Vas deferens - A model used to establish sympathetic cotransmission

Trends in Pharmacological Sciences

Volumn 31, Issue 3, 2010, Pages 131-139

  Burnstock, Geoffrey ^a   Verkhratsky, Alexej ^b  

^a ROYAL FREE AND UNIVERSITY COLLEGE MEDICAL SCHOOL   (United Kingdom)

^b UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID B RECEPTOR; ADENOSINE A1 RECEPTOR; ADENOSINE TRIPHOSPHATE; ALCOHOL; ALPHA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CALCITONIN GENE RELATED PEPTIDE; CALCIUM ION; CHOLINERGIC RECEPTOR; DOPAMINE 4 RECEPTOR; DOPAMINE BETA MONOOXYGENASE; DOPAMINE RECEPTOR; MUSCARINIC M1 RECEPTOR; MYOSIN LIGHT CHAIN PHOSPHATASE; NEUROPEPTIDE Y; NORADRENALIN; PROTEIN KINASE C; PURINERGIC P2X RECEPTOR; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2X2 RECEPTOR; PURINERGIC P2Y RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT;

ADRENERGIC TRANSMISSION; AGING; ALCOHOL CONSUMPTION; CALCIUM TRANSPORT; CASTRATION; CONTRACEPTION; DIABETES MELLITUS; HUMAN; HYPERTENSION; NEUROMODULATION; NEUROPATHY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REINNERVATION; REVIEW; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION; SYMPATHETIC INNERVATION; VAS DEFERENS; VASECTOMY;

ADENOSINE TRIPHOSPHATE; AGING; ANIMALS; HUMANS; MALE; MODELS, BIOLOGICAL; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEUROMUSCULAR JUNCTION; NEUROPEPTIDE Y; NEUROTRANSMITTER AGENTS; NOREPINEPHRINE; SYMPATHETIC NERVOUS SYSTEM; SYNAPTIC TRANSMISSION; VAS DEFERENS; VISCERA;

EID: 77449097628     PISSN: 01656147     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tips.2009.12.002     Document Type: Review

References (121)

1. Huković S. Responses of the isolated sympathetic nerveductus deferens preparation of the guinea-pig. Br. J. Pharmacol. Chemother. 16 (1961) 188-194
2. Jen P.Y., et al. Colocalisation of neuropeptides, nitric oxide synthase and immunomarkers for catecholamines in nerve fibres of the adult human vas deferens. J. Anat 195 (1999) 481-489
3. Ventura S., et al. Nitric oxide synthase is colocalized with vasoactive intestinal polypeptide in postganglionic parasympathetic nerves innervating the rat vas deferens. Neuroscience 83 (1998) 607-616
4. Maggi C.A., et al. Capsaicin-induced inhibition of motility of the rat isolated vas deferens: do multiple neuropeptides mediate the visceromotor effects of capsaicin?. J. Auton. Pharmacol. 7 (1987) 243-255
5. Keast J.R. Location and peptide content of pelvic neurons supplying the muscle and lamina propria of the rat vas deferens. J. Auton. Nerv. Syst. 40 (1992) 1-11
6. 2+ transients in varicosities of the mouse vas deferens. Br. J. Pharmacol. 135 (2002) 1845-1850
7. Burn J.H., and Rand M.J. Sympathetic postganglionic mechanism. Nature 184 (1959) 163-165
8. Maggi C.A., et al. A comparison of capsazepine and ruthenium red as capsaicin antagonists in the rat isolated urinary bladder and vas deferens. Br. J. Pharmacol. 108 (1993) 801-805
9. Song Z.M., et al. NADPH-diaphorase and other neuronal markers in nerves and ganglia supplying the guinea-pig vas deferens. J. Auton. Nerv. Syst. 48 (1994) 31-43
10. Vladimirova I., et al. Evidence for participation of nitric oxide in excitatory neurotransmission in rat vas deferens. Life Sci. 55 (1994) 1123-1128
11. Kaleczyc J., et al. NO-synthase-containing neurons of the pig inferior mesenteric ganglion, part of them innervating the ductus deferens. Acta Anat. (Basel) 151 (1994) 62-67
12. Jen P.Y., et al. Development of peptide-containing nerves in the human fetal vas deferens and seminal vesicle. Br. J. Urol. 75 (1995) 378-385
13. Campos H.A., and Dominguez J. Interaction between noradrenergic and histamine-containing neurons in the rat vas deferens. J. Pharmacol. Exp. Ther. 272 (1995) 732-738
14. Merrillees N.C. The nervous environment of individual smooth muscle cells of the guinea pig vas deferens. J. Cell Biol. 37 (1968) 794-817
15. Burnstock G., and Holman M.E. The transmission of excitation from autonomic nerve to smooth muscle. J. Physiol. 155 (1961) 115-133
16. Barden J.A., et al. Vesicle-associated proteins and P2X receptor clusters at single sympathetic varicosities in mouse vas deferens. J. Neurocytol. 28 (1999) 469-480
17. Burnstock G. Non-synaptic transmission at autonomic neuroeffector junctions. Neurochem. Int. 52 (2008) 14-25
18. Dale H.H. Nomenclature of fibres in the autonomic system and their effects. J. Physiol. 80 (1934) P10-P11
19. Von Euler U.S. Preparation, purification and evaluation of noradrenaline and adrenaline in organ extracts. Arch. Int. Pharmacodyn. Ther. 77 (1948) 477-485
20. Burnstock G., and Holman M.E. Autonomic nerve-smooth muscle transmission. Nature 187 (1960) 951-952
21. Sneddon P., and Burnstock G. Inhibition of excitatory junction potentials in guinea-pig vas deferens by α,β-methylene-ATP: further evidence for ATP and noradrenaline as cotransmitters. Eur. J. Pharmacol. 100 (1984) 85-90
22. Westfall D.P., et al. The postjunctional effects and neural release of purine compounds in the guinea-pig vas deferens. Eur. J. Pharmacol. 50 (1978) 27-38
23. Sneddon P., et al. The effect of P2 receptor antagonists and ATPase inhibition on sympathetic purinergic neurotransmission in the guinea-pig isolated vas deferens. Br. J. Pharmacol. 129 (2000) 1089-1094
24. Meldrum, L.A. and Burnstock, G. (1983) Evidence that ATP acts as a co-transmitter with noradrenaline in sympathetic nerves supplying the guinea-pig vas deferens. Eur. J. Pharmacol. 92, 161-163
25. Bulloch J.M., and McGrath J.C. Blockade of vasopressor and vas deferens responses by α,β-methylene ATP in the pithed rat. Br. J. Pharmacol. 94 (1988) 103-108
26. Burnstock, G. (1995) Noradrenaline and ATP: cotransmitters and neuromodulators. J. Physiol. Pharmacol. 46, 365-384
27. Levitt B., et al. High-pressure liquid chromatographic-fluorometric detection of adenosine and adenine nucleotides: application to endogenous content and electrically induced release of adenyl purines in guinea pig vas deferens. Anal. Biochem 137 (1984) 93-100
28. Neild T.O., and Hirst G.D.S. 'The γ-connection': a reply. Trends Pharmacol. Sci. 5 (1984) 56-57
29. Sneddon P., and Westfall D.P. Pharmacological evidence that adenosine triphosphate and noradrenaline are co-transmitters in the guinea-pig vas deferens. J. Physiol. 347 (1984) 561-580
30. Kirkpatrick K., and Burnstock G. Sympathetic nerve-mediated release of ATP from the guinea-pig vas deferens is unaffected by reserpine. Eur. J. Pharmacol. 138 (1987) 207-214
31. Kasakov L., et al. Direct evidence for concomitant release of noradrenaline, adenosine 5′-triphosphate and neuropeptide Y from sympathetic nerve supplying the guinea-pig vas deferens. J. Auton. Nerv. Syst. 22 (1988) 75-82
32. Banks F., et al. The purinergic component of human vas deferens contraction. Fertil. Steril. 85 (2006) 932-939
33. Khattab M.M., et al. Postjunctional synergism of norepinephrine with ATP and diadenosine tetraphosphate in guinea pig vas deferens. Role of protein kinase C and myosin light chain phosphatase. Pharmacology 80 (2007) 27-32
34. Smith N.C.E., and Burnstock G. Mechanism underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP. Eur. J. Pharmacol. 498 (2004) 241-248
35. Macleod G.T., et al. Calcium dependence of quantal secretion from visualized sympathetic nerve varicosities on the mouse vas deferens. J. Physiol. 480 (1994) 61-70
36. Stjärne L., and Stjärne E. Geometry, kinetics and plasticity of release and clearance of ATP and noradrenaline as sympathetic cotransmitters: roles for the neurogenic contraction. Prog. Neurobiol. 47 (1995) 45-94
37. Bennett M.R., et al. Quantal and non-quantal current and potential fields around individual sympathetic varicosities on release of ATP. Biophys. J. 80 (2001) 1311-1328
38. Brain K.L., et al. Intermittent ATP release from nerve terminals elicits focal smooth muscle Ca2+ transients in mouse vas deferens. J. Physiol. 541 (2002) 849-862
39. Young J.S., et al. Electrical and optical study of nerve impulse-evoked ATP-induced, P2X-receptor-mediated sympathetic neurotransmission at single smooth muscle cells in mouse isolated vas deferens. Neuroscience 148 (2007) 82-91
40. Brain K.L., and Cunnane T.C. Bretylium abolishes neurotransmitter release without necessarily abolishing the nerve terminal action potential in sympathetic terminals. Br. J. Pharmacol. 153 (2008) 831-839
41. Christopoulos A., et al. Pharmacological analysis of cannabinoid receptor activity in the rat vas deferens. Br. J. Pharmacol. 132 (2001) 1281-1291
42. Fuder H., and Muscholl E. Heteroreceptor-mediated modulation of noradrenaline and acetylcholine release from peripheral nerves. Rev. Physiol. Biochem. Pharmacol. 126 (1995) 265-412
43. Westfall T.C. Prejunctional effects of neuropeptide Y and its role as a cotransmitter. Handb. Exp. Pharmacol. 162 (2004) 137-184
44. Hughes J., et al. Effect of morphine on adrenergic transmission in the mouse vas deferens. Assessment of agonist and antagonist potencies of narcotic analgesics. Br. J. Pharmacol. 53 (1975) 371-381
45. Berzetei-Gurske I.P., et al. Determination of activity for nociceptin in the mouse vas deferens. Eur. J. Pharmacol. 302 (1996) R1-R2
46. Queiroz G., et al. ATP modulates noradrenaline release by activation of inhibitory P2Y receptors and facilitatory P2X receptors in the rat vas deferens. J. Pharmacol. Exp. Ther. 307 (2003) 809-815
47. Williams D.J., et al. The effect of epibatidine on spontaneous and evoked neurotransmitter release in the mouse and guinea pig isolated vas deferens. Br. J. Pharmacol. 150 (2007) 906-912
48. 2-Adrenoceptor-mediated prejunctional facilitation and postjunctional inhibition of sympathetic neuroeffector transmission in the guinea pig vas deferens. J. Pharmacol. Exp. Ther. 298 (2001) 623-633
49. 2B receptors in the prostatic portion of the rat vas deferens. Eur. J. Pharmacol. 448 (2002) 45-50
50. Ellis J.L., and Burnstock G. Modulation of neurotransmission in the guinea-pig vas deferens by capsaicin: involvement of calcitonin gene-related peptide and substance P. Br. J. Pharmacol. 98 (1989) 707-713
51. 4 receptors in guinea pig vas deferens. Eur. J. Pharmacol. 374 (1999) 255-261
52. Iram S., and Hoyle C.H. Potentiation of sympathetic neuromuscular transmission mediated by muscarinic receptors in guinea pig isolated vas deferens. Naunyn Schmiedebergs Arch. Pharmacol. 371 (2005) 212-220
53. Yoshida S., and Kuga T. Probable pre- and postsynaptic modifications by 5-hydroxytryptamine of contractile responses to electrical stimulation of isolated guinea-pig vas deferens. Jpn. J. Pharmacol. 41 (1986) 315-323
54. Mutafova-Yambolieva V.N., and Westfall D.P. Endothelin-3 can both facilitate and inhibit transmitter release in the guinea-pig vas deferens. Eur. J. Pharmacol. 285 (1995) 213-216
55. Gonçalves J., et al. Opposite modulation of cotransmitter release in guinea-pig vas deferens: increase of noradrenaline and decrease of ATP release by activation of prejunctional β-adrenoceptors. Naunyn Schmiedebergs Arch. Pharmacol. 353 (1996) 184-192
56. Todorov L.D., et al. Temporal dissociation of the release of the sympathetic co-transmitters ATP and noradrenaline. Clin. Exp. Pharmacol. Physiol. 21 (1994) 931-932
57. De Potter W.P., et al. Evidence for the co-storage and co-release of neuropeptide Y and noradrenaline from large dense cored vesicles in sympathetic nerves of the bovine vas deferens. Synapse 2 (1988) 157-162
58. Ghildyal P., et al. Post- and prejunctional consequences of ecto-ATPase inhibition: electrical and contractile studies in guinea-pig vas deferens. J. Physiol. 575 (2006) 469-480
59. Todorov L.D., et al. Neuronal release of soluble nucleotidases and their role in neurotransmitter inactivation. Nature 387 (1997) 76-79
60. Mihaylova-Todorova S.T., et al. Enzyme kinetics and pharmacological characterization of nucleotidases released from the guinea pig isolated vas deferens during nerve stimulation: evidence for a soluble ecto-nucleoside triphosphate diphosphohydrolase-like ATPase and a soluble ecto-5′-nucleotidase-like AMPase. J. Pharmacol. Exp. Ther. 302 (2002) 992-1001
61. Geffen L.B., and Livett B.G. Synaptic vesicles in sympathetic neurons. Physiol. Rev. 51 (1971) 98-157
62. Vardolov L., and Pennefather J.N. Regional variation in the distribution of alpha-adrenoreceptors in the vas deferens of the rat. Arch. Int. Pharmacodyn. Ther. 221 (1976) 212
63. Sneddon P., and Machaly M. Regional variation in purinergic and adrenergic responses in isolated vas deferens of rat, rabbit and guinea-pig. J. Auton. Pharmacol. 12 (1992) 421-428
64. Diniz C., et al. Regional differences in extracellular purine degradation in the prostatic and epididymal portions of the rat vas deferens. Clin. Exp. Pharmacol. Physiol. 32 (2005) 721-727
65. Knight D., et al. Regional differences in sympathetic purinergic transmission along the length of the mouse vas deferens. Synapse 47 (2003) 225-235
66. 1-adrenoceptor mediating contractions of rat vas deferens. Br. J. Pharmacol. 128 (1999) 1323-1331
67. 2A/D-adrenoceptor knockout mice. Br. J. Pharmacol. 138 (2003) 1069-1076
68. 2, in rat vas deferens. Naunyn Schmiedebergs Arch. Pharmacol. 360 (1999) 196-201
69. 2y-relaxing purinoceptors in the smooth muscle of mouse vas deferens. Br. J. Pharmacol. 107 (1992) 1152-1158
70. Mackenzie I., et al. Regulation of voltage-dependent excitatory responses to α,β-methylene ATP, ATP and non-adrenergic nerve stimulation by dihydropyridines in the guinea-pig vas deferens. Neuroscience 27 (1988) 317-332
71. 1-Adrenoceptors and calcium sources in adrenergic neurogenic contractions of rat vas deferens. Br. J. Pharmacol. 111 (1994) 151-158
72. 1-adrenoceptor-evoked contraction in the guinea-pig vas deferens. Neurourol. Urodyn. 28 (2009) 447-454
73. French A.M., and Scott N.C. A comparison of the effects of nifedipine and verapamil on rat vas deferens. Br. J. Pharmacol. 73 (1981) 321-323
74. Wright C.E., and Angus J.A. Effects of N-, P- and Q-type neuronal calcium channel antagonists on mammalian peripheral neurotransmission. Br. J. Pharmacol. 119 (1996) 49-56
75. 2X purinoceptors in rat vas deferens. Eur. J. Pharmacol. 263 (1994) 301-309
76. Hoyle C.H., et al. Antagonism of P2X receptors in guinea-pig vas deferens by diinosine pentaphosphate. Eur. J. Pharmacol. 333 (1997) R1-R2
77. Liang S.X., et al. Spatial distribution and developmental appearance of postjunctional P2X1 receptors on smooth muscle cells of the mouse vas deferens. Synapse 42 (2001) 1-11
78. 1 receptors. Nature 403 (2000) 86-89
79. 2 receptor expression by interstitial cells of Cajal in vas deferens implicated in semen emission. Auton. Neurosci. 84 (2000) 147-161
80. 1 in rat vas deferens. FEBS Lett. 489 (2001) 154-158
81. Menzies J.R.W., and Kennedy C. Perinuclear P2X(7)-like immunoreactivity in the guinea-pig vas deferens. Br. J. Pharmacol. 135 (2002) 50P
82. Chiu-Wei Y.F., et al. Post-natal change and regional variation of the response of the vas deferens of new-born rats to autonomic drugs. Q. J. Exp. Physiol. 69 (1984) 703-710
83. Francavilla S., et al. Postnatal development of epididymis and ductus deferens in the rat. A correlation between the ultrastructure of the epithelium and tubule wall, and the fluorescence-microscopic distribution of actin, myosin, fibronectin, and basement membrane. Cell Tissue Res. 249 (1987) 257-265
84. Furness J.B., et al. Distribution of adrenergic nerves and changes in neuromuscular transmission in the mouse vas deferens during postnatal development. Dev. Biol. 21 (1970) 491-505
85. MacDonald A., and McGrath J.C. Post-natal development of functional neurotransmission in rat vas deferens. Br. J. Pharmacol. 82 (1984) 25-34
86. Hourani S.M.O., et al. Characterization and ontogeny of P1-purinoceptors on rat vas deferens. Br. J. Pharmacol. 108 (1993) 754-758
87. Hourani S.M. Postnatal development of purinoceptors in rat visceral smooth muscle preparations. Gen. Pharmacol. 32 (1999) 3-7
88. Nagao T., et al. Changes in neuronal contribution to contractile responses of vas deferens of young and adult guinea pigs. J. Auton. Nerv. Syst. 50 (1994) 87-92
89. Ren L.M., et al. Developmental changes in sympathetic contraction of the circular muscle layer in the guinea-pig vas deferens. Eur. J. Pharmacol. 318 (1996) 411-417
90. Liang S.X., et al. Development of fast purinergic transmission in the mouse vas deferens. Synapse 37 (2000) 283-291
91. Swedin G. Abolition of the nerve-induced responses of the isolated vas deferens of the young rat by agents blocking α-adrenoceptors. Br. J. Pharmacol. 44 (1972) 160-161
92. Brock J.A., et al. Postnatal androgen deprivation dissociates the development of smooth muscle innervation from functional neurotransmission in mouse vas deferens. J. Physiol. 581 (2007) 665-678
93. Burnstock G. Release of vasoactive substances from endothelial cells by shear stress and purinergic mechanosensory transduction. J. Anat. 194 (1999) 335-342
94. 3 knockout mice reveal a major sensory role for urothelially released ATP. J. Neurosci. 21 (2001) 5670-5677
95. Knight G.E., et al. ATP is released from guinea pig ureter epithelium on distension. Am. J. Physiol. Renal Physiol. 282 (2002) F281-F288
96. 2. J. Physiol. 586 (2008) 4843-4857
97. Okpalaugo E.O., et al. Contractile responses of the rat vas deferens after epithelium removal. Life Sci. 70 (2002) 2943-2951
98. Venkova K.M., et al. Contractile responses of vas deferens from spontaneously hypertensive rats to electrical stimulation. Acad. Bulgaredes Sci. 38 (1985) 377-380
99. Guitart M., et al. Adrenergic and purinergic components in bisected vas deferens from spontaneously hypertensive rats. Br. J. Pharmacol. 128 (1999) 873-880
100. Ralevic V., and Burnstock G. Receptors for purines and pyrimidines. Pharmacol. Rev. 50 (1998) 413-492
101. 1-receptors in caudal arteries of spontaneously hypertensive rats. Eur. J. Pharmacol. 174 (1989) 237-251
102. Wang Y.T., et al. Augmented responsiveness to sympathetic nerve stimulation of isolated vas deferens of diabetic rats. Arch. Int. Pharmacodyn. Ther. 309 (1991) 160-169
103. Kaschube M., et al. The field-stimulated vas deferens of the streptozotocin-diabetic mouse: effects of prazosin, α,β-methylene ATP, and variation of stimulation parameters. J. Neural Transm. 77 (1989) 171-180
104. Longhurst P.A. The effects of testosterone or insulin treatment on contractile responses of the rat vas deferens following castration or streptozotocin-induced diabetes mellitus. Gen. Pharmacol. 21 (1990) 427-434
105. Boselli C., and Govoni S. Alcohol differentially affects noradrenergic and purinergic responses in the bisected rat vas deferens. Alcohol 22 (2000) 91-96
106. Alexander N.J., et al. Innervation of the rabbit ductus deferens after vasectomy and vasovasostomy. Biol. Reprod. 21 (1979) 161-171
107. Dixon J.S., et al. The effects of vasectomy on the autonomic innervation of the human vas deferens. J. Urol. 137 (1987) 1014-1016
108. Dixon J.S., et al. Structure and autonomic innervation of the human vas deferens: a review. Microsc. Res. Tech. 42 (1998) 423-432
109. DeGaris R.M., and Pennefather J.N. Prolonged supersensitivity to noradrenaline of smooth muscle of the epididymal half of the rat vas deferens denervated by vasectomy. J. Auton. Pharmacol. 7 (1987) 267-279
110. DeGaris R.M., and Pennefather J.N. Noradrenergic reinnervation of the rat vas deferens after vasovasostomy following vasectomy. Clin. Exp. Pharmacol. Physiol. 14 (1987) 353-360
111. MacDonald A., and McGrath J.C. The effects of castration on neurotransmission in the rat vas deferens. Br. J. Pharmacol. 69 (1980) 49-58
112. Dunn P.M. Fertility: purinergic receptors and the male contraceptive pill. Curr. Biol. 10 (2000) R305-R307
113. Anton P.G., and McGrath J.C. Further evidence for adrenergic transmission in the human vas deferens. J. Physiol. 273 (1977) 45-55
114. 2A/D-adrenoceptor knockout mice. Br. J. Pharmacol 136 (2002) 857-864
115. Burnstock G. Noradrenaline and ATP: cotransmitters and neuromodulators. J. Physiol. Pharmacol. 46 (1995) 365-384
116. Palani D., and Manchanda R. Effects of heptanol on neurogenic contractions of vas deferens: a comparative study of stimulation frequency in guinea pig and rat. J. Physiol. Sci. 56 (2006) 21-28
117. Cardoso, L. et al. (2010) Locally produced relaxin may affect testis and vas deferens function in rats. Reproduction 139, 185-196
118. Bojnik, E. et al. Comparative biochemical and pharmacological characterization of a novel, NOP receptor selective hexapeptide, Ac-RYYRIR-ol. Brain Res. Bull.(in press)
119. Burnstock G., and Costa M. Adrenergic Neurones: Their Organisation, Function and Development in the Peripheral Nervous System (1975), Chapman and Hall p. 1-225
120. Meldrum L.A., and Burnstock G. Evidence that ATP acts as a co-transmitter with noradrenaline in sympathetic nerves supplying the guinea-pig vas deferens. Eur. J. Pharmacol. 92 (1983) 161-163
121. 2 of ATP and noradrenaline co-transmission in the guinea-pig vas deferens. J. Auton. Pharmacol. 10 (1990) 363-372