Effect of epidermal growth factor receptor on airway remodeling in asthmatic mice and its mechanism

Chinese Journal of Contemporary Pediatrics

Volumn 12, Issue 2, 2010, Pages 137-140

  Li, Xiao Hui ^a   Luan, Bin ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Airway remodeling; Asthma; Epidermal growth factor receptor; Heparin binding epidermal growth factor like growth factor; Mice

Indexed keywords

4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; COLLAGEN; EPIDERMAL GROWTH FACTOR RECEPTOR; HEPARIN BINDING EPIDERMAL GROWTH FACTOR; MESSENGER RNA; OVALBUMIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHOPLASTY; BRONCHUS MUCOSA; CELL PROLIFERATION; CONTROLLED STUDY; GENE EXPRESSION; GOBLET CELL; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MALE; MOUSE; NONHUMAN; PERIODIC ACID SCHIFF STAIN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

AIRWAY REMODELING; ANIMALS; ASTHMA; IMMUNOHISTOCHEMISTRY; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; RECEPTOR, EPIDERMAL GROWTH FACTOR; TYRPHOSTINS;

EID: 77349105084     PISSN: 10088830     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Sumi Y, Hamid Q. Airway remodeling in asthma[J]. Allergol Int, 2007, 56(4):341-348.
2. Tamaoka M, Hassan M, McGovern T, Ramos-Barbon D, Jo T, Yoshizawa Y et al. The epidermal growth factor receptor mediates allergic airway remodeling in the rat [J]. Eur Respir J, 2008, 32(5):1213-1223.
3. Du Q, Chen Z, Zhou LF, Zhang Q, Huang M, Yin KS. Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma[J]. Can J Physiol Pharmacol, 2008, 86(7):449-457.
4. Puddicombe SM, Polosa R, Richter A, Krishna MT, Howarth PH, Holgate ST, Davies DE. Involvement of the epidermal growth factor receptor in epithelial repair in asthma[J]. FASEB J, 2000(7), 14:1362-1374.
5. Hamilton LM, Puddicombe SM, Dearman RJ, Kimber I, Sandström T, Wallin A et al. Altered protein tyrosine phosphorylation in asthmatic bronchial epithelium[J]. Eur Respir J, 2005, 25(6):978-985.
6. Fedorov IA, Wilson SJ, Davies DE, Holgate ST. Epithelial stress and structural remodelling in childhood asthma[J]. Thorax, 2005, 60(10):389-394.
7. Ellis AG, Nice EC, Weinstock J. Hish-performance liquid chromatographic an alysis of the tyrphostin AG1478, a specific inhibitor of the epidermal growth factor receptor tyrosine kinase, in mouse plasma[J].Chromatogr B Biomed Sci, 2001, 754(1):193-199.
8. Busse D, Doughty RS, Ramsey TT, Russell WE, Price JO, Flanagan WM et al. Reversible G1 arrest induced by inhibition of the epidermal growth factor receptor tyrosine kinase requires up-regulation of p27 Kip1 independent of MAPK activity[J]. J Biol Chem, 2000, 275(10):6987-6995.
9. Vargaftig BB, Singer M. Leukotrienes mediate part of Ova-induced lung effects in mice via EGFR[J]. Am J Physiol Lung Cell Mol Physiol, 2003, 285(6):L808-L818.