Drug clearance and arterial uptake after local perivascular delivery to the rat carotid artery

Journal of the American College of Cardiology

Volumn 29, Issue 7, 1997, Pages 1645-1650

  Lovich, Mark A ^a   Brown, Larry ^a   Edelman, Elazer R ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARIN; INULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CAROTID ARTERY; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DELIVERY SYSTEM; DRUG RECEPTOR BINDING; DRUG UPTAKE; IMPLANTATION; KIDNEY TUBULE ABSORPTION; NONHUMAN; PRIORITY JOURNAL; RAT; URINARY EXCRETION; VASCULAR SMOOTH MUSCLE;

ANALYSIS OF VARIANCE; ANIMALS; ARTERIES; BIOPOLYMERS; BLOOD VESSELS; CAPILLARIES; CARBON RADIOISOTOPES; DRUG DELIVERY SYSTEMS; FEMALE; GELS; HEPARIN; INULIN; RATS; RATS, SPRAGUE-DAWLEY; TISSUE DISTRIBUTION; TRITIUM;

EID: 0030914355     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0735-1097(97)00123-X     Document Type: Article

References (28)

1. Wolinsky H. Local delivery Let's keep our eyes on the wall . J Am Coll Cardiol. 24:1994;825-827.
2. Riessen R, Isner JM. Prospects for site-specific delivery of pharmacologic and molecular therapies. J Am Coll Cardiol. 23:1994;1234-1244.
3. Okada T, Bark DH, Mayberg MR. Localized release of perivascular heparin inhibits intimal proliferation after endothelial injury without systemic anticoagulation. Neurosurgery. 25:1989;892-898.
4. Edelman ER, Adams DA, Karnovsky MJ. Effect of controlled adventitial heparin delivery on smooth muscle cell proliferation following endothelial injury. Proc Natl Acad Sci U S A. 87:1990;3773-3777.
5. Nathan AN MA, Edelman ER. Tissue engineered perivascular endothelial cell implants regulate vascular injury. Proc Natl Acad Sci U S A. 92:1995;8139-8144.
6. Brown LR, Wei CL, Langer R. In vivo and in vitro release of macromolecules from polymeric drug delivery systems. J Pharm Sci. 72:1983;1181-1185.
7. Lovich MA, Edelman ER. Tissue average binding and equilibrium distribution an example with heparin in arterial tissues . Biophys J. 70:1996;1553-1559.
8. San Antonio JD, Slover J, Lawler J, Karnovsky MJ, Lander AD. Specificity in the interactions of extracellular matrix proteins with subpopulations of the glycosaminoglycan heparin. Biochemistry. 32:1993;4746-4755.
9. Castellot JJJ, Cochran DL, Karnovsky MJ. Effect of heparin on vascular smooth muscle cells I: Cell metabolism . J Cell Physiol. 124:1985;21-28.
10. Clowes AW, Karnovsky MJ. Suppression by heparin of smooth muscle cell proliferation in injured arteries. Nature. 265:1977;625-626.
11. Clowes AW, Clowes MM. Kinetics of cellular proliferation after arterial injury II: Inhibition of smooth muscle cell growth by heparin . Lab Invest. 52:1985;611-616.
12. Simons M, Edelman ER, Langer R, DeKeyser JL, Rosenberg RD. Antisense c-myb oligonucleotides inhibit intimal arterial smooth muscle accumulation in vivo. Nature. 359:1992;69-73.
13. Barzu T, Molho P, Tobelem G, Petitou M, Caen J. Binding and endocytosis of heparin by endothelial cells in culture. Biochim Biophys Acta. 845:1985;196-203.
14. Glimelius B, Busch C, Hook M. Binding of heparin on the surface of cultured human endothelial cells. Thromb Res. 12:1978;773-782.
15. Rogers C, Edelman ER. Controlled release of heparin reduces neointimal hyperplasia in stented rabbit arteries ramifications for local therapy . J Interven Cardiol. 5:1992;195-202.
16. Edelman ER, Nugent MA, Smith LT, Karnovsky MJ. Basic fibroblast growth factor enhances the coupling of intimal hyperplasia and proliferation of vasa vasorum in injured rat arteries. J Clin Invest. 89:1992;465-471.
17. Lambert T, Dev V, Rechavia E, Forrester JS, Litvack F, Eigler NL. Localized arterial wall drug delivery from a polymer-coated removable metallic stent kinetics, distribution, and bioactivity of forskolin . Circulation. 90:1994;1003-1011.
18. Gimple LW, Gertz DG, Haber HL, et al. Effect of chronic subcutaneous or intramural administration of heparin on femoral artery restenosis after balloon angioplasty in hypercholesterolemic rabbits: a quantitative angiographic and histopathological study 86 1992;86:1536-46.
19. Edelman ER, Simons M, Sirois MG, Rosenberg RD. C-myc in vasculoproliferative disease. Circ Res. 359:1995;69-73.
20. March KL, Mohanraj S, Ho PPK, Wilensky RL, Hathaway DR. Biodegradable microspheres containing a colchicine analogue inhibit DNA synthesis in vascular smooth muscle cells. Circulation. 89:1994;1929-1933.
21. Jones NS, Glenn MG, Orloff LA, Mayberg MR. Prevention of microvascular thrombosis with controlled-release transmural heparin. Arch Otolaryngol Head Neck Surg. 116:1990;779-785.
22. Lovich MA, Edelman ER. Computational simulations of local vascular heparin deposition and distribution. Am J Physiol. 271:1996;H2014-H2024.
23. Lovich MA, Edelman ER. Mechanisms of transmural heparin transport in the rat abdominal aorta after local vascular delivery. Circ Res. 77:1995;1143-1150.
24. Edelman ER, Nugent MA, Karnovsky MJ. Perivascular and intravenous bFGF administration vascular and solid organ deposition . Proc Natl Acad Sci U S A. 30:1993;1513-1517.
25. Wolinsky H, Glagov S. Nature of species differences in the medial distribution of aortic vasa vasorum in mammals. Circ Res. 20:1967;409-421.
26. Mayberg MR. Localized release of perivascular heparin. Perspect Neuro Surg. 1:1990;77-95.
27. Booth RFG, Martin JF, Honey AC, Hassall DG, Beesley JE, Moncada S. Rapid development of atherosclerotic lesions in the rabbit artery induced by perivascular manipulation. Atherosclerosis. 76:1989;257-268.
28. Huth F, Kojimahara M, Franken T, Rhedin P, Rosenbauer KA. Aortic alterations in rabbits following sheathing with Silastic and polyethylene tubes. Curr Top Pathol. 60:1975;1-32.