Novel phthalazinone and benzoxazinone containing thiazolidinediones as antidiabetic and hypolipidemic agents

European Journal of Medicinal Chemistry

Volumn 36, Issue 7-8, 2001, Pages 627-637

  Madhavan, Gurram R ^a   Chakrabarti, Ranjan ^a   Kumar, Sunil K B ^a   Misra, Parimal ^a   Mamidi, Rao N V S ^a   Balraju, V ^a   Kasiram, Katneni ^a   Babu, Ravi K ^a   Suresh, Juluri ^a   Lohray, Braj B ^a   Lohray, Vidya B ^a   Iqbal, Javed ^a   Rajagopalan, Ramanujam ^a  

^a DR REDDY S RESEARCH FOUNDATION   (India)

Author keywords

Benzoxazinone; Diabetes mellitus; Insulin resistance; Phthalazinone; Plasma glucose; PPAR ; Thiazolidinedione; Triglyceride lowering

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; 5 [4 [2 (1 OXO 1,2 DIHYDROPHTHALAZIN 2 YL)ETHOXY]PHENYLMETHYL]THIAZOLIDIN 2,4 DIONE; 5 [4 [2 (1 OXO 1,2 DIHYDROPHTHALAZIN 2 YL)ETHOXY]PHENYLMETHYLENE]THIAZOLIDIN 2,4 DIONE; 5 [4 [2 (2,3 BENZOXAZIN 4 ONE 2 YL)ETHOXY]PHENYLMETHYL]THIAZOLIDIN 2,4 DIONE DERIVATIVE; 5 [4 [2 (4 ETHYL 1 OXO 1,2 DIHYDROPHTHALAZIN 2 YL)ETHOXY]PHENYLMETHYL]THIAZOLIDIN 2,4 DIONE; 5 [4 [2 (4 ETHYL 1,2 DIHYDROPHTHALAZIN 2 YL)ETHOXY]PHENYLMETHYLENE]THIAZOLIDIN 2,4 DIONE; 5 [4 [2 (4 METHYL 1 OXO 1,2 DIHYDROPHTHALAZIN 2 YL)ETHOXY]PHENYLMETHYL]THIAZOLIDIN 2,4 DIONE; 5 [4 [2 (4 METHYL 1 OXO 1,2 DIHYDROPHTHALAZIN 2 YL)ETHOXY]PHENYLMETHYLENE]THIAZOLIDIN 2,4 DIONE; 5 [4 [2 (4 PHENYL 1 OXO 1,2 DIHYDROPHTHALAZIN 2 YL)ETHOXY]PHENYLMETHYL]THIAZOLIDIN 2,4 DIONE; 5 [4 [2 (4 PHENYL 1 OXO 1,2 DIHYDROPHTHALAZIN 2 YL)ETHOXY]PHENYLMETHYLENE]THIAZOLIDIN 2,4 DIONE; BENZOXAZINONE DERIVATIVE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHTHALAZINE DERIVATIVE; PIOGLITAZONE; ROSIGLITAZONE; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSAY; CHEMICAL REACTION; CHRONIC TOXICITY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; EXPOSURE; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN CELL; INSULIN RESISTANCE; MALE; MOUSE; NONHUMAN; RAT; REACTION ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

ANIMALS; ANTILIPEMIC AGENTS; BLOOD GLUCOSE; CELL LINE; CHROMANS; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; HYPOGLYCEMIC AGENTS; MALE; MICE; MICE, INBRED C57BL; OXAZINES; PHTHALAZINES; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 0035415402     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(01)01257-0     Document Type: Article

References (23)

1. Liver damage warnings for troglitazone
2. NIH abandons Rezulin in diabetes trial