Phase II pharmaceutical metabolites acetaminophen glucuronide and acetaminophen sulfate in wastewater

Environmental Chemistry

Volumn 7, Issue 1, 2010, Pages 111-122

  Sunkara, Manjula ^a,b   Wells, Martha J M ^a  

^a TENNESSEE TECHNOLOGICAL UNIVERSITY   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Conjugates; Pharmaceuticals; Phase I and Phase II metabolites; Wastewater treatment.

Indexed keywords

CONCENTRATION (COMPOSITION); DISEASE CONTROL; DRUG; METABOLITE; MODEL TEST; ORGANIC COMPOUND; PHENOL; SAMPLE PREPARATION; STEROID; SURFACE WATER; ULTRAVIOLET RADIATION; WASTE TREATMENT; WASTEWATER;

EID: 77649122095     PISSN: 14482517     EISSN: None     Source Type: Journal    
DOI: 10.1071/EN09098     Document Type: Article

References (35)

1. D. W. Kolpin, E. T. Furlong, M. T. Meyer, E. M. Thurman, S. D. Zaugg, L. B. Barber, H. T. Buxton, Pharmaceuticals, hormones, and other organic wastewater contaminants, in US streams, 1999-2000: a national reconnaissance. Environ. Sci. Technol. 2002, 36, 1202. doi:10.1021/ES011055J (Pubitemid 34228893)
2. J. Donn, M. Mendoza, J. Pritchard, PharmaWater I 2008 (Associated Press Archives). Available at http://nl.newsbank.com/ nl-search/we/Archives?p-action= print [Verified October 2008]
3. J. Donn, M. Mendoza, J. Pritchard, PharmaWater II 2008 (Associated Press Archives). Available at http://nl.newsbank.com/ nl-search/we/Archives?p-action= print [Verified October 2008]
4. J. Donn, M. Mendoza, J. Pritchard, PharmaWater III 2008 (Associated Press Archives). Available at http://nl.newsbank.com/ nl-search/we/Archives?p-action= print [Verified October 2008]
5. K. Levsen, S. Hans-Martin, B. Behnke, R. Dotzer, W. Dreher, M. Elend, H. Thiele, Structure elucidation of Phase II metabolites by tandem mass spectrometry: an overview. J. Chromatogr. A 2005, 1067, 55. doi:10.1016/J. CHROMA.2004.08.165 (Pubitemid 40363390)
6. W. Niessen, Liquid Chromatography-Mass Spectrometry, 3rd edn 2006, pp. 276-278 (CRC Press: Boca Raton, FL).
7. M. J. M. Wells, logDOW: key to understanding and regulating wastewater-derived contaminants. Environ. Chem. 2006, 3, 439. doi:10.1071/EN06045 (Pubitemid 44957793)
8. M. J. M. Wells, M.-L. Pellegrin, A. Morse, K. Y. Bell, L. J. Fono, Emerging pollutants. Water Environ. Res. 2008, 80, 2026. doi:10.2175/ 106143008X328897
9. M. J. M. Wells, A. Morse, K. Y. Bell, M.-L. Pellegrin, L. J. Fono, Emerging pollutants. Water Environ. Res. 2009, 81, 2211. doi:10.2175/ 106143009X12445568400854
10. O. A. H. Jones, N. Voulvoulis, J. N. Lester, Analytical method development for the simultaneous determination of five human pharmaceuticals in water and wastewater samples by gas chromatographymass spectrometry. Chromatographia 2003, 58, 7/8, 471.
11. T. A. Ternes, P. Kreckel, J. Mueller, Behaviour and occurrence of estrogens in municipal sewage treatment plants - II. Aerobic batch experiments with activated sludge. Sci. Total Environ. 1999, 225, 91. doi:10.1016/S0048- 9697(98)00335-0 (Pubitemid 29148049)
12. A. Gentili, D. Perret, S. Marchese, R. Mastropasqua, R. Curini, A. Di Corcia, Analysis of free estrogens and their conjugates in sewage and river waters by solid-phase extraction then liquid chromatographyelectrospray- tandem mass spectrometry. Chromatographia 2002, 56, 25. doi:10.1007/BF02490242
13. G. D'Ascenzo, A. Di Corcia, A. Gentili, R. Mancini, R. Mastropasqua, M. Nazzari, R. Samperi, Fate of natural estrogen conjugates in municipal sewage transport and treatment facilities. Sci. Total Environ. 2003, 302, 199. doi:10.1016/S0048-9697(02)00342-X (Pubitemid 36071298)
14. K. Komori, H. Tanaka, Y. Okayasu, M. Yasojima, C. Sato, Analysis and occurrence of estrogen in wastewater in Japan. Water Sci. Technol. 2004, 50, 93.
15. S. Reddy, C. R. Iden, B. J. Brownawell, Analysis of steroid conjugates in sewage influent and effluent by liquid chromatography-tandem mass spectrometry. Anal. Chem. 2005, 77, 7032. doi:10.1021/ AC050699X
16. S. R. Hutchins, M. V. White, F. M. Hudson, D. D. Fine, Analysis of lagoon samples from different concentrated animal feeding operations for estrogens and estrogen conjugates. Environ. Sci. Technol. 2007, 41, 738. doi:10.1021/ ES062234+ (Pubitemid 46210029)
17. T. Isobe, H. Shiraishi, M. Yasuda, A. Shinoda, H. Suzuki, M. Morita, Determination of estrogens and their conjugates in water using solid-phase extraction followed by liquid chromatography- tandem mass spectrometry. J. Chromatogr. A 2003, 984, 195. doi:10.1016/S0021-9673(02)01851-4 (Pubitemid 35454084)
18. F. Tilton, W. H. Benson, D. Schlenk, Evaluation of estrogenic activity from a municipal wastewater treatment plant with predominantly domestic input. Aquat. Toxicol. 2002, 61, 211. doi:10.1016/S0166-445X(02)00058-9 (Pubitemid 35287182)
19. A. Nieto, F. Borrull, E. Pocurull, R. M. Marce, Determination of natural and synthetic estrogens and their conjugates in sewage sludge by pressurized liquid extraction and liquid chromatography- tandem mass spectrometry. J. Chromatogr. A 2008, 1213, 224. doi:10.1016/J.CHROMA.2008.10.043
20. M. P. Fernandez, T.-N. Noguerol, S. Lacorte, I. Buchanan, B. Pina, Toxicity identification fractionation of environmental estrogens in waste water and sludge using gas and liquid chromatography coupled to mass spectrometry and recombinant yeast assay. Anal. Bioanal. Chem. 2009, 393, 957. doi:10.1007/S00216-008-2516-8
21. S. Castiglioni, E. Zuccato, E. Crisci, C. Chiabrando, R. Fanelli, R. Bagnati, Identification and measurement of illicit drugs and their metabolites in urban wastewater by liquid chromatography- tandem mass spectrometry. Anal. Chem. 2006, 78, 8421. doi:10.1021/ AC061095B
22. C. Postigo, M. J. Lopez de Alda, D. Barcelo, Fully automated determination in the low nanogram per liter level of different classes of drugs of abuse in sewage water by on-line solidphase extraction-liquid chromatography-electrospray-tandem mass spectrometry. Anal. Chem. 2008, 80, 3123. doi:10.1021/AC702060J (Pubitemid 351620696)
23. M. J. M. Wells, Principles of extraction and the extraction of semivolatile organics from liquids, in Sample Preparation Techniques in Analytical Chemistry (Ed. S. Mitra) 2003, pp. 37-138 (Wiley: Hoboken, NJ).
24. M. J. M. Wells, C. R. Clark, Liquid chromatographic elution characteristics of some solutes used to measure column void volume on C18 bonded phases. Anal. Chem. 1981, 53, 1341. doi:10.1021/ AC00232A009
25. M.V.Vertzoni, H. A. Archontaki, P. Galanopoulou, Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of acetaminophen and its major metabolites in rabbit plasma and urine after a toxic dose. J. Pharm. Biomed. Anal. 2003, 32, 487. doi:10.1016/S0731-7085(03)00246-2 (Pubitemid 38021839)
26. A. K. Hewavitharana, S. Lee, P. A. Dawson, D. Markovich, P. N. Shaw, Development of an HPLC-MS/MS method for the selective determination of paracetamol metabolites in mouse urine. Anal. Biochem. 2008, 374, 106. doi:10.1016/J.AB.2007.11.011
27. R. Kostiainen, T. Kotiaho, T. Kuuranne, S. Auriola, Liquid chromatography/atmospheric pressure ionization-mass spectrometry in drug metabolism studies. J. Mass Spectrom. 2003, 38, 357. doi:10.1002/ JMS.481
28. J. L. Santos, I. Aparicio, E. Alonso, M. Callejon, Simultaneous determination of pharmaceutically active compounds in wastewater samples by solid phase extraction and high-performance liquid chromatography with diode array and fluorescence detectors. Anal. Chim. Acta 2005, 550, 116. doi:10.1016/J.ACA.2005.06.064 (Pubitemid 41317684)
29. S. Taniyasu, K. Kannan, M. K. So, A. Gulkowska, E. Sinclair, T. Okazawa, N. Yamashita, Analysis of fluorotelomer alcohols, fluorotelomer acids, and short- and long-chain perfluorinated acids in water and biota. J. Chromatogr. A 2005, 1093, 89. doi:10.1016/ J.CHROMA.2005.07.053
30. M. S. Young, K. Tran, SPE considerations for UPLC-MS determination of perfluorinated carboxylic acids and perfluorosulfonates in various matrices, in Preprints of Extended Abstracts presented at the ACS National Meeting, American Chemical Society, Division of Environmental Chemistry, San Francisco, CA, 10-14 September 2006, Vol.46(2), pp. 835-839 (Division of Environmental Chemistry, American Chemical Society).
31. H. Filik, M. Hayvali, E. Kilic, R. Apak, D. Aksu, Z.Yanaz, T. Cengel, Development of an optical fibre reflectance sensor for p-aminophenol detection based on immobilised bis-8-hydroxyquinoline. Talanta 2008, 77, 103. doi:10.1016/J.TALANTA.2008.05.045
32. C. T. Jafvert, J. C. Westall, E. Grieder, R. P. Schwarzenbach, Distribution of hydrophobic ionogenic organic compounds between octanol and water: organic acids. Environ. Sci. Technol. 1990, 24, 1795. doi:10.1021/ES00082A002
33. R. P. Schwarzenbach, P. M. Gschwend, D. M. Imboden, Environmental Organic Chemistry, 2nd edn 2003, pp. 270-272 (Wiley-Interscience: Hoboken, NJ).
34. J. E. A. Comer, High-throughput measurement of logD and pKa, in Drug Bioavailability: Estimation of Solubility, Permeability, Absorption and Bioavailability (Eds H. van de Waterbeemd, H. Lennernas, P. Artursson) 2003, pp. 21-25 (Wiley-VCH: Weinheim).
35. S. K. Bhal, ACD/Labs PhysChem Software Application Notes 2007. Available at http://www.acdlabs.com/appnotes/physchem/ [Verified April 2009]