A contraction-mediating receptor for UTP, presumably P2Y2, in rat vas deferens

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 360, Issue 2, 1999, Pages 196-201

  Bültmann, Ralph ^a   Klebroff, Werner ^a   Starke, Klaus ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Ecto nucleotidase; Evans blue; P2 receptors; P2X1 receptor; P2Y2 receptor; Rat vas deferens; UTP

Indexed keywords

EVANS BLUE; NUCLEOTIDASE; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; ENZYME ACTIVITY; NONHUMAN; NUCLEOTIDE METABOLISM; RAT; RECEPTOR AFFINITY; RECEPTOR BINDING; SMOOTH MUSCLE CONTRACTION; VAS DEFERENS;

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANIMALS; COLORING AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; DRUG SYNERGISM; EVANS BLUE; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; N-GLYCOSYL HYDROLASES; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P2; URACIL NUCLEOTIDES; VAS DEFERENS;

EID: 0032874878     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002109900049     Document Type: Article

References (49)

1. 2-purinoceptors mediating contraction of the guinea-pig vas deferens and urinary bladder. Br J Pharmacol 112:219-225
2. 2X-purinoceptors. Gen Pharmacol 24:637-640
3. 4 nucleotide receptor. Br J Pharmacol 124:428-430
4. Bolego C, Pinna C, Abbracchio MP, Cattabeni F, Puglisi L (1995) The bipbasic response of rat vesical smooth muscle to ATP. Br J Pharmacol 114:1557-1562
5. 2-purinoceptor antagonists discriminate three contraction-mediating receptors for ATP in rat vas deferens. Naunyn-Schmiedeberg's Arch Pharmacol 349:74-80
6. 2X-purinoceptors. Naunyn-Schmiedeberg's Arch Pharmacol 347:527-533
7. Bültmann R, Driessen B, Gonçalves J, Starke K (1995) Functional consequences of inhibition of nucleotide breakdown in rat vas deferens: a study with Evans blue. Naunyn-Schmiedeberg's Arch Pharmacol 351:555-560
8. Bültmann R, Trendelenburg M, Tuluc F, Wittenburg H, Starke K (1999) Concomitant blockade of P2X-receptors and ecto-nucleotidases by P2-receptor antagonists: functional consequences in rat vas deferens. Naunyn-Schmiedeberg's Arch Pharmacol 359:339-344
9. 4 receptors: characterization of a suramin and PPADS-insensitive response to UTP. Br J Pharmacol 119:1301-1303
10. Chen ZP, Krull N, Xu S, Levy A, Lightman SL (1996) Molecular cloning and functional characterization of a rat pituitary G protein-coupled adenosine triphosphate (ATP) receptor. Endocrinology 137:1833-1840
11. 6 receptors and the distribution and properties of an extended family of ATP-gated ion channels. J Neurosci 16:2495-2507
12. Communi D, Boeynaems JM (1997) Receptors responsive to extracellular pyrimidine nucleotides. Trends Pharmacol Sci 18: 83-86
13. 2Y4 receptor. Eur J Pharmacol 317:383-389
14. 6 receptor. Biochem Biophys Res Commun 222:303-308
15. 2X-purinoceptor ligands. Br J Pharmacol 113:1432-1438
16. 2-purinergic receptors for extracellular ATP and other nucleotides. Am J Physiol 265:C577-C606
17. 2 purinoceptors in the rat isolated perfused kidney. Eur J Pharmacol 306:139-152
18. Fredholm BB, Abbracchio MP, Burnstock G, Dubyak GR, Harden TK, Jacobson KA, Schwabe U, Williams M (1997) Towards a revised nomenclature for P1 and P2 receptors. Trends Pharmacol Sci 18:79-82
19. García-Velasco G, Sánchez M, Hidalgo A, García de Boto MJ (1995) Pharmacological dissociation of UTP- and ATP-elicited contractions and relaxations in isolated rat aorta. Eur J Pharmacol 294:521-529
20. Harden TK, Lazarowski ER, Boucher RC (1997) Release, metabolism and interconversion of adenine and uridine nucleotides: implications for G protein-coupled P2 receptor agonist selectivity. Trends Pharmacol Sci 18:43-46
21. Harden TK, Barnard EA, Boeynaems HM, Burnstock G, Dubyak G, Hourani SMO, Insel PA (1998) P2Y receptors. In: The IUPHAR compendium of receptor characterization and classification. IUPHAR Media, London, pp 209-217
22. 2-purinoceptors on the rat colon muscularis mucosae. Br J Pharmacol 110:501-505
23. Humphrey PPA, Khakh BS, Kennedy C, King BF, Burnstock G (1998) P2X receptors. In: The IUPHAR compendium of receptor characterization and classification. IUPHAR Media, London, pp 195-208
24. Johnson CR, Charlton SJ, Hourani SMO (1996) Responses of the longitudinal muscle and the muscularis mucosac of the rat duodenum to adenine and uracil nucleotides. Br J Pharmacol 117:823-830
25. i, membrane potential and force in isolated rat small arteries. J Vasc Res 29:385-395
26. 2x purinoceptors mediating the electrophysiological and contractile effects of purine nucleotides in rat vas deferens. Br J Pharmacol 115:177-185
27. Khoyi MA, Westfall DP, Buxton ILQ, Akhtar-Khavari F, Rezaei E, Salaices M, Sanchez-Garcia P (1988) Norepinephrine and potassium induced calcium translocation in rat vas deferens. J Pharmacol Exp Ther 246:917-923
28. Kügelgen I von, Bültmann R, Starke K (1990) Interaction of adenine nucleotides, UTP and suramin in mouse vas deferens: suramin-sensitive and suramin-insensitive components in the contractile effect of ATP. Naunyn-Schmiedeberg's Arch Pharmacol 342:198-205
29. 2U-purinoceptor: potent activation by diadenosine tetraphosphate. Br J Pharmacol 116:1619-1627
30. Lustig KD, Shiau AK, Brake AJ, Julius D (1993) Expression cloning of an ATP receptor from mouse neuroblastoma cells. Proc Natl Acad Sci USA 90:5113-5117
31. McLaren GJ, Sneddon P, Kennedy C (1995) Comparison of the electrophysiological actions of ATP and UTP in single dissociated cells of the rat tail artery. Br J Pharmacol 116:55P
32. McLaren GJ, Burke KS, Buchanan KJ, Sneddon P, Kennedy C (1998) Evidence that ATP acts at two sites to evoke contraction in the rat isolated tail artery. Br J Pharmacol 124:5-12
33. 3H]α,β-methylene ATP binding in rat vas deferens. NaunynSchmiedeberg's Arch Pharmacol 350:113-122
34. 2 receptors: identification of a UDP-selective, a UTP-selective, and an ATP- and UTP-specific receptor. Mol Pharmacol 50:224-229
35. O'Connor SE, Dainty IA, Leff P (1991) Further subclassification of ATP receptors based on agonist studies. Trends Pharmacol Sci 12:137-141
36. Otsuguro K, Ito S, Ohta T, Nakazato Y (1996) Influence of purines and pyrimidines on circular muscle of the rat proximal stomach. Eur J Pharmacol 317:97-105
37. Plesner L (1995) Ecto-ATPases: identities and functions, Int Rev Cytol 158:141-214
38. Ralevic V, Burnstock G (1991) Effects of purines and pyrimidines on the rat mesenteric arterial bed. Circ Res 69:1583-1590
39. 2-purinoceptor mediating vasoconstriction by UTP, ATP and related nucleotides in the isolated pulmonary vascular bed of the rat. Br J Pharmacol 118:1415-1420
40. Sakai K, Akima M, Matsushita H (1979) Femoral vascular responses to purine and pyrimidine derivatives: release of 5-hydroxytryptamine by purine derivatives in isolated, cross-circulated rat hindlimb. Jpn J Pharmacol 29:243-251
41. Stone TW, Paton DM (1989) Possible subtypes of ATP receptor producing contraction of rat vas deferens, revealed by cross-desensitisation. Gen Pharmacol 20:61-64
42. 7). Science 272:735-738
43. Tawada Y, Furukawa KI, Shigekawa M (1987) ATP-induced calcium transient in cultured rat aortic smooth muscle cells. J Biochem 102:1499-1509
44. 2X purinoceptors. Naunyn-Schmiedeberg's Arch Pharmacol 351:603-609
45. 2X receptor for extracellular ATP. Nature 371:516-519
46. 1 MF-2 vas deferens cells. Eur J Pharmacol 215:317-320
47. Vesperinas G, Feddersen M, Levin J, Huidobro-Toro (1989) The use of ryanodine and calcium channel blockers to characterize intra- and extracellular calcium pools mobilized by noradrenaline in the rat vas deferens. Eur J Pharmacol 165:309-313
48. Waud DR (1976) Analysis of dose-response relationships. In: Narahashi T, Bianchi CP (eds) Advances in general and cellular pharmacology, vol 1. Plenum, New York London, pp 145-178
49. 2-purinoceptor subtypes and ecto-nucleotidases by compounds related to Evans blue or trypan blue. Naunyn-Schmiedeberg's Arch Pharmacol 354:491-497