Synthesis and characterization of iodinated tetrahydroquinolines targeting the G protein-coupled estrogen receptor GPR30

Journal of Medicinal Chemistry

Volumn 53, Issue 3, 2010, Pages 1004-1014

  Ramesh, Chinnasamy ^a   Nayak, Tapan K ^b,d   Burai, Ritwik ^a   Dennis, Megan K ^b   Hathaway, Helen J ^b,c   Sklar, Larry A ^b,c   Prossnitz, Eric R ^b,c   Arterburn, Jeffrey B ^a,c  

^a NEW MEXICO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF NEW MEXICO   (United States)

^d UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 (6 BROMOBENZO[D][1,3]DIOXOL 5 YL) 6 IODO 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLIN 8 YL)ETHANONE; 1 [4 (6 IODOBENZO[1,3]DIOXOL 5 YL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLIN 8 YL]ETHANONE; 1 {2 [4 (6 BROMOBENZO[1,3]DIOXOL 5 YL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLIN 8 YL]ETHYL} 3 (3 IODOPHENYL)UREA; 4 (6 BROMOBENZO[1,3]DIOXOL 5 YL) 7 IODO 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE; 4 (6 BROMOBENZO[1,3]DIOXOL 5 YL) 8 IODO 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; G PROTEIN COUPLED ESTROGEN RECEPTOR; G PROTEIN COUPLED RECEPTOR; IODINE 125; N {1 [4 (6 BROMOBENZO[1,3]DIOXOL 5 YL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLIN 8 YL]ETHYLIDENE} N' (5 IODOPYRIDIN 2 YL) HYDRAZINE; N {2 [4 (6 BROMOBENZO[1,3]DIOXOL 5 YL) 3A,4,5,9B TETRAHYDRO 3H CYCLOPENTA[C]QUINOLIN 8 YL]ETHYL} 4 IODOBENZAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; QUINOLINE DERIVATIVE; TETRAHYDRO 3H CYCLOPENTA[C]QUINOLINE; TRACER; UNCLASSIFIED DRUG;

ADRENAL GLAND; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CALCIUM MOBILIZATION; CANCER CELL CULTURE; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DEIODINATION; DRUG CLEARANCE; DRUG DISTRIBUTION; ENDOMETRIUM CANCER; ENZYME ACTIVATION; ENZYME SPECIFICITY; FEMALE; GENITAL SYSTEM; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; LIGAND BINDING; LIPOPHILICITY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SYNTHESIS; TARGET ORGAN; TISSUE DISTRIBUTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BINDING, COMPETITIVE; CALCIUM; CERCOPITHECUS AETHIOPS; COS CELLS; ENDOMETRIAL NEOPLASMS; ENZYME ACTIVATION; ESTROGENS; FEMALE; HUMANS; IODINE RADIOISOTOPES; MICE; MICE, NUDE; QUINOLINES; RECEPTORS, ESTROGEN; RECEPTORS, G-PROTEIN-COUPLED;

EID: 77249119272     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9011802     Document Type: Article

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