Luminal flow patterns dictate arterial drug deposition in stent-based delivery

Journal of Controlled Release

Volumn 133, Issue 1, 2009, Pages 24-30

  Kolachalama, Vijaya B ^a   Tzafriri, Abraham R ^a   Arifin, Davis Y ^b   Edelman, Elazer R ^a,c  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b SINGAPORE MIT ALLIANCE   (Singapore)

^c HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Computational fluid dynamics; Drug eluting stents; Pulsatile blood flow; Strut design

Indexed keywords

ARTIFICIAL ORGANS; DYNAMICS; FLOW PATTERNS; FLUID DYNAMICS; HEMODYNAMICS; PULSATILE FLOW; STRUTS;

ARTERIAL TREES; DRUG DISTRIBUTIONS; DRUG UPTAKES; DRUG-ELUTING STENTS; DYNAMIC FLOWS; ENDOVASCULAR STENTS; LOCAL DELIVERIES; LOCAL FLOWS; LUMINAL FLOWS; PULSATILE BLOOD FLOW; PULSATILITY; RECIRCULATION ZONES; SPATIO TEMPORALS; TEMPORAL PERIODICITIES; TISSUE ABSORPTIONS;

COMPUTATIONAL FLUID DYNAMICS;

DRUG;

ARTICLE; COMPUTATIONAL FLUID DYNAMICS; DRUG ABSORPTION; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG ELUTING STENT; MATHEMATICAL MODEL; PRIORITY JOURNAL;

ALGORITHMS; AREA UNDER CURVE; ARTERIES; BLOOD FLOW VELOCITY; BLOOD VISCOSITY; COMPUTER SIMULATION; CORONARY RESTENOSIS; DIFFUSION; DRUG DELIVERY SYSTEMS; DRUG-ELUTING STENTS; HEMORHEOLOGY; HUMANS; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; PULSATILE FLOW;

EID: 57049166451     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2008.09.075     Document Type: Article

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