In vitro assessment of cytochrome P450 inhibition and induction potential of azacitidine

Cancer Chemotherapy and Pharmacology

Volumn 65, Issue 5, 2010, Pages 995-1000

  Chen, Yong ^a   Liu, Lisa ^a   Laille, Eric ^a   Kumar, Gondi ^a   Surapaneni, Sekhar ^a  

^a CELGENE CORPORATION   (United States)

Author keywords

Azacitidine; CYP induction; CYP inhibition; Cytochrome P450; Drug drug interactions

Indexed keywords

AZACITIDINE; CYTOCHROME P450; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5;

ARTICLE; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG INHIBITION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; LIVER CELL; LIVER MICROSOME; PRIORITY JOURNAL;

ANTIMETABOLITES, ANTINEOPLASTIC; AZACITIDINE; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; ENZYME INHIBITORS; HEPATOCYTES; HUMANS; MICROSOMES, LIVER;

EID: 77649186121     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-010-1245-9     Document Type: Article

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