Simulating properties of in vitro epithelial cell morphogenesis

PLoS Computational Biology

Volumn 2, Issue 10, 2006, Pages 1193-1209

  Grant, Mark R ^a   Mostov, Keith E ^b   Tlsty, Thea D ^b   Hunt, C Anthony ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOLOGY; ITERATIVE METHODS; SOFTWARE AGENTS;

CELL-BE; CELL/B.E; CELL/BE; EPITHELIAL CELLS; GROWTH CONDITIONS; GROWTH FEATURE; IN-SILICO; IN-VITRO; MULTICELLULAR STRUCTURE; PROPERTY;

CELLS;

ARTICLE; CELL FUNCTION; COMPUTER MODEL; COMPUTER PROGRAM; EPITHELIUM CELL; IN VITRO STUDY; MORPHOGENESIS; PHENOTYPE; SIMULATION; BIOLOGICAL MODEL; BIOLOGY; CELL SHAPE; COMPUTER SIMULATION; CYTOLOGY;

CELL SHAPE; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; EPITHELIAL CELLS; MODELS, BIOLOGICAL; PHENOTYPE;

EID: 33750439801     PISSN: 1553734X     EISSN: 15537358     Source Type: Journal    
DOI: 10.1371/journal.pcbi.0020129     Document Type: Article

References (24)

1. O'Brien LE, Zegers MM, Mostov KE (2002) Opinion: Building epithelial architecture: Insights from three-dimensional culture models. Nat Rev Mol Cell Biol 3: 531-537.
2. Galle J, Loeffler M, Drasdo D (2005) Modeling the effect of deregulated proliferation and apoptosis on the growth dynamics of epithelial cell populations in vitro. Biophys J 88: 62-75.
3. Walker DC, Hill G, Wood SM, Smallwood RH, Southgate J (2004) Agent-based computational modeling of wounded epithelial cell monolayers. IEEE Trans Nanobioscience 3: 153-163.
4. Brenner S (1998) Biological computation. In: Bock GR, editor. The limits of reductionism in biology. Chichester (United Kingdom): Wiley. pp. 106-116.
5. Noble D (2003) The future: Putting Humpty-Dumpty together again. Biochem Soc Trans 31: 156-158.
6. Hall HG, Farson DA, Bissell MJ (1982) Lumen formation by epithelial cell lines in response to collagen overlay: A morphogenetic model in culture. Proc Natl Acad Sci U S A 79: 4672-4676.
7. Wang AZ, Ojakian GK, Nelson WJ (1990) Steps in the morphogenesis of a polarized epithelium. I. Uncoupling the roles of cell-cell and cell-substratum contact in establishing plasma membrane polarity in multicellular epithelial (MDCK) cysts. J Cell Sci 95 (Part 1): 137-151.
8. Ojakian GK, Ratcliffe DR, Schwimmer R (2001) Integrin regulation of cell-cell adhesion during epithelial tubule formation. J Cell Sci 114: 941-952.
9. Palsson B (2000) The challenges of in silico biology. Nat Biotechnol 18: 1147-1150.
10. Warren SL, Nelson WJ (1987) Nonmitogenic morphoregulatory action of pp60v-src on multicellular epithelial structures. Mol Cell Biol 7: 1326-1337.
11. Mills KR, Reginato M, Debnath J, Queenan B, Brugge JS (2004) Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is required for induction of autophagy during lumen formation in vitro. Proc Natl Acad Sci U S A 101: 3438-3443.
12. Lin HH, Yang TP, Jiang ST, Yang HY, Tang MJ (1999) Bcl-2 overexpression prevents apoptosis-induced Madin-Darby canine kidney simple epithelial cyst formation. Kidney Int 55: 168-178.
13. Nelson WJ (2003) Epithelial cell polarity from the outside looking in. News Physiol Sci 18: 143-146.
14. Madin SH, Darby NB Jr (1958) Established kidney cell lines of normal adult bovine and ovine origin. Proc Soc Exp Biol Med 98: 574-576.
15. Nelson CM, Jean RP, Tan JL, Liu WF, Sniadecki NJ, et al. (2005) Emergent patterns of growth controlled by multicellular form and mechanics. Proc Natl Acad Sci U S A 102: 11594-11599.
16. Schwimmer R, Ojakian GK (1995) The alpha 2 beta 1 integrin regulates collagen-mediated MDCK epithelial membrane remodeling and tubule formation. J Cell Sci 108 (Part 6): 2487-2498.
17. Thiery JP (2002) Epithelial-mesenchymal transitions in tumour progression. Nat Rev Cancer 2: 442-454.
18. Wodarz A (2000) Tumor suppressors: Linking cell polarity and growth control. Curr Biol 10: R624-R626.
19. Debnath J, Brugge JS (2005) Modelling glandular epithelial cancers in three-dimensional cultures. Nat Rev Cancer 5: 675-688.
20. Tlsty TD, Crawford YG, Holst CR, Fordyce CA, Zhang J, et al. (2004) Genetic and epigenetic changes in mammary epithelial cells may mimic early events in carcinogenesis. J Mammary Gland Biol Neoplasia 9: 263-274.
21. Li H, Findlay IA, Sheppard DN (2004) The relationship between cell proliferation, Cl-secretion, and renal cyst growth: A study using CFTR inhibitors. Kidney Int 66: 1926-1938.
22. Jiang ST, Chiang HC, Cheng MH, Yang TP, Chuang WJ, et al. (1999) Role of fibronectin deposition in cystogenesis of Madin-Darby canine kidney cells. Kidney Int 56: 92-103.
23. Wang AZ, Ojakian GK, Nelson WJ (1990) Steps in the morphogenesis of a polarized epithelium. II. Disassembly and assembly of plasma membrane domains during reversal of epithelial cell polarity in multicellular epithelial (MDCK) cysts. J Cell Sci 95 (Part 1): 153-165.
24. McAteer JA, Evan AP, Gardner KD (1987) Morphogenetic clonal growth of kidney epithelial cell line MDCK. Anat Rec 217: 229-239.