The Salmonella membrane protein IgaA modulates the activity of the RcsC-YojN-RcsB and PhoP-PhoQ regulons

Journal of Bacteriology

Volumn 186, Issue 22, 2004, Pages 7481-7489

  Tierrez, Alberto ^a   García Del Portillo, Francisco ^a  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; LIPOPOLYSACCHARIDE; MEMBRANE PROTEIN; MUTANT PROTEIN; PHOP PROTEIN; PROTEIN INTRACELLULAR GROWTH ATTENUATOR; PROTEIN RCSB; UNCLASSIFIED DRUG;

ALLELE; ARTICLE; BACTERIAL GENE; BACTERIAL MUTATION; BACTERIAL VIRULENCE; CELL GROWTH; FIBROBLAST; GENE CONTROL; GENE EXPRESSION; GENE MUTATION; GENE REPRESSION; GENETIC ANALYSIS; GENETIC TRANSCRIPTION; NONHUMAN; PAG GENE; PHENOTYPE; PRIORITY JOURNAL; REGULON; SALMONELLA ENTERICA; SALMONELLA TYPHIMURIUM; SEROTYPE; UGD GENE;

BACTERIAL CAPSULES; BACTERIAL PROTEINS; GENE EXPRESSION REGULATION, BACTERIAL; MEMBRANE PROTEINS; MULTIENZYME COMPLEXES; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN KINASES; SALMONELLA TYPHIMURIUM; SIGNAL TRANSDUCTION;

BACTERIA (MICROORGANISMS); NEGIBACTERIA; SALMONELLA; SALMONELLA ENTERICA; SALMONELLA ENTERICA SUBSP. ENTERICA SEROVAR TYPHIMURIUM; SALMONELLA TYPHIMURIUM;

EID: 7744239346     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.186.22.7481-7489.2004     Document Type: Article

References (38)

1. Akbar, S., L. M. Schechter, C. P. Lostroh, and C. A. Lee. 2003. AraC/XylS family members, HilD and HilC, directly activate virulence gene expression independently of HilA in Salmonella typhimurium. Mol. Microbiol. 47:715-728.
2. Arricau, N., D. Hermant, H. Waxin, C. Ecobichon, P. S. Duffey, and M. Y. Popoff. 1998. The RcsB-RcsC regulatory system of Salmonella typhi differentially modulates the expression of invasion proteins, fiagellin and Vi antigen in response to osmolarity. Mol. Microbiol. 29:835-850.
3. Cano, D. A., G. Dominguez-Bernal, A. Tierrez, F. García-Del Portillo, and J. Casadesús. 2002. Regulation of capsule synthesis and cell motility in Salmonella enterica by the essential gene igaA. Genetics 162:1513-1523.
4. Cano, D. A., M. Martinez-Moya, M. G. Pucciarelli, E. A. Groisman, J. Casadesus, and F. Garcia-Del Portillo. 2001. Salmonella enterica serovar Typhimurium response involved in attenuation of pathogen intracellular proliferation. Infect. Immun. 69:6463-6474.
5. Carballes, F., C. Bertrand, J. P. Bouche, and K. Cam. 1999. Regulation of Escherichia coli cell division genes ftsA and ftsZ by the two-component system rcsC-rcsB. Mol. Microbiol. 34:442-450.
6. Chen, M. H., S. Takeda, H. Yamada, Y. Ishii, T. Yamashino, and T. Mizuno. 2001. Characterization of the RcsC→YojN→RcsB phosphorelay signaling pathway involved in capsular synthesis in Eschenchia coli. Biosci. Biotechnol. Biochem. 65:2364-2367.
7. Clavel, T., J. C. Lazzaroni, A. Vianney, and R. Portalier. 1996. Expression of the tolQRA genes of Escherichia coli K-12 is controlled by the RcsC sensor protein involved in capsule synthesis. Mol. Microbiol. 19:19-25.
8. Clements, M., S. Eriksson, D. Tezcan-Merdol, J. C. Hinten, and M. Rhen. 2001. Virulence gene regulation in Salmonella enterica. Ann. Med. 33:178-185.
9. Costa, C. S., M. J. Pettinari, B. S. Mendez, and D. N. Anton. 2003. Null mutations in the essential gene yrfF (mucM) are not lethal in rcsB, yojN or rcsC strains of Salmonella enterica serovar Typhimurium. FEMS Microbiol. Lett. 222:25-32.
10. Cotter, P. A., and V. J. DiRita. 2000. Bacterial virulence gene regulation: an evolutionary perspective. Annu. Rev. Microbiol. 54:519-565.
11. Davalos-Garcia, M., A. Conter, I. Toesca, C. Gutierrez, and K. Cam. 2001. Regulation of osmC gene expression by the two-component system rcsB-rcsC in Escherichia coli. J. Bacteriol. 183:5870-5876.
12. Domínguez-Bernal, G., M. G. Pucciarelli, F. Ramos-Morales, M. García-Quintanilla, D. A. Cano, J. Casadesus, and F. García-del Portillo. 2004. Repression of the RcsC-YojN-RcsB phosphorelay by the IgaA protein is a requisite for Salmonella virulence. Mol. Microbiol. 53:1437-1449.
13. Ernst, R. K., T. Guina, and S. I. Miller. 1999. How intracellular bacteria survive: surface modifications that promote resistance to host innate immune responses. J. Infect. Dis. 179:5326-5330.
14. Ernst, R. K., T. Guina, and S. I. Miller. 2001. Salmonella typhimurium outer membrane remodeling: role in resistance to host innate immunity. Microbes Infect. 3:1327-1334.
15. Garcia-del Portillo, F. 1999. Molecular and cellular biology of Salmonella pathogenesis, p. 3-49. In J. W. Cary, J. E. Linz, and D. Bhatnagar (ed.), Microbial foodborne diseases: mechanisms of pathogenesis and toxin synthesis. Technomic Publishing Co., Inc.. Lancaster, Pa.
16. 2+ as an extracellular signal: environmental regulation of Salmonella virulence. Cell 84:165-174.
17. Gottesman, S. 1995. Regulation of capsule synthesis: modification of the two-component paradigm by an accessory unstable regulator, p. 253-262. In J. A. Hoch and T. J. Silhavy (ed.). Two-component signal transduction. American Society for Microbiology, Washington, D.C.
18. Groisman, E. A. 2001, The pleiotropic two-component regulatory system PhoP-PhoQ. J. Bacteriol. 183:1835-1842.
19. Gunn, J. S., K. B. Lim, J. Krueger, K. Kim, L. Guo, M. Hackett, and S. I. Miller. 1998. PmrA-PmrB-regulated genes necessary for 4-aminoarabinose lipid A modification and polymyxin resistance. Mol. Microbiol. 27:1171-1182.
20. Hagiwara, D., M. Sugiura, T. Oshima, H. Mori, H. Aiba, T. Yamashino, and T. Mizuno. 2003. Genome-wide analyses revealing a signaling network of the RcsC-YojN-RcsB phosphorelay system in Escherichia coli. J. Bacteriol. 185: 5735-5746.
21. Hansen-Wester, I., and M. Hensel. 2001. Salmonella pathogenicity islands encoding type III secretion systems. Microbes Infect. 3:549-559.
22. Hoiseth, S. K., and B. A. Stocker. 1981. Aromatic-dependent Salmonella typhimurium are non-virulent and effective as live vaccines. Nature 291:238-239.
23. Island, M. D., B. Y. Wei, and R. J. Kadner. 1992. Structure and function of the uhp genes for the sugar phosphate transport system in Escherichia coli and Salmonella typhimurium. J. Bacteriol. 174:2754-2762.
24. Lostroh, C. P., and C. A. Lee. 2001. The Salmonella pathogenicity island-1 type III secretion system. Microbes Infect. 3:1281-1291.
25. Majdalani, N., D. Hernandez, and S. Gottesman. 2002. Regulation and mode of action of the second small RNA activator of RpoS translation, RprA. Mol. Microbiol. 46:813-826.
26. Martinez-Moya, M., M. A. de Pedro, H. Schwarz, and F. Garcia-del Portillo. 1998. Inhibition of Salmonella intracellular proliferation by non-phagocytic eucaryotic cells. Res. Microbiol. 149:309-318.
27. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
28. Mouslim, C., M. Delgado, and E. A. Groisman. Activation of the RcsC/YojN/RcsB phosphorelay system attenuates Salmonella virulence. Mol. Microbiol., in press.
29. Mouslim, C., and E. A. Groisman. 2003. Control of the Salmonella ugd gene by three two-component regulatory systems. Mol. Microbiol. 47:335-344.
30. Mouslim, C., T. Latifi, and E. A. Groisman. 2003. Signal-dependent requirement for the co-activator protein RcsA in transcription of the RcsB-regulated ugd gene. J. Biol. Chem. 278:50588-50595.
31. Ohl, M. E., and S. I. Miller. 2001. Salmonella: a model for bacterial pathogenesis. Annu. Rev. Med. 52:259-274.
32. Pegues, D. A., M. J. Hantman, I. Behlau, and S. I. Miller. 1995. PhoP/PhoQ transcriptional repression of Salmonella typhimurium invasion genes: evidence for a role in protein secretion. Mol. Microbiol. 17:169-181.
33. Petit, C., G. P. Rigg, C. Pazzani, A. Smith, V. Sieberth, M. Stevens, G. Boulnois, K. Jann, and I. S. Roberts. 1995. Region 2 of the Escherichia coli K5 capsule gene cluster encoding proteins for the biosynthesis of the K5 polysaccharide. Mol. Microbiol. 17:611-620.
34. 2+ transport locus of Salmonella typhimurium encodes a P-type ATPase. J. Biol. Chem. 266:815-823.
35. Soncini, F. C., and E. A. Groisman. 1996. Two-component regulatory systems can interact to process multiple environmental signals. J. Bacteriol. 178:6796-6801.
36. Soncini, F. C., E. G. Vescovi, and E. A. Groisman. 1995. Transcriptional autoregulation of the Salmonella typhimurium phoPQ operon. J. Bacteriol. 177:4364-4371.
37. Stevenson, G., K. Andrianopoulos, M. Hobbs, and P. R. Reeves. 1996. Organization of the Escherichia coli K-12 gene cluster responsible for production of the extracellular polysaccharide colanic acid. J. Bacteriol. 178:4885-4893.
38. Wehland, M., and F. Bernhard. 2000. The RcsAB box. Characterization of a new operator essential for the regulation of exopolysaccharide biosynthesis in enteric bacteria. J. Biol. Chem. 275:7013-7020.