Platelet-activating factor and evidence of oxidative stress in the bronchoalveolar fluid of thoroughbred colts during race training

Journal of Veterinary Internal Medicine

Volumn 24, Issue 2, 2010, Pages 414-419

  Michelotto Jr , P V ^a,b   Muehlmann, L A ^a   Zanatta, A L ^a   Bieberbach, E W R ^a   Fernandes, L C ^a   Nishiyama, A ^a  

^a FEDERAL UNIVERSITY OF PARANÁ   (Brazil)

^b PONTIFICAL CATHOLIC UNIVERSITY OF PARANÁ   (Brazil)

Author keywords

Alveolar macrophage; Horse; Inflammatory airway disease

Indexed keywords

THROMBOCYTE ACTIVATING FACTOR;

ANIMAL; ANIMAL EXPERIMENT; ARTICLE; CHEMISTRY; CYTOLOGY; HORSE; LUNG ALVEOLUS MACROPHAGE; LUNG LAVAGE; MALE; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY; RESPIRATORY SYSTEM; SPORT;

ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; HORSES; MACROPHAGES, ALVEOLAR; MALE; OXIDATIVE STRESS; PHYSICAL CONDITIONING, ANIMAL; PLATELET ACTIVATING FACTOR; RESPIRATORY SYSTEM; SPORTS;

ANIMALIA; CONGIOPODIDAE; EQUIDAE;

EID: 77649085617     PISSN: 08916640     EISSN: 19391676     Source Type: Journal    
DOI: 10.1111/j.1939-1676.2010.0459.x     Document Type: Article

References (39)

1. Christley R, Rush BR. Inflammatory airway disease. In: McGorum BC, Dixon PM, Robinson NE, Schumacher J, eds. Equine Respiratory Medicine and Surgery. Philadelphia, PA: Saunders Elsevier; 2007:591-599.
2. Couetil LL, Denicola DB. Blood gas, plasma lactate and bronchoalveolar lavage cytology analyses in racehorses with respiratory disease. Equine Vet J 1999;30(Suppl):77-82.
3. Sanchez A, Couetil LL, Ward MP, Clark SP. Effect of airway disease on blood gas exchange in racehorses. J Vet Intern Med 2005;19:87-92.
4. Wilsher S, Allen WR, Wood JLN. Factors associated with failure of Thoroughbred horses to train and race. Equine Vet J 2006;38:113-118.
5. Riihimaki M, Raine A, Elfman L, Pringle J. Markers of respiratory inflammation in horses in relation to seasonal changes in air quality in a conventional racing stable. Can J Vet Res 2008;72:432-439.
6. Riihimaki M, Lilliehook I, Raine A, et al. Clinical alterations and mRNA levels of IL-4 and IL-5 in bronchoalveolar cells of horses with transient pulmonary eosinophilia. Res Vet Sci 2008;85:52-55.
7. Marathe GK, Prescott SM, Zimmerman GA, McIntyre TM. Oxidized LDL contains inflammatory PAF-like phospholipids. Trends Cardiovasc Med 2001;11:139-142.
8. Owen JS, Baker PRS, O'Flaherty JT, et al. Stress-induced platelet-activating factor synthesis in human neutrophils. Biochim Biophys Acta 2005;1733:120-129.
9. Gabrijelcic J, Casas A, Rabinovich RA, et al. Formoterol protects against platelet-activating factor-induced effects in asthma. Eur Respir J 2004;23:71-75.
10. Goggel R, Uhlig S. The inositol trisphosphate pathway mediates platelet-activating-factor-induced pulmonary oedema. Eur Respir J 2005;25:849-857.
11. Fairbairn SM, Marr KA, Lees P, Cunningham FM. Effects of platelet activating factor on the distribution of radiolabelled leucocytes and platelets in normal horses and asymptomatic horses with chronic obstructive pulmonary disease. Res Vet Sci 1996;61:107-113.
12. Miskovic M, Couetil LL, Thompson CA. Lung function and airway cytologic profiles in horses with recurrent airway obstruction maintained in low-dust environments. J Vet Intern Med 2007;21: 1060-1066.
13. Berndt A, Derksen FJ, Robinson NE. Endotoxin concentrations within the breathing zone of horses are higher in stables than on pasture. Vet J 2008. Doi: 10.1016/j.tvjl.2008.09.001.
14. Couetil LL, Hoffman AM, Hodgson J, et al. Inflammatory airway disease of horses. J Vet Intern Med 2007;21:356-361.
15. McKane SA, Canfield PJ, Rose RJ. Equine bronchoalveolar lavage cytology: Survey of Thoroughbred racehorses in training. Austr Vet J 1993;70:401-404.
16. Hare JE, Viel L. Pulmonary eosinophilia associated with increased airway responsiveness in young racing horses. J Vet Intern Med 1998;12:163-170.
17. Denguezli-Bouzgarrou M, Saad HB, Cheikh IB, et al. Role of lung inflammatory mediators as a cause of training-induced lung function changes in runners. Sci Sports 2007;22:35-42.
18. Peters-Golden M. The alveolar macrophage: The forgotten cell in asthma. Am J Respir Cell Mol Biol 2004;31:3-7.
19. Laan TT, Bull S, Pirie R, Fink-Gremmels J. The role of alveolar macrophages in the pathogenesis of recurrent airway obstruction in horses. J Vet Intern Med 2006;20:167-174.
20. Raidal SL, Rose RJ, Love DN. Effects of training on resting peripheral blood and BAL-derived leucocyte function in horses. Equine Vet J 2001;33:238-243.
21. 21 indicators with greatly improved fluorescence properties. J Biol Chem 1985;260:3440-3450.
22. Muehlmann LA, Zanatta AL, Farias CLA, et al. Dietary supplementation with soybean lecithin increases pulmonary PAF bioactivity in asthmatic rats. J Nutr Biochem 2009, April 14. Doi: 10.1016/j.jnutbio.2009.03.001.
23. Woods PS, Robinson NE, Swanson MC, et al. Airborne dust and aeroallergen concentration in a horse stable under two different management systems. Equine Vet J 1993;25:208-213.
24. Holcombe SJ, Jackson C, Gerber V, et al. Stabling is associated airway inflammation in young Arabian horses. Equine Vet J 2001;33:244-249.
25. Uhlig S, Goggel R, Engel S. Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. Pharmacol Resp 2005;57(Suppl):206-21.
26. Dawson J, Lees P, Sedgwick AD. Platelet activating factor as a mediator of equine cell locomotion. Vet Res Commun 1988;12:101-107.
27. Lee YM, Hybertson BM, Cho YG, Repine JE. Platelet-activating factor induces lung inflammation and leak in rats: Hydrogen peroxide production along neutrophil-lung endothelial cell interfaces. J Lab Clin Med 2002;140:312-319.
28. Ishii S, Nagase T, Shindou H, et al. Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. J Immunol 2004;172:7095-7102.
29. Tsangaris I, Lekka ME, Kitsiouli E, et al. Bronchoalveolar lavage alterations during prolonged ventilation of patients without acute lung injury. Eur Respir J 2003;21:495-501.
30. Clavijo LC, Carter MB, Matheson PJ, et al. PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. J Appl Physiol 2001;90:261-268.
31. West JB, Tyler WS, Birks EK, Mathieu-Costello O. Exerciseinduced pulmonary hemorrhage. In: Rantanen NW, Hauser ML, eds. Dubai International Equine Symposium: The Diagnosis and Treatment of Respiratory Disease. USA: Neyenesch Printers Inc; 1997:353-368.
32. Kikuchi M, Shirasaki H, Himi T. Platelet-activating factor (PAF) increases NO production in human endothelial cells-realtime monitoring by DAR-4M AM. Prostaglandins Leukot Essent Fatty Acids 2008;78:305-309.
33. Ramirez R, Chong T, Victorino GP. Angiotensin II effect on hydraulic permeability: Interaction with endothelin-1, nitric oxide, and platelet activating factor. J Surg Res 2006;134:259-264.
34. Mills PC, Higgins AJ. Oxidant injury, nitric oxide and pulmonary vascular function: Implications for the exercising horse. Vet J 1997;153:125-148.
35. Mills PC, Marlin DJ, Demoncheaux E, et al. Nitric oxide and exercise in the horse. J Physiol 1996;495:863-874.
36. Brkovic A, Sirois MG. Vascular permeability induced by VEGF family members in vivo: Role of endogenous PAF and NO synthesis. J Cell Biochem 2007;100:727-737.
37. Xu W, Zheng S, Dweik RA, Erzurum SC. Role of epithelial nitric oxide in airway viral infection. Free Radic Biol Med 2006;41:19-28.
38. Kirschvink N, Moffarts B, Lekeux P. The oxidant/antioxidant equilibrium in horses. Vet J 2008;177:178-191.
39. Raidal SL, Love DN, Bailey GD, Rose RJ. The effect of high intensity exercise on the functional capacity of equine pulmonary alveolar macrophages and BAL-derived lymphocytes. Res Vet Sci 2000;68:249-253.