Epidermal langerhans cells are not required for UV-induced immunosuppression

Journal of Immunology

Volumn 183, Issue 9, 2009, Pages 5548-5553

  Wang, Liangchun ^a   Jameson, Stephen C ^a   Hogquist, Kristin A ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LANGERIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL EXPANSION; CONTACT ALLERGY; CONTROLLED STUDY; DENDRITIC CELL; DNA DAMAGE; EPIDERMIS; IMMUNE RESPONSE; IN VIVO STUDY; LANGERHANS CELL; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; ULTRAVIOLET B RADIATION;

ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGENS, SURFACE; CD8-POSITIVE T-LYMPHOCYTES; DENDRITIC CELLS; DERMATITIS, CONTACT; EPIDERMIS; GENE KNOCK-IN TECHNIQUES; IMMUNOSUPPRESSION; LANGERHANS CELLS; LECTINS, C-TYPE; MANNOSE-BINDING LECTINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OVALBUMIN; ULTRAVIOLET RAYS;

EID: 77349115170     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0900235     Document Type: Article

References (41)

1. Erkin, G., Y. Ugur, C. K. Gurer, E. Asan, P. Korkusuz, S. Sahin, and F. Kolemen. 2007. Effect of PUVA, narrow-band UVB and cyclosporin on inflammatory cells of the psoriatic plaque. J. Cutan. Pathol. 34: 213-219.
2. Stern, R. S. 2007. Psoralen and ultraviolet: a light therapy for psoriasis. N. Engl. J. Med. 357: 682-690.
3. Ullrich, S. E. 2005. Mechanisms underlying UV-induced immune suppression. Mutation Res. 571: 185-205.
4. Toews, G. B., P. R. Bergstresser, and J. W. Streilein. 1980. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J. Immunol. 124: 445-453.
5. Kolgen, W., H. Both, H. van Weelden, K. L. Guikers, C. A. Bruijnzeel-Koomen, E. F. Knol, W. A. van Vloten, and F. R. De Gruijl. 2002. Epidermal Langerhans cell depletion after artificial ultraviolet B irradiation of human skin in vivo: apoptosis versus migration. J. Invest. Dermatol. 118: 812-817.
6. Cruz, P. D., Jr., R. E. Tigelaar, and P. R. Bergstresser. 1990. Langerhans cells that migrate to skin after intravenous infusion regulate the induction of contact hypersensitivity. J. Immunol. 144: 2486-2492. (Pubitemid 20136647)
7. Bursch, L. S., L. Wang, B. Igyarto, A. Kissenpfennig, B. Malissen, D. H. Kaplan, and K. A. Hogquist. 2007. Identification of a novel population of Langerin+ dendritic cells. J. Exp. Med. 204: 3147-3156.
8. Ginhoux, F., M. P. Collin, M. Bogunovic, M. Abel, M. Leboeuf, J. Helft, J. Ochando, A. Kissenpfennig, B. Malissen, M. Grisotto, et al. 2007. Bloodderived dermal langerin+ dendritic cells survey the skin in the steady state. J. Exp. Med. 204: 3133-3146.
9. Poulin, L. F., S. Henri, B. de Bovis, E. Devilard, A. Kissenpfennig, and B. Malissen. 2007. The dermis contains langerin+ dendritic cells that develop and function independently of epidermal Langerhans cells. J. Exp. Med. 204: 3119-3131.
10. Wang, L., L. S. Bursch, A. Kissenpfennig, B. Malissen, S. C. Jameson, and K. A. Hogquist. 2008. Langerin expressing cells promote skin immune responses under defined conditions. J. Immunol. 180: 4722-4727.
11. Obhrai, J. S., M. Oberbarnscheidt, N. Zhang, D. L. Mueller, W. D. Shlomchik, F. G. Lakkis, M. J. Shlomchik, and D. H. Kaplan. 2008. Langerhans cells are not required for efficient skin graft rejection. J. Invest. Dermatol. 128: 1950-1955.
12. Kaplan, D. H., A. Kissenpfennig, and B. E. Clausen. 2008. Insights into Langerhans cell function from Langerhans cell ablation models. Eur. J. Immunol. 38: 2369-2376.
13. Kaplan, D. H., M. C. Jenison, S. Saeland, W. D. Shlomchik, and M. J. Shlomchik. 2005. Epidermal langerhans cell-deficient mice develop enhanced contact hypersensitivity. Immunity 23: 611-620.
14. Kissenpfennig, A., S. Henri, B. Dubois, C. Laplace-Builhe, P. Perrin, N. Romani, C. H. Tripp, P. Douillard, L. Leserman, D. Kaiserlian, et al. 2005. Dynamics and function of Langerhans cells in vivo: dermal dendritic cells colonize lymph node areas distinct from slower migrating Langerhans cells. Immunity 22: 643-654.
15. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
16. Schwarz, A., A. Maeda, K. Kernebeck, H. van Steeg, S. Beissert, and T. Schwarz. 2005. Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J. Exp. Med. 201: 173-179.
17. Aberer, W., G. Schuler, G. Stingl, H. Honigsmann, and K. Wolff. 1981. Ultraviolet light depletes surface markers of Langerhans cells. J. Invest. Dermatol. 76: 202-210.
18. Tang, A., and M. C. Udey. 1991. Inhibition of epidermal Langerhans cell function by low dose ultraviolet B radiation. Ultraviolet B radiation selectively modulates ICAM-1 (CD54) expression by murine Langerhans cells. J. Immunol. 146: 3347-3355.
19. Weiss, J. M., A. C. Renkl, R. W. Denfeld, R. de Roche, M. Spitzlei, E. Schopf, and J. C. Simon. 1995. Low-dose UVB radiation perturbs the functional expression of B7.1 and B7.2 co-stimulatory molecules on human Langerhans cells. Eur. J. Immunol. 25: 2858-2862.
20. + T regulatory cells and is dependent on host-derived IL-10. J. Immunol. 176: 2635-2644.
21. Schwarz, A., A. Maeda, and T. Schwarz. 2007. Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells. J. Immunol. 178: 877-886. (Pubitemid 46095160)
22. Stingl, G., K. Tamaki, and S. I. Katz. 1980. Origin and function of epidermal Langerhans cells. Immunol. Rev. 53: 149-174. (Pubitemid 11119137)
23. Romani, N., S. Holzmann, C. H. Tripp, F. Koch, and P. Stoitzner. 2003. Langerhans cells: dendritic cells of the epidermis. Apmis 111: 725-740.
24. Bennett, C. L., E. van Rijn, S. Jung, K. Inaba, R. M. Steinman, M. L. Kapsenberg, and B. E. Clausen. 2005. Inducible ablation of mouse Langerhans cells diminishes but fails to abrogate contact hypersensitivity. J. Cell Biol. 169: 569-576.
25. + T cell proliferation in vivo. J. Immunol. 181: 418-430.
26. Obata, M., and H. Tagami. 1985. Alteration in murine epidermal Langerhans cell population by various UV irradiations: quantitative and morphologic studies on the effects of various wavelengths of monochromatic radiation on Ia-bearing cells. J. Invest. Dermatol. 84: 139-145.
27. Moodycliffe, A. M., I. Kimber, and M. Norval. 1992. The effect of ultraviolet B irradiation and urocanic acid isomers on dendritic cell migration. Immunology 77: 394-399.
28. Sontag, Y., C. L. Guikers, A. A. Vink, F. R. de Gruijl, H. van Loveren, J. Garssen, L. Roza, M. L. Kripke, J. C. van der Leun, and W. A. van Vloten. 1995. Cells with UV-specific DNA damage are present in murine lymph nodes after in vivo UV irradiation. J. Invest. Dermatol. 104: 734-738.
29. McLoone, P., G. M. Woods, and M. Norval. 2005. Decrease in langerhans cells and increase in lymph node dendritic cells following chronic exposure of mice to suberythemal doses of solar simulated radiation. Photochem. Photobiol. 81: 1168-1173.
30. Rivas, J. M., and S. E. Ullrich. 1994. The role of IL-4, IL-10, and TNF-α in the immune suppression induced by ultraviolet radiation. J. Leukocyte Biol. 56: 769-775.
31. Nishigori, C., D. B. Yarosh, S. E. Ullrich, A. A. Vink, C. D. Bucana, L. Roza, and M. L. Kripke. 1996. Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes. Proc. Natl. Acad. Sci. USA 93: 10354-10359.
32. Ullrich, S. E. 1995. The role of epidermal cytokines in the generation of cutaneous immune reactions and ultraviolet radiation-induced immune suppression. Photochem. Photobiol. 62: 389-401.
33. De Fabo, E. C., and F. P. Noonan. 1983. Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J. Exp. Med. 158: 84-98.
34. Shreedhar, V., T. Giese, V. W. Sung, and S. E. Ullrich. 1998. A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression. J. Immunol. 160: 3783-3789.
35. Schwarz, T. 2008. 25 years of UV-induced immunosuppression mediated by T cells-from disregarded T suppressor cells to highly respected regulatory T cells. Photochem. Photobiol. 84: 10-18.
36. Schade, N., C. Esser, and J. Krutmann. 2005. Ultraviolet B radiation-induced immunosuppression: molecular mechanisms and cellular alterations. Photochem. Photobiol. Sci. 4: 699-708.
37. - but not plasmacytoid dendritic cells. J. Exp. Med. 205: 1621-1634.
38. Nagao, K., F. Ginhoux, W. W. Leitner, S. Motegi, C. L. Bennett, B. E. Clausen, M. Merad, and M. C. Udey. 2009. Murine epidermal Langerhans cells and langerin-expressing dermal dendritic cells are unrelated and exhibit distinct functions. Proc. Natl. Acad. Sci. USA 106: 3312-3317.
39. + dendritic cells. Nat. Immunol. 10: 488-495.
40. Haniffa, M., F. Ginhoux, X. N. Wang, V. Bigley, M. Abel, I. Dimmick, S. Bullock, M. Grisotto, T. Booth, P. Taub, C. Hilkens, M. Merad, and M. Collin. 2009. Differential rates of replacement of human dermal dendritic cells and macrophages during hematopoietic stem cell transplantation. J. Exp. Med. 206: 371-385.
41. + antigen-presenting cells in human dermis respond rapidly to CCR7 ligands. J. Immunol. 176: 5730-5734.