Investigation of the subtypes of α1-adrenoceptor mediating contractions of rat vas deferens

British Journal of Pharmacology

Volumn 128, Issue 6, 1999, Pages 1323-1331

  Honner, Valerie ^a   Docherty, J R ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

5 Methyl urapidil; A61603; Prazosin; Rat vas deferens; RS17053; (1A) adrenoceptors; (1B) adrenoceptors; (1D) adrenoceptors

Indexed keywords

2 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 4,4 DIMETHYL 1,3(2H,4H) ISOQUINOLINEDIONE; 2 [[2 (2,6 DIMETHOXYPHENOXY)ETHYL]AMINOMETHYL] 1,4 BENZODIOXAN; 5 CHLORO N [2 (2 CYCLOPROPYLMETHOXYPHENOXY)ETHYL] ALPHA,ALPHA DIMETHYL 1H INDOLE 3 ETHANAMINE; 8 [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] 8 AZASPIRO[4.5]DECANE 7,9 DIONE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 1 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 1A ADRENERGIC RECEPTOR; ALPHA 1D ADRENERGIC RECEPTOR; ALPHA ETHYL 3,4,5 TRIMETHOXY ALPHA [3 [[2 (2 METHOXYPHENOXY)ETHYL]AMINO]PROPYL]BENZENEACETONITRILE FUMARATE; BENOXATHIAN; METHOXAMINE; N [5 (4,5 DIHYDRO 1H IMIDAZOL 2 YL) 5,6,7,8 TETRAHYDRO 2 HYDROXY 1 NAPHTHYL]METHANESULFONAMIDE; NIFEDIPINE; NIGULDIPINE; NORADRENALIN; PHENTOLAMINE; PHENYLEPHRINE; PRAZOSIN; SPIPERONE; UNCLASSIFIED DRUG; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA ADRENERGIC RECEPTOR STIMULATING AGENT; IMIDAZOLE DERIVATIVE; INDOLE DERIVATIVE; TETRALIN DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; EPIDIDYMIS; LIGAND BINDING; MALE; NERVE STIMULATION; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; VAS DEFERENS; ANIMAL; COMPARATIVE STUDY; DOSE RESPONSE; DRUG EFFECT; IN VITRO STUDY; INNERVATION; MUSCLE CONTRACTION; PHYSIOLOGY; WISTAR RAT;

ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; EPIDIDYMIS; IMIDAZOLES; INDOLES; MALE; METHOXAMINE; MUSCLE CONTRACTION; NIFEDIPINE; NOREPINEPHRINE; PHENYLEPHRINE; PRAZOSIN; RATS; RATS, WISTAR; RECEPTORS, ADRENERGIC, ALPHA-1; TETRAHYDRONAPHTHALENES; VAS DEFERENS;

EID: 0032586078     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0702913     Document Type: Article

References (38)

1. 1-adrenoceptor mediating contraction of rat aorta, vas deferens and spleen. Br. J. Pharmacol., 109, 80-87.
2. ARUNLAKSHANA, O. & SCHILD, H.O. (1959). Some quantitative uses of drug antagonists. Br. J. Pharmacol. Chemother., 14, 48-52.
3. BROWN, D.A., DOCHERTY, J.R., FRENCH, A.M., MACDONALD, A., MCGRATH, J.C. & SCOTT, N.C. (1983). Separation of noradrenergic and non-adrenergic contractions to field stimulation in the rat vas deferens. Br. J. Pharmacol., 79, 379-393.
4. BUCKNER, S.A., OHEIM, K.W., MORSE, P.A., KNEPPER, S.M. & HANCOCK, A.A. (1996). Alpha 1-adrenoceptor-induced contractility in rat aorta is mediated by the alpha 1D subtype. Eur. J. Pharmacol., 297, 241-248.
5. 1-Adrenoceptors and calcium sources in adrenergic neurogenic contractions of rat vas deferens. Br. J. Pharmacol., 111, 151-158.
6. 2-adrenoceptors in rat vas deferens. Br. J. Pharmacol., 108, 336-341.
7. 1B-adrenoceptor mediating contraction of the rat spleen. Br. J. Pharmacol., 115, 467-475.
8. BYLUND, D.B., EILENBERG, D.C., HEIBLE, J.P., LANGER, S.Z., LEFKOWITZ, R.J., MINNEMAN, K.P., MOLINOFF, P.B., RUFFOLO, R.R. & TRENDELENBURG, U. (1994) International Union of Pharmacology nomenclature of adrenoceptors. Pharmacol. Rev., 46, 121-136.
9. 1D-Adrenoceptors contribute to the neurogenic vasopressor response in pithed rats. Fund. Clin. Pharmacol., 12, 584-589.
10. 1-adrenoceptor. Br. J. Pharmacol., 119, 1093-1100.
11. 1-adrenergic receptor. Proc. Natl. Acad. Sci. U.S.A., 85, 7159-7163.
12. DENG, X.F., CHEMTOB, S. & VARMA, D.R. (1996). Characterization of α1D-adrenoceptor subtype in rat myocardium, aorta and other tissues. Br. J. Pharmacol., 119, 269-276.
13. DOCHERTY, J.R. (1987). Alpha-1 adrenoceptor subclassification in vascular smooth muscle: a premature proposal? Trends Pharmacol. Sci., 8, 123-124.
14. 2-adrenoceptors: Evidence for and against a further subdivision. Pharmacol. Ther., 44, 241-284.
15. 2-adrenoceptor adrenoceptors. Eur. J. Pharmacol., 361, 1-15.
16. 1-adrenoceptor classification. Eur. J. Pharmacol., 268, 141-149.
17. FLAVAHAN, N.A. & VANHOUTTE, P.M. (1986). Alpha-1 adrenoceptor subclassification in vascular smooth muscle. Trends Pharmacol. Sci., 7, 347-349.
18. 1-adrenoceptors in human prostate: implications for adrenoceptor classification. Mol. Pharmacol., 49, 209-215.
19. 1-adrenergic receptor that mediates smooth muscle contraction in human prostate has the pharmacological properties of the cloned human α1C subtype. Mol. Pharmacol., 45, 703-708.
20. GOETZ, A.S., KING, H.K., WARD, S.D.C., TRUE, T.A., RIMELE, T.J. & SAUSSY, D.L. (1995). BMY 7378 is a selective antagonist of the D subtype of α1-adrenoceptors. Eur. J. Pharmacol., 272, R5-R6.
21. 2+ in smooth muscle. Nature, 329, 333-335.
22. 1-adrenoceptor recognition sites by urapidil derivatives and other selective antagonists. Br. J. Pharmacol., 97, 691-700.
23. 1-adrenoceptor antagonists at prostatic α-adrenoceptors: binding, functional and in vivo studies. Br. J. Pharmacol., 118, 871-878.
24. 1A receptor subtype. J. Pharmacol. Exp. Ther., 274, 97-103.
25. 1A-adrenergic receptor. J. Biol. Chem., 266, 6365-6369.
26. 1B-adrenoceptor mediated components in the tension response of the rat vas deferens to electrical field stimulation. Br. J. Pharmacol., 105, 727-731.
27. 1A-adrenoceptor mediating contraction of rat epididymal vas deferens, rat hepatic portal vein and human prostate distinguished by the antagonist RS 17053. Br. J. Pharmacol., 119, 407-415.
28. 3H] prazosin binding. Mol. Pharmacol., 29, 321-330.
29. 1-adrenoceptors in vascular smooth muscle. Br. J. Pharmacol., 99, 197-201.
30. 1-adrenoceptor subtypes in the human prostate: functional and binding studies. Br. J. Urol., 74, 572-578.
31. 1-adrenoceptor subtypes in the rat vas deferens: binding and functional studies. Br. J. Pharmacol., 107, 697-704.
32. 1D-adrenergic receptor cDNA. Mol. Pharmacol., 40, 876-883.
33. ROKOSH, D.G., BAILEY, B.A., STEWART, A.F.R., KARNS, L.R., LONG, C.S. & SIMPSON, P.C. (1994). Distribution of α1C-adrenergic receptor mRNA in adult rat tissues by RNase protection and comparison with α1B and α1D. Biochem. Biophys. Res. Comm., 200, 1177-1184.
34. 1-adrenoceptor subtypes: selective antagonists suggest the existence of a fourth subtype. Eur. J. Pharmacol., 227, 433-436.
35. 1-adrenergic receptor subtype. J. Biol. Chem., 265, 8183-8189.
36. 1a-Adrenoceptor polymorphism: pharmacological characterization and association with benign prostatic hypertrophy. Br. J. Pharmacol., 118, 1403-1408.
37. 1-adrenoceptor subtypes in human prostate: comparison with those in rat vas deferens and spleen. Eur. J. Pharmacol., 265, 61-66.
38. 1-adrenoceptors and their subtypes in human and rat hippocampus. Neuroscience, 40, 307-320.