메뉴 건너뛰기




Volumn 74, Issue 1, 2010, Pages 16-26

Integration of panitumumab into the treatment of colorectal cancer

Author keywords

Colorectal cancer; EGF receptor; Monoclonal antibodies; Panitumumab

Indexed keywords

ANTIBIOTIC AGENT; B RAF KINASE; BEVACIZUMAB; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROPYRIMIDINE DERIVATIVE; FLUOROURACIL; FOLINIC ACID; GROWTH FACTOR; IMMUNOGLOBULIN G2; IRINOTECAN; K RAS PROTEIN; LOPERAMIDE; MAGNESIUM; OXALIPLATIN; PANITUMUMAB;

EID: 77249159315     PISSN: 10408428     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.critrevonc.2009.06.005     Document Type: Review
Times cited : (24)

References (47)
  • 1
    • 33646568784 scopus 로고    scopus 로고
    • Patterns of care incidence, mortality and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic region of the world
    • Kamangar F., Dores G.M., and Anderson W.F. Patterns of care incidence, mortality and prevalence across five continents: defining priorities to reduce cancer disparities in different geographic region of the world. J Clin Oncol 26 (2006) 2137-2150
    • (2006) J Clin Oncol , vol.26 , pp. 2137-2150
    • Kamangar, F.1    Dores, G.M.2    Anderson, W.F.3
  • 2
    • 0033874892 scopus 로고    scopus 로고
    • Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer
    • De Gramont A., Figer A., Seymour M., et al. Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer. J Clin Oncol 18 (2000) 2938-2947
    • (2000) J Clin Oncol , vol.18 , pp. 2938-2947
    • De Gramont, A.1    Figer, A.2    Seymour, M.3
  • 3
    • 0034712536 scopus 로고    scopus 로고
    • Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomized trial
    • Douillard J.Y., Cunningham D., Roth A.D., et al. Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomized trial. Lancet 355 (2000) 1041-1047
    • (2000) Lancet , vol.355 , pp. 1041-1047
    • Douillard, J.Y.1    Cunningham, D.2    Roth, A.D.3
  • 4
    • 1342290189 scopus 로고    scopus 로고
    • FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study
    • Tournigand C., Andre T., Achille E., et al. FOLFIRI followed by FOLFOX6 or the reverse sequence in advanced colorectal cancer: a randomized GERCOR study. J Clin Oncol 22 (2004) 229-237
    • (2004) J Clin Oncol , vol.22 , pp. 229-237
    • Tournigand, C.1    Andre, T.2    Achille, E.3
  • 5
    • 36749096406 scopus 로고    scopus 로고
    • Monoclonal antibodies in the treatment of advanced colorectal cancer
    • Capdevila J., Saura C., Macarulla T., et al. Monoclonal antibodies in the treatment of advanced colorectal cancer. Eur J Surg Oncol 33 Suppl 2 (2007) S24-S34
    • (2007) Eur J Surg Oncol , vol.33 , Issue.SUPPL. 2
    • Capdevila, J.1    Saura, C.2    Macarulla, T.3
  • 6
    • 0028955388 scopus 로고
    • Epidermal growth factor-related peptides and their receptors in human malignancies
    • Salomon D.S., Brandt R., Ciardello F., and Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19 3 (1995) 183-232
    • (1995) Crit Rev Oncol Hematol , vol.19 , Issue.3 , pp. 183-232
    • Salomon, D.S.1    Brandt, R.2    Ciardello, F.3    Normanno, N.4
  • 7
    • 0034799139 scopus 로고    scopus 로고
    • A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor
    • Ciardiello F., and Tortora G. A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin Cancer Res 7 (2001) 2958-2970
    • (2001) Clin Cancer Res , vol.7 , pp. 2958-2970
    • Ciardiello, F.1    Tortora, G.2
  • 8
    • 77249113000 scopus 로고    scopus 로고
    • http://www.emea.europa.eu/humandocs/Humans/EPAR/erbitux/erbitux.htm
  • 9
    • 0035117355 scopus 로고    scopus 로고
    • Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody for cancer therapy
    • Yang X.D., Jia X.C., Corvalan J.R., et al. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody for cancer therapy. Crit Rev Oncol Hematol 38 (2001) 17-23
    • (2001) Crit Rev Oncol Hematol , vol.38 , pp. 17-23
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3
  • 10
    • 10744221013 scopus 로고    scopus 로고
    • Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody
    • Foon K.A., Yang X.D., Weiner L.M., et al. Preclinical and clinical evaluations of ABX-EGF, a fully human anti-epidermal growth factor receptor antibody. Int J Radiat Oncol Biol Phys 58 (2004) 984-990
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 984-990
    • Foon, K.A.1    Yang, X.D.2    Weiner, L.M.3
  • 11
    • 0033559606 scopus 로고    scopus 로고
    • Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy
    • Yang X.D., Jia X.C., Corvalan J.R., et al. Eradication of established tumors by a fully human monoclonal antibody to the epidermal growth factor receptor without concomitant chemotherapy. Cancer Res 59 (1999) 1236-1243
    • (1999) Cancer Res , vol.59 , pp. 1236-1243
    • Yang, X.D.1    Jia, X.C.2    Corvalan, J.R.3
  • 12
    • 33751088993 scopus 로고    scopus 로고
    • Mono- and combination-therapeutic activity of panitumumab on human A431 epidermoid and HT-29 colon carcinomas xenografts: correlation with pharmacodynamic parameters
    • Freeman D., McDorman K., Bush T., et al. Mono- and combination-therapeutic activity of panitumumab on human A431 epidermoid and HT-29 colon carcinomas xenografts: correlation with pharmacodynamic parameters. Eur J Cancer Suppl (2004) Abstr 95
    • (2004) Eur J Cancer Suppl
    • Freeman, D.1    McDorman, K.2    Bush, T.3
  • 13
    • 77249102328 scopus 로고    scopus 로고
    • http://www.emea.europa.eu/humandocs/Humans/EPAR/vectibix/vectibix.htm
  • 14
    • 38949178132 scopus 로고    scopus 로고
    • Updated results from a dose and schedule study of Panitumumab (ABX-EGF) monotherapy in patients with advanced solid malignancies
    • Weiner L.M., Belldegrun A.S., Crawford J., et al. Updated results from a dose and schedule study of Panitumumab (ABX-EGF) monotherapy in patients with advanced solid malignancies. Clin Cancer Res 14 (2008) 502-508
    • (2008) Clin Cancer Res , vol.14 , pp. 502-508
    • Weiner, L.M.1    Belldegrun, A.S.2    Crawford, J.3
  • 15
    • 77249166326 scopus 로고    scopus 로고
    • Stephenson JJ, Cohn A, Crawford J, et al. Administration of panitumumab (Pmab) every two weeks (Q2W) as a 30-min or 60-min infusion: safety and pharmacokinetics (PK) from a phase 1 study in patients with solid tumors. Gastrointestinal Cancers Symposium, Orlando, 2007; Abstr. 368.
    • Stephenson JJ, Cohn A, Crawford J, et al. Administration of panitumumab (Pmab) every two weeks (Q2W) as a 30-min or 60-min infusion: safety and pharmacokinetics (PK) from a phase 1 study in patients with solid tumors. Gastrointestinal Cancers Symposium, Orlando, 2007; Abstr. 368.
  • 17
    • 77249125132 scopus 로고    scopus 로고
    • ®. http://www.emea.europa.eu/humandocs/Humans/EPAR/vectibix/vectibix.htm. Accessed on March 31, 2008.
    • ®. http://www.emea.europa.eu/humandocs/Humans/EPAR/vectibix/vectibix.htm. Accessed on March 31, 2008.
  • 18
    • 34548147248 scopus 로고    scopus 로고
    • Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer
    • Hecht J.R., Patnaik A., Berlin J., et al. Panitumumab monotherapy in patients with previously treated metastatic colorectal cancer. Cancer 110 (2007) 980-987
    • (2007) Cancer , vol.110 , pp. 980-987
    • Hecht, J.R.1    Patnaik, A.2    Berlin, J.3
  • 19
    • 77249161952 scopus 로고    scopus 로고
    • Berlin J, Neubauer M, Swanson P, et al. Panitumumab antitumor activity in patients (pts) with metastatic colorectal cancer (mmCRC) expressing ≥ 10% epidermal growth factor receptor (EGFR). American Society of Clinical Oncology, Orlando, 2006; Abstr. 3548.
    • Berlin J, Neubauer M, Swanson P, et al. Panitumumab antitumor activity in patients (pts) with metastatic colorectal cancer (mmCRC) expressing ≥ 10% epidermal growth factor receptor (EGFR). American Society of Clinical Oncology, Orlando, 2006; Abstr. 3548.
  • 20
    • 42049120871 scopus 로고    scopus 로고
    • Panitumumab (Pmab) efficacy in patients (pts) with metastatic colorectal cancer (mCRC) with low or undetectable levels of epidermal growth factor receptor (EGFr): Final efficacy and KRAS analyses
    • Orlando, Poster
    • Hecht R, Mitchell EP, Baranda J, et al. Panitumumab (Pmab) efficacy in patients (pts) with metastatic colorectal cancer (mCRC) with low or undetectable levels of epidermal growth factor receptor (EGFr): Final efficacy and KRAS analyses. Gastrointestinal Cancers Symposium, Orlando, 2008; Poster 343.
    • (2008) Gastrointestinal Cancers Symposium , pp. 343
    • Hecht, R.1    Mitchell, E.P.2    Baranda, J.3
  • 21
    • 77249110976 scopus 로고    scopus 로고
    • Yoshino T, Muro K, Doi T, et al. Phase 2 study of Panitumumab (Pmab) monotherapy in Japanese patients (pts) with metastatic colorectal cancer (mCRC) after the failure of fluoropyrimidine, irinotecan (CPT-11) and oxaliplatin (OHP) chemotherapy. Gastrointestinal Cancers Symposium, Orlando, 2008; Abstr. 366.
    • Yoshino T, Muro K, Doi T, et al. Phase 2 study of Panitumumab (Pmab) monotherapy in Japanese patients (pts) with metastatic colorectal cancer (mCRC) after the failure of fluoropyrimidine, irinotecan (CPT-11) and oxaliplatin (OHP) chemotherapy. Gastrointestinal Cancers Symposium, Orlando, 2008; Abstr. 366.
  • 22
    • 34147103678 scopus 로고    scopus 로고
    • Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer
    • Van Cutsem E., Peeters M., Siena S., et al. Open-label phase III trial of panitumumab plus best supportive care compared with best supportive care alone in patients with chemotherapy-refractory metastatic colorectal cancer. J Clin Oncol 25 (2007) 1658-1664
    • (2007) J Clin Oncol , vol.25 , pp. 1658-1664
    • Van Cutsem, E.1    Peeters, M.2    Siena, S.3
  • 23
    • 38049044037 scopus 로고    scopus 로고
    • An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy
    • Van Cutsem E., Siena S., Humblet Y., et al. An open-label, single-arm study assessing safety and efficacy of panitumumab in patients with metastatic colorectal cancer refractory to standard chemotherapy. Ann Oncol 19 (2008) 92-98
    • (2008) Ann Oncol , vol.19 , pp. 92-98
    • Van Cutsem, E.1    Siena, S.2    Humblet, Y.3
  • 24
    • 34247480064 scopus 로고    scopus 로고
    • Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line treatment of metastatic colorectal cancer
    • Berlin J., Posey J., Tchekmedyian S., et al. Panitumumab with irinotecan/leucovorin/5-fluorouracil for first-line treatment of metastatic colorectal cancer. Clin Colorectal Cancer 6 (2007) 427-432
    • (2007) Clin Colorectal Cancer , vol.6 , pp. 427-432
    • Berlin, J.1    Posey, J.2    Tchekmedyian, S.3
  • 25
    • 77249145108 scopus 로고    scopus 로고
    • Phase III study (PRIME/200505203) of panitumumab (pmab) with FOLFOX compared with FOLFOX alone in patients (pts) with previously untreated metastatic colorectal cancer (mCRC): pooled safety data
    • Abstr. 4034
    • Siena S., Tabernero J., Burkes R.L., et al. Phase III study (PRIME/200505203) of panitumumab (pmab) with FOLFOX compared with FOLFOX alone in patients (pts) with previously untreated metastatic colorectal cancer (mCRC): pooled safety data. J Clin Oncol 26 (2008) Abstr. 4034
    • (2008) J Clin Oncol , vol.26
    • Siena, S.1    Tabernero, J.2    Burkes, R.L.3
  • 26
    • 59949102930 scopus 로고    scopus 로고
    • A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer
    • Hecht J.R., Mitchell E., Chidiac T., et al. A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer. J Clin Oncol 27 (2008) 672-680
    • (2008) J Clin Oncol , vol.27 , pp. 672-680
    • Hecht, J.R.1    Mitchell, E.2    Chidiac, T.3
  • 27
    • 41549167668 scopus 로고    scopus 로고
    • A randomised phase III study on capecitabine, oxaliplatin and bevacizumab with or without cetuximab in first-line advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG). An interim analysis of toxicity
    • Tol J., Koopman M., Rodenburg C.J., et al. A randomised phase III study on capecitabine, oxaliplatin and bevacizumab with or without cetuximab in first-line advanced colorectal cancer, the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG). An interim analysis of toxicity. Ann Oncol 19 4 (2008) 734-738
    • (2008) Ann Oncol , vol.19 , Issue.4 , pp. 734-738
    • Tol, J.1    Koopman, M.2    Rodenburg, C.J.3
  • 28
    • 77249117457 scopus 로고    scopus 로고
    • Peeters M, Wilson G, Ducreux M, et al. Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Pooled safety results. American Society of Clinical Oncology, Chicago, 2008; Abstr. 4064.
    • Peeters M, Wilson G, Ducreux M, et al. Phase III study (20050181) of panitumumab (pmab) with FOLFIRI versus FOLFIRI alone as second-line treatment (tx) in patients (pts) with metastatic colorectal cancer (mCRC): Pooled safety results. American Society of Clinical Oncology, Chicago, 2008; Abstr. 4064.
  • 29
    • 77249179000 scopus 로고    scopus 로고
    • nd-line treatment (tx): Interim analysis. American Society of Clinical Oncology, Chicago, 2008; Abstr. 15007.
    • nd-line treatment (tx): Interim analysis. American Society of Clinical Oncology, Chicago, 2008; Abstr. 15007.
  • 30
    • 64649098897 scopus 로고    scopus 로고
    • A phase II, open-label, randomized clinical trial of skin toxicity evaluation (STEPP) in metastatic colorectal cancer (mCRC) patients (pts) receiving 2nd line FOLFIRI or irinotecan-only chemotherapy (CT) with panitumumab (pmab): Early analysis
    • Orlando, Poster
    • Mitchell EP, LaCouture ME, Shearer H, et al. A phase II, open-label, randomized clinical trial of skin toxicity evaluation (STEPP) in metastatic colorectal cancer (mCRC) patients (pts) receiving 2nd line FOLFIRI or irinotecan-only chemotherapy (CT) with panitumumab (pmab): Early analysis. Gastrointestinal Cancers Symposium, Orlando, 2008; Poster 462.
    • (2008) Gastrointestinal Cancers Symposium , pp. 462
    • Mitchell, E.P.1    LaCouture, M.E.2    Shearer, H.3
  • 31
    • 77249129504 scopus 로고    scopus 로고
    • Asmis TR, Shah MA, Haviland D, Kemeny N. Panitumumab with or without chemotherapy in metastatic colorectal cancer (mCRC): Safety and unusual activity, even following progression on cetuximab. Gastrointestinal Cancers Symposium, Orlando, 2008; Abstr. 484.
    • Asmis TR, Shah MA, Haviland D, Kemeny N. Panitumumab with or without chemotherapy in metastatic colorectal cancer (mCRC): Safety and unusual activity, even following progression on cetuximab. Gastrointestinal Cancers Symposium, Orlando, 2008; Abstr. 484.
  • 32
    • 77249136600 scopus 로고    scopus 로고
    • Peeters M, Van Cutsem E, Berlin J, et al. Safety of panitumumab, a fully human monoclonal antibody against the epidermal growth factor receptor (EGFr), in patients (pts) with metastatic colorectal cancer (mCRC) across clinical trials. American Society of Clinical Oncology, Chicago, 2007; Abstr. 4138.
    • Peeters M, Van Cutsem E, Berlin J, et al. Safety of panitumumab, a fully human monoclonal antibody against the epidermal growth factor receptor (EGFr), in patients (pts) with metastatic colorectal cancer (mCRC) across clinical trials. American Society of Clinical Oncology, Chicago, 2007; Abstr. 4138.
  • 33
    • 42649145667 scopus 로고    scopus 로고
    • Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
    • Amado R.G., Wolf M., Peeters M., et al. Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer. J Clin Oncol 26 (2008) 1626-1634
    • (2008) J Clin Oncol , vol.26 , pp. 1626-1634
    • Amado, R.G.1    Wolf, M.2    Peeters, M.3
  • 34
    • 42049120871 scopus 로고    scopus 로고
    • Panitumumab (pmab) efficacy in patients (pts) with metastatic colorectal cancer (mCRC) with low or undetectable levels of epidermal growth factor receptor (EGFr): Final efficacy and KRAS analyses
    • Orlando, Poster
    • Hecht R, Mitchell EP, Baranda J, et al. Panitumumab (pmab) efficacy in patients (pts) with metastatic colorectal cancer (mCRC) with low or undetectable levels of epidermal growth factor receptor (EGFr): Final efficacy and KRAS analyses. Gastrointestinal Cancers Symposium, Orlando, 2008; Poster 343.
    • (2008) Gastrointestinal Cancers Symposium , pp. 343
    • Hecht, R.1    Mitchell, E.P.2    Baranda, J.3
  • 35
    • 40149088765 scopus 로고    scopus 로고
    • KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab
    • De Roock W., Piessevaux H., De Schutter J., et al. KRAS wild-type state predicts survival and is associated to early radiological response in metastatic colorectal cancer treated with cetuximab. Ann Oncol 19 (2008) 508-515
    • (2008) Ann Oncol , vol.19 , pp. 508-515
    • De Roock, W.1    Piessevaux, H.2    De Schutter, J.3
  • 36
    • 34247278727 scopus 로고    scopus 로고
    • Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy
    • Di Fiore F., Blanchard F., Charbonnier F., et al. Clinical relevance of KRAS mutation detection in metastatic colorectal cancer treated by Cetuximab plus chemotherapy. Br J Cancer 96 (2007) 1166-1169
    • (2007) Br J Cancer , vol.96 , pp. 1166-1169
    • Di Fiore, F.1    Blanchard, F.2    Charbonnier, F.3
  • 37
    • 34047248571 scopus 로고    scopus 로고
    • Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies
    • Benvenuti S., Sartore-Bianchi A., Di Nicolantonio F., et al. Oncogenic activation of the RAS/RAF signaling pathway impairs the response of metastatic colorectal cancers to anti-epidermal growth factor receptor antibody therapies. Cancer Res 67 (2007) 2643-2648
    • (2007) Cancer Res , vol.67 , pp. 2643-2648
    • Benvenuti, S.1    Sartore-Bianchi, A.2    Di Nicolantonio, F.3
  • 38
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and KRAS mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S., Garrett C.R., Meropol N.J., et al. Expression of epiregulin and amphiregulin and KRAS mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 25 (2007) 3230-3237
    • (2007) J Clin Oncol , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3
  • 39
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis C.S., Khambata-Ford S., Jonker D.J., et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Eng J Med 359 (2008) 1757-1765
    • (2008) N Eng J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 40
    • 57449095367 scopus 로고    scopus 로고
    • Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
    • Di Nicolantonio F., Martini M., Molinari F., et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol 26 (2008) 5705-5712
    • (2008) J Clin Oncol , vol.26 , pp. 5705-5712
    • Di Nicolantonio, F.1    Martini, M.2    Molinari, F.3
  • 41
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study
    • Moroni M., Veronese S., Benvenuti S., et al. Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 6 (2005) 279-286
    • (2005) Lancet Oncol , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3
  • 42
    • 34548258303 scopus 로고    scopus 로고
    • Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab
    • Sartore-Bianchi A., Moroni M., Veronese S., et al. Epidermal growth factor receptor gene copy number and clinical outcome of metastatic colorectal cancer treated with panitumumab. J Clin Oncol 25 (2007) 3228-3245
    • (2007) J Clin Oncol , vol.25 , pp. 3228-3245
    • Sartore-Bianchi, A.1    Moroni, M.2    Veronese, S.3
  • 43
    • 77249133350 scopus 로고    scopus 로고
    • Humblet Y, Peeters M, Siena S, et al. Association of skin toxicity (ST) severity with clinical outcomes and health-related quality of life (HRQoL) with panitunumab (Pmab). American Society of Clinical Oncology, Chicago, 2007; Abstr. 4038.
    • Humblet Y, Peeters M, Siena S, et al. Association of skin toxicity (ST) severity with clinical outcomes and health-related quality of life (HRQoL) with panitunumab (Pmab). American Society of Clinical Oncology, Chicago, 2007; Abstr. 4038.
  • 45
    • 36148941301 scopus 로고    scopus 로고
    • Cetuximab for the treatment of colorectal cancer
    • Jonker D.J., O'Callaghan C.J., Karapetis C.S., et al. Cetuximab for the treatment of colorectal cancer. N Eng J Med 357 20 (2007) 2040-2048
    • (2007) N Eng J Med , vol.357 , Issue.20 , pp. 2040-2048
    • Jonker, D.J.1    O'Callaghan, C.J.2    Karapetis, C.S.3
  • 46
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsen E., Kohne C.-H., Hitre E.H., et al. Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360 (2009) 1408-1417
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsen, E.1    Kohne, C.-H.2    Hitre, E.H.3
  • 47
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, Leucovorin and Oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C., Bondarenko I., Makhson A., et al. Fluorouracil, Leucovorin and Oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 27 (2009) 663-671
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.