Influence of ciproflo xacin on femoral fractures healing in rats;Influência da ciprofloxacina na consolidação óssea de fraturas de fêmur em ratos

Acta Ortopedica Brasileira

Volumn 17, Issue 4, 2009, Pages 228-231

  Kupczik, Fabiano ^a   Vialle, Luiz Roberto Gomes ^a   Nobre, Leonardo Oliveira ^a   de Almeida Vieira, Lucas ^a   Fernandes, André Eugênio Omine ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Ciprofloxacin; Fracture healing; Fracture healing drug effects; Rats

Indexed keywords

EID: 77649116884     PISSN: 14137852     EISSN: None     Source Type: Journal    
DOI: 10.1590/S1413-78522009000400007     Document Type: Article

References (34)

1. Singer BR, McLauchlan GJ, Robinson CM, Christie J. Epidemiology of fractures in 15000 adults: the influence of age and gender. J Bone Joint Surg Br. 1998;80:243-8.
2. Fernandes HJA, Reis FB. Fraturas da diáfise de fêmur. In: Franco SF, Lourenço PRB. Traumatologia ortopédica. Rio de Janeiro: Revinter; 2004. p. 19-30.
3. Muller ME, Allgöwer M, Schneider R, Willenegger H, eds. Manual de Osteossíntese. 3a. ed. São Paulo: Manole; 1993.
4. Campbell WC, editor. Cirurgia ortopédica de Campbell. 8a. ed. São Paulo: Manole; 1996.
5. Rockwood CA Jr, Green DP, Bucholz RW, editors. Fraturas em adultos. 3a. ed. São Paulo: Manole; 1993,.p.179-91.
6. Hessen MT, Ingerman MJ, Kaufman DH, Weiner P, Santoro J, Korzeniowski OM, et al. Clinical efficacy of ciprofloxacin therapy for gram-negative bacillary osteomyelitis. Am J Med. 1987;82:262-5.
7. Waldvogel FA. Use of quinolones for the treatment of osteomyelitis and septic arthritis. Rev Infect Dis. 1989;11(Suppl 5):1259-63.
8. Lew DP, Waldvogel FA. Quinolones and osteomyelitis: state-of-the-art. Drugs. 1995;49(Suppl 2):100-11.
9. Suh B, Lorber B. Quinolones. Med Clin North Am.1995;79:869-94.
10. Knapp TP, Patzakis MJ, Lee J, Seipel PR, Abdollahi K, Reisch RB. Comparison of intravenous and oral antibiotic therapy in the treatment of fractures caused by lowvelocity gunshots. A prospective, randomized study of infection rates. J Bone Joint Surg Am. 1996;78:1167-71.
11. Lew DP, Waldvogel FA. Use of quinolones in osteomyelitis and infected orthopaedic prosthesis. Drugs. 1999;58(Suppl 2):85-91.
12. Patzakis MJ, Bains RS, Lee J, Shepherd L, Singer G, Ressler R et al. Prospective, randomized, double-blind study comparing single-agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds. J Orthop Trauma. 2000;14:529-33.
13. Pavoni GL, Falcone M, Baiocchi P, Tarasi A, Cassone M, Serra P et al. Conservative medical therapy of infections following osteosynthesis: a retrospective analysis of a six-year experience. J Chemother. 2002;14:378-83.
14. Ingham B, Brentnall DW, Dale EA, MacFadzean JA. Arthropathy induced by antibacterial fused N-alkyl-3-pyridone-carboxylic acids. Toxicol Lett. 1977;1:21-6.
15. Mont MA, Mathur SK, Frondoza CG, Hungerford DS. The effects of ciprofloxacin on human chondrocytes in cell culture. Infection. 1996;24:151-5.
16. Stahlmann R, Lode H. Toxicity of quinolones. Drugs 1999;58 Suppl 2:37-42.
17. Stahlmann R, Kuhner S, Shakibaei M, Schwabe R, Flores J, Evander SA et al. Chondrotoxicity of ciprofloxacin in immature beagle dogs: immunohistochemistry, electron microscopy and drug plasma concentrations. Arch Toxicol. 2000;73:564-72.
18. Multhaupt HA, Alvarez JC, Rafferty PA, Warhol MJ, Lackman RD. Fluoroquinolone's effect on growth of human chondrocytes and chondrosarcomas. In vitro and in vivo correlation. J Bone Joint Surg Am. 2001;83 Suppl 2 (Pt 1):56-61.
19. Stahlmann R. Clinical toxicological aspects of quinolones.Toxicol Lett. 2002;127:269-77.
20. Li P, Cheng NN, Chen BY, Wang YM. In vivo and in vitro chondrotoxicity of ciprofloxacin in juvenile rats. Acta Pharmacol Sin. 2004;25:1262-6.
21. Mussi Filho S, Vidigal L, Canova RA, Cruz HA, Zaniolo FJ, Vialle LRG. Estudo experimental dos efeitos da heparina de baixo peso molecular (enoxaparina) na formação de calo ósseo em fêmur de ratos. Acta Ortop Bras. 2006;14:78-82.
22. Vialle E, Vialle LR, Boechat R, Bley JP, Scussiato R, Busato, T et al. Produção de fratura padronizada de fêmur em ratos. Rev Bras Ortop. 2004; 39:323-9.
23. Pedroni MA. Avaliação da força de flexão de três pontos sobre o calo ósseo nas fraturas diafisárias de fêmures de ratos fixadas com dois diâmetros de hastes diferentes (dissertação). Curitiba: Pontifície Universidade Católica do Paraná; 2005.
24. Oliphant CM, Green GM. Quinolones: a comprehensive review. Am Fam Physician. 2002;65:455-64.
25. Menschik M, Neumüller J, Steiner CW, Erlacher L, Köller M, Ullrich R et al. Effects of ciprofloxacin and ofloxacin on adult human cartilage in vitro. Antimicrob Agents Chemother. 1997; 41:2562-5.
26. Miller MD, editor. Review of orthopaedics. 3rd ed. Philadelphia: Saunders Company; 2000.
27. Utvag SE, Reikeras O. Effects of nail rigidity on fracture healing, strength and mineralisation in rat femoral bone. Arch Ortop Trauma Surg. 1998;118:7-13.
28. Probst A, Jansen H, Ladas A, Spiegel HU. Callus formation and fixation rigidity: a fracture model in rats. J Orthop Res. 1999;17: 256-60.
29. An YH., Draughn RA, editors. Mechanical testing of bone and the bone-implant interface. Boca Raton: CRC Press; 2000. p.3-16; 207-17.
30. Engesaerter LB, Ekeland A, Langeland N. Methods for testing the mechanical properties of the rat femur. Acta Orthop Scand. 1978;49:512-8.
31. Huddleston PM, Steckelberg JM, Hanssen AD, Rouse MS, Bolander ME, Patel R. Ciprofloxacin inhibition of experimental fracture-healing. J Bone Joint Surg Am. 2000; 82:161-73.
32. Tuncay I, Ozbek H, Kosem M, Unal O. A comparison of effects of fluoroquinolones on fracture healing (an experimental study in rats). Ulus Travma Acil Cerrahi Derg. 2005;11:17-22.
33. Kaartinen E, Paavolainen P, Holmstom T, Slatis P. Loss of bone strength intramedullary nailing. Acta Orthop Scand. 1985;56:487-90.
34. Grundnes O, Reikeras O. Closed versus open medullary nailing of femoral fractures: Blood flow and healing studied in rats. Acta Orthop Scand. 1992;63:492-6