메뉴 건너뛰기




Volumn 12, Issue 1, 2010, Pages 34-39

The current state of biomarkers in systemic sclerosis

Author keywords

Biomarkers; Fibrosis; Pulmonary hypertension; Scleroderma

Indexed keywords

ANGIOGENIC FACTOR; BIOLOGICAL MARKER; BRAIN NATRIURETIC PEPTIDE; CARBON MONOXIDE; CELL ADHESION MOLECULE;

EID: 77249118710     PISSN: 15233774     EISSN: 15346307     Source Type: Journal    
DOI: 10.1007/s11926-009-0081-6     Document Type: Review
Times cited : (17)

References (49)
  • 1
    • 34547822481 scopus 로고    scopus 로고
    • Scleroderma renal crisis: Patient characteristics and long-term outcomes
    • DOI 10.1093/qjmed/hcm052
    • H Penn AJ Howie EJ Kingdon, et al. 2007 Scleroderma renal crisis: patient characteristics and long-term outcomes QJM 100 485 494 10.1093/qjmed/hcm052 1:STN:280:DC%2BD2svjtVWgtQ%3D%3D 17601770 (Pubitemid 47241915)
    • (2007) QJM , vol.100 , Issue.8 , pp. 485-494
    • Penn, H.1    Howie, A.J.2    Kingdon, E.J.3    Bunn, C.C.4    Stratton, R.J.5    Black, C.M.6    Burns, A.7    Denton, C.P.8
  • 4
    • 0033978653 scopus 로고    scopus 로고
    • Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: Association with extent of skin sclerosis and severity of pulmonary fibrosis
    • 1:CAS:528:DC%2BD3cXos1Kgug%3D%3D 10648031
    • S Sato T Nagaoka M Hasegawa, et al. 2000 Serum levels of connective tissue growth factor are elevated in patients with systemic sclerosis: association with extent of skin sclerosis and severity of pulmonary fibrosis J Rheumatol 27 149 154 1:CAS:528:DC%2BD3cXos1Kgug%3D%3D 10648031
    • (2000) J Rheumatol , vol.27 , pp. 149-154
    • Sato, S.1    Nagaoka, T.2    Hasegawa, M.3
  • 5
    • 28544437285 scopus 로고    scopus 로고
    • Circulating levels of active transforming growth factor β1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score
    • DOI 10.1093/rheumatology/kei088
    • M Dziadzio RE Smith DJ Abraham, et al. 2005 Circulating levels of active transforming growth factor beta1 are reduced in diffuse cutaneous systemic sclerosis and correlate inversely with the modified Rodnan skin score Rheumatology (Oxford) 44 1518 1524 10.1093/rheumatology/kei088 1:CAS:528:DC%2BD2MXht1GltrzE (Pubitemid 41742468)
    • (2005) Rheumatology , vol.44 , Issue.12 , pp. 1518-1524
    • Dziadzio, M.1    Smith, R.E.2    Abraham, D.J.3    Black, C.M.4    Denton, C.P.5
  • 6
    • 84870007262 scopus 로고    scopus 로고
    • A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity
    • Oct 8 (Epub ahead of print). This study used data from in vitro studies of scleroderma fibroblasts to develop a mechanistically derived gene expression profile. This TGF-β responsive gene signature from skin biopsies correlated with the diffuse subset of scleroderma and with more significant skin and lung disease
    • •• Sargent JL, Milano A, Bhattacharyya S, et al.: A TGFbeta-responsive gene signature is associated with a subset of diffuse scleroderma with increased disease severity. J Invest Dermatol 2009 Oct 8 (Epub ahead of print). This study used data from in vitro studies of scleroderma fibroblasts to develop a mechanistically derived gene expression profile. This TGF-β responsive gene signature from skin biopsies correlated with the diffuse subset of scleroderma and with more significant skin and lung disease.
    • J Invest Dermatol 2009
    • Sargent, J.L.1    Milano, A.2    Bhattacharyya, S.3
  • 7
    • 59649118981 scopus 로고    scopus 로고
    • Molecular framework for response to imatinib mesylate in systemic sclerosis
    • 10.1002/art.24221 1:CAS:528:DC%2BD1MXjt1Cnsrk%3D 19180499
    • L Chung DF Fiorentino MJ Benbarak, et al. 2009 Molecular framework for response to imatinib mesylate in systemic sclerosis Arthritis Rheum 60 584 591 10.1002/art.24221 1:CAS:528:DC%2BD1MXjt1Cnsrk%3D 19180499
    • (2009) Arthritis Rheum , vol.60 , pp. 584-591
    • Chung, L.1    Fiorentino, D.F.2    Benbarak, M.J.3
  • 9
    • 0021853312 scopus 로고
    • Collagen synthesis in scleroderma: Selection of fibroblast populations during subcultures
    • DOI 10.1007/BF00509236
    • T Krieg JS Perlish R Fleischmajer O Braun-Falco 1985 Collagen synthesis in scleroderma: selection of fibroblast populations during subcultures Arch Dermatol Res 277 373 376 10.1007/BF00509236 1:STN:280:DyaL2M3nvVejuw%3D%3D 4026379 (Pubitemid 15059779)
    • (1985) Archives of Dermatological Research , vol.277 , Issue.5 , pp. 373-376
    • Krieg, T.1    Perlish, J.S.2    Fleischmajer, R.3    Braun-Falco, O.4
  • 10
    • 0024590005 scopus 로고
    • Serum type III procollagen peptide concentrations in systemic sclerosis and Raynaud's phenomenon: Relationship to disease activity and duration
    • 10.1093/rheumatology/28.2.98 1:STN:280:DyaL1M3gvVSqsA%3D%3D 2706431
    • CM Black A McWhirter NK Harrison, et al. 1989 Serum type III procollagen peptide concentrations in systemic sclerosis and Raynaud's phenomenon: relationship to disease activity and duration Br J Rheumatol 28 98 103 10.1093/rheumatology/28.2.98 1:STN:280:DyaL1M3gvVSqsA%3D%3D 2706431
    • (1989) Br J Rheumatol , vol.28 , pp. 98-103
    • Black, C.M.1    McWhirter, A.2    Harrison, N.K.3
  • 11
    • 0028867758 scopus 로고
    • Predictive value of serum III procollagen for diagnosis of pulmonary involvement in patients with scleroderma
    • 10.1183/09031936.95.08081263 1:STN:280:DyaK287itVSnsQ%3D%3D 8575585
    • E Diot P Diot C Valat, et al. 1995 Predictive value of serum III procollagen for diagnosis of pulmonary involvement in patients with scleroderma Eur Respir J 8 1559 1565 10.1183/09031936.95.08081263 1:STN:280: DyaK287itVSnsQ%3D%3D 8575585
    • (1995) Eur Respir J , vol.8 , pp. 1559-1565
    • Diot, E.1    Diot, P.2    Valat, C.3
  • 12
    • 0033785184 scopus 로고    scopus 로고
    • Circulating collagen metabolites in systemic sclerosis. Differences between limited and diffuse form and relationship with pulmonary involvement
    • 10.1093/rheumatology/39.10.1110 1:CAS:528:DC%2BD3cXnvVKrt7c%3D
    • A Scheja M Wildt FA Wollheim, et al. 2000 Circulating collagen metabolites in systemic sclerosis. Differences between limited and diffuse form and relationship with pulmonary involvement Rheumatology (Oxford) 39 1110 1113 10.1093/rheumatology/39.10.1110 1:CAS:528:DC%2BD3cXnvVKrt7c%3D
    • (2000) Rheumatology (Oxford) , vol.39 , pp. 1110-1113
    • Scheja, A.1    Wildt, M.2    Wollheim, F.A.3
  • 13
    • 0028918813 scopus 로고
    • The use of serologic markers for collagen synthesis and degradation in systemic sclerosis
    • 10.1016/0190-9622(95)90341-0 1:STN:280:DyaK2M3gsVKgtg%3D%3D 7896946
    • L Heickendorff H Zachariae P Bjerring, et al. 1995 The use of serologic markers for collagen synthesis and degradation in systemic sclerosis J Am Acad Dermatol 32 584 588 10.1016/0190-9622(95)90341-0 1:STN:280:DyaK2M3gsVKgtg%3D%3D 7896946
    • (1995) J Am Acad Dermatol , vol.32 , pp. 584-588
    • Heickendorff, L.1    Zachariae, H.2    Bjerring, P.3
  • 14
    • 2342459078 scopus 로고    scopus 로고
    • Serological assessment of type i collagen burden in scleroderma spectrum disorders: A systematic review
    • 1:STN:280:DC%2BD2c3ksFKrtw%3D%3D 15144134
    • M Dziadzio RE Smith DJ Abraham, et al. 2004 Serological assessment of type I collagen burden in scleroderma spectrum disorders: a systematic review Clin Exp Rheumatol 22 356 367 1:STN:280:DC%2BD2c3ksFKrtw%3D%3D 15144134
    • (2004) Clin Exp Rheumatol , vol.22 , pp. 356-367
    • Dziadzio, M.1    Smith, R.E.2    Abraham, D.J.3
  • 15
    • 0034691244 scopus 로고    scopus 로고
    • Cyclophosphamide is associated with pulmonary function and survival benefit in patients with scleroderma and alveolitis
    • 1:CAS:528:DC%2BD3cXkslylsb8%3D 10858177
    • B White WC Moore FM Wigley, et al. 2000 Cyclophosphamide is associated with pulmonary function and survival benefit in patients with scleroderma and alveolitis Ann Intern Med 132 947 954 1:CAS:528:DC%2BD3cXkslylsb8%3D 10858177
    • (2000) Ann Intern Med , vol.132 , pp. 947-954
    • White, B.1    Moore, W.C.2    Wigley, F.M.3
  • 16
    • 37849030474 scopus 로고    scopus 로고
    • Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease
    • 10.1164/rccm.200705-655OC 1:CAS:528:DC%2BD1cXht12mt7k%3D 17901414
    • C Strange MB Bolster MD Roth, et al. 2008 Bronchoalveolar lavage and response to cyclophosphamide in scleroderma interstitial lung disease Am J Respir Crit Care Med 177 91 98 10.1164/rccm.200705-655OC 1:CAS:528: DC%2BD1cXht12mt7k%3D 17901414
    • (2008) Am J Respir Crit Care Med , vol.177 , pp. 91-98
    • Strange, C.1    Bolster, M.B.2    Roth, M.D.3
  • 17
    • 2642535906 scopus 로고    scopus 로고
    • Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis
    • 1:CAS:528:DC%2BD2cXlsFWgt74%3D 15170923
    • K Yanaba M Hasegawa K Takehara S Sato 2004 Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis J Rheumatol 31 1112 1120 1:CAS:528:DC%2BD2cXlsFWgt74%3D 15170923
    • (2004) J Rheumatol , vol.31 , pp. 1112-1120
    • Yanaba, K.1    Hasegawa, M.2    Takehara, K.3    Sato, S.4
  • 18
    • 66149133635 scopus 로고    scopus 로고
    • Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma
    • 10.3899/jrheum.080633 1:CAS:528:DC%2BD1MXkvFemt7c%3D 19286849 In this study, serum collected from patients in the Scleroderma Lung Study was examined for these two glycoproteins that are secreted by pneumocytes. Researchers showed clear correlations of these markers with clinical measures of active lung disease in scleroderma including CT evidence of ground glass, BAL fluid cytology, and pulmonary function
    • FN Hant A Ludwicka-Bradley HJ Wang, et al. 2009 Surfactant protein D and KL-6 as serum biomarkers of interstitial lung disease in patients with scleroderma J Rheumatol 36 773 780 10.3899/jrheum.080633 1:CAS:528: DC%2BD1MXkvFemt7c%3D 19286849 In this study, serum collected from patients in the Scleroderma Lung Study was examined for these two glycoproteins that are secreted by pneumocytes. Researchers showed clear correlations of these markers with clinical measures of active lung disease in scleroderma including CT evidence of ground glass, BAL fluid cytology, and pulmonary function
    • (2009) J Rheumatol , vol.36 , pp. 773-780
    • Hant, F.N.1    Ludwicka-Bradley, A.2    Wang, H.J.3
  • 19
    • 0036010517 scopus 로고    scopus 로고
    • Gene expression in bronchoalveolar lavage cells from scleroderma patients
    • 1:CAS:528:DC%2BD38XjsFWkt7s%3D 11970906
    • IG Luzina SP Atamas R Wise, et al. 2002 Gene expression in bronchoalveolar lavage cells from scleroderma patients Am J Respir Cell Mol Biol 26 549 557 1:CAS:528:DC%2BD38XjsFWkt7s%3D 11970906
    • (2002) Am J Respir Cell Mol Biol , vol.26 , pp. 549-557
    • Luzina, I.G.1    Atamas, S.P.2    Wise, R.3
  • 20
    • 25444500667 scopus 로고    scopus 로고
    • Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: A sensitive indicator of active pulmonary fibrosis
    • DOI 10.1002/art.21257
    • M Kodera M Hasegawa K Komura, et al. 2005 Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis Arthritis Rheum 52 2889 2896 10.1002/art.21257 1:CAS:528:DC%2BD2MXhtFeltrnL 16142750 (Pubitemid 41369120)
    • (2005) Arthritis and Rheumatism , vol.52 , Issue.9 , pp. 2889-2896
    • Kodera, M.1    Hasegawa, M.2    Komura, K.3    Yanaba, K.4    Takehara, K.5    Sato, S.6
  • 22
    • 37749052490 scopus 로고    scopus 로고
    • Can CCL2 serum levels be used in risk stratification or to monitor treatment response in systemic sclerosis?
    • 10.1136/ard.2006.067967 1:CAS:528:DC%2BD1cXhs1ejtLc%3D 17604287 In this large cross-sectional study, the chemokine CCL2 was noted to be elevated in scleroderma and levels correlated with fibrotic disease features. This marker is notable for having clear variability with phenotype being higher in those with earlier, active disease
    • MT Carulli C Handler JG Coghlan, et al. 2008 Can CCL2 serum levels be used in risk stratification or to monitor treatment response in systemic sclerosis? Ann Rheum Dis 67 105 109 10.1136/ard.2006.067967 1:CAS:528: DC%2BD1cXhs1ejtLc%3D 17604287 In this large cross-sectional study, the chemokine CCL2 was noted to be elevated in scleroderma and levels correlated with fibrotic disease features. This marker is notable for having clear variability with phenotype being higher in those with earlier, active disease
    • (2008) Ann Rheum Dis , vol.67 , pp. 105-109
    • Carulli, M.T.1    Handler, C.2    Coghlan, J.G.3
  • 23
    • 23444434159 scopus 로고    scopus 로고
    • Autoantibodies in systemic sclerosis
    • DOI 10.1016/j.semarthrit.2005.03.005, PII S004901720500051X
    • VD Steen 2005 Autoantibodies in systemic sclerosis Semin Arthritis Rheum 35 35 42 10.1016/j.semarthrit.2005.03.005 1:CAS:528:DC%2BD2MXntVOisL0%3D 16084222 (Pubitemid 41111469)
    • (2005) Seminars in Arthritis and Rheumatism , vol.35 , Issue.1 , pp. 35-42
    • Steen, V.D.1
  • 24
    • 0037331671 scopus 로고    scopus 로고
    • Predictors of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement
    • DOI 10.1002/art.10775
    • V Steen TA Medsger Jr 2003 Predictors of isolated pulmonary hypertension in patients with systemic sclerosis and limited cutaneous involvement Arthritis Rheum 48 516 522 10.1002/art.10775 12571862 (Pubitemid 36278021)
    • (2003) Arthritis and Rheumatism , vol.48 , Issue.2 , pp. 516-522
    • Steen, V.1    Medsger Jr., T.A.2
  • 26
    • 0021740883 scopus 로고
    • Carbon monoxide diffusing capacity as predictor of outcome in systemic sclerosis
    • DOI 10.1016/0002-9343(84)90183-9
    • M Peters-Golden RA Wise MC Hochberg, et al. 1984 Carbon monoxide diffusing capacity as predictor of outcome in systemic sclerosis Am J Med 77 1027 1034 10.1016/0002-9343(84)90183-9 1:STN:280:DyaL2M%2FmvFGhsA%3D%3D 6507456 (Pubitemid 15221764)
    • (1984) American Journal of Medicine , vol.77 , Issue.6 , pp. 1027-1034
    • Peters-Golden, M.1    Wise, R.A.2    Hochberg, M.C.3
  • 27
    • 0037309384 scopus 로고    scopus 로고
    • Predictors of end stage lung disease in a cohort of patients with scleroderma
    • DOI 10.1136/ard.62.2.146
    • C Morgan C Knight M Lunt, et al. 2003 Predictors of end stage lung disease in a cohort of patients with scleroderma Ann Rheum Dis 62 146 150 10.1136/ard.62.2.146 1:STN:280:DC%2BD3s%2FhvVOhsQ%3D%3D 12525384 (Pubitemid 36135390)
    • (2003) Annals of the Rheumatic Diseases , vol.62 , Issue.2 , pp. 146-150
    • Morgan, C.1    Knight, C.2    Lunt, M.3    Black, C.M.4    Silman, A.J.5
  • 28
    • 66449099999 scopus 로고    scopus 로고
    • The three-year incidence of pulmonary arterial hypertension associated with systemic sclerosis in a multicenter nationwide longitudinal study in France
    • 10.1002/art.24525 19479881
    • E Hachulla P de Groote V Gressin, et al. 2009 The three-year incidence of pulmonary arterial hypertension associated with systemic sclerosis in a multicenter nationwide longitudinal study in France Arthritis Rheum 60 1831 1839 10.1002/art.24525 19479881
    • (2009) Arthritis Rheum , vol.60 , pp. 1831-1839
    • Hachulla, E.1    De Groote, P.2    Gressin, V.3
  • 29
    • 38149040974 scopus 로고    scopus 로고
    • High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis
    • 10.1002/art.23187 1:CAS:528:DC%2BD1cXhslOjtbg%3D 18163505 This is the first study to examine biomarkers to predict the development of pulmonary vascular disease in a prospective cohort study. Elevated levels of NT-proBNP predicted development of pulmonary vascular disease in this cohort
    • Y Allanore D Borderie J Avouac, et al. 2008 High N-terminal pro-brain natriuretic peptide levels and low diffusing capacity for carbon monoxide as independent predictors of the occurrence of precapillary pulmonary arterial hypertension in patients with systemic sclerosis Arthritis Rheum 58 284 291 10.1002/art.23187 1:CAS:528:DC%2BD1cXhslOjtbg%3D 18163505 This is the first study to examine biomarkers to predict the development of pulmonary vascular disease in a prospective cohort study. Elevated levels of NT-proBNP predicted development of pulmonary vascular disease in this cohort
    • (2008) Arthritis Rheum , vol.58 , pp. 284-291
    • Allanore, Y.1    Borderie, D.2    Avouac, J.3
  • 30
    • 74449089129 scopus 로고    scopus 로고
    • Natriuretic peptides in systemic sclerosis-related pulmonary arterial hypertension
    • Jun 16 (Epub ahead of print)
    • Dimitroulas T, Giannakoulas G, Karvounis H, et al.: Natriuretic peptides in systemic sclerosis-related pulmonary arterial hypertension. Semin Arthritis Rheum 2009 Jun 16 (Epub ahead of print).
    • Semin Arthritis Rheum 2009
    • Dimitroulas, T.1    Giannakoulas, G.2    Karvounis, H.3
  • 31
    • 33846347690 scopus 로고    scopus 로고
    • N-terminal brain natriuretic peptide in scleroderma-associated pulmonary arterial hypertension
    • author reply 141
    • Mathai SC, Hassoun PM: N-terminal brain natriuretic peptide in scleroderma-associated pulmonary arterial hypertension. Eur Heart J 2007, 28:140-141; author reply 141.
    • Eur Heart J 2007 , vol.28 , pp. 140-141
    • Mathai, S.C.1    Hassoun, P.M.2
  • 33
    • 0029999963 scopus 로고    scopus 로고
    • Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma
    • 10.1172/JCI118851 1:CAS:528:DyaK28XkvVeis7g%3D 8698871
    • R Sgonc MS Gruschwitz H Dietrich, et al. 1996 Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma J Clin Invest 98 785 792 10.1172/JCI118851 1:CAS:528: DyaK28XkvVeis7g%3D 8698871
    • (1996) J Clin Invest , vol.98 , pp. 785-792
    • Sgonc, R.1    Gruschwitz, M.S.2    Dietrich, H.3
  • 34
    • 0030071159 scopus 로고    scopus 로고
    • Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis
    • 10.1136/ard.55.2.122 1:STN:280:DyaK283mtlGktw%3D%3D 8712862
    • AL Herrick K Illingworth A Blann, et al. 1996 Von Willebrand factor, thrombomodulin, thromboxane, beta-thromboglobulin and markers of fibrinolysis in primary Raynaud's phenomenon and systemic sclerosis Ann Rheum Dis 55 122 127 10.1136/ard.55.2.122 1:STN:280:DyaK283mtlGktw%3D%3D 8712862
    • (1996) Ann Rheum Dis , vol.55 , pp. 122-127
    • Herrick, A.L.1    Illingworth, K.2    Blann, A.3
  • 35
    • 14944346766 scopus 로고    scopus 로고
    • Screening for pulmonary hypertension in systemic sclerosis: The longitudinal development of tricuspid gradient in 227 consecutive patients, 1992-2001
    • (Oxford) 2005
    • Hesselstrand R, Ekman R, Eskilsson J, et al.: Screening for pulmonary hypertension in systemic sclerosis: the longitudinal development of tricuspid gradient in 227 consecutive patients, 1992-2001. Rheumatology (Oxford) 2005, 44:366-371
    • Rheumatology , vol.44 , pp. 366-371
    • Hesselstrand, R.1    Ekman, R.2    Eskilsson, J.3
  • 37
    • 47949095665 scopus 로고    scopus 로고
    • Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosis-associated pulmonary arterial hypertension
    • 10.1136/ard.2007.080424 1:CAS:528:DC%2BD1cXhtVSktbjM 18029384
    • F Iannone MT Riccardi S Guiducci, et al. 2008 Bosentan regulates the expression of adhesion molecules on circulating T cells and serum soluble adhesion molecules in systemic sclerosis-associated pulmonary arterial hypertension Ann Rheum Dis 67 1121 1126 10.1136/ard.2007.080424 1:CAS:528:DC%2BD1cXhtVSktbjM 18029384
    • (2008) Ann Rheum Dis , vol.67 , pp. 1121-1126
    • Iannone, F.1    Riccardi, M.T.2    Guiducci, S.3
  • 38
    • 0030883691 scopus 로고    scopus 로고
    • Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease
    • 1:STN:280:DyaK2svjtVOhtw%3D%3D 9284832
    • DJ Abraham R Vancheeswaran MR Dashwood, et al. 1997 Increased levels of endothelin-1 and differential endothelin type A and B receptor expression in scleroderma-associated fibrotic lung disease Am J Pathol 151 831 841 1:STN:280:DyaK2svjtVOhtw%3D%3D 9284832
    • (1997) Am J Pathol , vol.151 , pp. 831-841
    • Abraham, D.J.1    Vancheeswaran, R.2    Dashwood, M.R.3
  • 39
    • 0029166732 scopus 로고
    • Plasma endothelin-1 levels in patients with systemic sclerosis: Influence of pulmonary or systemic arterial hypertension
    • 10.1136/ard.54.9.730 1:CAS:528:DyaK2MXoslShs74%3D 7495344
    • S Morelli C Ferri L Di Francesco, et al. 1995 Plasma endothelin-1 levels in patients with systemic sclerosis: influence of pulmonary or systemic arterial hypertension Ann Rheum Dis 54 730 734 10.1136/ard.54.9.730 1:CAS:528: DyaK2MXoslShs74%3D 7495344
    • (1995) Ann Rheum Dis , vol.54 , pp. 730-734
    • Morelli, S.1    Ferri, C.2    Di Francesco, L.3
  • 41
    • 0031876649 scopus 로고    scopus 로고
    • Different patterns of endothelial cell activation in renal and pulmonary vascular disease in scleroderma
    • 10.1093/qjmed/91.8.561 1:STN:280:DyaK1M7gvFOmtQ%3D%3D 9893759
    • RJ Stratton JG Coghlan JD Pearson, et al. 1998 Different patterns of endothelial cell activation in renal and pulmonary vascular disease in scleroderma QJM 91 561 566 10.1093/qjmed/91.8.561 1:STN:280:DyaK1M7gvFOmtQ%3D%3D 9893759
    • (1998) QJM , vol.91 , pp. 561-566
    • Stratton, R.J.1    Coghlan, J.G.2    Pearson, J.D.3
  • 42
    • 35348891629 scopus 로고    scopus 로고
    • Antiangiogenic plasma activity in patients with systemic sclerosis
    • DOI 10.1002/art.22861
    • MJ Mulligan-Kehoe MC Drinane J Mollmark, et al. 2007 Antiangiogenic plasma activity in patients with systemic sclerosis Arthritis Rheum 56 3448 3458 10.1002/art.22861 1:CAS:528:DC%2BD2sXht12rtLfN 17907150 In this article, the authors demonstrate that plasma from scleroderma patients is angiostatic in in vitro models of angiogenesis. Angiostatin appears to be at least partially responsible for this abnormality and levels of this molecule are noted to be elevated in scleroderma plasma (Pubitemid 47585441)
    • (2007) Arthritis and Rheumatism , vol.56 , Issue.10 , pp. 3448-3458
    • Mulligan-Kehoe, M.J.1    Drinane, M.C.2    Mollmark, J.3    Casciola-Rosen, L.4    Hummers, L.K.5    Hall, A.6    Rosen, A.7    Wigley, F.M.8    Simons, M.9
  • 43
    • 34247564964 scopus 로고    scopus 로고
    • Angiogenic and angiostatic factors in systemic sclerosis: Increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers
    • 10.1186/ar596 12453314
    • O Distler A Del Rosso R Giacomelli, et al. 2002 Angiogenic and angiostatic factors in systemic sclerosis: increased levels of vascular endothelial growth factor are a feature of the earliest disease stages and are associated with the absence of fingertip ulcers Arthritis Res 4 R11 10.1186/ar596 12453314
    • (2002) Arthritis Res , vol.4 , pp. 11
    • Distler, O.1    Del Rosso, A.2    Giacomelli, R.3
  • 44
    • 65649133084 scopus 로고    scopus 로고
    • Abnormalities in the regulators of angiogenesis in patients with scleroderma
    • 10.3899/jrheum.080516 19228661
    • LK Hummers A Hall FM Wigley M Simons 2009 Abnormalities in the regulators of angiogenesis in patients with scleroderma J Rheumatol 36 576 582 10.3899/jrheum.080516 19228661
    • (2009) J Rheumatol , vol.36 , pp. 576-582
    • Hummers, L.K.1    Hall, A.2    Wigley, F.M.3    Simons, M.4
  • 46
    • 0033850755 scopus 로고    scopus 로고
    • Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis
    • DOI 10.1002/1529-0131(200004)43:4<889::AID-ANR21>3.0.CO;2-5
    • M Hebbar JP Peyrat L Hornez, et al. 2000 Increased concentrations of the circulating angiogenesis inhibitor endostatin in patients with systemic sclerosis Arthritis Rheum 43 889 893 10.1002/1529-0131(200004)43:4<889::AID- ANR21>3.0.CO;2-5 1:CAS:528:DC%2BD3cXivFOit7w%3D 10765935 (Pubitemid 30677581)
    • (2000) Arthritis and Rheumatism , vol.43 , Issue.4 , pp. 889-893
    • Semsei, I.1    Zeher, M.2    Takacs, I.3    Urban, L.4    Szegedi, G.5    Bachmann, M.6
  • 47
    • 45749100869 scopus 로고    scopus 로고
    • Disturbed angiogenesis in systemic sclerosis: High levels of soluble endoglin
    • DOI 10.1093/rheumatology/ken100
    • J Wipff J Avouac D Borderie, et al. 2008 Disturbed angiogenesis in systemic sclerosis: high levels of soluble endoglin Rheumatology (Oxford) 47 972 975 10.1093/rheumatology/ken100 1:CAS:528:DC%2BD1cXnsF2ksrc%3D Soluble endoglin is notable for having predictive capability in other disease states. In this study, the authors show that soluble endoglin strikingly correlates with a particular phenotype in scleroderma that associates with vascular disease (centromere antibody, digital ulcers, low DLCO), making this a very exciting biomarker candidate (Pubitemid 351865917)
    • (2008) Rheumatology , vol.47 , Issue.7 , pp. 972-975
    • Wipff, J.1    Avouac, J.2    Borderie, D.3    Zerkak, D.4    Lemarechal, H.5    Kahan, A.6    Boileau, C.7    Allanore, Y.8
  • 49
    • 67649227647 scopus 로고    scopus 로고
    • Preeclampsia: The role of angiogenic factors in its pathogenesis
    • A Wang S Rana SA Karumanchi 2009 Preeclampsia: the role of angiogenic factors in its pathogenesis Physiology (Bethesda) 24 147 158
    • (2009) Physiology (Bethesda) , vol.24 , pp. 147-158
    • Wang, A.1    Rana, S.2    Karumanchi, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.