Elevated lactate in ethylene glycol poisoning: True or false?

Clinica Chimica Acta

Volumn 411, Issue 7-8, 2010, Pages 601-604

  Meng, Qing H ^a   Adeli, Khosrow ^b   Zello, Gordon A ^c   Porter, William H ^d   Krahn, John ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF SASKATCHEWAN   (Canada)

^d UNIVERSITY OF KENTUCKY MEDICAL CENTER   (United States)

Author keywords

Blood gas analyzer; Ethylene glycol; Glycolic acid; Interference; Lactate

Indexed keywords

4 METHYLPYRAZOLE; ETHYLENE GLYCOL; GLYCOLIC ACID; LACTIC ACID;

ADULT; AGED; ALCOHOL BLOOD LEVEL; ALCOHOL CONSUMPTION; ALCOHOL INTOXICATION; ANALYZER; ANAMNESIS; ARTICLE; BLOOD CHEMISTRY; BLOOD GAS ANALYSIS; CASE REPORT; CONTROLLED STUDY; DIALYSIS; DIFFERENTIAL DIAGNOSIS; FALSE POSITIVE RESULT; HUMAN; INTERMETHOD COMPARISON; LACTATE BLOOD LEVEL; MALE; PRIORITY JOURNAL;

AGED; ETHYLENE GLYCOL; FALSE POSITIVE REACTIONS; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; GLYCOLATES; HUMANS; LACTIC ACID; MALE; MIDDLE AGED;

EID: 77649184433     PISSN: 00098981     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cca.2010.01.003     Document Type: Article

References (18)

1. Takayesu J.K., Bazari H., Linshaw M. Case records of the Massachusetts General Hospital. Case 7-2006. A 47-year-old man with altered mental status and acute renal failure. N Engl J Med 2006, 354:1065-1072.
2. Porter W.H., Crellin M., Rutter P.W., Oeltgen P. Interference by glycolic acid in the Beckman synchron method for lactate: a useful clue for unsuspected ethylene glycol intoxication. Clin Chem 2000, 46:874-875.
3. Woo M.Y., Greenway D.C., Nadler S.P., Cardinal P. Artifactual increase of lactate in ethylene glycol poisoning. J Emerg Med 2003, 25:289-293.
4. Lindsay S., Akhtar J., Krenzelok E.P., Brooks D. Artifactual increase of plasma L-lactate in the presence of glycolate-a potential for misdiagnosis. J Toxicol Clin Toxicol 2003, 41:476.
5. Brindley P.G., Butler M.S., Cembrowski G., Brindley D.N. Falsely elevated point-of-care lactate measurement after ingestion of ethylene glycol. CMAJ 2007, 176:1097-1099.
6. Pernet P., Bénéteau-Burnat B., Vaubourdolle M., Maury E., Offenstadt G. False increase of blood lactate reveals ethylene glycol poisoning. Am J Emerg Med 2009, 27:132.e1-132.e2.
7. Verelst S., Vermeersch P., Desmet K. Ethylene glycol poisoning presenting with a falsely elevated lactate concentration. Clin Toxicol (Phila) 2009, 47:236-238.
8. Manini A.F., Hoffman R.S., McMartin K.E., Nelson L.S. Relationship between serum glycolate and falsely elevated lactate in severe ethylene glycol poisoning. J Anal Toxicol 2009, 33:174-176.
9. Chaudhry S.D., Pandurangan M., Pinnell A.E. Lactate gap and ethylene glycol poisoning. Eur J Anaesthesiol 2008, 25:511-513.
10. Jacobsen D., Ovrebø S., Ostborg J., Sejersted O.M. Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by hemodialysis. Acta Med Scand 1984, 216:409-416.
11. Gabow P.A., Clay K., Sullivan J.B., Lepoff R. Organic acids in ethylene glycol intoxication. Ann Intern Med 1986, 105:16-20.
12. Vasavada N., Williams C., Hellman R.N. Ethylene glycol intoxication: case report and pharmacokinetic perspectives. Pharmacotherapy 2003, 23:1652-1658.
13. Castanares-Zapatero D., Fillée C., Philippe M., Hantson P. Survival with extreme lactic acidosis following ethylene glycol poisoning?. Can J Anaesth 2008, 55:318-319.
14. Morgan T.J., Clark C., Clague A. Artifactual increase of measured plasma L-lactate concentration in the presence of glycolate. Crit Care Med 1999, 27:2177-2179.
15. Brent J. Current management of ethylene glycol poisoning. Drugs 2001, 61:979-988.
16. Lien D., Mader T.J. Survival from profound alcohol-related lactic acidosis. J Emerg Med 1999, 17:841-846.
17. Fall P.J., Szerlip H.M. Lactic acidosis: from sour milk to septic shock. J Intensive Care Med 2005, 20:255-271.
18. Jorens P.G., Demey H.E., Schepens P.J., Coucke V., Verpooten G.A., Couttenye M.M., Van Hoof V. Unusual D-lactic acid acidosis from propylene glycol metabolism in overdose. J Toxicol Clin Toxicol 2004, 42:163-169.