Assay of radical scavenging activity of antidotes against chemical warfare agents of DPPH test using sequential injection technique

Journal of Applied Biomedicine

Volumn 5, Issue 2, 2007, Pages 81-84

  Kolečkář, Vít ^a,b   Jun, Daniel ^b,c   Opletal, Luboš ^a   Jahodář, Luděk ^a   Kuča, Kamil ^b,c  

^a Charles University in Prague Faculty of Pharmacy   (Czech Republic)

^b UNIVERSITY OF DEFENCE   (Czech Republic)

^c UNIVERSITY OF DEFENCE   (Czech Republic)

Author keywords

Analysis; Antidote; Antioxidant; Radical; Warfare agent

Indexed keywords

1 (4 CARBAMOYLPYRIDINIO) 1' (2 HYDROXYIMINOMETHYLPYRIDINIO)DIMETHYL ETHER; 1,1 DIPHENYL 2 PICRYLHYDRAZYL; 7 METHOXYTACRINE; ANTIDOTE; ASCORBIC ACID; ATROPINE; BENACTYZINE; CHEMICAL WARFARE AGENT; CHOLINESTERASE REACTIVATOR; DIMERCAPROL; METHOXIME; OBIDOXIME; PRALIDOXIME; PYRIDOSTIGMINE; SCAVENGER; TRIHEXYPHENIDYL; TRIMEDOXIME; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARMY; ARTICLE; ASSAY; BIOLOGICAL ACTIVITY; CHEMICAL REACTION; CORRELATION ANALYSIS; CZECH REPUBLIC; DRUG DETERMINATION; DRUG SCREENING; INTOXICATION; LABORATORY AUTOMATION; SEQUENTIAL INJECTION ANALYSIS; SPECTROPHOTOMETRY;

EID: 34250679336     PISSN: 1214021X     EISSN: 12140287     Source Type: Journal    
DOI: 10.32725/jab.2007.011     Document Type: Article

References (14)

1. Aruoma OI: Nutrition and health aspects of free radicals and antioxidants. Food Chem. Toxicol. 32:671-683, 1994.
2. Aruoma OI: Methodological considerations for characterizing potential antioxidant actions of bioactive components in plant foods. Mutat. Res. 523-524:9-20, 2003.
3. Bajgar J: Organophosphates/nerve agents poisoning: mechanism of action, diagnosis, prophylaxis and treatment. Adv. Clin. Chem. 38:151-216, 2004.
4. Blokhina O, Virolainen E, Fagerstedt KV: Antioxidants, oxidative damage and oxygen deprivation stress: a review. Ann. Bot. (Lond.) 91:179-94, 2003.
5. Bondet V, Brand-Williams W, Berset C: Kinetics and Mechanisms of Antioxidant Activity using the DPPH Free radical method. Food Sci. Technol. 30:609-615, 1997.
6. Cantuti-Castelvetri I, Shukitt-Hale B, Joseph JA: Neurobehavioral aspects of antioxidants in aging. Int. J. Dev. Neurosci. 18:367-381, 2000.
7. Halliwell B: How to characterize a biological antioxidant. Free. Radic. Res. Commun. 9:1-32, 1990.
8. Hollman PCH, Katan MB: Dietary flavonoids: intake, health effects and bioavailability. Food Chem. Toxicol. 37:937-942, 1999.
9. Jun D, Kuca K, Hronek M, Opletal L: Effect of some acetylcholinesterase reactivators on human platelet aggregation in vitro. J. Appl. Toxicol. 26:258-61, 2006.
10. Paulova H, Bochorakova H, Taborska E: In vitro methods for estimation of the antioxidant activity of natural compounds. Chem. Listy. 98:174-179, 2004.
11. Polášek M, Skála P, Opletal L, Jahodář L: Rapid automated assay of anti-oxidation /radical-scavenging activity of natural substances by sequential injection technique (SIA) using spectrophotometric detection. Anal. Bioanal. Chem. 379:754-758, 2004.
12. Ruzicka J, Marshall GD: Sequential injection: A new concept for chemical sensors, process analysis and laboratory assays. Anal. Chim. Acta. 237:329-343, 1990.
13. Surh YJ, Chun KS, Cha HH, Keum YS, Park KK, Lee SS: Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activation. Mutat. Res. 480-481:243-268, 2001.
14. Vaya J, Aviram M: Nutritional antioxidants mechanisms of action, analyses of activities and medical applications. Curr. Med. Chem. 1:99-117, 2001.