-
1
-
-
33845344395
-
Plasma insulin response to oral and intravenous glucose administration
-
Elrick H., Stimmler L., Hlad C.J., and Ari Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 24 (1964) 1076-1082
-
(1964)
J Clin Endocrinol Metab
, vol.24
, pp. 1076-1082
-
-
Elrick, H.1
Stimmler, L.2
Hlad, C.J.3
Ari, Y.4
-
2
-
-
0022461548
-
Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses
-
Nauck M.A., Homberger E., Siegel E.G., et al. Incretin effects of increasing glucose loads in man calculated from venous insulin and C-peptide responses. J Clin Endocrinol 63 (1986) 492-498
-
(1986)
J Clin Endocrinol
, vol.63
, pp. 492-498
-
-
Nauck, M.A.1
Homberger, E.2
Siegel, E.G.3
-
3
-
-
33644618433
-
The biology of incretin hormones
-
Drucker D.J. The biology of incretin hormones. Cell Metab 3 (2006) 153-165
-
(2006)
Cell Metab
, vol.3
, pp. 153-165
-
-
Drucker, D.J.1
-
4
-
-
0018193765
-
Electroimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) in man
-
Buchan A.M., Polak J.M., Capella C., Solcia E., and Pearse A.G. Electroimmunocytochemical evidence for the K cell localization of gastric inhibitory polypeptide (GIP) in man. Histochemistry 56 (1978) 37-44
-
(1978)
Histochemistry
, vol.56
, pp. 37-44
-
-
Buchan, A.M.1
Polak, J.M.2
Capella, C.3
Solcia, E.4
Pearse, A.G.5
-
5
-
-
0027391607
-
Preserved incretin activity of glucagon-like peptide 1 [7-36 amid] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus
-
Nauck M.A., Heimesaat M.M., Orskov C., Holst J.J., Ebert R., and Creutzfeldt W. Preserved incretin activity of glucagon-like peptide 1 [7-36 amid] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus. J Clin Invest 91 (1993) 301-307
-
(1993)
J Clin Invest
, vol.91
, pp. 301-307
-
-
Nauck, M.A.1
Heimesaat, M.M.2
Orskov, C.3
Holst, J.J.4
Ebert, R.5
Creutzfeldt, W.6
-
7
-
-
0030667056
-
Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans
-
Nauck M.A., Niedereichholzs U., Ettler R., et al. Glucagon-like peptide 1 inhibition of gastric emptying outweighs its insulinotropic effects in healthy humans. Am J Physiol Endocrinol Metab 273 (1997) E981-E988
-
(1997)
Am J Physiol Endocrinol Metab
, vol.273
-
-
Nauck, M.A.1
Niedereichholzs, U.2
Ettler, R.3
-
8
-
-
0032005005
-
Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans
-
Flint A., Raben A., Astrup A., and Holst J.J. Glucagon-like peptide-1 promotes satiety and suppresses energy intake in humans. J Clin Invest 101 (1998) 515-520
-
(1998)
J Clin Invest
, vol.101
, pp. 515-520
-
-
Flint, A.1
Raben, A.2
Astrup, A.3
Holst, J.J.4
-
9
-
-
0035489990
-
Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic β-cell proliferation
-
Buteau J., Foisy S., Rhodes C.J., Carpenter L., Biden T.J., and Prentki M. Protein kinase Czeta activation mediates glucagon-like peptide-1-induced pancreatic β-cell proliferation. Diabetes 50 (2001) 2237-2243
-
(2001)
Diabetes
, vol.50
, pp. 2237-2243
-
-
Buteau, J.1
Foisy, S.2
Rhodes, C.J.3
Carpenter, L.4
Biden, T.J.5
Prentki, M.6
-
10
-
-
0028883257
-
Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amid
-
Kolligs F., Fehmann H.C., Goke R., and Goke B. Reduction of the incretin effect in rats by the glucagon-like peptide 1 receptor antagonist exendin (9-39) amid. Diabetes 44 (1995) 16-19
-
(1995)
Diabetes
, vol.44
, pp. 16-19
-
-
Kolligs, F.1
Fehmann, H.C.2
Goke, R.3
Goke, B.4
-
11
-
-
0028803336
-
Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects
-
Deacon C.F., Nauck M.A., Toft-Nielsen M., Pridal L., Willms B., and Holst J.J. Both subcutaneously and intravenously administered glucagon-like peptide 1 are rapidly degraded from the NH2-terminus in type II diabetic patients and in healthy subjects. Diabetes 44 (1995) 1126-1131
-
(1995)
Diabetes
, vol.44
, pp. 1126-1131
-
-
Deacon, C.F.1
Nauck, M.A.2
Toft-Nielsen, M.3
Pridal, L.4
Willms, B.5
Holst, J.J.6
-
12
-
-
34447267513
-
Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis
-
Amori R.E., Lau J., and Pittas A.G. Efficacy and safety of incretin therapy in type 2 diabetes: systematic review and meta-analysis. JAMA 298 (2007) 194-206
-
(2007)
JAMA
, vol.298
, pp. 194-206
-
-
Amori, R.E.1
Lau, J.2
Pittas, A.G.3
-
13
-
-
48749089599
-
Emerging incretin based therapies for type 2 diabetes: incretin mimetics and DPP-4 inhibitors
-
Stonehouse A., Okerson T., Kendall D., and Maggs D. Emerging incretin based therapies for type 2 diabetes: incretin mimetics and DPP-4 inhibitors. Curr Diabetes Rev 4 (2008) 101-109
-
(2008)
Curr Diabetes Rev
, vol.4
, pp. 101-109
-
-
Stonehouse, A.1
Okerson, T.2
Kendall, D.3
Maggs, D.4
-
14
-
-
45849115827
-
Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension
-
Jackson E.K., and Mi Z. Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension. Hypertension 51 (2008) 1637-1642
-
(2008)
Hypertension
, vol.51
, pp. 1637-1642
-
-
Jackson, E.K.1
Mi, Z.2
-
15
-
-
0026648961
-
Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom: further evidence for an exendin receptor on dispersed acini from guinea pig pancreas
-
Eng J., Kleinman W.A., Singh L., Singh G., and Raufman J.P. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom: further evidence for an exendin receptor on dispersed acini from guinea pig pancreas. J Biol Chem 267 (1992) 7402-7405
-
(1992)
J Biol Chem
, vol.267
, pp. 7402-7405
-
-
Eng, J.1
Kleinman, W.A.2
Singh, L.3
Singh, G.4
Raufman, J.P.5
-
17
-
-
0038497464
-
Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes
-
Kolterman O.G., Buse J.B., Fineman M.S., et al. Synthetic exendin-4 (exenatide) significantly reduces postprandial and fasting plasma glucose in subjects with type 2 diabetes. J Clin Endocrinol Metab 88 (2003) 3082-3089
-
(2003)
J Clin Endocrinol Metab
, vol.88
, pp. 3082-3089
-
-
Kolterman, O.G.1
Buse, J.B.2
Fineman, M.S.3
-
18
-
-
15444367142
-
Pharmacokinetics, pharmacodynamics and safety of exenatide in patients with type 2 diabetes mellitus
-
Kolterman O.G., Kim D.D., Shen L., et al. Pharmacokinetics, pharmacodynamics and safety of exenatide in patients with type 2 diabetes mellitus. Am Health Syst Pharm 62 (2005) 173-181
-
(2005)
Am Health Syst Pharm
, vol.62
, pp. 173-181
-
-
Kolterman, O.G.1
Kim, D.D.2
Shen, L.3
-
19
-
-
0034456212
-
Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats
-
Szayna M., Doyle M.E., Betkey J.A., et al. Exendin-4 decelerates food intake, weight gain, and fat deposition in Zucker rats. Endocrinology 141 (2000) 1936-1941
-
(2000)
Endocrinology
, vol.141
, pp. 1936-1941
-
-
Szayna, M.1
Doyle, M.E.2
Betkey, J.A.3
-
20
-
-
0033513455
-
Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats
-
Xu G., Stoffers D.A., Habener J.F., and Bonner-Weir S. Exendin-4 stimulates both β-cell replication and neogenesis, resulting in increased β-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48 (1999) 2270-2276
-
(1999)
Diabetes
, vol.48
, pp. 2270-2276
-
-
Xu, G.1
Stoffers, D.A.2
Habener, J.F.3
Bonner-Weir, S.4
-
21
-
-
65949122087
-
One-year treatment with exenatide improves β-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial
-
Bunck M.C., Diamant M., Cornér A., et al. One-year treatment with exenatide improves β-cell function, compared with insulin glargine, in metformin-treated type 2 diabetic patients: a randomized, controlled trial. Diabetes Care 32 (2009) 762-768
-
(2009)
Diabetes Care
, vol.32
, pp. 762-768
-
-
Bunck, M.C.1
Diamant, M.2
Cornér, A.3
-
22
-
-
7444228521
-
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes
-
Exenatide-113 Clinical Study Group
-
Buse J.B., Henry R.R., Han J., Kim D.D., Fineman M.S., Baron A.D., and Exenatide-113 Clinical Study Group. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in sulfonylurea-treated patients with type 2 diabetes. Diabetes Care 27 (2004) 2628-2635
-
(2004)
Diabetes Care
, vol.27
, pp. 2628-2635
-
-
Buse, J.B.1
Henry, R.R.2
Han, J.3
Kim, D.D.4
Fineman, M.S.5
Baron, A.D.6
-
23
-
-
18144401971
-
Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes
-
DeFronzo R.A., Ratner R.E., Han J., Kim D.D., Fineman M.S., and Baron A.D. Effects of exenatide (exendin-4) on glycemic control and weight over 30 weeks in metformin-treated patients with type 2 diabetes. Diabetes Care 28 (2005) 1092-1100
-
(2005)
Diabetes Care
, vol.28
, pp. 1092-1100
-
-
DeFronzo, R.A.1
Ratner, R.E.2
Han, J.3
Kim, D.D.4
Fineman, M.S.5
Baron, A.D.6
-
24
-
-
17144371646
-
Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea
-
Kendall D.M., Riddle M.C., Rosenstock J., et al. Effects of exenatide (exendin-4) on glycemic control over 30 weeks in patients with type 2 diabetes treated with metformin and a sulfonylurea. Diabetes Care 28 (2005) 1083-1091
-
(2005)
Diabetes Care
, vol.28
, pp. 1083-1091
-
-
Kendall, D.M.1
Riddle, M.C.2
Rosenstock, J.3
-
25
-
-
63149173251
-
Standards of medical care
-
American Diabetes Association
-
American Diabetes Association. Standards of medical care. Diabetes Care 32 suppl 1 (2009) S13-S61
-
(2009)
Diabetes Care
, vol.32
, Issue.SUPPL. 1
-
-
-
26
-
-
34247259577
-
The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes
-
Zinman B., Hoogwerf B.J.D.G.S., et al. The effect of adding exenatide to a thiazolidinedione in suboptimally controlled type 2 diabetes. Ann Intern Med 146 (2007) 477-485
-
(2007)
Ann Intern Med
, vol.146
, pp. 477-485
-
-
Zinman, B.1
Hoogwerf, B.J.D.G.S.2
-
27
-
-
38549162147
-
Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years
-
Klonoff D.C., Buse J.B., Nielsen L.L., et al. Exenatide effects on diabetes, obesity, cardiovascular risk factors and hepatic biomarkers in patients with type 2 diabetes treated for at least 3 years. Curr Med Res Opin 24 (2008) 275-286
-
(2008)
Curr Med Res Opin
, vol.24
, pp. 275-286
-
-
Klonoff, D.C.1
Buse, J.B.2
Nielsen, L.L.3
-
28
-
-
33845472504
-
Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes
-
Aschner P., Kipnes M.S., Lunceford J.K., Sanchez M., Mickel C., and Williams-Herman D.E. Effect of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy on glycemic control in patients with type 2 diabetes. Diabetes Care 29 (2006) 2632-2637
-
(2006)
Diabetes Care
, vol.29
, pp. 2632-2637
-
-
Aschner, P.1
Kipnes, M.S.2
Lunceford, J.K.3
Sanchez, M.4
Mickel, C.5
Williams-Herman, D.E.6
-
29
-
-
33845476757
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone
-
Sitagliptin Study 020 Group
-
Charbonnel B., Karasik A., Liu J., Wu M., Meininger G., and Sitagliptin Study 020 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing metformin therapy in patients with type 2 diabetes inadequately controlled with metformin alone. Diabetes Care 29 (2006) 2638-2643
-
(2006)
Diabetes Care
, vol.29
, pp. 2638-2643
-
-
Charbonnel, B.1
Karasik, A.2
Liu, J.3
Wu, M.4
Meininger, G.5
-
30
-
-
33751557143
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
-
Sitagliptin Study 019 Group
-
Rosenstock J., Brazg R., Andryuk P.J., Lu K., Stein P., and Sitagliptin Study 019 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study. Clin Ther 28 (2006) 1556-1568
-
(2006)
Clin Ther
, vol.28
, pp. 1556-1568
-
-
Rosenstock, J.1
Brazg, R.2
Andryuk, P.J.3
Lu, K.4
Stein, P.5
-
31
-
-
33748442464
-
Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes
-
Blonde L., Klein E.J., Han J., et al. Interim analysis of the effects of exenatide treatment on A1C, weight and cardiovascular risk factors over 82 weeks in 314 overweight patients with type 2 diabetes. Diabetes Obes Metab 8 (2006) 436-447
-
(2006)
Diabetes Obes Metab
, vol.8
, pp. 436-447
-
-
Blonde, L.1
Klein, E.J.2
Han, J.3
-
32
-
-
50649112783
-
Drug-induced pancreatitis: incidence, management and prevention
-
Balani A.R., and Grendell J.H. Drug-induced pancreatitis: incidence, management and prevention. Drug Safety 31 (2008) 823-837
-
(2008)
Drug Safety
, vol.31
, pp. 823-837
-
-
Balani, A.R.1
Grendell, J.H.2
-
33
-
-
65949111736
-
Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective, cohort study
-
Noel R.A., Braun D.K., Patterson R.E., and Bloomgren G. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective, cohort study. Diabetes Care 32 (2009) 834-838
-
(2009)
Diabetes Care
, vol.32
, pp. 834-838
-
-
Noel, R.A.1
Braun, D.K.2
Patterson, R.E.3
Bloomgren, G.4
-
34
-
-
74349099732
-
FDA reviews incidences of acute pancreatitis in patients taking Byetta
-
Idris I. FDA reviews incidences of acute pancreatitis in patients taking Byetta. Diabetes Obes Metab 10 (2008) 96-98
-
(2008)
Diabetes Obes Metab
, vol.10
, pp. 96-98
-
-
Idris, I.1
-
35
-
-
67649304917
-
Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide
-
Dore D.D., Seeger J.D., and Arnold Chan K. Use of a claims-based active drug safety surveillance system to assess the risk of acute pancreatitis with exenatide or sitagliptin compared to metformin or glyburide. Curr Med Res Opin 25 (2009) 1019-1027
-
(2009)
Curr Med Res Opin
, vol.25
, pp. 1019-1027
-
-
Dore, D.D.1
Seeger, J.D.2
Arnold Chan, K.3
-
37
-
-
33749871472
-
Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes
-
Herman G.A., Bergman A., Stevens C., et al. Effect of single oral doses of sitagliptin, a dipeptidyl peptidase-4 inhibitor, on incretin and plasma glucose levels after an oral glucose tolerance test in patients with type 2 diabetes. J Clin Endocrinol Metab 91 (2006) 4612-4619
-
(2006)
J Clin Endocrinol Metab
, vol.91
, pp. 4612-4619
-
-
Herman, G.A.1
Bergman, A.2
Stevens, C.3
-
39
-
-
67650245531
-
Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin
-
Matveyenko A.V., Dry S., Cox H.I., et al. Beneficial endocrine but adverse exocrine effects of sitagliptin in the human islet amyloid polypeptide transgenic rat model of type 2 diabetes: interactions with metformin. Diabetes 58 (2009) 1604-1615
-
(2009)
Diabetes
, vol.58
, pp. 1604-1615
-
-
Matveyenko, A.V.1
Dry, S.2
Cox, H.I.3
-
40
-
-
55549136417
-
Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study
-
DeFronzo R.A., Okerson T., Viswanathan P., Guan X., Holcombe J.H., and MacConell L. Effects of exenatide versus sitagliptin on postprandial glucose, insulin and glucagon secretion, gastric emptying, and caloric intake: a randomized, cross-over study. Curr Med Res Opin 24 (2008) 2943-2952
-
(2008)
Curr Med Res Opin
, vol.24
, pp. 2943-2952
-
-
DeFronzo, R.A.1
Okerson, T.2
Viswanathan, P.3
Guan, X.4
Holcombe, J.H.5
MacConell, L.6
-
41
-
-
61349099439
-
Diagnosis and classification of diabetes mellitus
-
American Diabetes Association
-
American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 32 suppl 1 (2009) S62-S67
-
(2009)
Diabetes Care
, vol.32
, Issue.SUPPL. 1
-
-
-
43
-
-
34249891874
-
Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes
-
Kim D., MacConell L., Zhuang D., et al. Effects of once-weekly dosing of a long-acting release formulation of exenatide on glucose control and body weight in subjects with type 2 diabetes. Diabetes Care 30 (2007) 1487-1493
-
(2007)
Diabetes Care
, vol.30
, pp. 1487-1493
-
-
Kim, D.1
MacConell, L.2
Zhuang, D.3
-
44
-
-
53249142132
-
Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomized, open-label, non-inferiority study
-
DURATION-1 Study Group
-
Drucker D.J., Buse J.B., Taylor K., et al., DURATION-1 Study Group. Exenatide once weekly versus twice daily for the treatment of type 2 diabetes: a randomized, open-label, non-inferiority study. Lancet 372 (2008) 1240-1250
-
(2008)
Lancet
, vol.372
, pp. 1240-1250
-
-
Drucker, D.J.1
Buse, J.B.2
Taylor, K.3
-
45
-
-
67649532460
-
Exenatide once weekly elicited improvements in blood pressure and lipid profile over 52 weeks in patients with type 2 diabetes
-
November 9, New Orleans, Louisiana. Abstract 1239
-
Bergenstal R, Kim T, Trautmann M, et al. Exenatide once weekly elicited improvements in blood pressure and lipid profile over 52 weeks in patients with type 2 diabetes. In: Program and Abstracts of the American Heart Association Scientific Sessions; November 9, 2008; New Orleans, Louisiana. Abstract 1239.
-
(2008)
Program and Abstracts of the American Heart Association Scientific Sessions
-
-
Bergenstal, R.1
Kim, T.2
Trautmann, M.3
-
46
-
-
0032908654
-
Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta)
-
Young A.A., Gedulin B.R., Bhavsar S., et al. Glucose-lowering and insulin-sensitizing actions of exendin-4: studies in obese diabetic (ob/ob, db/db) mice, diabetic fatty Zucker rats, and diabetic rhesus monkeys (Macaca mulatta). Diabetes 48 (1999) 1026-1034
-
(1999)
Diabetes
, vol.48
, pp. 1026-1034
-
-
Young, A.A.1
Gedulin, B.R.2
Bhavsar, S.3
-
47
-
-
0034108646
-
Potent derivatives of glucagon-like peptide 1 with pharmacokinetic properties suitable for once-daily administration
-
Knudsen L.B., Nielsen P.F., Huusfeldt P.O., et al. Potent derivatives of glucagon-like peptide 1 with pharmacokinetic properties suitable for once-daily administration. J Med Chem 43 (2000) 1664-1669
-
(2000)
J Med Chem
, vol.43
, pp. 1664-1669
-
-
Knudsen, L.B.1
Nielsen, P.F.2
Huusfeldt, P.O.3
-
49
-
-
62449129181
-
Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU)
-
LEAD-1 SU Study Group
-
Marre M., Shaw J., Brandle M., et al., LEAD-1 SU Study Group. Liraglutide, a once-daily human GLP-1 analogue, added to a sulphonylurea over 26 weeks produces greater improvements in glycaemic and weight control compared with adding rosiglitazone or placebo in subjects with type 2 diabetes (LEAD-1 SU). Diabet Med 26 (2009) 268-278
-
(2009)
Diabet Med
, vol.26
, pp. 268-278
-
-
Marre, M.1
Shaw, J.2
Brandle, M.3
-
50
-
-
62449169287
-
Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes mellitus (LEAD-2 Met)
-
LEAD-2 Metformin Study Group
-
Nauck M., Frid A., Hermansen K., et al., LEAD-2 Metformin Study Group. Efficacy and safety comparison of liraglutide, glimepiride, and placebo, all in combination with metformin in type 2 diabetes mellitus (LEAD-2 Met). Diabetes Care 32 (2009) 84-90
-
(2009)
Diabetes Care
, vol.32
, pp. 84-90
-
-
Nauck, M.1
Frid, A.2
Hermansen, K.3
-
51
-
-
0037844361
-
Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative
-
Agerso H., and Vicini P. Pharmacodynamics of NN2211, a novel long acting GLP-1 derivative. Eur J Pharm Sci 19 (2003) 141-150
-
(2003)
Eur J Pharm Sci
, vol.19
, pp. 141-150
-
-
Agerso, H.1
Vicini, P.2
-
52
-
-
59449101432
-
Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial
-
LEAD-3 (Mono) Study Group
-
Garber A., Henry R., Ratner R., et al., LEAD-3 (Mono) Study Group. Liraglutide versus glimepiride monotherapy for type 2 diabetes (LEAD-3 Mono): a randomised, 52-week, phase III, double-blind, parallel-treatment trial. Lancet 373 (2009) 473-481
-
(2009)
Lancet
, vol.373
, pp. 473-481
-
-
Garber, A.1
Henry, R.2
Ratner, R.3
-
53
-
-
67650066860
-
Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD)
-
LEAD-4 Study Investigators
-
Zinman B., Gerich J., Buse J.B., et al., LEAD-4 Study Investigators. Efficacy and safety of the human glucagon-like peptide-1 analog liraglutide in combination with metformin and thiazolidinedione in patients with type 2 diabetes (LEAD-4 Met+TZD). Diabetes Care 32 (2009) 1224-1230
-
(2009)
Diabetes Care
, vol.32
, pp. 1224-1230
-
-
Zinman, B.1
Gerich, J.2
Buse, J.B.3
-
54
-
-
56249125773
-
Significantly better glycemic control and weight reduction with liraglutide, a once-daily human GLP-1 analog, compared with insulin glargine: all as add-on to metformin and a sulfonylurea in type 2 diabetes
-
Abstract 536-P
-
Russell-Jones D., Vaag A., Schmitz O., et al. Significantly better glycemic control and weight reduction with liraglutide, a once-daily human GLP-1 analog, compared with insulin glargine: all as add-on to metformin and a sulfonylurea in type 2 diabetes. Diabetes 57 (2008) A159-A160 Abstract 536-P
-
(2008)
Diabetes
, vol.57
-
-
Russell-Jones, D.1
Vaag, A.2
Schmitz, O.3
-
55
-
-
67649666737
-
Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6)
-
LEAD-6 Study Group
-
Buse J.B., Rosenstock J., Sesti G., et al., LEAD-6 Study Group. Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6). Lancet 374 (2009) 39-47
-
(2009)
Lancet
, vol.374
, pp. 39-47
-
-
Buse, J.B.1
Rosenstock, J.2
Sesti, G.3
-
56
-
-
67649189310
-
Liraglutide effect and action in diabetes (LEAD) trial
-
Madsbad S. Liraglutide effect and action in diabetes (LEAD) trial. Expert Rev Endocrinol Metab 4 (2009) 119-129
-
(2009)
Expert Rev Endocrinol Metab
, vol.4
, pp. 119-129
-
-
Madsbad, S.1
-
58
-
-
72449170180
-
-
US Food and Drug Administration Accessed November 3, 2009
-
US Food and Drug Administration. Liraglutide. Briefing materials (April 2, 2009). http://www.fda.gov/ohrms/dockets/ac/09/briefing/2009-4422b2-01-FDA.pdf Accessed November 3, 2009
-
(2009)
Liraglutide. Briefing materials
-
-
-
59
-
-
67649523294
-
Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study
-
Nauck M.A., Ratner R.E., Kapitza C., Berria R., Boldrin M., and Balena R. Treatment with the human once-weekly glucagon-like peptide-1 analog taspoglutide in combination with metformin improves glycemic control and lowers body weight in patients with type 2 diabetes inadequately controlled with metformin alone: a double-blind placebo-controlled study. Diabetes Care 32 (2009) 1237-1243
-
(2009)
Diabetes Care
, vol.32
, pp. 1237-1243
-
-
Nauck, M.A.1
Ratner, R.E.2
Kapitza, C.3
Berria, R.4
Boldrin, M.5
Balena, R.6
-
60
-
-
58349104177
-
Pharmacokinetics and pharmacodynamics of a new GLP-1 agonist AVE0010 in type 2 diabetes patients
-
June 6-10, 2008; San Francisco, California Abstract 520-P
-
Distiller L.A., and Ruus P. Pharmacokinetics and pharmacodynamics of a new GLP-1 agonist AVE0010 in type 2 diabetes patients. Program and Abstracts of the 68th Scientific Sessions of the American Diabetes Association. June 6-10, 2008; San Francisco, California (2008) A154-A155 Abstract 520-P
-
(2008)
Program and Abstracts of the 68th Scientific Sessions of the American Diabetes Association
-
-
Distiller, L.A.1
Ruus, P.2
-
61
-
-
57349168543
-
Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes
-
Albiglutide Study Group
-
Matthews J.E., Stewart M.W., De Boever E.H., et al., Albiglutide Study Group. Pharmacodynamics, pharmacokinetics, safety, and tolerability of albiglutide, a long-acting glucagon-like peptide-1 mimetic, in patients with type 2 diabetes. J Clin Endocrinol Metab 93 (2008) 4810-4817
-
(2008)
J Clin Endocrinol Metab
, vol.93
, pp. 4810-4817
-
-
Matthews, J.E.1
Stewart, M.W.2
De Boever, E.H.3
-
62
-
-
53249109948
-
Incretin mimetics and dipeptidyl peptidase-4 inhibitors: innovative treatment therapies for type 2 diabetes
-
Davidson J.A., Parente E.B., and Gross J.L. Incretin mimetics and dipeptidyl peptidase-4 inhibitors: innovative treatment therapies for type 2 diabetes. Arq Bras Endocrinol Metabol 52 (2008) 1039-1049
-
(2008)
Arq Bras Endocrinol Metabol
, vol.52
, pp. 1039-1049
-
-
Davidson, J.A.1
Parente, E.B.2
Gross, J.L.3
-
63
-
-
58149330590
-
Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
-
Ferrannini E., Fonseca V., Zinman B., et al. Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy. Diabetes Obes Metab 11 (2009) 157-166
-
(2009)
Diabetes Obes Metab
, vol.11
, pp. 157-166
-
-
Ferrannini, E.1
Fonseca, V.2
Zinman, B.3
-
64
-
-
42149194313
-
Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes
-
Rosenstock J., Sankoh S., and List J.F. Glucose-lowering activity of the dipeptidyl peptidase-4 inhibitor saxagliptin in drug-naive patients with type 2 diabetes. Diabetes Obes Metab 10 (2008) 376-386
-
(2008)
Diabetes Obes Metab
, vol.10
, pp. 376-386
-
-
Rosenstock, J.1
Sankoh, S.2
List, J.F.3
-
65
-
-
34248999413
-
Discovery of alogliptin: a potent, selective bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV
-
Feng J., Zhang Z., Wallace M.B., et al. Discovery of alogliptin: a potent, selective bioavailable, and efficacious inhibitor of dipeptidyl peptidase IV. J Med Chem 50 (2007) 2297-2300
-
(2007)
J Med Chem
, vol.50
, pp. 2297-2300
-
-
Feng, J.1
Zhang, Z.2
Wallace, M.B.3
-
66
-
-
58149171060
-
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes mellitus and inadequate glycemic control: a randomized, double-blind, placebo-controlled study
-
Alogliptin Study 010 Group
-
DeFronzo R.A., Fleck P.R., Wilson C.A., Mekke Q., and Alogliptin Study 010 Group. Efficacy and safety of the dipeptidyl peptidase-4 inhibitor alogliptin in patients with type 2 diabetes mellitus and inadequate glycemic control: a randomized, double-blind, placebo-controlled study. Diabetes Care 31 (2008) 2315-2317
-
(2008)
Diabetes Care
, vol.31
, pp. 2315-2317
-
-
DeFronzo, R.A.1
Fleck, P.R.2
Wilson, C.A.3
Mekke, Q.4
|