Synthesis and anti-inflammatory evaluation of some condensed [4-(3,4-dimethylphenyl)-1(2H)-oxo-phthalazin-2-yl]acetic acid hydrazide

European Journal of Medicinal Chemistry

Volumn 45, Issue 4, 2010, Pages 1267-1277

  Abd alla, Mosaad S M ^a   Hegab, Mohamed I ^b   Abo Taleb, Nageh A ^a   Hasabelnaby, Sherifa M ^a   Goudah, A ^c  

^a Helwan   (Egypt)

^b NATIONAL RESEARCH CENTRE   (Egypt)

^c Cairo University   (Egypt)

Author keywords

1(2H) Oxo phthalazine; 1,3,4 Oxadiazole; 1,3,4 Triazole; 1,34 Thiadiazol; Anti inflammatory; Pyrazole

Indexed keywords

1 [2 [4 (3,4 DIMETHYLPHENYL) 1 OXOPHTHALAZIN 2(1H) YL]ACETYL] 4 BENZYLTHIOSEMICARBAZIDE; 1 [2 [4 (3,4 DIMETHYLPHENYL) 1 OXOPHTHALAZIN 2(1H) YL]ACETYL] 4 ETHYLSEMICARBAZIDE; 1 [2 [4 (3,4 DIMETHYLPHENYL) 1 OXOPHTHALAZIN 2(1H) YL]ACETYL] 4 METHYLTHIOSEMICARBAZIDE; 1 [2 [4 (3,4 DIMETHYLPHENYL) 1 OXOPHTHALAZIN 2(1H) YL]ACETYL] 4 PHENYLSEMICARBAZIDE; 1 [2 [4 (3,4 DIMETHYLPHENYL) 1 OXOPHTHALAZIN 2(1H) YL]ACETYL] 4 PHENYLTHIOSEMICARBAZIDE; 1 [2 [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]ACETYL]THIOSEMICARBAZIDE; 2 [(5 MERCAPTO 4 BENZYL 4H 1,2,4 TRIAZOL 3 YL)METHYL] 4 (3,4 DIMETHYLPHENYL)PHTHALAZIN 1(2H) ONE; 2 [(5 MERCAPTO 4 METHYL 4H 1,2,4 TRIAZOL 3 YL)METHYL] 4 (3,4 DIMETHYLPHENYL)PHTHALAZIN 1(2H) ONE; 2 [(5 MERCAPTO 4 PHENYL 4H 1,2,4 TRIAZOL 3 YL)METHYL] 4 (3,4 DIMETHYLPHENYL)PHTHALAZIN 1(2H) ONE; 2 [(5 MERCAPTO 4H 1,2,4 TRIAZOL 3 YL)METHYL] 4 (3,4 DIMETHYLPHENYL)PHTHALAZIN 1(2H) ONE; 2 [(6 METHYL 7H PYRAZOLO[5,1 C][1,2,4]TRIAZOL 3 YL)METHYL] 4 (3,4 DIMETHYLPHENYL)PHTHALAZIN 1(2H) ONE; 2 [2 (3,5 DIMETHYL 1H PYRAZOL 1 YL) 2 OXOETHYL] 4 (3,4 DIMETHYLPHENYL)PHTHALAZIN 1(2H) ONE; 4 (3,4 DIMETHYL) 2 [(5 BENZYLAMINO 1,3,4 THIADIAZOL 2 YL)METHYL]PHTHALAZIN 1(2H) ONE; 4 (3,4 DIMETHYL) 2 [(5 METHYLAMINO 1,3,4 THIADIAZOL 2 YL)METHYL]PHTHALAZIN 1(2H) ONE; 4 (3,4 DIMETHYL) 2 [(5 PHENYLAMINO 1,3,4 THIADIAZOL 2 YL)METHYL]PHTHALAZIN 1(2H) ONE; 4 (3,4 DIMETHYLPHENYL) 2 [(4,5 DIHYDRO 5 THIOOXO 1,3,4 OXADIAZOL 2 YL)METHYL]PHTHALAZIN 1(2H) ONE; 5 [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]METHYL 1,2,4 TRIAZOL 3 ONE; 5 METHYL 3 OXO 2 [1' (2H) OXO 4' (3,4 DIMETHYLPHENYL)PHTHALAZIN 2' YLMETHYLCARBONYL] 3,4 DIHYDROPYRAZOL; [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]ACETIC ACID (1 FURYLMETHYLIDENE)HYDRAZIDE; [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]ACETIC ACID [(2 HYDROXYPHENYL)METHYLIDENEHYDRAZIDE]; [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]ACETIC ACID [(2 METHOXYPHENYL)METHYLIDENEHYDRAZIDE]; [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]ACETIC ACID [1 (2 CHLOROPHENYL)METHYLIDENEHYDRAZIDE]; [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]ACETIC ACID [1 (3,4,5 TRIMETHOXYPHENYL)METHYLIDENEHYDRAZIDE]; ANTIINFLAMMATORY AGENT; INDOMETACIN; N ACETYL 1 [2 [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]ACETO]HYDRAZIDE; N BENZOYL 1 [2 [4 (3,4 DIMETHYLPHENYL) 1(2H) OXO PHTHALAZIN 2 YL]ACETO]HYDRAZIDE; N' (2 CYANOETHYL) 2 [4 (3,4 DIMETHYLPHENYL) 1 OXOPHTHALAZIN 2(1H) YL]ACETOHYDRAZIDE; N' (ETHOXYMETHYLENE) 2 [4 (3,4 DIMETHYLPHENYL) 1 OXOPHTHALAZIN 2(1H) YL]ACETOHYDRAZIDE; N',N' DIACETYL 2 [4 (3,4 DIMETHYLPHENYL) 1 OXOPHTHALAZIN 2(1H) YL]ACETOHYDRAZIDE; UNCLASSIFIED DRUG;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; NONHUMAN; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ANTI-INFLAMMATORY AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; PHTHALAZINES; SPECTROPHOTOMETRY, INFRARED;

EID: 77649189038     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2009.10.028     Document Type: Article

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