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Volumn 33, Issue SUPPL. 2, 2007, Pages

Monoclonal antibodies in the treatment of advanced colorectal cancer

Author keywords

Bevacizumab; Cetuximab; Colorectal cancer; Monoclonal antibodies; Panitumumab; Targeted therapy

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; MONOCLONAL ANTIBODY; OXALIPLATIN; PANITUMUMAB; PLACEBO; TRANSFORMING GROWTH FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULOTROPIN; VECTIBIX;

EID: 36749096406     PISSN: 07487983     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejso.2007.09.025     Document Type: Review
Times cited : (18)

References (64)
  • 1
    • 2142703727 scopus 로고    scopus 로고
    • Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment
    • Grothey A., Sargent D., Goldberg R.M., and Schmoll H.J. Survival of patients with advanced colorectal cancer improves with the availability of fluorouracil-leucovorin, irinotecan, and oxaliplatin in the course of treatment. J Clin Oncol 22 (2004) 1209-1214
    • (2004) J Clin Oncol , vol.22 , pp. 1209-1214
    • Grothey, A.1    Sargent, D.2    Goldberg, R.M.3    Schmoll, H.J.4
  • 2
    • 0030795612 scopus 로고    scopus 로고
    • The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions
    • Alroy I., and Yarden Y. The ErbB signaling network in embryogenesis and oncogenesis: signal diversification through combinatorial ligand-receptor interactions. FEBS Lett 410 (1997) 83-86
    • (1997) FEBS Lett , vol.410 , pp. 83-86
    • Alroy, I.1    Yarden, Y.2
  • 3
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering B.M., and Coffer P.J. Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376 (1995) 599-602
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 4
    • 0002145419 scopus 로고    scopus 로고
    • New technologies in epidermal growth factor receptor-targeted cancer therapy
    • Baselga J. New technologies in epidermal growth factor receptor-targeted cancer therapy. Signal 1 (2000) 12-21
    • (2000) Signal , vol.1 , pp. 12-21
    • Baselga, J.1
  • 5
    • 0034777482 scopus 로고    scopus 로고
    • Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival
    • Brabender J., Danenberg K.D., Metzger R., et al. Epidermal growth factor receptor and HER2-neu mRNA expression in non-small cell lung cancer is correlated with survival. Clin Cancer Res 7 (2001) 1850-1855
    • (2001) Clin Cancer Res , vol.7 , pp. 1850-1855
    • Brabender, J.1    Danenberg, K.D.2    Metzger, R.3
  • 6
    • 0025606461 scopus 로고
    • Epidermal growth factor receptor expression in colorectal cancer
    • Steele R.J., Kelly P., Ellul B., and Eremin O. Epidermal growth factor receptor expression in colorectal cancer. Br J Surg 77 12 (1990) 1352-1354
    • (1990) Br J Surg , vol.77 , Issue.12 , pp. 1352-1354
    • Steele, R.J.1    Kelly, P.2    Ellul, B.3    Eremin, O.4
  • 7
    • 0031441193 scopus 로고    scopus 로고
    • Cell cycle regulation in irradiated and nonirradiated cells
    • Iliakis G. Cell cycle regulation in irradiated and nonirradiated cells. Semin Oncol 24 6 (1997) 602-615
    • (1997) Semin Oncol , vol.24 , Issue.6 , pp. 602-615
    • Iliakis, G.1
  • 8
    • 0021254542 scopus 로고
    • Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity
    • Gill G.N., Kawamoto T., Cochet C., et al. Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem 259 (1984) 7755-7760
    • (1984) J Biol Chem , vol.259 , pp. 7755-7760
    • Gill, G.N.1    Kawamoto, T.2    Cochet, C.3
  • 9
    • 0034114769 scopus 로고    scopus 로고
    • Blockade of receptors for growth factors: an anticancer therapy
    • Mendelsohn J. Blockade of receptors for growth factors: an anticancer therapy. Clin Cancer Res 6 (2000) 747-753
    • (2000) Clin Cancer Res , vol.6 , pp. 747-753
    • Mendelsohn, J.1
  • 10
    • 0034084314 scopus 로고    scopus 로고
    • Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics and tumor angiogenesis
    • Huang S.M., and Harari P.M. Modulation of radiation response after epidermal growth factor receptor blockade in squamous cell carcinomas: inhibition of damage repair, cell cycle kinetics and tumor angiogenesis. Clin Cancer Res 6 (2000) 2166-2174
    • (2000) Clin Cancer Res , vol.6 , pp. 2166-2174
    • Huang, S.M.1    Harari, P.M.2
  • 11
    • 0036094194 scopus 로고    scopus 로고
    • Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
    • Prewett M.C., Hooper A.T., Bassi R., Ellis L.M., Waksal H.W., and Hicklin D.J. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res 8 (2002) 994-1003
    • (2002) Clin Cancer Res , vol.8 , pp. 994-1003
    • Prewett, M.C.1    Hooper, A.T.2    Bassi, R.3    Ellis, L.M.4    Waksal, H.W.5    Hicklin, D.J.6
  • 12
    • 0002823211 scopus 로고    scopus 로고
    • Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that express epidermal growth factor receptor (EGFR)
    • Saltz L.B., Rubin M., Hochster H., et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that express epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 20 (2001) 3a
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Saltz, L.B.1    Rubin, M.2    Hochster, H.3
  • 13
    • 2142641698 scopus 로고    scopus 로고
    • Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor
    • Saltz L.B., Meropol N.J., Loehrer Sr. P.J., Needle M.N., Kopit J., and Mayer R.J. Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 22 (2004) 1201-1208
    • (2004) J Clin Oncol , vol.22 , pp. 1201-1208
    • Saltz, L.B.1    Meropol, N.J.2    Loehrer Sr., P.J.3    Needle, M.N.4    Kopit, J.5    Mayer, R.J.6
  • 14
    • 3242720345 scopus 로고    scopus 로고
    • Cetuximab monotherapy and cetuximab plus irinotecan-refractory metastatic colorectal cancer
    • Cunningham D., Humblet Y., Siena S., et al. Cetuximab monotherapy and cetuximab plus irinotecan-refractory metastatic colorectal cancer. N Engl J Med 351 (2004) 337-345
    • (2004) N Engl J Med , vol.351 , pp. 337-345
    • Cunningham, D.1    Humblet, Y.2    Siena, S.3
  • 15
    • 0344773402 scopus 로고    scopus 로고
    • The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies
    • [abstract 817]
    • Saltz L., Kies M., Abbruzzese J.L., Azarnia N., and Needle M. The presence and intensity of the cetuximab-induced acne-like rash predicts increased survival in studies across multiple malignancies. Proc Am Soc Clin Oncol 22 (2003) 204 [abstract 817]
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 204
    • Saltz, L.1    Kies, M.2    Abbruzzese, J.L.3    Azarnia, N.4    Needle, M.5
  • 16
    • 36749055574 scopus 로고    scopus 로고
    • Van Cutsem E, Humblet Y, Gelderblom H, et al. Cetuximab dose-escalation study in patients with metastatic colorectal cancer (mCRC) with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic and efficacy data of a randomized study. ASCO Gastrointestinal Cancer Symposium, 2007 [abstract 237].
  • 17
    • 34547542923 scopus 로고    scopus 로고
    • MABEL - a large multinational study of cetuximab plus irinotecan in metastatic colorectal cancer progressing on irinotecan
    • [abstract 3549]
    • Wilke H., Glynne-Jones R., Thaler J., et al. MABEL - a large multinational study of cetuximab plus irinotecan in metastatic colorectal cancer progressing on irinotecan. Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3549]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Wilke, H.1    Glynne-Jones, R.2    Thaler, J.3
  • 18
    • 36749038692 scopus 로고    scopus 로고
    • Cetuximab plus capecitabine (CAP) and oxaliplatin (LOHP) (CAPOX) as salvage treatment for patients with metastatic colorectal cancer (CRC) relapsing after oxaliplatin-based chemotherapy
    • [abstract 235]
    • Souglakos J., Androulakis N., Tzardi M., et al. Cetuximab plus capecitabine (CAP) and oxaliplatin (LOHP) (CAPOX) as salvage treatment for patients with metastatic colorectal cancer (CRC) relapsing after oxaliplatin-based chemotherapy. ASCO Gastrointestinal Cancer Symposium (2006) [abstract 235]
    • (2006) ASCO Gastrointestinal Cancer Symposium
    • Souglakos, J.1    Androulakis, N.2    Tzardi, M.3
  • 19
    • 23844435339 scopus 로고    scopus 로고
    • Cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer (mCRC): an international phase II study
    • [abstract 3535]
    • Diaz-Rubio E., Tabernero J., Van Cutsem E., et al. Cetuximab in combination with oxaliplatin/5-fluorouracil (5-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer (mCRC): an international phase II study. Proc Am Soc Clin Oncol 23 (2005) 16S [abstract 3535]
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Diaz-Rubio, E.1    Tabernero, J.2    Van Cutsem, E.3
  • 20
    • 45249117578 scopus 로고    scopus 로고
    • FOLFOX-4 plus cetuximab in untreated patients with advanced colorectal cancer. A phase II study of the Gruppo Oncologico dell'Italia Meridionale (prot. GOIM 2402)
    • [abstract 3559]
    • Colucci G., Giuliani F., Mattioli R., et al. FOLFOX-4 plus cetuximab in untreated patients with advanced colorectal cancer. A phase II study of the Gruppo Oncologico dell'Italia Meridionale (prot. GOIM 2402). Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3559]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Colucci, G.1    Giuliani, F.2    Mattioli, R.3
  • 21
    • 33750905700 scopus 로고    scopus 로고
    • Phase III study of irinotecan/5-FU/LV (FOLFIRI) or oxaliplatin/5-FU/LV (FOLFOX) ± cetuximab (C225) for patients (pts) with untreated metastatic adeno carcinoma of the colon or rectum (mCRC): CALGB 80203 preliminary results
    • [abstract 3509]
    • Venook A., Niedzwiecki D., Hollis D., et al. Phase III study of irinotecan/5-FU/LV (FOLFIRI) or oxaliplatin/5-FU/LV (FOLFOX) ± cetuximab (C225) for patients (pts) with untreated metastatic adeno carcinoma of the colon or rectum (mCRC): CALGB 80203 preliminary results. Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3509]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Venook, A.1    Niedzwiecki, D.2    Hollis, D.3
  • 22
    • 33749038520 scopus 로고    scopus 로고
    • The impact of cetuximab on the capecitabine plus oxaliplatin (XELOX) combination in first-line treatment of metastatic colorectal cancer (MCC): a randomized phase II trial of the Swiss Group for Clinical Cancer Research (SAKK)
    • [abstract 3551]
    • Borner M., Mingrone W., Koeberle D., et al. The impact of cetuximab on the capecitabine plus oxaliplatin (XELOX) combination in first-line treatment of metastatic colorectal cancer (MCC): a randomized phase II trial of the Swiss Group for Clinical Cancer Research (SAKK). Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3551]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Borner, M.1    Mingrone, W.2    Koeberle, D.3
  • 23
    • 33750705748 scopus 로고    scopus 로고
    • Cetuximab with irinotecan in first-line treatment of epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer (mCRC). Preliminary safety results (CRYSTAL)
    • [abstract 3555]
    • Lang I., Zaluski J., Changchein C.R., et al. Cetuximab with irinotecan in first-line treatment of epidermal growth factor receptor (EGFR)-expressing metastatic colorectal cancer (mCRC). Preliminary safety results (CRYSTAL). Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3555]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Lang, I.1    Zaluski, J.2    Changchein, C.R.3
  • 24
    • 0001407137 scopus 로고    scopus 로고
    • Erbitux (IMC-C225) plus weekly irinotecan, fluorouracil, and leucoverin in colorectal cancer that express the epidermal growth factor receptor
    • [abstract 536]
    • Rosenberg A.H., Loehrer P.J., Needle M.N., et al. Erbitux (IMC-C225) plus weekly irinotecan, fluorouracil, and leucoverin in colorectal cancer that express the epidermal growth factor receptor. Proc Am Soc Clin Oncol 21 (2002) [abstract 536]
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Rosenberg, A.H.1    Loehrer, P.J.2    Needle, M.N.3
  • 25
    • 36749079137 scopus 로고    scopus 로고
    • Folprecht G, Lutz M, Schefski P, et al. Cetuximab/irinotecan/high-dose-5-fluorouracil/leucovorin (HD-5-FU/LV) in the first-line therapy of metastatic colorectal cancer (CRC). ASCO Gastrointestinal Cancers Symposium, 2004 [abstract 283].
  • 26
    • 16244372110 scopus 로고    scopus 로고
    • Cetuximab plus FOLFIRI as first-line treatment for metastatic colorectal cancer
    • [abstract 3513]
    • Rougier P., Raoul J.-L., Van Laethem J.-L., et al. Cetuximab plus FOLFIRI as first-line treatment for metastatic colorectal cancer. Proc Am Soc Clin Oncol 22 (2004) 14S [abstract 3513]
    • (2004) Proc Am Soc Clin Oncol , vol.22
    • Rougier, P.1    Raoul, J.-L.2    Van Laethem, J.-L.3
  • 27
    • 36749000929 scopus 로고    scopus 로고
    • Hohler T. Phase I/II study of cetuximab combined with 5-fluorouracil/leucovorin plus weekly oxaliplatin in first-line treatment of epidermal growth factor receptor-expressing metastatic colorectal cancer. Presented at the 30th European Society of Medical Oncology Congress, Vienna, Austria; October 29 to November 2004.
  • 29
    • 33750017775 scopus 로고    scopus 로고
    • Optimal dose of cetuximab (C) given every 2 weeks (q2w): a phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (q1w) and q2w schedules in patients (pts) with metastatic colorectal cancer (mCRC)
    • [abstract 3085]
    • Tabernero J., Cervantes A., Martinelli E., et al. Optimal dose of cetuximab (C) given every 2 weeks (q2w): a phase I pharmacokinetic (PK) and pharmacodynamic (PD) study of weekly (q1w) and q2w schedules in patients (pts) with metastatic colorectal cancer (mCRC). Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3085]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Tabernero, J.1    Cervantes, A.2    Martinelli, E.3
  • 30
    • 0036842170 scopus 로고    scopus 로고
    • Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types
    • Baselga J., Rischin D., Ranson M., et al. Phase I safety, pharmacokinetic, and pharmacodynamic trial of ZD1839, a selective oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with five selected solid tumor types. J Clin Oncol 20 (2002) 4292-4302
    • (2002) J Clin Oncol , vol.20 , pp. 4292-4302
    • Baselga, J.1    Rischin, D.2    Ranson, M.3
  • 31
    • 24644513947 scopus 로고    scopus 로고
    • Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?
    • Perez-Soler R., and Saltz L. Cutaneous adverse effects with HER1/EGFR-targeted agents: is there a silver lining?. J Clin Oncol 23 (2005) 5235-5246
    • (2005) J Clin Oncol , vol.23 , pp. 5235-5246
    • Perez-Soler, R.1    Saltz, L.2
  • 32
    • 6344272498 scopus 로고    scopus 로고
    • ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): an updated analysis
    • [abstract 3511]
    • Hecht J., Patnaik A., Malik I., et al. ABX-EGF monotherapy in patients (pts) with metastatic colorectal cancer (mCRC): an updated analysis. Proc Am Soc Clin Oncol 22 (2004) 14S [abstract 3511]
    • (2004) Proc Am Soc Clin Oncol , vol.22
    • Hecht, J.1    Patnaik, A.2    Malik, I.3
  • 33
    • 36749047800 scopus 로고    scopus 로고
    • Van Cutsem E, Peeters M, Siena S, et al. Panitumumab significantly improves progression-free survival in patients with metastatic colorectal cancer. World Congress on Gastrointestinal Cancer, 2006 [abstract O-027].
  • 34
    • 1542344622 scopus 로고    scopus 로고
    • Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor
    • Vanhoefer U., Tewes M., Rojo F., et al. Phase I study of the humanized antiepidermal growth factor receptor monoclonal antibody EMD72000 in patients with advanced solid tumors that express the epidermal growth factor receptor. J Clin Oncol 22 (2004) 175-184
    • (2004) J Clin Oncol , vol.22 , pp. 175-184
    • Vanhoefer, U.1    Tewes, M.2    Rojo, F.3
  • 35
    • 0036782278 scopus 로고    scopus 로고
    • VEGF and the quest for tumour angiogenesis factors
    • Ferrara N. VEGF and the quest for tumour angiogenesis factors. Nat Rev Cancer 2 10 (2002) 795-803
    • (2002) Nat Rev Cancer , vol.2 , Issue.10 , pp. 795-803
    • Ferrara, N.1
  • 36
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain R.K. Molecular regulation of vessel maturation. Nat Med 9 6 (2003) 685-693
    • (2003) Nat Med , vol.9 , Issue.6 , pp. 685-693
    • Jain, R.K.1
  • 37
    • 14644440555 scopus 로고    scopus 로고
    • Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis
    • Hicklin D.J., and Ellis L.M. Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23 5 (2005) 1011-1027
    • (2005) J Clin Oncol , vol.23 , Issue.5 , pp. 1011-1027
    • Hicklin, D.J.1    Ellis, L.M.2
  • 38
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak H.F. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 20 21 (2002) 4368-4380
    • (2002) J Clin Oncol , vol.20 , Issue.21 , pp. 4368-4380
    • Dvorak, H.F.1
  • 39
    • 18144427143 scopus 로고    scopus 로고
    • Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors
    • Gray M.J., Wey J.S., Belcheva A., et al. Neuropilin-1 suppresses tumorigenic properties in a human pancreatic adenocarcinoma cell line lacking neuropilin-1 coreceptors. Cancer Res 65 9 (2005) 3664-3670
    • (2005) Cancer Res , vol.65 , Issue.9 , pp. 3664-3670
    • Gray, M.J.1    Wey, J.S.2    Belcheva, A.3
  • 40
    • 0027197245 scopus 로고
    • Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo
    • Kim K.J., Li B., Winer J., et al. Inhibition of vascular endothelial growth factor-induced angiogenesis suppresses tumour growth in vivo. Nature 362 6423 (1993) 841-844
    • (1993) Nature , vol.362 , Issue.6423 , pp. 841-844
    • Kim, K.J.1    Li, B.2    Winer, J.3
  • 41
    • 0029004025 scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis
    • Dvorak H.F., Brown L.F., Detmar M., and Dvorak A.M. Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis. Am J Pathol 146 5 (1995) 1029-1039
    • (1995) Am J Pathol , vol.146 , Issue.5 , pp. 1029-1039
    • Dvorak, H.F.1    Brown, L.F.2    Detmar, M.3    Dvorak, A.M.4
  • 43
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G., Baruchel S., Rak J., et al. Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 105 8 (2000) R15-R24
    • (2000) J Clin Invest , vol.105 , Issue.8
    • Klement, G.1    Baruchel, S.2    Rak, J.3
  • 44
    • 0037208589 scopus 로고    scopus 로고
    • Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer
    • Kabbinavar F., Hurwitz H.I., Fehrenbacher L., et al. Phase II, randomized trial comparing bevacizumab plus fluorouracil (FU)/leucovorin (LV) with FU/LV alone in patients with metastatic colorectal cancer. J Clin Oncol 21 1 (2003) 60-65
    • (2003) J Clin Oncol , vol.21 , Issue.1 , pp. 60-65
    • Kabbinavar, F.1    Hurwitz, H.I.2    Fehrenbacher, L.3
  • 45
    • 20544478429 scopus 로고    scopus 로고
    • Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial
    • Kabbinavar F.F., Schulz J., McCleod M., et al. Addition of bevacizumab to bolus fluorouracil and leucovorin in first-line metastatic colorectal cancer: results of a randomized phase II trial. J Clin Oncol 23 16 (2005) 3697-3705
    • (2005) J Clin Oncol , vol.23 , Issue.16 , pp. 3697-3705
    • Kabbinavar, F.F.1    Schulz, J.2    McCleod, M.3
  • 46
    • 2542561964 scopus 로고    scopus 로고
    • Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer
    • Hurwitz H., Fehrenbacher L., Novotny W., et al. Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer. N Engl J Med 350 23 (2004) 2335-2342
    • (2004) N Engl J Med , vol.350 , Issue.23 , pp. 2335-2342
    • Hurwitz, H.1    Fehrenbacher, L.2    Novotny, W.3
  • 47
    • 33748752619 scopus 로고    scopus 로고
    • A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the eastern cooperative oncology group study E2200
    • Giantonio B.J., Levy D.E., O'Dwyer P.J., Meropol N.J., Catalano P.J., and Benson III A.V. A phase II study of high-dose bevacizumab in combination with irinotecan, 5-fluorouracil, leucovorin, as initial therapy for advanced colorectal cancer: results from the eastern cooperative oncology group study E2200. Ann Oncol 17 9 (2006) 1399-1403
    • (2006) Ann Oncol , vol.17 , Issue.9 , pp. 1399-1403
    • Giantonio, B.J.1    Levy, D.E.2    O'Dwyer, P.J.3    Meropol, N.J.4    Catalano, P.J.5    Benson III, A.V.6
  • 48
    • 33750288107 scopus 로고    scopus 로고
    • Preliminary results from a phase II study of infusional 5-FU, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab as first-line treatment for metastatic colorectal cancer (mCRC)
    • [abstract 3579]
    • Kopetz S., Eng C., Adinin R.B., et al. Preliminary results from a phase II study of infusional 5-FU, leucovorin, and irinotecan (FOLFIRI) plus bevacizumab as first-line treatment for metastatic colorectal cancer (mCRC). Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3579]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Kopetz, S.1    Eng, C.2    Adinin, R.B.3
  • 49
    • 33750737920 scopus 로고    scopus 로고
    • Efficacy and safety of bevacizumab in combination with irinotecan and infusional 5-FU as first-line treatment for patients with metastatic colorectal cancer
    • [abstract 3544]
    • Sobrero A., Carrion R.P., Chiara S., et al. Efficacy and safety of bevacizumab in combination with irinotecan and infusional 5-FU as first-line treatment for patients with metastatic colorectal cancer. Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3544]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Sobrero, A.1    Carrion, R.P.2    Chiara, S.3
  • 50
    • 33750909668 scopus 로고    scopus 로고
    • A randomized trial of first-line irinotecan/fluoropymidine combinations with or without celecoxib in metastatic colorectal cancer (BICC-C)
    • [abstract 3506]
    • Fuchs C., Marshall J., Mitchell E., et al. A randomized trial of first-line irinotecan/fluoropymidine combinations with or without celecoxib in metastatic colorectal cancer (BICC-C). Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3506]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Fuchs, C.1    Marshall, J.2    Mitchell, E.3
  • 51
    • 21244481589 scopus 로고    scopus 로고
    • High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: results from the Eastern Cooperative Oncology Group (ECOG) study E3200
    • [abstract 2]
    • Giantonio B., Catalano P.J., Meropol N.J., et al. High-dose bevacizumab improves survival when combined with FOLFOX4 in previously treated advanced colorectal cancer: results from the Eastern Cooperative Oncology Group (ECOG) study E3200. Proc Am Soc Clin Oncol 23 (2005) 1S [abstract 2]
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Giantonio, B.1    Catalano, P.J.2    Meropol, N.J.3
  • 52
    • 34248147447 scopus 로고    scopus 로고
    • First efficacy and safety results from XELOX-1/NO16966, a randomised 2 × 2 factorial phase III trial of XELOX vs. FOLFOX4 1 bevacizumab or placebo in first-line metastatic colorectal cancer (MCRC)
    • [abstract LBA3]
    • Cassidy J., Diaz Rubio E., Scheithauer W., et al. First efficacy and safety results from XELOX-1/NO16966, a randomised 2 × 2 factorial phase III trial of XELOX vs. FOLFOX4 1 bevacizumab or placebo in first-line metastatic colorectal cancer (MCRC). Ann Oncol 17 Suppl. 9 (2006) [abstract LBA3]
    • (2006) Ann Oncol , vol.17 , Issue.SUPPL. 9
    • Cassidy, J.1    Diaz Rubio, E.2    Scheithauer, W.3
  • 53
    • 36749022016 scopus 로고    scopus 로고
    • Saltz LB, Clarke S, Diaz-Rubio E, et al. Bevacizumab (Bev) in combination with XELOX or FOLFOX4: efficacy results from XELOX-1/NO16966, a randomized phase III trial in the first-line treatment of metastatic colorectal cancer (MCRC). ASCO Gastrointestinal Cancer Symposium, 2007 [abstract 238].
  • 54
    • 33749016960 scopus 로고    scopus 로고
    • Safety and efficacy of oxaliplatin/fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer (mCRC): final analysis of the TREE-Study
    • [abstract 3510]
    • Hochster H.S., Hart L.L., Ramanathan R.K., Hainsworth J.D., Hedrick E.E., and Childs B.H. Safety and efficacy of oxaliplatin/fluoropyrimidine regimens with or without bevacizumab as first-line treatment of metastatic colorectal cancer (mCRC): final analysis of the TREE-Study. Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3510]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Hochster, H.S.1    Hart, L.L.2    Ramanathan, R.K.3    Hainsworth, J.D.4    Hedrick, E.E.5    Childs, B.H.6
  • 55
    • 33748999448 scopus 로고    scopus 로고
    • Safety of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: updated results from a large observational registry in the US (BRiTE)
    • [abstract 3536]
    • Hedrick E., Kozloff M., Hainsworth J., et al. Safety of bevacizumab plus chemotherapy as first-line treatment of patients with metastatic colorectal cancer: updated results from a large observational registry in the US (BRiTE). Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3536]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Hedrick, E.1    Kozloff, M.2    Hainsworth, J.3
  • 56
    • 33749585632 scopus 로고    scopus 로고
    • Preliminary safety of bevacizumab with first-line Folfox, Capox, Folfiri and capecitabine for mCRC - first B.E.A. Trial
    • [abstract 3534]
    • Berry S.R., Cunningham D., Michael M., et al. Preliminary safety of bevacizumab with first-line Folfox, Capox, Folfiri and capecitabine for mCRC - first B.E.A. Trial. Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3534]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Berry, S.R.1    Cunningham, D.2    Michael, M.3
  • 57
    • 33746833739 scopus 로고    scopus 로고
    • Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: an NCI Treatment Referral Center Trial TRC-0301
    • Chen H.X., Mooney M., Boron M., et al. Phase II multicenter trial of bevacizumab plus fluorouracil and leucovorin in patients with advanced refractory colorectal cancer: an NCI Treatment Referral Center Trial TRC-0301. J Clin Oncol 24 21 (2006) 3354-3360
    • (2006) J Clin Oncol , vol.24 , Issue.21 , pp. 3354-3360
    • Chen, H.X.1    Mooney, M.2    Boron, M.3
  • 58
    • 0033818695 scopus 로고    scopus 로고
    • Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells
    • Ciardello F., Bianco R., Damiano V., et al. Antiangiogenic and antitumor activity of anti-epidermal growth factor receptor C225 monoclonal antibody in combination with vascular endothelial growth factor antisense oligonucleotide in human GEO colon cancer cells. Clin Cancer Res 6 (2000) 3739-3747
    • (2000) Clin Cancer Res , vol.6 , pp. 3739-3747
    • Ciardello, F.1    Bianco, R.2    Damiano, V.3
  • 59
    • 21244475037 scopus 로고    scopus 로고
    • Randomised phase II study of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer
    • [abstract 3508]
    • Saltz L.B., Lenz H., Hochster S., et al. Randomised phase II study of cetuximab/bevacizumab/irinotecan (CBI) versus cetuximab/bevacizumab (CB) in irinotecan-refractory colorectal cancer. Proc Am Soc Clin Oncol 23 (2005) 16S [abstract 3508]
    • (2005) Proc Am Soc Clin Oncol , vol.23
    • Saltz, L.B.1    Lenz, H.2    Hochster, S.3
  • 60
    • 33749237209 scopus 로고    scopus 로고
    • A phase I pharmacokinetic and molecular pharmacodynamic of the combination of two anti-EGFR therapies, the monoclonal antibody cetuximab, and the tyrosine kinase inhibitor gefitinib, in patients with advanced colorectal, head and neck, and non-small cell lung cancer
    • [abstract 3006]
    • Baselga J., Schöffski P., Rojo F., et al. A phase I pharmacokinetic and molecular pharmacodynamic of the combination of two anti-EGFR therapies, the monoclonal antibody cetuximab, and the tyrosine kinase inhibitor gefitinib, in patients with advanced colorectal, head and neck, and non-small cell lung cancer. Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3006]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Baselga, J.1    Schöffski, P.2    Rojo, F.3
  • 61
    • 36749000343 scopus 로고    scopus 로고
    • Julie C, Lutz MP, Aust D, et al. Pathological analysis of hepatic injury after oxaliplatin-based neoadjuvant chemotherapy of colorectal cancer liver metastases: results of the EORTC intergroup phase III study 40983. ASCO Gastrointestinal Cancer Symposium, 2007 [abstract 241].
  • 62
    • 33845251252 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy including bevacizumab in potentially curable metastatic colorectal cancer
    • [abstract 3546]
    • Gruenberger B., Scheithauer W., Tamandl D., et al. Neoadjuvant chemotherapy including bevacizumab in potentially curable metastatic colorectal cancer. Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3546]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Gruenberger, B.1    Scheithauer, W.2    Tamandl, D.3
  • 63
    • 36749089339 scopus 로고    scopus 로고
    • A phase II study of oxaliplatin (OX), capecitabine (CAP), and bevacizumab (BV) in the treatment of metastatic colorectal cancer
    • [abstract 3541]
    • Bendell J.C., Fernando N., Morse M., et al. A phase II study of oxaliplatin (OX), capecitabine (CAP), and bevacizumab (BV) in the treatment of metastatic colorectal cancer. Proc Am Soc Clin Oncol 24 (2006) 18S [abstract 3541]
    • (2006) Proc Am Soc Clin Oncol , vol.24
    • Bendell, J.C.1    Fernando, N.2    Morse, M.3
  • 64
    • 12944332507 scopus 로고    scopus 로고
    • Bevacizumab (Avastin), a monoclonal antibody to vascular endothelial growth factor, prolongs progression-free survival in first-line colorectal cancer in subjects who are not suitable candidates for first-line CPT-11
    • [abstract 3516]
    • Kabbinavar F., Schultz J., McCleod M., et al. Bevacizumab (Avastin), a monoclonal antibody to vascular endothelial growth factor, prolongs progression-free survival in first-line colorectal cancer in subjects who are not suitable candidates for first-line CPT-11. Proc Am Soc Clin Oncol 22 (2004) 14S [abstract 3516]
    • (2004) Proc Am Soc Clin Oncol , vol.22
    • Kabbinavar, F.1    Schultz, J.2    McCleod, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.