Discovery of substituted biphenyl imidazoles as potent, bioavailable bombesin receptor subtype-3 agonists

Bioorganic and Medicinal Chemistry Letters

Volumn 20, Issue 6, 2010, Pages 1913-1917

  He, Shuwen ^a   Dobbelaar, Peter H ^a   Liu, Jian ^a   Jian, Tianying ^a   Sebhat, Iyassu K ^a   Lin, Linus S ^a   Goodman, Allan ^b   Guo, Cheng ^b   Guzzo, Peter R ^b   Hadden, Mark ^b   Henderson, Alan J ^b   Ruenz, Megan ^b   Sargent, Bruce J ^b   Yet, Larry ^b   Kelly, Theresa M ^a   Palyha, Oksana ^a   Kan, Yanqing ^a   Pan, Jie ^a   Chen, Howard ^a   Marsh, Donald J ^a   Shearman, Lauren P ^a   Strack, Alison M ^a   Metzger, Joseph M ^a   Feighner, Scott D ^a   Tan, Carina ^a   Howard, Andrew D ^a   Tamvakopoulos, Constantin ^a   Peng, Qianping ^a   Guan, Xiao Ming ^a   Reitman, Marc L ^a   Patchett, Arthur A ^a   Wyvratt Jr , Matthew J ^a   Nargund, Ravi P ^a   more..

^a MERCK RESEARCH LABORATORIES   (United States)

^b Albany Molecular Research   (United States)

Author keywords

Agonist; Biphenyl imidazole; Bombesin receptor subtype 3; BRS3

Indexed keywords

BOMBESIN DERIVATIVE; BOMBESIN RECEPTOR 3 AGONIST; IMIDAZOLE DERIVATIVE; RY 337; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG ACTIVITY; DRUG BINDING; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; HUMAN; MOUSE; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; BIOLOGICAL AVAILABILITY; DRUG DISCOVERY; HUMANS; IMIDAZOLES; RATS; RECEPTORS, BOMBESIN; STRUCTURE-ACTIVITY RELATIONSHIP;

BOVINE RESPIRATORY SYNCYTIAL VIRUS; RODENTIA;

EID: 77549083576     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.01.154     Document Type: Article

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