1142

  Lang, Alexander E ^a,b   Schmidt, Gudula ^a   Schlosser, Andreas ^b   Hey, Timothy D ^c   Larrinua, Ignacio M ^c   Sheets, Joel J ^c   Mannherz, Hans G ^d,e   Aktories, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY OF FREIBURG   (Germany)

^c Discovery Research   (United States)

^d MAX PLANCK INSTITUTE OF MOLECULAR PHYSIOLOGY   (Germany)

^e RUHR UNIVERSITY BOCHUM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; ADENOSINE DIPHOSPHATE RIBOSE; AMINO ACID; BACTERIAL TOXIN; GLUTAMINE; PHOTORHABDUS LUMINESCENS TOXIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID; BACTERIUM; ENZYME ACTIVITY; NEMATODE; POLYMERIZATION; PROTEIN; TOXIN;

ACTIN POLYMERIZATION; ARTICLE; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; INSECT CELL; MOLECULAR MECHANICS; PHAGOCYTOSIS; PHOTORHABDUS LUMINESCENS; PRIORITY JOURNAL;

ACTINS; ADENOSINE DIPHOSPHATE RIBOSE; ADP RIBOSE TRANSFERASES; ANIMALS; BACTERIAL TOXINS; CELL LINE; GLUTAMINE; HELA CELLS; HEMOCYTES; HUMANS; MOTHS; PHAGOCYTOSIS; PHOTORHABDUS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; STRESS FIBERS; THREONINE; THYMOSIN;

BACTERIA (MICROORGANISMS); HEXAPODA; NEMATODA; PHOTORHABDUS LUMINESCENS;

EID: 77649193972     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1184557     Document Type: Article

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25. We thank Agilent Technologies for supporting us with instrumentation, R. S. Goody (Dortmund, Germany) for help in stopped-flow measurements, and M. Geyer (Dortmund, Germany) for providing profilin. The study was financially supported by the Deutsche Forschungsgemeinschaft DFG to K.A. and H.G.M.