Effects of IL-1 molecules on growth patterns of 3-MCA-induced cell lines: An interplay between immunogenicity and invasive potential

Journal of Immunotoxicology

Volumn 7, Issue 1, 2010, Pages 27-38

  Voronov, Elena ^a   Reich, Eli ^a   Dotan, Shahar ^a   Dransh, Pavel ^a   Cohen, Idan ^a   Huszar, Monica ^b   Fogel, Mina ^b   Kleinman, Hynda K ^c   White, Rosalyn M ^a   Apte, Ron N ^a  

^a BEN GURION UNIVERSITY OF THE NEGEV   (Israel)

^b KAPLAN MEDICAL CENTER   (Israel)

^c NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

3 MCA induced carcinogenesis; Angiogenesis; IL 1; Tumor growth

Indexed keywords

3 METHYLCHOLANTHRENE; CELL ADHESION MOLECULE; CELL SURFACE MARKER; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1; INTERLEUKIN 6; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; STROMAL CELL DERIVED FACTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANCER CELL; CANCER CELL CULTURE; CANCER GROWTH; CANCER INVASION; CARCINOGENESIS; CELL DIFFERENTIATION; CELL TYPE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; FIBROSARCOMA; IMMUNOGENICITY; IMMUNOLOGICAL MEMORY; IMMUNOSUPPRESSIVE TREATMENT; INFLAMMATION; INOCULATION; KNOCKOUT MOUSE; LABELING INDEX; MEMORY CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; SARCOMA CELL; T LYMPHOCYTE; TUMOR CELL; TUMOR IMMUNITY;

ANIMALS; AORTA, THORACIC; CELL LINE, TUMOR; CHICK EMBRYO; CULTURE MEDIA, CONDITIONED; CYTOKINES; ENDOTHELIAL CELLS; FEMALE; FIBROSARCOMA; INTERLEUKIN-1; METHYLCHOLANTHRENE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEOPLASM INVASIVENESS; NEOPLASM TRANSPLANTATION; NEOVASCULARIZATION, PATHOLOGIC; SARCOMA, EXPERIMENTAL; SPLEEN; TUMOR CELLS, CULTURED;

MUS;

EID: 77649171837     PISSN: 1547691X     EISSN: 1547691X     Source Type: Journal    
DOI: 10.3109/15476910903405528     Document Type: Conference Paper

References (42)

1. Allavena, P., Sica, A., Garlanda, C., and Mantovani, A. 2008. The Yin-Yang of tumor-associated macrophages in neoplastic progression and immune surveillance. Immunol. Rev. 222:155-161.
2. Apte, R. N., Dotan, S., Elkabets, M., White, M. R., Reich, E., Carmi, Y., Song, X., Dvozkin, T., Krelin, Y., and Voronov, E. 2006a. The involvement of IL-1 in tumorigenesis, tumor invasiveness, metastasis and tumor-host interactions. Cancer Metastasis Rev 25:387-408.
3. Apte, R. N., Krelin, Y., Song, X., Dotan, S., Recih, E., Elkabets, M., Carmi, Y., Dvorkin, T., White, R. M., Gayvoronsky, L., Segal, S., and Voronov, E. 2006b. Effects of microenvironment- and malignant cell-derived interleukin-1 in carcinogenesis, tumor invasiveness, and tumor-host interactions. Eur. J. Cancer 42:751-759.
4. Apte, R. N., and Voronov, E. 2002. Interleukin-1-A major pleiotropic cytokine in tumor-host interactions. Semin. Cancer Biol. 12:277-290.
5. Apte, R. N., and Voronov, E. 2008. Is interleukin-1 a good or bad 'guy' in tumor immunobiology and immunotherapy? Immunol. Rev. 222:222-241.
6. Arend, W. P. 2002. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 13:323-340.
7. Blankenstein, T., and Qin, Z. 2003. The role of IFNγ in tumor transplantation immunity and inhibition of chemical carcinogenesis. Curr. Opin. Immunol. 15:148-154.
8. Bunt, S. K., Sinha, P., Clements, V. K., Leips, J., and Ostrand-Rosenberg, S. 2006. Inflammation induces myeloid-derived suppressor cells that facilitate tumor progression. J. Immunol. 176:284-290.
9. Chen, H., Tan, Y., Cai, S., Ma, W., Guo, Z., Du, J., and Cai, S. 2007. The role of SDF-1 and its receptor CXCR4 in tumor metastasis. Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 24:1180-1183.
10. Dinarello, C. A. 1996. Biologic basis for interleukin-1 in disease. Blood 87:2095-2147.
11. Dinarello, C. A. 2008. Inflammation in human disease: Anti-cytokine therapy. Biol. Blood Marrow Trans. 15:134-136.
12. Dinarello, C. A., and Moldawer, L. L 2002. Pro-inflammatory and Antiinflammatory Cytokines in Rheumatoid Arthritis, Third Edition. Thousand Oaks, CA: Amgen Inc. (One Amgen Center Drive Thousand Oaks, CA 91320-91799 edn).
13. Dvorkin, T., Song, X., Argov, S., White, R. M., Zoller, M., Segal, S., Dinarello, C. A., Voronov, E., and Apte, R. N. 2006. Immune phenomena involved in the in vivo regression of fibrosarcoma cells expressing cell-associated IL-1α. J. Leukocyte Biol. 80:96-106.
14. Elkabets, M., Krelin, Y., Dotan, S., Cerwenka, A., Porgador, A., Lichtenstein, R. G., White, M. R., Zoller, M., Iwakura, Y., Dinarello, C. A., Voronov, E., and Apte, R. N. (2009). Host-derived interleukin-1α is important in determining the immunogenicity of 3-methylcholantrene tumor cells. J. Immunol. 182:4874-4881.
15. Gho, Y. S., Kleinman, H. K., and Sosne, G. 1999. Angiogenic activity of human soluble intercellular adhesion molecule-1. Cancer Res. 59:5128-5132.
16. Horai, R., Asano, M., Sudo, K., Kanuka, H., Suzuki, M., Nishihara, M., Takahashi, M., and Iwakura, Y. 1998. Production of mice deficient in genes for interleukin (IL)- 1α, IL-1β, IL-1α/β, and IL-1 receptor antagonist shows that IL-1β is crucial in turpentine-induced fever development and glucocorticoid secretion. J. Exp. Med. 187:1463-1475.
17. Horai, R., Saijo, S., Tanioka, H., Nakae, S., Sudo, K., Okahara, A., Ikuse, T., Asano, M., and Iwakura, Y. 2000. Development of chronic inflammatory arthropathy resembling rheumatoid arthritis in interleukin 1 receptor antagonist-deficient mice. J. Exp. Med. 191:313-320.
18. Kortesidis, A., Zannettino, A., Isenmann, S., Shi, S., Lapidot, T., and Gronthos, S. 2005. Stromal-derived factor-1 promotes the growth, survival, and development of human bone marrow stromal stem cells. Blood 105:3793-3801.
19. Krelin, Y., Voronov, E., Dotan, S., Elkabets, M., Reich, E., Fogel, M., Huszar, M., Iwakura, Y., Segal, S., Dinarello, C. A., and Apte, R. N. 2007. Interleukin-1β-driven inflammation promotes the development and invasiveness of chemical carcinogen-induced tumors. Cancer Res. 67:1062-1071.
20. Lazar-Molnar, E., Hegyesi, H., Toth, S., and Falus, A. 2000. Autocrine and paracrine regulation by cytokines and growth factors in melanoma. Cytokine 12:547-554.
21. Lorusso, G., and Ruegg, C. 2008. The tumor microenvironment and its contribution to tumor evolution toward metastasis. Histochem. Cell Biol. 130:1091-1103.
22. Mantovani, A., and Dejana, E. 1989. Cytokines as communication signals between leukocytes and endothelial cells. Immunol. Today 10:370-375.
23. Martin, M. U., and Falk, W. (1997). The interleukin-1 receptor complex and interleukin-1 signal transduction. Eur. Cytokine Network 8:5-17.
24. Nakae, S., Asano, M., Horai, R., and Iwakura, Y. 2001a. Interleukin-1α, but not interleukin-1β, is required for T-cell-dependent antibody production. Immunology 104:402-409.
25. Nakae, S., Asano, M., Horai, R., Sakaguchi, N., and Iwakura, Y. 2001b. IL-1 enhances T-cell-dependent antibody production through induction of CD40 ligand and OX40 on T-cells. J. Immunol. 167:90-97.
26. Nakae, S., Naruse-Nakajima, C., Sudo, K., Horai, R., Asano, M., and Iwakura, Y. 2001c. IL-1α, but not IL-1β, is required for contact-allergen-specific T-cell activation during the sensitization phase in contact hypersensitivity. Int. Immunol. 13:1471-1478.
27. Nazarenko, I., Marhaba, R., Reich, E., Voronov, E., Vitacolonna, M., Hildebrand, D., Elter, E., Rajasagi, M., Apte, R. N., and Zoller, M. 2008. Tumorigenicity of IL-1α- and IL-1β-deficient fibrosarcoma cells. Neoplasia 10:549-562.
28. Orimo, A., Gupta, P. B., Sgroi, D. C., Arenzana-Seisdedos, F., Delaunay, T., Naeem, R., Carey, V. J., Richardson, A. L., and Weinberg, R. A. 2005. Stromal fibroblasts present in invasive human breast carcinomas promote tumor growth and angiogenesis through elevated SDF-1/CXCL12 secretion. Cell 121:335-348.
29. Ostman, A., and Augsten, M. 2009. Cancer-associated fibroblasts and tumor growth-bystanders turning into key players. Curr. Opin. Genet. Dev. 19:67-73.
30. Ostrand-Rosenberg, S. 2008. Immune surveillance: A balance between protumor and anti-tumor immunity. Curr. Opin. Genet. Dev. 18:11-18.
31. Philip, M., Rowley, D. A., and Schreiber, H. 2004. Inflammation as a tumor promoter in cancer induction. Semin. Cancer Biol. 14:433-439.
32. Qin, Z., Kim, H. J., Hemme, J., and Blankenstein, T. 2002. Inhibition of methylcholanthrene-induced carcinogenesis by an interferon-α receptor-dependent foreign body reaction. J. Exp. Med. 195:1479-1490.
33. Smyth, M. J., Dunn, G. P., and Schreiber, R. D. 2006. Cancer immunosurveillance and immunoediting: The roles of immunity in suppressing tumor development and shaping tumor immunogenicity. Adv. Immunol. 90:1-50.
34. Song, X., Krelin, Y., Dvorkin, T., Bjorkdahl, O., Segal, S., Dinarello, C. A., Voronov, E., and Apte, R. N. 2005. CD11b+/Gr-1+ immature myeloid cells mediate suppression of T-cells in mice bearing tumors of IL-1α-secreting cells. J. Immunol. 175:8200-8208.
35. Song, X., Voronov, E., Dvorkin, T., Fima, E., Cagnano, E., Benharroch, D., Shendler, Y., Bjorkdahl, O., Segal, S., Dinarello, C. A., and Apte, R. N. 2003. Differential effects of IL-1α and IL-1β on tumorigenicity patterns and invasiveness. J. Immunol. 171:6448-6456.
36. Stylianou, E., and Saklatvala, J. 1998. Interleukin-1. Int. J. Biochem. Cell Biol. 30:1075-1079.
37. Swann, J. B., Hayakawa, Y., Zerafa, N., Sheehan, K. C., Scott, B., Schreiber, R. D., Hertzog, P., and Smyth, M. J. 2007. Type I IFN contributes to NK cell homeostasis, activation, and anti-tumor function. J. Immunol. 178:7540-7549.
38. Swann, J. B., Vesely, M. D., Silva, A., Sharkey, J., Akira, S., Schreiber, R. D., and Smyth, M. J. 2008. Demonstration of inflammation-induced cancer and cancer immunoediting during primary tumorigenesis. Proc. Natl. Acad. Sci. USA 105:652-656.
39. Voronov, E., Carmi, Y., and Apte, R. N. 2007. Role of IL-1-mediated inflammation in tumor angiogenesis. Adv. Exp. Med. Biol. 601:265-270.
40. Voronov, E., Shouval, D. S., Krelin, Y., Cagnano, E., Benharroch, D., Iwakura, Y., Dinarello, C. A., and Apte, R. N. 2003. IL-1 is required for tumor invasiveness and angiogenesis. Proc. Natl. Acad. Sci. USA 100:2645-2650.
41. Whiteside, T. L. 2008. The tumor microenvironment and its role in promoting tumor growth. Oncogene 27:5904-5912.
42. Witz, I. P. 2008. Tumor-microenvironment interactions: Dangerous liaisons. Adv. Cancer Res. 100:203-229.