The effects of low-molecular-weight heparin (enoxaparin) on bony callus formation in rats' femurs - An experimental study;Estudo experimental dos efeitos da heparina de baixo peso molecular (enoxaparina) na formação de calo ósseo em fêmures de ratos

Acta Ortopedica Brasileira

Volumn 14, Issue 2, 2006, Pages 78-82

  Mussi Filho, Salim ^a,b   Vidigal, Leandro ^b   Canova, Rodrigo Abbud ^b   Da Cruz, Henrique Abreu ^b   Zaniolo, Francisco José ^c   Gomes Vialle, Luiz Roberto ^c  

^a Orthopaedics and Traumatology Service ^*  (Brazil)

^b Orthopaedics and Traumatology Service

^c NONE

Author keywords

Enoxaparin; Fractures; Heparin; Low Molecular Weight; Venous Thrombosis

Indexed keywords

EID: 33746653045     PISSN: 14137852     EISSN: None     Source Type: Journal    
DOI: 10.1590/s1413-78522006000200004     Document Type: Article

References (15)

1. Agnelli G, Cosmi B, Di Filippo P, Ranucci V, Veschi F, Longetti et al. A randomized, double-blind, placebo-controled trial of dermatan sulphate for prevention of deep vein thrombosis in hip fracture. Thromb Haemost. 1992; 67:203-8.
2. Caiafa JS. Trombose venosa profunda e cirurgia. Rev Col Bras Cirurg. 1994; 21:340-9.
3. Morrison RS, Chassin MR, Siu AL. The medical consultant's role in caring for patients with hip fracture. Ann Intern Med. 1998; 12:1010-20.
4. Weitz JI. Low-molecular-weight heparins. N Engl J Med. 1997; 10:688-99.
5. Green D, Hirsh J, Heit J, Prins M, Davidson B, Lensing AW. Low molecular weight heparin: a critical analysis of clinical trials. Pharmacol Rev. 1994, 46:89-109.
6. Anderson FA, Wheeler HB. Venous thromboembolism. Risks factors and prophylaxis. Clin Chest Med. 1995,16: 235-51.
7. Steele N, Dodenhoff RM, Ward AJ, Morse MH. Thromboprophylaxis in pelvic and acetabular trauma surgery. The role of early treatment with low-molecular-weight heparin. J Bone Joint Surg Br. 2005; 87:209-12.
8. Monreal M, Lafoz E, Olive A, Rio L, Vedia C. Comparison of subcutaneous unfractionated heparin with a low molecular weight heparin (Fragmin® ) in patients with venous thromboembolism and contraindications to coumarin. Thromb Haemost. 1994; 71:7-11.
9. Stinchfield FE, Sankaran B, Samilson, R. The effect of anticoagulant therapy on bone repair. J Bone Joint Surg Am. 1956; 2:270-82.
10. Goss-Sampson MA, Kriss A. Effects of pentobarbital and ketamine-xylazine anaesthesia on somatosensory, brainstem auditory and peripheral sensory-motor responses in the rat. Lab anim. 1991; 25:360-6.
11. Vialle E, Vialle LR, Boechat R. Produção de fratura padronizada de fêmur em ratos. Rev Bras Ortop. 2004; 39:323-9.
12. Huo MH, Troiano NW, Pelker RR, Gundberg CM. The influence of ibuprofen on fracture repair: biomechanical, biochemical, histologic, and histomorphometric parameters in rats. J Orthop Res. 1991; 9:383-90.
13. Plamer AJ, Koppenhagen K, Kirchhof B, Weber U, Bergemann R. Efficacy and safety of low molecular weight heparin, unfractionated heparin and warfarin for tromb-embolism prophylaxis in orthopaedic surgery: a meta-analysis of randomized clinical trials. Haemostasis. 1997; 27:75-84.
14. Udupa KN, Prasad GC. Chemical and histochemical studies of organic constituents in fracture repair in rats. J Bone Joint Surg Br. 1963; 45:770-9.
15. Street JT, McGrath M, O'Regan K, Wakai A, McGuinness A, Redmond HP. Thomboprophylaxis using a low molecular weight heparin delays fracture repair. Clin Orthop. 2000; 381:278-89.