Design, synthesis, and preliminary pharmacological evaluation of new imidazolinones as l-DOPA prodrugs

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 5, 2010, Pages 1834-1843

  Giorgioni, Gianfabio ^a   Claudi, Francesco ^a   Ruggieri, Sabrina ^a   Ricciutelli, Massimo ^a   Palmieri, Giovanni F ^a   Stefano, Antonio Di ^b   Sozio, Piera ^b   Cerasa, Laura S ^b   Chiavaroli, Annalisa ^b   Ferrante, Claudio ^b   Orlando, Giustino ^b   Glennon, Richard A ^c  

^a UNIVERSITY OF CAMERINO   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Dopamine release; DPPH; l DOPA prodrug; Parkinson's disease

Indexed keywords

1,1 DIPHENYL 2 PICRYLHYDRAZYL; IMIDAZOLE DERIVATIVE; IMIDAZOLINE 4 ONE; LEVODOPA; METHYL 2 [4 (3,4 DIHYDROXYBENZYL) 2,2 DIETHYL 5 OXOIMIDAZOLIDIN 1 YL] ACETATE; METHYL 2 [4 (3,4 DIHYDROXYBENZYL) 2,2 DIMETHYL 5 OXOIMIDAZOLIDIN 1 YL] ACETATE; PRODRUG; SCAVENGER; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; CORPUS STRIATUM; DOPAMINERGIC ACTIVITY; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG RELEASE; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; ENZYME STABILITY; HUMAN; HYDROLYSIS; INTESTINE ABSORPTION; NEUROCHEMISTRY; NONHUMAN; SOLUBILITY; STOMACH;

ADMINISTRATION, ORAL; ANIMALS; DOPAMINE; DRUG DESIGN; FREE RADICAL SCAVENGERS; HUMANS; HYDROLYSIS; IMIDAZOLES; KINETICS; LEVODOPA; NEUROPROTECTIVE AGENTS; PARKINSON DISEASE; PRODRUGS; RATS;

EID: 77249113697     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.01.041     Document Type: Article

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