Development and optimization of a reversed-phase high-performance liquid chromatographic method for the determination of acetaminophen and its major metabolites in rabbit plasma and urine after a toxic dose

Journal of Pharmaceutical and Biomedical Analysis

Volumn 32, Issue 3, 2003, Pages 487-493

  Vertzoni, M V ^a   Archontaki, H A ^a   Galanopoulou, P ^b  

^a UNIVERSITY OF ATHENS   (Greece)

^b UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

Author keywords

Acetaminophen; Acetaminophen glucuronide; Acetaminophen sulfate; Rabbit plasma and urine; Reversed phase HPLC with UV detection

Indexed keywords

3 AMINOPHENOL; BUFFER; DRUG METABOLITE; GLUCURONIDE; METHANOL; PARACETAMOL; SULFATE; ALCOHOL; ANALGESIC AGENT; CENTRAL DEPRESSANT AGENT; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS;

ANALYTIC METHOD; AQUEOUS SOLUTION; ARTICLE; BLOOD ANALYSIS; CALIBRATION; CONCENTRATION RESPONSE; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG URINE LEVEL; FLOW RATE; INTERMETHOD COMPARISON; LETHAL DOSE; MATHEMATICAL MODEL; NONHUMAN; PARTICLE SIZE; PH MEASUREMENT; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REVERSED PHASE LIQUID CHROMATOGRAPHY; STANDARD; STATISTICAL PARAMETERS; URINALYSIS; ANIMAL; BIOTRANSFORMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; RABBIT; REPRODUCIBILITY; SOLUTION AND SOLUBILITY; TOXIC HEPATITIS;

ACETAMINOPHEN; ANALGESICS, NON-NARCOTIC; ANIMALS; BIOTRANSFORMATION; CALIBRATION; CENTRAL NERVOUS SYSTEM DEPRESSANTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ETHANOL; HEPATITIS, TOXIC; INDICATORS AND REAGENTS; RABBITS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SOLUTIONS;

EID: 0142155211     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0731-7085(03)00246-2     Document Type: Article

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