Hyperleptinemia in horses: Responses to administration of a small dose of lipopolysaccharide endotoxin in mares and geldings

Journal of Animal Science

Volumn 88, Issue 3, 2010, Pages 926-936

  Huff, N K ^a   Thompson, Jr ^a   Mitcham, P B ^a   Storer, W A ^a  

^a LOUISIANA STATE UNIVERSITY AGRICULTURAL CENTER   (United States)

Author keywords

Endotoxin; Gelding; Hematologic; Hyperleptinemia; Mare

Indexed keywords

ENDOTOXIN; ENDOTOXIN, ESCHERICHIA COLI; GROWTH HORMONE; HYDROCORTISONE; INSULIN; LEPTIN; LIPOPOLYSACCHARIDE; PROLACTIN;

ANIMAL; ANIMAL DISEASE; ARTICLE; BLOOD; BREATHING RATE; FEMALE; HEART RATE; HORSE; HORSE DISEASE; IMMUNOLOGY; LEUKOCYTE COUNT; MALE; PATHOPHYSIOLOGY; PHYSIOLOGY; THROMBOCYTE COUNT;

ANIMALS; ENDOTOXINS; FEMALE; GROWTH HORMONE; HEART RATE; HORSE DISEASES; HORSES; HYDROCORTISONE; INSULIN; LEPTIN; LEUKOCYTE COUNT; LIPOPOLYSACCHARIDES; MALE; PLATELET COUNT; PROLACTIN; RESPIRATORY RATE;

EQUIDAE; ESCHERICHIA COLI;

EID: 77649146000     PISSN: 00218812     EISSN: 15253163     Source Type: Journal    
DOI: 10.2527/jas.2009-2337     Document Type: Article

References (35)

1. Agarwal, S. K., K. Vogel, S. R. Weitsman, and D. A. Magoffin. 1999. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulosa and theca cells of the human ovary. J. Clin. Endocrinol. Metab. 84:1072-1076.
2. Allen, G. K., C. Campbell-Beggs, J. A. Robinson, P. J. Johnson, and E. M. Green. 1996. Induction of early-phase endotoxin tolerance in horses. Equine Vet. J. 28:269-274.
3. 3-adrenergic receptor in adipose tissue. Am. J. Physiol. Endocrinol. Metab. 274:E992-E997.
4. Bueno, A. C., T. L. Seahorn, J. Cornick-Seahorn, D. W. Horohov, and R. M. Moore. 1999. Plasma and urine nitric oxide concentrations in horses given below a low dose of endotoxin. Am. J. Vet. Res. 60:969-976.
5. Cartmill, J. A., D. L. Thompson Jr., L. R. Gentry, H. E. Pruett, and C. A. Johnson. 2003a. Effects of dexamethasone, glucose infusion, adrenocorticotropin, and propylthiouracil on plasma leptin concentrations in horses. Domest. Anim. Endocrinol. 24:1-14.
6. Cartmill, J. A., D. L. Thompson Jr., W. A. Storer, J. C. Crowley, N. K. Huff, and C. A. Waller. 2005. Effect of dexamethasone, feeding time, and insulin infusion on leptin concentrations in stallions. J. Anim. Sci. 83:1875-1881.
7. Cartmill, J. A., D. L. Thompson Jr., W. A. Storer, L. R. Gentry, and N. K. Huff. 2003b. Endocrine responses in mares and geldings with high body condition scores grouped by high vs. low resting leptin concentrations. J. Anim. Sci. 81:2311-2321.
8. Clark, E. S., and J. N. Moore. 1989. The effects of slow infusion of a low dosage of endotoxin in healthy horses. Equine Vet. J. Suppl. 7:33-37.
9. Colborn, D. R., D. L. Thompson Jr., M. S. Rahmanian, and T. L. Roth. 1991a. Plasma concentrations of cortisol, prolactin, luteinizing hormone, and follicle-stimulating hormone in stallions after physical exercise and injection of secretagogue before and after sulpiride treatment in winter. J. Anim. Sci. 69:3724-3732.
10. Colborn, D. R., D. L. Thompson Jr., T. L. Roth, J. S. Capehart, and K. L. White. 1991b. Responses of cortisol and prolactin to sexual excitement and stress in stallions and geldings. J. Anim. Sci. 69:2556-2562.
11. Faggioni, R., G. Fantuzzi, C. Gabay, A. Moser, C. A. Dinarello, K. R. Feingold, and C. Grunfeld. 1999. Leptin deficiency enhances sensitivity to endotoxin-induced lethality. Am. J. Physiol. 276:R136-R142.
12. Faggioni, R., K. R. Feingold, and C. Grunfeld. 2001. Leptin regulation of the immune response and the immunodeficiency of malnutrition. FASEB J. 15:2565-2571.
13. Faggioni, R., F. Giamila, J. Fuller, C. A. Dinarello, K. R. Feingold, and C. Grunfeld. 1998. IL-1β mediates leptin induction during inflammation. Am. J. Physiol. Regul. Integr. Comp. Physiol. 274:R204-R208.
14. Gainsford, T., T. A. Willson, D. Metcalf, E. Handman, C. McFarlane, A. Ng, N. A. Nicola, W. S. Alexander, and D. J. Hilton. 1996. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc. Natl. Acad. Sci. USA 93:14564-14568.
15. Gentry, L. R., D. L. Thompson Jr., G. T. Gentry Jr., K. A. Davis, R. A. Godke, and J. A. Cartmill. 2002. The relationship between body condition, leptin, and reproductive and hormonal characteristics of mares during the seasonal anovulatory period. J. Anim. Sci. 80:2695-2703.
16. Grunfeld, C., C. Zhao, J. Fuller, A. Pollock, A. Moser, J. Friedman, and K. R. Feingold. 1996. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters: A role for leptin in the anorexia of infection. J. Clin. Invest. 97:2152-2157.
17. Henneke, D. R., G. D. Potter, J. L. Kreider, and B. F. Yeates. 1983. Relationship between condition score, physical measurements and body fat percentage in mares. Equine Vet. J. 15:371-373.
18. Henson, M. C., and V. D. Castracane. 2003. Leptin and Reproduction. Plenum Publishers, New York, NY.
19. Huff, N. K., D. L. Thompson Jr., L. R. Gentry, and C. G. Depew. 2008. Hyperleptinemia in mares: Prevalence in lactating mares and effect on rebreeding success. J. Equine Vet. Sci. 28:579-586.
20. Kronfeld, D. S., K. H. Treiber, T. M. Hess, R. K. Splan, B. M. Byrd, W. B. Staniar, and N. W. White. 2006. Metabolic syndrome in healthy ponies facilitates nutritional countermeasures against pasture laminitis. J. Nutr. 136(Suppl. 7):2090S-2093S.
21. Mantzoros, C. S., D. W. Cramer, R. F. Liberman, and R. L. Barbieri. 2000. Predictive value of serum and follicular fluid leptin concentrations during assisted reproductive cycles in normal women and in women with the polycystic ovarian syndrome. Hum. Reprod. 15:539-544.
22. Mastronardi, C. A., W. H. Yu, V. Rettori, and S. McCann. 2000. Lipopolysaccharide-induced leptin release is not mediated by nitric oxide, but is blocked by dexamethasone. Neuroimmuno-modulation 8:91-97.
23. Rabb, M. H., D. L. Thompson Jr., B. E. Barry, D. R. Colborn, F. Garza Jr., and K. E. Hehnke. 1989. Effects of sexual stimulation, with and without ejaculation, on serum concentrations of LH, FSH, testosterone, cortisol and prolactin in stallions. J. Anim. Sci. 67:2724-2729.
24. Sarraf, P., R. C. Frederich, E. M. Turner, G. Ma, N. T. Jaskowiak, D. J. Rivet, J. S. Flier, B. B. Lowell, D. L. Fraker, and H. R. Alexander. 1997. Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexic. J. Exp. Med. 185:171-175.
25. Spicer, L. J. 2001. Leptin: A possible metabolic signal affecting reproduction. Domest. Anim. Endocrinol. 21:251-270.
26. Spicer, L. J., and C. C. Francisco. 1997. The adipose obese gene product, leptin: Evidence of a direct inhibitory role in ovarian function. Endocrinology 138:3374-3379.
27. Sticker, L. S., D. L. Thompson Jr., L. D. Bunting, J. M. Fernandez, C. L. DePew, and M. R. Nadal. 1995a. Feed deprivation of mares: Plasma metabolite and hormonal concentrations and responses to exercise. J. Anim. Sci. 73:3696-3704.
28. Sticker, L. S., D. L. Thompson Jr., J. M. Fernandez, L. D. Bunting, and C. L. DePew. 1995b. Dietary protein and(or) energy restriction in mares: Plasma growth hormone, IGF-1, prolactin, cortisol, and thyroid hormone responses to feeding, glucose, and epinephrine. J. Anim. Sci. 73:1424-1432.
29. Takahashi, N., W. Waelput, and Y. Guisez. 1999. Leptin is an endogenous protective protein against the toxicity exerted by tumor necrosis factor. J. Exp. Med. 189:207-212.
30. Tetens, J., R. M. Moore, G. L. Hosgood, S. C. Eades, M. L. Keowen, and D. W. Horohov. 2004. Effects of infusion of adenosine triphosphate-magnesium chloride on cardiopulmonary and clinicopathologic variables, cytokine activity, and endothelin concentration in horses administered a low dose of endotoxin. Am. J. Vet. Res. 65:225-237.
31. Thompson, D. L. Jr., C. L. DePew, A. Ortiz, L. S. Sticker, and M. S. Rahmanian. 1994. Growth hormone and prolactin concentrations in plasma of horses: Sex differences and the effects of acute exercise and administration of growth hormone releasing hormone. J. Anim. Sci. 72:2911-2918.
32. Thompson, D. L. Jr., F. Garza Jr., P. S. Mitchell, and R. L. St. George. 1988. Effects of short-term stress, xylazine tranquilization and anesthetization with xylazine plus ketamine on plasma concentrations of cortisol, luteinizing hormone, follicle stimulating hormone and prolactin in ovariectomized pony mares. Theriogenology 30:937-946.
33. Thompson, D. L. Jr., M. S. Rahmanian, C. L. DePew, D. W. Burleigh, C. J. DeSouza, and D. R. Colborn. 1992. Growth hormone in mares and stallions: Pulsatile secretion, response to growth hormone-releasing hormone and effects of exercise, sexual stimulation, and pharmacological agents. J. Anim. Sci. 70:1201-1207.
34. Toribio, R. E., C. W. Kohn, J. Hardy, and T. J. Rosol. 2005. Alterations in serum parathyroid hormone and electrolyte concentrations and urinary excretion of electrolytes in horses with induced endotoxemia. J. Vet. Intern. Med. 19:223-231.
35. Waller, C. A., D. L. Thompson Jr., J. A. Cartmill, W. A. Storer, and N. K. Huff. 2006. Reproduction in high body condition mares with high versus low leptin concentrations. Theriogenology 66:923-928.