Relationship between serum glycolate and falsely elevated lactate in severe ethylene glycol poisoning

Journal of Analytical Toxicology

Volumn 33, Issue 3, 2009, Pages 174-176

  Manini, Alex F ^a,b,d   Hoffman, Robert S ^a,b   McMartin, Kenneth E ^c   Nelson, Lewis S ^a,b  

^a NEW YORK CITY POISON CONTROL CENTER   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d ELMHURST HOSPITAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 METHYLPYRAZOLE; BICARBONATE; BUFFER; CROSS REACTING ANTIBODY; ETHYLENE GLYCOL; GLYCOLIC ACID; LACTIC ACID; SODIUM CHLORIDE;

AGED; ALCOHOL INTOXICATION; ARTICLE; BLOOD SAMPLING; CASE REPORT; COMATOSE PATIENT; CORRELATION COEFFICIENT; FLUID RESUSCITATION; GAS CHROMATOGRAPHY; HEMODIALYSIS; HUMAN; LACTATE BLOOD LEVEL; MALE; SPECTROPHOTOMETRY;

EID: 65749093054     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/33.3.174     Document Type: Article

References (7)

1. D. Jacobsen, S. Ovebrø, J. Ostborg, and O. Sejersted. Glycolate causes the acidosis in ethylene glycol poisoning and is effectively removed by hemodialysis. Acta Med. Scand. 216: 409-416 (1984).
2. M. Woo, D. Greenway, S. Nadler, and P. Cardinal. Artifactual elevation of lactate in ethylene glycol poisoning. J. Emerg. Med. 25: 289-293 (2003).
3. W. Porter, M. Crellin, P.W. Rutter, and P. Oeltgen. Interference by glycolic acid in the Beckman synchron method for lactate: a useful clue for unsuspected ethylene glycol intoxication. Clin. Chem. 46: 874-875 (2000). (Pubitemid 30397459)
4. T. Morgan, C. Clark, and A. Claque. Artifactual elevation of measured plasma L-lactate concentration in the presence of glycolate. Crit. Care Med. 27: 2177-2179 (1999). (Pubitemid 29508333)
5. P.G. Brindley, M.S. Butler, G. Cembrowski, and D.N. Brindley. Falsely elevated point of care lactate measurement after ingestion of ethylene glycol. C. M. A. J. 176: 1097-1099 (2007).
6. A. Fraser and W. MacNeil. Colorimetric and gas chromatographic procedures for glycolic acid in serum: the major toxic metabolite of ethylene glycol. J. Toxicol. Clin. Toxicol. (Phila) 31: 397-405 (1993). (Pubitemid 23265198)
7. J. Brent, K. McMartin, S. Phillips, K. Burkhart, J. Donovan, M. Wells, and K. Kulig. Fomepizole for the treatment of ethylene glycol poisoning. N. Eng. J. Med. 340: 832-838 (1999).