Markers of respiratory inflammation in horses in relation to seasonal changes in air quality in a conventional racing stable

Canadian Journal of Veterinary Research

Volumn 72, Issue 5, 2008, Pages 432-439

  Riihimäki, Miia ^a   Raine, Amanda ^b   Elfman, Lena ^c   Pringle, John ^a  

^a SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BETA 1,3 GLUCAN; ENDOTOXIN; INTERLEUKIN 10; INTERLEUKIN 6; MESSENGER RNA;

AIR ANALYSIS; AIR QUALITY; AIR SAMPLING; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOLOGY; DISEASE MARKER; DUST; ENDOSCOPY; ENVIRONMENTAL FACTOR; ENVIRONMENTAL TEMPERATURE; GENE EXPRESSION; GENE EXPRESSION REGULATION; HORSE DISEASE; HUMIDITY; IMMUNOREGULATION; INNATE IMMUNITY; LUNG LAVAGE; NEUTROPHIL; NONHUMAN; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY TRACT INFLAMMATION; SEASONAL VARIATION; SUMMER; TEMPERATURE MEASUREMENT; TREND STUDY; UPREGULATION; WINTER;

AIR POLLUTION, INDOOR; ANIMALS; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; DUST; ENDOTOXINS; FEMALE; HORSE DISEASES; HORSES; HOUSING, ANIMAL; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-6; LUNG DISEASES, OBSTRUCTIVE; MALE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEASONS; TEMPERATURE;

EQUIDAE;

EID: 56749178109     PISSN: 08309000     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (53)

1. Robinson NE. International Workshop on Equine Chronic Airway Disease. Michigan State University 16-18 June 2000. Equine Vet J 2001;33:5-19.
2. Robinson NE. Inflammatory airway disease: Defining the syndrome. Conclusions of the Havemeyer Workshop. Equine vet Educ 2003;15:61-63.
3. Couetil LL, Hoffman AM, Hodgson J, et al. Inflammatory airway disease in horses, ACVIM consensus statement. J Vet Intern Med 2007;21:356-361.
4. Robinson NE, Derksen FJ, Olszewski MA, Buechner-Maxwell VA. The pathogenesis of chronic obstructive pulmonary disease of horses. Br Vet J 1996;152:283-306.
5. Gerber V, Robinson NE, Luethi S. Marti E, Wampfler B, Straub R. Airway inflammation and mucus in two age groups of asymptomatic well-performing sport horses. Equine Vet J 2003;35: 491-495.
6. Jost U, Klukowska-Rotzler J, Dolf G, et al. A region on equine chromosome 13 is linked to recurrent airway obstruction in horses. Equine Vet J 2007;39:236-241.
7. Ramseyer A, Gaillard C, Burger D, et al. Effects of genetic and environmental factors on chronic lower airway disease in horses. J Vet Intern Med 2007;21:149-156.
8. Holcombe SJ, Jackson C, Gerber V, et al. Stabling is associated with airway inflammation in young Arabian horses. Equine Vet J 2001;33:244-249.
9. McGorum BC, Dixon PM, Halliwell RE. Responses of horses affected with chronic obstructive pulmonary disease to inhalation challenges with mould antigens. Equine Vet J 1993;25:261-267.
10. McPherson EA, Lawson GH, Murphy JR, Nicholson JM, Breeze RG, Pirie HM. Chronic obstructive pulmonary disease (COPD) in horses: Aetiological studies: responses to intradermal and inhalation antigenic challenge. Equine Vet J 1979;11:159-166.
11. Pirie RS, Collie DD, Dixon PM, McGorum BC. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 2: Effects of inhaled HDS on control and heaves horses. Equine Vet J 2002;34:337-342.
12. Pirie RS, Dixon PM, McGorum BC. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 3: Effect of fractionation of HDS. Equine Vet J 2002;34:343-347.
13. Pirie RS, McLachlan G, McGorum BC. Evaluation of nebulised hay dust suspensions (HDS) for the diagnosis and investigation of heaves. 1: Preparation and composition of HDS. Equine Vet J 2002;34:332-336.
14. Pirie RS, Collie DD, Dixon PM, McGorum BC. Inhaled endotoxin and organic dust particulates have synergistic proinflammatory effects in equine heaves (organic dust-induced asthma). Clin Exp Allergy 2003;33:676-683.
15. Pirie RS, Dixon PM, Collie DD, McGorum BC. Pulmonary and systemic effects of inhaled endotoxin in control and heaves horses. Equine Vet J 2001;33:311-318.
16. Pirie RS, Dixon PM, McGorum BC. Endotoxin contamination contributes to the pulmonary inflammatory and functional response to Aspergillus fumigatus extract inhalation in heaves horses. Clin Exp Allergy 2003;33:1289-1296.
17. Riihimaki M, Lilliehook I, Raine A, Berg M, Pringle J. Clinical alterations and mRNA levels of IL-4 and IL-5 in bronchoalveolar cells of horses with transient pulmonary eosinophilia. Res Vet Sci 2008;85:52-55.
18. Ainsworth DM, Grunig G, Matychak MB, et al. Recurrent airway obstruction (RAO) in horses is characterized by IFN-gamma and IL-8 production in bronchoalveolar lavage cells. Vet Immunol Immunopathol 2003;96:83-91.
19. Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001;25:402-408.
20. The Swedish Work Environment Authority, AFS 2005:17: Swedish Board of Agriculture, 2003:12.
21. Regulations on farm animal housing DFS 2004:17: Swedish Animal Welfare Agency 2004:1.
22. Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest 2000; 117:1162-1172.
23. Xing Z, Gauldie J, Cox G, et al. IL-6 is an antiinflammatory cytokine required for controlling local or systemic acute inflammatory responses. J Clin Invest 1998;101:311-320.
24. Giguere S, Viel L, Lee E, MacKay RJ, Hernandez J, Franchini M. Cytokine induction in pulmonary airways of horses with heaves and effect of therapy with inhaled fluticasone propionate. Vet Immunol Immunopathol 2002;85:147-158.
25. Morris DD, Crowe N, Moore JN, Moldawer LL. Endotoxin-induced production of interleukin 6 by equine peritoneal macrophages in vitro. Am J Vet Res 1992;53:298-1301.
26. McGorum BC, Ellison J, Cullen RT. Total and respirable airborne dust endotoxin concentrations in three equine management systems. Equine Vet J 1998;30:430-434.
27. Laan TT, Bull S, Pirie R, Fink-Gremmels J. The role of alveolar macrophages in the pathogenesis of recurrent airway obstruction in horses. J Vet Intern Med 2006;20:167-174.
28. Davis MS, Malayer JR, Vandeventer L, Royer CM, McKenzie EC, Williamson KK. Cold weather exercise and airway cytokine expression. J Appl Physiol 2005;98:2132-2136.
29. Davis MS, Williams CC, Meinkoth JH, et al. Influx of neutrophils and persistence of cytokine expression in airways of horses after performing exercise while breathing cold air. Am J Vet Res 2007;68:185-189.
30. Chen Y, Thai P, Zhao YH, Ho YS, DeSouza MM, Wu R. Stimulation of airway mucin gene expression by interleukin (IL)-17 through IL-6 paracrine/ autocrine loop. J Bio Chem 2003;278:17036-17023.
31. Gerber V, Robinson NE, Venta RJ, Rawson J, Jefcoat AM, Hotchkiss JA. Mucin genes in horse airways: MUC5AC, but not MUC2, may play a role in recurrent airway obstruction. Equine Vet J 2003;35:252-257.
32. Virchow JC, Jr., Kroegel C, Walker C, Matthys H. Inflammatory determinants of asthma severity: Mediator and cellular changes in bronchoalveolar lavage fluid of patients with severe asthma. J Allergy Clin Immunol 1996;98:S27-33; discussion S33-40.
33. Broide DH, Lotz M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic asthma airways. J Allergy Clin Immunol 1992;89:958-967.
34. Tutluoglu B, Atis S, Anakkaya AN, Altug E, Tosun GA, Yaman M. Sensitization to horse hair, symptoms and lung function in grooms. Clin Exp Allergy 2002;32:1170-1173.
35. Quaedvlieg V, Henket M, Sele J, Louis R. Cytokine production from sputum cells in eosinophilic versus non-eosinophilic asthmatics. Clin Exp Jmmunol 2006;143:161-166.
36. Koulis A, Robinson DS. The anti-inflammatory effects of interleukin-10 in allergic disease. Clin Exp Allergy 2000;30:747-750.
37. Laan TT, Bull S, Pirie RS, Fink-Gremmels J. Evaluation of cytokine production by equine alveolar macrophages exposed to lipopolysaccharide, Aspergillus fumigatus, and a suspension of hay dust. Am J Vet Res 2005;66:1584-1589.
38. van den Hoven R, Duvigneau JC, Hartl RT, Gemeiner M. Clenbuterol affects the expression of messenger RNA for interleukin 10 in peripheral leukocytes from horses challenged intrabronchially with lipopolysaccharides. Vet Res Commun 2006;30:921-928.
39. Davidson AJ, Hodgkinson JE, Proudman CJ, Matthews JB. Cytokine responses to Cyathostominae larvae in the equine large intestinal wall. Res Vet Sci 2005;78:169-176.
40. Colavita AM, Hastie AT, Musani AI, et al. Kinetics of IL-10 production after segmental antigen challenge of atopic asthmatic subjects. J Allergy Clin Immunol 2000;106:880-886.
41. Clements JM, Pirie RS. Respirable dust concentrations in equine stables. Part 1: Validation of equipment and effect of various management systems. Res Vet Sci 2007;83:256-262.
42. Vandenput S, Duvivier DH, Votion D, Art T, Lekeux P. Environmental control to maintain stabled COPD horses in clinical remission: effects on pulmonary function. Equine Vet J 1998;30:93-96.
43. Vandenput S, Istasse L, Nicks B, Lekeux P. Airborne dust and aeroallergen concentrations in different sources of feed and bedding for horses. Vet Q 1997;19:54-158.
44. Woods PS, Robinson NE, Swanson MC, Reed CE, Broadstone RV, Derksen FJ. Airborne dust and aeroallergen concentration in a horse stable under two different management systems. Equine Vet J 1993;25:208-213.
45. Vandenput S, Votion D, Duvivier DH, et al. Effect of a set stabled environmental control on pulmonary function and airway reactivity of COPD affected horses. Vet J 1998;155:189-195.
46. Robinson NE, Karmaus W, Holcombe SJ, Carr EA, Derksen FJ. Airway inflammation in Michigan pleasure horses: Prevalence and risk factors. Equine Vet J 2006;38:293-299.
47. Clements JM, Pirie RS. Respirable dust concentrations in equine stables. Part 2: The benefits of soaking hay and optimising the environment in a neighbouring stable. Res Vet Sci 2007;83:263-268.
48. Rosenthal FS, Gruntman A, Couetil LL. A comparison of total, respirable, and real-time airborne particulate sampling in horse barns. J Occup Environ Hyg 2006;3:599-605.
49. Crichlow EC, Yoshida K, Wallace K. Dust levels in a riding stable. Equine Vet J 1980;12:185-188.
50. Webster AJ, Clarke AF, Madelin TM, Wathes CM. Air hygiene in stables. 1: Effects of stable design, ventilation and management on the concentration of respirable dust. Equine Vet J 1987;119:448-453.
51. Zeitler MH. [Concentration and size distribution of air-borne dust particles in horse stables]. Berl Munch Tierarztl Wochenschr 1985;98:241-246.
52. Clarke AF. A review of environmental and host factors in relation to equine respiratory disease. Equine Vet J 1987;19:435-441.
53. Jacobs RR. Analyses of endotoxins. International Journal Occupational Enviromental Health 1997;3:42-48.