Prospective, randomized, double-blind study comparing single-agent antibiotic therapy, ciprofloxacin, to combination antibiotic therapy in open fracture wounds

Journal of Orthopaedic Trauma

Volumn 14, Issue 8, 2000, Pages 529-533

  Patzakis, Michael J ^a   Bains, Ravi S ^a   Lee, Jackson ^a   Shepherd, Lane ^a   Singer, Gordon ^a   Ressler, Ron ^a   Harvey, Frances ^a   Holtom, Paul ^a  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

Author keywords

Antibiotics; Ciprofloxacin; Open fractures

Indexed keywords

ANTIINFECTIVE AGENT; CIPROFLOXACIN;

ADULT; AGED; ARTICLE; CHI SQUARE DISTRIBUTION; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG COMBINATION; DRUG EFFECT; FEMALE; FOLLOW UP; HUMAN; INJURY SCALE; MALE; MIDDLE AGED; OPEN FRACTURE; PROBABILITY; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; REFERENCE VALUE; TREATMENT OUTCOME; WOUND HEALING; WOUND INFECTION;

ADULT; AGED; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS; CHI-SQUARE DISTRIBUTION; CIPROFLOXACIN; DOUBLE-BLIND METHOD; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; FRACTURES, OPEN; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PROBABILITY; PROSPECTIVE STUDIES; REFERENCE VALUES; TREATMENT OUTCOME; WOUND HEALING; WOUND INFECTION;

EID: 0034327305     PISSN: 08905339     EISSN: None     Source Type: Journal    
DOI: 10.1097/00005131-200011000-00002     Document Type: Article

References (17)

1. Fischer MD, Gustilo RB, Varecka TF. The timing of flap coverage, bone-grafting, and intramedullary nailing in patients who have a fracture of the tibial shaft with extensive soft-tissue injury. J Bone Joint Surg Am 1991;73:1316-1322.
2. Gustilo RB, Anderson JT. Prevention of infection in the treatment of one thousand and twenty-five open fractures of long bones: retrospective and prospective analysis; J Bone Joint Surg Am 1976; 58:453-458.
3. Gustilo RB, Mendoza, RM, Williams DN. Problems and management of open fractures: new classification of open fractures. J Trauma 1984;24:742-746.
4. Henry SL, Ostermann, PAW, Seligson D. The antibiotic bead pouch technique: the management of severe compound fractures; Clin Orthop 1993;295:54-62.
5. Kindsfater K, Jonassen EA. Osteomyelitis in grade ii and iii open tibia fractures with late debridement. J Trauma 1995;9:121-127.
6. Knapp TP, Patzakis MJ, Lee J, Seipel PR, Abdollahi K, Reisch RB. Comparison of intravenous and oral antibiotic therapy in the treatment of fractures caused by low-velocity gunshots. J Bone Joint Surg Am 1996;78:1167-1171.
7. Lee J. Efficacy of cultures in the management of open fractures. Clin Orthop 1997;339:71-75.
8. Olson S. Open fractures of the tibial shaft - current treatment. J Bone Joint Surg Am 1996;78:1428-1437.
9. Ostermann PAW, Seligson D, Henry S. Local antibiotic therapy for severe open fractures: a review of 1085 consecutive cases. J Bone Joint Surg Br 1995;77:93-97.
10. Patzakis MJ, Harvey JP, Ivler D. The role of antibiotics in the management of open fractures. J Bone Joint Surg Am 1974;56: 532-541.
11. Patzakis MJ, Wilkins J. Factors influencing infection rate in open fracture wounds. Clin Orthop 1989;243:36-40.
12. Patzakis MJ, Wilkins J, Moore TM. Use of antibiotics in open tibial fractures. Clin Orthop 1983;178:31-35.
13. Sanders R, Swiontkowski M, Nunley J, Spiegel P. The management of fractures with soft-tissue disruptions. J Bone Joint Surg Am 1993;75:778-787.
14. Templeman DC, Gulli B, Tsukayama DT, Gustilo RB. Update on the management of open fractures of the tibial shaft. Clin Orthop 1998;350:18-25.
15. Vasenius J, Tulikoura I, Vainionpaa S, Rokkanen P. Clindamycin versus cloxacillin in the treatment of 240 open fractures: a randomized prospective study. Annales Chirugiae et Gynaecologiae 1998;87:224-228.
16. Yokoyama K, Itoman M, Shindo M, Kai H, Ueta S, Kobayashi A. Deep infection and fracture healing in immediate and delayed locked intramedullary nailing for open femoral fractures. Orthopaedics 1999;22:485-490.
17. Wilkins J, Patzakis MJ. Choice and duration of antibiotics in open fractures. Orthop Clin North Am 1991;22:433-437.