Lesion complexity determines arterial drug distribution after local drug delivery

Journal of Controlled Release

Volumn 142, Issue 3, 2010, Pages 332-338

  Tzafriri, Abraham R ^a   Vukmirovic, Neda ^a   Kolachalama, Vijaya B ^a   Astafieva, Irina ^b   Edelman, Elazer R ^a,c  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b ABBOTT VASCULAR   (United States)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Arteries; Drugs; Lesion; Pharmacokinetics; Stents

Indexed keywords

ARTERIES; BINDING PROTEINS; CRYOPRESERVED; DEPOSITION PATTERNS; DIETARY MANIPULATION; DISEASED VESSELS; DRUG DISTRIBUTION; EVEROLIMUS; LIPID CONTENT; LOCAL DRUG DELIVERY; PACLITAXEL; SERIAL SECTIONING; SIROLIMUS; SPECIFIC BINDING; TRANSIENT RESPONSE; VASCULAR INJURY;

DRUG DELIVERY; GENE EXPRESSION; PHARMACOKINETICS;

NUTRITION;

DRUG BINDING PROTEIN; EVEROLIMUS; FK 506 BINDING PROTEIN; LIPID; PACLITAXEL; RAPAMYCIN; RAPAMYCIN DERIVATIVE; TUBULIN;

ABDOMINAL AORTA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTERY LESION; ARTERY MEDIA; ARTICLE; BLOOD VESSEL INJURY; CADAVER; CELL INFILTRATION; CONTROLLED STUDY; DATA ANALYSIS; DRUG BINDING; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RABBIT; STEADY STATE; STENT; TISSUE SECTION; ULTRASTRUCTURE;

ANIMALS; AORTA, ABDOMINAL; ATHEROSCLEROSIS; CHOLESTEROL; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; DRUG-ELUTING STENTS; HUMANS; MALE; PACLITAXEL; PROTEIN BINDING; RABBITS; SIROLIMUS; TISSUE DISTRIBUTION; TUNICA INTIMA;

EID: 77349086362     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2009.11.007     Document Type: Article

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