Actions of redox-active compound resveratrol under hydrogen peroxide insult in C6 astroglial cells

Toxicology in Vitro

Volumn 24, Issue 3, 2010, Pages 916-920

  Quincozes Santos, André ^a   Andreazza, Ana Cristina ^a   Gonçalves, Carlos Alberto ^a   Gottfried, Carmem ^a  

^a Research Group in Neuroglial Plasticity   (Brazil)

Author keywords

C6; Genoprotection; Genotoxicity; Reactive oxygen species; Resveratrol

Indexed keywords

ASCORBIC ACID; HYDROGEN PEROXIDE; LACTATE DEHYDROGENASE; RESVERATROL; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; ASTROCYTE; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; GENOTOXICITY; LIPID PEROXIDATION; MEMBRANE DAMAGE; MICRONUCLEUS TEST; NEUROPROTECTION; NONHUMAN; OXIDATIVE STRESS;

ANIMALS; ANTIOXIDANTS; ASCORBIC ACID; ASTROCYTES; CELL LINE; CELL SURVIVAL; COLORING AGENTS; DNA DAMAGE; HYDROGEN PEROXIDE; L-LACTATE DEHYDROGENASE; MEMBRANE LIPIDS; MICRONUCLEUS TESTS; OXIDANTS; OXIDATION-REDUCTION; RATS; STILBENES; TARS; TETRAZOLIUM SALTS; THIAZOLES;

EID: 77649179116     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tiv.2009.11.016     Document Type: Article

References (37)

1. Baur J.A., and Sinclair D.A. Therapeutic potential of resveratrol: the in vivo evidence. Nature Rev. Drug Discov. 5 (2006) 493-506
2. Benda P., Lightbody J., Sato G., Levine L., and Sweet W. Differentiated rat glial cell strain in tissue culture. Science 161 (1968) 370-371
3. de Almeida L.M., Pineiro C.C., Leite M.C., Brolese G., Tramontina F., Feoli A.M., Gottfried C., and Goncalves C.A. Resveratrol increases glutamate uptake, glutathione content, and S100B secretion in cortical astrocyte cultures. Cell Mol. Neurobiol. 27 (2007) 661-668
4. de la Lastra C.A., and Villegas I. Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochem. Soc. Trans. 35 (2007) 1156-1160
5. Dong W., Li N., Gao D., Zhen H., Zhang X., and Li F. Resveratrol attenuates ischemic brain damage in the delayed phase after stroke and induces messenger RNA and protein express for angiogenic factors. J. Vasc. Surg. 48 (2008) 709-714
6. dos Santos A.Q., Nardin P., Funchal C., de Almeida L.M., Jacques-Silva M.C., Wofchuk S.T., Goncalves C.A., and Gottfried C. Resveratrol increases glutamate uptake and glutamine synthetase activity in C6 glioma cells. Arch. Biochem. Biophys. 453 (2006) 161-167
7. Esterbauer H., and Cheeseman K.H. Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal. Methods Enzymol 186 (1990) 407-421
8. Fenech M. Cytokinesis-block micronucleus cytome assay. Nature Protoc. 2 (2007) 1084-1104
9. Feng Z., and Zhang J.T. Protective effect of melatonin on beta-amyloid-induced apoptosis in rat astroglioma C6 cells and its mechanism. Free Radical Biol. Med. 37 (2004) 1790-1801
10. Gatz S.A., and Wiesmuller L. Take a break - resveratrol in action on DNA. Carcinogenesis 29 (2008) 321-332
11. Hagmar L., Bonassi S., Stromberg U., Brogger A., Knudsen L.E., Norppa H., and Reuterwall C. Chromosomal aberrations in lymphocytes predict human cancer: a report from the European study group on cytogenetic biomarkers and health (ESCH). Cancer Res. 58 (1998) 4117-4121
12. Halliwell B. Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?. Arch. Biochem. Biophys. 476 (2008) 107-112
13. Halliwell B., and Gutteridge J.M. Lipid peroxidation, oxygen radicals, cell damage, and antioxidant therapy. Lancet 1 (1984) 1396-1397
14. Han D., Sen C.K., Roy S., Kobayashi M.S., Tritschler H.J., and Packer L. Protection against glutamate-induced cytotoxicity in C6 glial cells by thiol antioxidants. Am. J. Physiol. 273 (1997) R1771-R1778
15. Hansen M.B., Nielsen S.E., and Berg K. Re-examination and further development of a precise and rapid dye method for measuring cell growth/cell kill. J. Immunol. Methods 119 (1989) 203-210
16. Harikumar K.B., and Aggarwal B.B. Resveratrol: a multitargeted agent for age-associated chronic diseases. Cell Cycle 7 (2008) 1020-1035
17. Joseph J., Cole G., Head E., and Ingram D. Nutrition, brain aging, and neurodegeneration. J. Neurosci. 29 (2009) 12795-12801
18. Langcake P., and Pryce R.J. A new class of phytoalexins from grapevines. Experientia 33 (1977) 151-152
19. Lowry O.H., Rosebrough N.J., Farr A.L., and Randall R.J. Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193 (1951) 265-275
20. Lukiw W.J., Zhao Y., and Cui J.G. An NF-kappaB-sensitive micro RNA-146a-mediated inflammatory circuit in Alzheimer disease and in stressed human brain cells. J. Biol. Chem. 283 (2008) 31315-31322
21. Mangoura D., Sakellaridis N., Jones J., and Vernadakis A. Early and late passage C-6 glial cell growth: similarities with primary glial cells in culture. Neurochem. Res. 14 (1989) 941-947
22. Murias M., Jager W., Handler N., Erker T., Horvath Z., Szekeres T., Nohl H., and Gille L. Antioxidant, prooxidant and cytotoxic activity of hydroxylated resveratrol analogues: structure-activity relationship. Biochem. Pharmacol. 69 (2005) 903-912
23. Nakamura T., and Lipton S.A. Molecular mechanisms of nitrosative stress-mediated protein misfolding in neurodegenerative diseases. Cell Mol. Life Sci. 64 (2007) 1609-1620
24. Nonomura S., Kanagawa H., and Makimoto A. Chemical constituents of polygonaceous plants. I. Studies on the components of Ko-J O-Kon (Polygonum Cuspidatum Sieb. Et Zucc.). Yakugaku Zasshi 83 (1963) 988-990
25. Parker K.K., Norenberg M.D., and Vernadakis A. "Transdifferentiation" of C6 glial cells in culture. Science 208 (1980) 179-181
26. Perticone P., Gensabella G., and Cozzi R. Damage proneness induced by genomic DNA demethylation in mammalian cells cultivated in vitro. Mutagenesis 12 (1997) 259-264
27. Quincozes-Santos A., Andreazza A.C., Nardin P., Funchal C., Goncalves C.A., and Gottfried C. Resveratrol attenuates oxidative-induced DNA damage in C6 Glioma cells. Neurotoxicology 28 (2007) 886-891
28. Quincozes-Santos A., Nardin P., de Souza D.F., Gelain D.P., Moreira J.C., Latini A., Goncalves C.A., and Gottfried C. The Janus face of resveratrol in astroglial cells. Neurotox. Res. 16 (2009) 30-41
29. Ren L.Q., Garrett D.K., Syapin M., and Syapin P.J. Differential fibronectin expression in activated C6 glial cells treated with ethanol. Mol. Pharmacol. 58 (2000) 1303-1309
30. Reyes S., Herrera L.A., Ostrosky P., and Sotelo J. Quinacrine enhances carmustine therapy of experimental rat glioma. Neurosurgery 49 (2001) 969-973
31. Siddique Y.H., and Afzal M. Antigenotoxic effect of apigenin against mitomycin C induced genotoxic damage in mice bone marrow cells. Food Chem. Toxicol. 47 (2009) 536-539
32. Siemann E.H., and Creasy L.L. Concentration of the phytoalexin resveratrol in wine. Am. J. Enol. Viticult. 43 (1992) 49-52
33. Sinha K., Chaudhary G., and Gupta Y.K. Protective effect of resveratrol against oxidative stress in middle cerebral artery occlusion model of stroke in rats. Life Sci. 71 (2002) 655-665
34. Slamon N.D., and Pentreath V.W. Antioxidant defense against antidepressants in C6 and 1321N1 cells. Chem. Biol. Interact. 127 (2000) 181-199
35. Sun A.Y., Wang Q., Simonyi A., and Sun G.Y. Botanical phenolics and brain health. Neuromolecular Med. 10 (2008) 259-274
36. Vieira de Almeida L.M., Pineiro C.C., Leite M.C., Brolese G., Leal R.B., Gottfried C., and Goncalves C.A. Protective effects of resveratrol on hydrogen peroxide induced toxicity in primary cortical astrocyte cultures. Neurochem. Res. 33 (2008) 8-15
37. Wang D.D., and Bordey A. The astrocyte odyssey. Prog. Neurobiol. 86 (2008) 342-367