Novel vascular endothelial growth factor D variants with increased biological activity

Journal of Biological Chemistry

Volumn 284, Issue 23, 2009, Pages 16037-16048

  Toivanen, Pyry I ^a,b   Nieminen, Tiina ^a,b   Viitanen, Lenita ^c   Alitalo, Annamari ^a   Roschier, Miia ^a   Jauhiainen, Suvi ^a   Markkanen, Johanna E ^a   Laitinen, Olli H ^a   Airenne, Tomi T ^c   Salminen, Tiina A ^c   Johnson, Mark S ^c   Airenne, Kari J ^a   Ylä Herttuala, Seppo ^b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b Finland Ark Therapeutics Oy   (Finland)

^c ÅBO AKADEMI UNIVERSITY   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; BIOLOGICAL ACTIVITIES; BLOOD FLOW; COVALENTLY BOUND; CYSTEINE RESIDUES; DIMER INTERFACE; DISULFIDE BRIDGE; FUNCTIONAL PROPERTIES; HYDROPHOBIC AMINO ACIDS; LYMPHANGIOGENESIS; MONOMER RATIO; PLATELET-DERIVED GROWTH FACTORS; SKELETAL MUSCLE; STRUCTURAL DETERMINANTS; SUBUNIT INTERFACES; THERAPEUTIC APPLICATION; VASCULAR ENDOTHELIAL GROWTH FACTOR; VESSEL FORMATION;

AMINATION; AMINES; AMINO ACIDS; BLOOD; BLOOD VESSELS; OLIGOMERS; ORGANIC ACIDS; PEPTIDES; PLATELETS; SELF ASSEMBLY;

BIOACTIVITY;

CYSTEINE; DIMER; ISOLEUCINE; LEUCINE; MONOMER; MUTANT PROTEIN; PROTEIN KINASE B; PROTEIN SUBUNIT; RECOMBINANT VASCULOTROPIN; RECOMBINANT VASCULOTROPIN D DELTANDELTAC; UNCLASSIFIED DRUG; VALINE; VASCULOTROPIN D; VASCULOTROPIN RECEPTOR 2; VASCULOTROPIN RECEPTOR 3; VASCULOTROPIN RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BETA SHEET; BINDING AFFINITY; BINDING ASSAY; BIOLOGICAL ACTIVITY; BLOOD VESSEL PERMEABILITY; CELL SURVIVAL; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; DRUG SCREENING; GENE ACTIVITY; GENE FUNCTION; GENE MUTATION; GENETIC VARIABILITY; MOLECULAR MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FOLDING; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RECEPTOR BINDING; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; ANGIOGENESIS; ANIMAL; BINDING SITE; BLOOD FLOW VELOCITY; CHEMICAL STRUCTURE; CHEMISTRY; CORONARY ARTERY BLOOD FLOW; GENETICS; HEART; HEART MUSCLE; HOMEOSTASIS; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN CONFORMATION; SKELETAL MUSCLE; SWINE; VASCULARIZATION;

ANIMALS; BINDING SITES; BLOOD FLOW VELOCITY; CORONARY CIRCULATION; GENETIC VARIATION; HEART; HOMEOSTASIS; HUMANS; MODELS, MOLECULAR; MUSCLE, SKELETAL; MYOCARDIUM; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN CONFORMATION; RECEPTORS, VASCULAR ENDOTHELIAL GROWTH FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; SWINE; VASCULAR ENDOTHELIAL GROWTH FACTOR D; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 67650156457     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.001123     Document Type: Article

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