Effect of PUVA, narrow-band UVB and cyclosporin on inflammatory cells of the psoriatic plaque

Journal of Cutaneous Pathology

Volumn 34, Issue 3, 2007, Pages 213-219

  Erkin, Gul ^a   Uǧur, Yeşim ^a   Gürer, Cansel Köse ^a   Aşan, Esin ^a   Korkusuz, Petek ^a   Şahin, Sedef ^a   Kölemen, Fikret ^a  

^a HACETTEPE UNIVERSITY   (Turkey)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CD68 ANTIGEN; CD8 ANTIGEN; CD86 ANTIGEN; CYCLOSPORIN A; HLA DR ANTIGEN; METHOXSALEN; T6 ANTIGEN;

ANTIGEN EXPRESSION; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; DENDRITIC CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFLAMMATION; INFLAMMATORY CELL; LYMPHOCYTE; MACROPHAGE; PROTEIN EXPRESSION; PSORIASIS; PUVA; SKIN BIOPSY; TREATMENT OUTCOME; ULTRAVIOLET B RADIATION;

ANTIGEN-PRESENTING CELLS; ANTIGENS, CD; CELL COUNT; CYCLOSPORINE; DENDRITIC CELLS; FLUORESCENT ANTIBODY TECHNIQUE, DIRECT; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KERATINOCYTES; LYMPHOCYTE SUBSETS; MACROPHAGES; PSORIASIS; PUVA THERAPY; SKIN; ULTRAVIOLET THERAPY;

EID: 33846894493     PISSN: 03036987     EISSN: 16000560     Source Type: Journal    
DOI: 10.1111/j.1600-0560.2006.00591.x     Document Type: Article

References (26)

1. Gudjhonson JE, Johnston A, Sigmundsdottir H, Valdimarsson H. Immunopathogenic mechanisms in psoriasis. Clin Exp Immunol 2004; 135: 1.
2. Fredriksson T, Pettersson U. Severe psoriasis-oral therapy with a new retinoid. Dermatologica 1978; 14: 63.
3. Korkusuz P, Dagdeviren A, Asan E. Immunophenotypic analysis of human spleen compartments. Ann Anat 2002; 184: 431.
4. Abbas AK, Murphy KM, Sher A. Functional diversity of helper T lymphocytes. Nature 1996; 383: 787.
5. Barker JN. Genetics aspects of psoriasis. Clin Exp Dermatol 2001; 26: 321.
6. Lin WJ, Norris DA, Achziger M, Kotzin BL, Tomkinson B. Oligoclonal expansion of intraepidermal T cells in proriasis skin lesions. J Invest Dermatol 2001; 117: 1546.
7. Vollmerr S, Menssen A, Prinz JC. Dominant lesional T cell receptor rearrangements persist in relapsing psoriasis but are absent from non-lesional skin: evidence for a stable antigen specific pathogenic T cell response in psoriasis vulgaris. J Invest Dermatol 2001; 117: 1296.
8. Porcelli SA, Modlin RL. The CD1 system: antigen presenting molecules for T cell recognition of lipids and glycolipids. Annu Rev Immunol 1999; 17: 297.
9. Kupper TS. T cells, immunosurveillance and cutaneous immunity. J Dermatol Sci 2000; 24 (Suppl. 1): S41.
10. Rattis FM, Peguet-Navarro J, Staquet MJ, et al. Expression and function of B7 (CD80) and B7-2 (CD86) on human epidermal Langerhans cells. Eur J Immunol 1996; 26: 449.
11. Ohki O, Yokozeki H, Katayama I, et al. Functional CD86 (B7-2/B70) is predominantly expressed on Langerhans cells in atopic dermatitis. Br J Dermatol 1997; 136: 838.
12. Ferenczi K, Burack L, Pope M, Krueger JG, Austin LM. CD 69, HLA-DR and the IL-2R identify persistently activated T cells in psoriasis vulgaris lesional skin: blood and skin comparisons by flow cytometry. J Autoimmun 2000; 14: 63.
13. Weiss JM, Renkl AC, Denfeld RW, et al. Low-dose UVB radiation perturbs the functional expression of B7.1 and B7.2 costimulatory molecules on human Langerhans cells. Eur J Immunol 1995; 25: 2858.
14. Nakamura K, Yasaka N, Asahina A et al. Increased numbers of CD68 antigen positive dendritic epidermal cells and upregulation of CLA (cutaneous lymphocyte-associated antigen) expression on these cells in various skin diseases. J Dermatol Sci 1998; 18: 170.
15. Baadsgaard O, Gupta AK, Taylor RS, Ellis CN, Voorhees JJ, Cooper KD. Psoriatic epidermal cells demonstrate increased numbers and function of non-Langerhans antigen-presenting cells. J Invest Dermatol 1989; 92: 190.
16. Burgdorf WHC, Zelger B. The histiocytoses. In: Elder DE, Elenitsas R, Johnson BL Jr, Murphy GF, eds. Lever's Histopathology of the Skin. Philadelphia: Lippincott Williams & Wilkins, 2005; 681.
17. Ashworth J, Mackie RM. A quantitative analysis of the Langerhans cell in chronic plaque psoriasis. Clin Exp Dermatol 1986; 11: 594.
18. Jensen AM, Llado MB, Skov L, Hansen ER, Larsen JK, Baadsgard O. Calcipotriol inhibits the proliferation of hyperproliferative CD29 positive keratinocytes in psoriatic epidermis in the absence of an effect on the function and number of antigen-presenting cells. Br J Dermatol 1998; 139: 984.
19. Coven TR, Murphy FP, Gilleaudeau P, Cardinale I, Krueger JG. Trimethylpsoralen bath PUVA is a remittive treatment for psoriasis vulgaris. Evidence that epidermal immunocytes are direct therapeutic targets. Arch Dermatol 1998; 134: 1263.
20. Tjioe M, Smits T, van de Kerkhof PC, Gerritsen MJ. The differential effect of broad band vs narrow band UVB with respect to photodamage and cutaneous inflammmation. Exp Dermatol 2003; 12: 729.
21. Gupta AK, Baadsgaard O, Ellis CN, Voorhes JJ, Cooper KD. Lymphocytes and macrophages of the epidermis and dermis in lesional psoriatic skin, but not epidermal Langerhans cells, are depleted by treatment with cyclosporin A. Arch Dermatol Res 1989; 281: 219.
22. Horrocks C, Duncan JI, SewellHF, Omerod AD, Thomson AW. Differential effects of cyclosporine A on Langerhans cells and regulatory T-cell populations in severe psoriasis: an immunohistochemical and flow cytometric analysis. J Autoimmun 1990; 3: 559.
23. Nestle FO, Zheng XG, Thompson CB, Turka LA, Nickoloff BJ. Characterization of dermal dendritic cells obtained from normal human skin reveals phenotypic and functionally distinctive subsets. J Immunol 1993; 151: 6535.
24. Sepulveda-Merrill C, Mayall S, Hamblin AS, Breathnach SM. Antigen presenting capacity in normal human dermis is mainly subserved by CD1a+ cells. Br J Dermatol 1994; 131: 15.
25. Bos JD, Hulsebosch HJ, Krieg SR, Bakker PM, Cormane RH. Immunocompetent cells in psoriasis. In situ immunophenotyping by monoclonal antibodies. Arch Dermatol Res 1983; 275: 181.
26. Krueger JG, Wolfe JT, Nabeya RT, et al. Successful ultraviolet B treatment of psoriasis is accompanied by a reversal of keratinocyte pathology and by selective depletion of intraepidermal T cells. J Exp Med 1995; 182: 2057.