Deletion and aberrant CpG island methylation of Caspase 8 gene in medulloblastoma

Oncology Reports

Volumn 12, Issue 3, 2004, Pages 663-666

  Gonzalez Gomez, Pilar ^a   Bello, M Josefa ^a   Inda, M Mar ^b   Alonso, M Eva ^a   Arjona, Dolores ^a   Amiñoso, Cinthia ^a   Lopez Marin, Isabel ^a   De Campos, Jose M ^c   Sarasa, Jose L ^d   Castresana, Javier S ^b   Rey, Juan A ^a  

^a HOSPITAL UNIVERSITARIO LA PAZ   (Spain)

^b UNIVERSITY OF NAVARRA   (Spain)

^c HOSPITAL UNIVERSITARIO RÍO HORTEGA   (Spain)

^d Hospital UniversitarioFundación Jiménez Díaz   (Spain)

Author keywords

Aberrant methylation; CASP8 Caspase 8; CpG island; Homozygous deletion; Medulloblastoma; PNET

Indexed keywords

CASP8 PROTEIN, HUMAN; CASPASE; CASPASE 8; DNA; PRIMER DNA;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BIOSYNTHESIS; BRAIN TUMOR; CHEMISTRY; CHILD; CPG ISLAND; DNA METHYLATION; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; GENE SILENCING; GENETIC TRANSCRIPTION; GENETICS; HOMOZYGOTE; HUMAN; MALE; MEDULLOBLASTOMA; METABOLISM; MIDDLE AGED; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PRESCHOOL CHILD; PROMOTER REGION; SEQUENCE HOMOLOGY; TUMOR CELL LINE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; BASE SEQUENCE; BRAIN NEOPLASMS; CASPASE 8; CASPASES; CELL LINE, TUMOR; CHILD; CHILD, PRESCHOOL; CPG ISLANDS; DNA; DNA METHYLATION; DNA PRIMERS; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HOMOZYGOTE; HUMANS; MALE; MEDULLOBLASTOMA; MIDDLE AGED; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); SEQUENCE HOMOLOGY, NUCLEIC ACID; TRANSCRIPTION, GENETIC;

EID: 7744227335     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.12.3.663     Document Type: Article

References (27)

1. Giangaspero F, Bigner SH, Kleihues P, Pietsch T and Trojanowski JQ: Medulloblastoma. In: Pathology and Genetics of Tumours of The Nervous System. World Health Organization Classification of Tumours. Kleihues P and Cavenee WK (eds). IARC Press, Lyon, pp129-137, 2000.
2. Adesina AM, Nalbantoglu J and Cavenee WK: P53 mutation and mdm2 gene amplification are uncommon in medullo-blastomas. Cancer Res 54: 5649-5651, 1994.
3. Bayani J, Zielenska M, Marrano P, Kwan Y, Taylor MD, Jay V, Rutka JT and Squire JA: Molecular cytogenetic analysis of medulloblastomas and supratentorial primitive neuroectodermal tumors by using conventional banding, comparative genomic hybridization and spectral karyotyping. J Neurosurg 93: 437-448. 2000.
4. Cohen N, Betts DR, Tavori U, Toren A, Ram T, Constatini S, Grotzer MA, Amariglio N, Rechavi G and Trakhetenbrot L: Karyotypic evolution pathways in medulloblastoma/primitive neuroectodermal tumor determined with a combination of spectral karyotyping, G-banding, and fluorescence in situ hybridization. Cancer Genet Cytogenet 149: 44-52, 2004. (Pubitemid 38177557)
5. Mollenhauer J, Wiemann S, Scheurlen W, Korn B, Hayashi Y, Wilgenbus KK, von Deimling A and Poutska A: DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3-26.1 is deleted in malignant brain tumors. Nat Genet 17: 32-39, 1997. (Pubitemid 27377529)
6. Fruhwald MC, O'Dorisio MS, Rush LJ, Reiter JL, Smiraglia DJ, Wengeer G, Costello JF, White PS, Hrahe R, Brodeur GM and Plass C: Gene amplification in PNETs/medulloblastomas: mapping of a novel amplified gene within the MYCN amplicon. J Medical Genet 37: 501-509, 2000. (Pubitemid 30428236)
7. Baylin SB, Herman JG, Graff JR, Vertino PM and Issa JPJ: Alterations in the DNA methylation: a fundamental aspect of neoplasia. Adv Cancer Res 72: 141-196, 1998. (Pubitemid 27435555)
8. Waha A, Waha A, Koch A, Meyer-Puttlitz B, Weggen S, Sörensen N, Tonn JC, Albrecht S, Goodyer CG, Berthold F, Wiestler OD and Pietsch T: Epigenetic silencing of the HIC-1 gene in human medulloblastoma. J Neuropathol Exp Neurol 62: 1192-1201, 2003. (Pubitemid 37413829)
9. Fruhwald MC, O'Dorisio MS, Dai Z, Tanner SM, Balster DA, Gao X, Wright FA and Plass C: Aberrant promoter methylation of previously unidentified target genes is a common abnormality in medulloblastomas - Implication for tumors biology and potential clinical utility. Oncogene 20: 5033-5042, 2001. (Pubitemid 32769793)
10. Gonzalez-Gomez P, Bello MJ, Lomas J, Arjona D, Alonso ME, Amiñoso C, de Campos JM, Vaquero J, Sarasa JL, Casartelli C and Rey JA: Epigenetic changes in pilocytic astrocytomas and medulloblastomas. Int J Mol Med 11: 655-660, 2003.
11. Grotzer MA, Eggert A, Zuzak TJ, Janss AJ, Marwaha S, Wieerodt BR, Ikegaki N, Brodeur GM and Philips PC: Resistance to TRAIL-induced apoptosis in primitive neuro-ectodermal brain tumor cells correlates with loss of caspase-8 expression. Oncogene 19: 4604-4610, 2000.
12. Herman JG, Graff JR, Myohannen S, Nelkin BD and Baylin BD: Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands. Proc Natl Acad Sci USA 93: 9821-9826, 1996. (Pubitemid 26296693)
13. Alonso ME, Bello MJ, Gonzalez-Gomez P, Arjona D, de Campos JM, Gutierrez M and Rey JA: Aberrant CpG island methylation of multiple genes in ependymal tumors. J Neuro-Oncol 67: 159-165, 2004. (Pubitemid 38418264)
14. Rey JA, Bello MJ, Jimenez-Lara A, Vaquero J, Kusak ME, de Campos JM, Sarasa JL and Pestana A: Loss of heterozygosity for distal markers on 22q in human gliomas. Int J Cancer 51: 703-706, 1992.
15. Gonzalez-Gomez P, Bello MJ, Alonso ME, Arjona D, Lomas J, de Campos JM, Isla A and Rey JA: CpG island methylation status and mutation analysis of the RB1 gene essential promoter region and protein-binding pocket domain in nervous system tumours. Br J Cancer 88: 109-114, 2003. (Pubitemid 36241226)
16. Fan X, Inda MM, Tufion T and Castresana JS: Improvement of the methylation specific PCR technical conditions for detection of p16 promoter hypermethylation in small amounts of tumor DNA. Oncol Rep 9: 181-183, 2002.
17. Teitz T, Wei T, Valentine MB, Vanin EF, Grenet J, Valentine VA, Behm FG, Look AT, Lahti JM and Kidd VJ: Caspase 8 is deleted or silenced preferentially in childhood neuroblastomas with amplification of MYCN. Nat Med 6: 529-535, 2000. (Pubitemid 30305902)
18. Lindsey JC, Lusher ME, Anderton JA, Bailey S, Gilbertson RJ, Pearson AD, Ellison DW and Clifford SC: Identification of tumor-specific epigenetic events in medulloblastoma development by hypermethylation profiling. Carcinogenesis 25: 661-668, 2003. (Pubitemid 38618517)
19. Deltour S, Guerardel C and Leprince D: Recruitment of SMRT/N-CoR-mSin3A-HDAC-repressing complexes is not a general mechanism for BTB/POZ transcriptional repressors: the case of HIC-1 and gammaFBP-B. Proc Natl Acad Sci USA 96: 14831-14836, 1999. (Pubitemid 30019725)
20. Damman R, Li C, Yoon JH, Chin PL, Bates S and Pfeifer GP: Epigenetic inactivation of a RAS association domain family protein from the lung tumor suppressor locus 3p21.3. Nat Genet 25:315-319, 2000. (Pubitemid 30437320)
21. Zuzak TJ, Steinhoff DF, Sutton LN, Phillips PC, Eggert A and Grptzer MA: Loss of caspase 8 mRNA expression is common in childhood primitive neuroectodermal brain tumour/medulloblastoma. Eur J Cancer 38: 83-91, 2002. (Pubitemid 34031830)
22. Pingoud-Meier C, Lang D, Janss AJ, Rorke LB, Phillips PC, Shalaby T and Grotzer MA: Loss of caspase-8 protein expression correlates with unfavorable survival outcome in childhood medulloblastoma. Clin Cancer Res 9: 6401-6409, 2003. (Pubitemid 38031826)
23. Gonzalez-Gomez P, Bello MJ, Lomas J, Arjona D, Alonso ME, Amiñoso C, Lopez-Marin I, Anselmo NP, Sarasa JL, Gutierrez M, Casartelli C and Rey JA: Aberrant methylation of multiple genes in neuroblastic tumours: relationship with MYCN amplifictaion and allelic status at 1p. Eur J Cancer 39: 1478-1485, 2003. (Pubitemid 36773792)
24. Iolascon A, Borriello A, Giordani L, Cucciolla V, Moretti A, Monno F, Crinti V, Marzullo A, Criscuolo M and Delia Regione F: Caspase 3 and 8 deficiency in human neuroblastoma Cancer Genet Cytogenet 146: 41-47, 2003. (Pubitemid 37117433)
25. Gonzalez-Gomez P, Bello MJ, Alonso ME, Lomas J, Arjona D, de Campos JM, Vaquero J, Isla A, Lassaletta L, Gutierrez M, Sarasa JL and Rey JA: CpG island methylation in sporadic and neurofibromatosis type 2-associated schwannomas. Clin Cancer Res 9: 5601-5606, 2003. (Pubitemid 37499480)
26. Gonzalez-Gomez P, Bello MJ, Arjona D, Alonso ME, Lomas J, de Campos JM, Kusak ME, Gutierrez J, Sarasa JL and Rey JA: Aberrant promoter methylation in neurofibromas and neuro-fibrosarcomas. Oncol Rep 10: 1519-1523, 2003.
27. Grenet J, Teitz T, Wei T, Valentine V and Kidd VJ: Structure and chromosome localization of the human CASP8 gene. Gene 226: 225-232, 1999. (Pubitemid 29087103)