Lyophilization of water-in-oil emulsions to prepare phospholipid-based anhydrous reverse micelles for oral peptide delivery

European Journal of Pharmaceutical Sciences

Volumn 39, Issue 5, 2010, Pages 373-379

  Wang, Ting ^a   Wang, Ning ^a   Hao, Aijun ^b   He, Xia ^a   Li, Tiefu ^c   Deng, Yingjie ^c  

^a JINING MEDICAL UNIVERSITY   (China)

^b LIAONING UNIVERSITY   (China)

^c SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Blood glucose reduction; Drug release; Insulin; Nanoparticle; Oily formulation; Solubilization

Indexed keywords

GLUCOSE; NANOPARTICLE; OIL; PEPTIDE; PHOSPHATIDYLCHOLINE; PHOSPHOLIPID; PIG INSULIN; WATER;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ACTIVITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MECHANISM; DRUG RELEASE; DRUG STABILITY; DRUG STORAGE; EMULSION; FREEZE DRYING; GLUCOSE BLOOD LEVEL; HYDROPHILICITY; LIGHT SCATTERING; MALE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT; REVERSE MICELLE; SCANNING ELECTRON MICROSCOPY; SOLUBILIZATION; SOYBEAN; STORAGE TEMPERATURE; X RAY CRYSTALLOGRAPHY;

ADMINISTRATION, ORAL; ANIMALS; BLOOD GLUCOSE; CALORIMETRY, DIFFERENTIAL SCANNING; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIABETES MELLITUS, EXPERIMENTAL; FREEZE DRYING; INSULIN; MICELLES; MICROSCOPY, ELECTRON, SCANNING; PEPTIDES; PHOSPHOLIPIDS; RATS; SCATTERING, RADIATION;

EID: 77549088566     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejps.2010.01.006     Document Type: Article

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