Falsely elevated point-of-care lactate measurement after ingestion of ethylene glycol

CMAJ. Canadian Medical Association Journal

Volumn 176, Issue 8, 2007, Pages 1097-1099

  Brindley, Peter G ^a,c   Butler, Matthew S ^b   Cembrowski, George ^a   Brindley, David N ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF ALBERTA HOSPITAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ETHYLENE GLYCOL; GLYCOLIC ACID; LACTIC ACID; NEUROMUSCULAR BLOCKING AGENT; SEDATIVE AGENT;

ACIDOSIS; ADULT; ANAMNESIS; ARTERIAL GAS; ARTICLE; CASE REPORT; CLINICAL FEATURE; COMPUTER ASSISTED TOMOGRAPHY; DIAGNOSTIC ERROR; DIALYSIS; DIFFERENTIAL DIAGNOSIS; FALSE POSITIVE RESULT; FEMALE; HEMODYNAMICS; HOSPITAL ADMISSION; HUMAN; INTESTINE ISCHEMIA; INTOXICATION; LAPAROTOMY; RADIATION DETECTOR; RESUSCITATION; URINALYSIS;

EID: 34247547796     PISSN: 08203946     EISSN: 14882329     Source Type: Journal    
DOI: 10.1503/cmaj.061288     Document Type: Article

References (10)

1. Shirey T, Sivilotti M. Reaction of lactate electrodes to glycolate. Crit Care Med 1999;27:2305-7.
2. Morgan TJ, Clark C, Clague A. Artifactual elevation of measured plasma L-lactate concentration in the presence of glycolate. Crit Care Med 1999;27:2177-9.
3. Woo MY, Greenway DC, Nadler SP, et al. Artifactual elevation of lactate in ethylene glycol poisoning. J Emerg Med 2003;25:289-93.
4. Porter WH, Crellin M, Rutter PW, et al. Interference by glycolic acid in the Beckman synchron method for lactate: a useful clue for unsuspected ethylene glycol intoxication. Clin Chem 2000;46:874-5.
5. Booth ED, Dofferhoff O, Boogaard PJ, et al. Comparison of the metabolism of ethylene glycol and glycolic acid in vitro by precision-cut tissue slices from female rat, rabbit and human liver. Xenobiotica 2004;34:31-48.
6. National Institutes of Health; National Library of Medicine, Specialized Information Services. Ethylene glycol. Household products database. Available: http://householdproducts.nlm.nih.gov/cgi-bin/household/brands?tbl=chem&id= 193 (accessed 2007 Feb 1).
7. Murray MJ, Gonze MD, Nowak LR, et al. Serum D-lactate levels as an aid to diagnosing acute intestinal ischemia. Am J Surg 1994;167:575-8.
8. Lange H, Jackel R. Usefulness of plasma lactate concentration in the diagnosis of acute abdominal disease. Eur J Surg 1994;160:381-4.
9. Eder AP, McGrath CM, Dowdy YG, et al. Ethylene glycol poisoning: toxicokinetic and analytical factors affecting laboratory diagnosis. Clin Chem 1998;44:168-77.
10. Litovitz TL, Smilkstein M, Felberg L, et al. 1996 annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 1997;15:447-500.