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Volumn 41, Issue 2, 1998, Pages 212-220

Non-invasive tracing of liver intermediary metabolism in normal subjects and in moderately hyperglycaemic NIDDM subjects. Evidence against increased gluconeogenesis and hepatic fatty acid oxidation in NIDDM

Author keywords

Fatty acid oxidation; Gluconeogenesis; Krebs cycle; Mass spectrometry; Stable isotope

Indexed keywords

ACETIC ACID; CARBON 13; FATTY ACID; GLUCOSE; GLUTAMIC ACID; GLYCEROL; LACTIC ACID; PYRUVATE DEHYDROGENASE; PYRUVIC ACID;

EID: 0031952156     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050892     Document Type: Article
Times cited : (49)

References (44)
  • 1
    • 0024026298 scopus 로고
    • The triumvirate: β-cells, muscles, liver. A collusion responsible for NIDDM
    • De Fronzo RA (1988) The triumvirate: β-cells, muscles, liver. A collusion responsible for NIDDM. Diabetes 37: 667-687
    • (1988) Diabetes , vol.37 , pp. 667-687
    • De Fronzo, R.A.1
  • 2
    • 0024511329 scopus 로고
    • Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM
    • Consoli A, Nurjhan N, Capani F, Gerich JE (1989) Predominant role of gluconeogenesis in increased hepatic glucose production in NIDDM. Diabetes 38: 550-557
    • (1989) Diabetes , vol.38 , pp. 550-557
    • Consoli, A.1    Nurjhan, N.2    Capani, F.3    Gerich, J.E.4
  • 5
    • 0028558591 scopus 로고
    • Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM
    • Jeng CY, Sheu WHH, Fuh MMT, Chen YDI, Reaven GM (1994) Relationship between hepatic glucose production and fasting plasma glucose concentration in patients with NIDDM. Diabetes 43: 1440-1444
    • (1994) Diabetes , vol.43 , pp. 1440-1444
    • Jeng, C.Y.1    Sheu, W.H.H.2    Fuh, M.M.T.3    Chen, Y.D.I.4    Reaven, G.M.5
  • 6
    • 0030012782 scopus 로고    scopus 로고
    • Measurement of post-absorptive glucose kinetics in non-insulin-dependent diabetic patients: Methodological aspects
    • Rigalleau V, Beylot M, Laville M et al. (1996) Measurement of post-absorptive glucose kinetics in non-insulin-dependent diabetic patients: methodological aspects. Eur J Clin Invest 26: 231-236
    • (1996) Eur J Clin Invest , vol.26 , pp. 231-236
    • Rigalleau, V.1    Beylot, M.2    Laville, M.3
  • 9
    • 0028936422 scopus 로고    scopus 로고
    • Tracing hepatic gluconeogenesis relative to citric acid cycle activity in vitro and in vivo
    • Beylot M, Soloviev MV, David F, Landau BR, Brunengraber H (1996) Tracing hepatic gluconeogenesis relative to citric acid cycle activity in vitro and in vivo. J Biol Chem 270: 1509-1514
    • (1996) J Biol Chem , vol.270 , pp. 1509-1514
    • Beylot, M.1    Soloviev, M.V.2    David, F.3    Landau, B.R.4    Brunengraber, H.5
  • 11
    • 0020063476 scopus 로고
    • 12C in the pathway of gluconeogenesis in vivo
    • 12C in the pathway of gluconeogenesis in vivo. Federation Proc 41: 104-109
    • (1985) Federation Proc , vol.41 , pp. 104-109
    • Hetenyi Jr., G.1
  • 12
    • 0029025630 scopus 로고
    • Lactate and pyruvate isotopic enrichments in plasma and tissues of post-absorptive and starved rats
    • Large V, Soloviev MV, Brunengraber H, Beylot M (1995) Lactate and pyruvate isotopic enrichments in plasma and tissues of post-absorptive and starved rats. Am J Physiol 268: E880-E888
    • (1995) Am J Physiol , vol.268
    • Large, V.1    Soloviev, M.V.2    Brunengraber, H.3    Beylot, M.4
  • 13
    • 0025776369 scopus 로고
    • Non-invasive tracing of Krebs cycle metabolism in liver
    • Magnusson I, Schumann WC, Bartsch GE et al. (1991) Non-invasive tracing of Krebs cycle metabolism in liver. J Biol Chem 266: 6975-6984
    • (1991) J Biol Chem , vol.266 , pp. 6975-6984
    • Magnusson, I.1    Schumann, W.C.2    Bartsch, G.E.3
  • 14
    • 0029044616 scopus 로고
    • Estimates of Krebs cycle activity and contributions of gluconeogenesis to hepatic glucose production in fasting healthy subjects and IDDM patients
    • Landau BR, Chandramouli V, Schumann WC et al. (1995) Estimates of Krebs cycle activity and contributions of gluconeogenesis to hepatic glucose production in fasting healthy subjects and IDDM patients. Diabetologia 38: 831-838
    • (1995) Diabetologia , vol.38 , pp. 831-838
    • Landau, B.R.1    Chandramouli, V.2    Schumann, W.C.3
  • 15
    • 0015523324 scopus 로고
    • The conjugation of phenylacetatic acid in man, sub-human primates and some non-primate species
    • James MO, Smith RL, Williams RT, Reidenberg M (1957) The conjugation of phenylacetatic acid in man, sub-human primates and some non-primate species. Proc R Soc Lond 182: 25-35
    • (1957) Proc R Soc Lond , vol.182 , pp. 25-35
    • James, M.O.1    Smith, R.L.2    Williams, R.T.3    Reidenberg, M.4
  • 16
    • 0031031340 scopus 로고    scopus 로고
    • Use of the labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis
    • Large V, Brunengraber H, Odeon M, Beylot M (1997) Use of the labeling pattern of liver glutamate to calculate rates of citric acid cycle and gluconeogenesis. Am J Physiol 272: E51-E58
    • (1997) Am J Physiol , vol.272
    • Large, V.1    Brunengraber, H.2    Odeon, M.3    Beylot, M.4
  • 17
    • 15844413142 scopus 로고    scopus 로고
    • Noninvasive probing of citric acid cycle intermediates in primate liver with PAGN
    • Yang D, Previs SF, Fernandez CA et al. (1996) Noninvasive probing of citric acid cycle intermediates in primate liver with PAGN. Am J Physiol 270: E882-E889
    • (1996) Am J Physiol , vol.270
    • Yang, D.1    Previs, S.F.2    Fernandez, C.A.3
  • 18
    • 0027997162 scopus 로고
    • Measurement of plasma protein synthesis rate in infant pig: An investigation of alternate tracer approaches
    • Jahoor F, Burrin DG, Reeds PJ, Frazer M (1994) Measurement of plasma protein synthesis rate in infant pig: an investigation of alternate tracer approaches. Am J Physiol 267: R221-R227
    • (1994) Am J Physiol , vol.267
    • Jahoor, F.1    Burrin, D.G.2    Reeds, P.J.3    Frazer, M.4
  • 19
    • 0019214136 scopus 로고
    • Increased ketonaemia in hyperthyroidism: Evidence for a β-adrenergic mechanism
    • Beylot M, Riou JP, Bienvenu F, Mornex R (1983) Increased ketonaemia in hyperthyroidism: evidence for a β-adrenergic mechanism. Diabetologia 19: 505-510
    • (1983) Diabetologia , vol.19 , pp. 505-510
    • Beylot, M.1    Riou, J.P.2    Bienvenu, F.3    Mornex, R.4
  • 20
    • 0001754536 scopus 로고
    • Immunoassay of insulin with insulin antibody precipitate
    • Hales CM, Randle PJ (1963) Immunoassay of insulin with insulin antibody precipitate. Biochem J 56: 136-142
    • (1963) Biochem J , vol.56 , pp. 136-142
    • Hales, C.M.1    Randle, P.J.2
  • 23
    • 0025157915 scopus 로고
    • 13C labelled glucose at a very low level of enrichment in man
    • 13C labelled glucose at a very low level of enrichment in man. Diabetologia 33: 449-456
    • (1990) Diabetologia , vol.33 , pp. 449-456
    • Tissot, S.1    Normand, S.2    Guilluy, R.3
  • 24
    • 0027337193 scopus 로고
    • Determination of the labeling pattern of glucose by gas chromatography-mass spectrometry
    • Beylot M, Previs SF, David F, Brunengraber H (1993) Determination of the labeling pattern of glucose by gas chromatography-mass spectrometry. Anal Biochem 212: 526-531
    • (1993) Anal Biochem , vol.212 , pp. 526-531
    • Beylot, M.1    Previs, S.F.2    David, F.3    Brunengraber, H.4
  • 25
    • 0029360338 scopus 로고
    • 13C]glycerol and mass isotopomer distribution analysis of glucose
    • 13C]glycerol and mass isotopomer distribution analysis of glucose. Am J Physiol 269: E516-E523
    • (1995) Am J Physiol , vol.269
    • Peroni, O.1    Large, V.2    Beylot, M.3
  • 26
    • 0027296425 scopus 로고
    • Assay of the human liver citric acid cycle probe phenylacetylglutamine and of phenylacetate in plasma by gas chromatography-mass spectrometry
    • Yang D, Agarwal KC, Beylot M, Soloviev MV, Brunengraber H (1993) Assay of the human liver citric acid cycle probe phenylacetylglutamine and of phenylacetate in plasma by gas chromatography-mass spectrometry. Anal Biochem 212: 277-282
    • (1993) Anal Biochem , vol.212 , pp. 277-282
    • Yang, D.1    Agarwal, K.C.2    Beylot, M.3    Soloviev, M.V.4    Brunengraber, H.5
  • 27
    • 0027337194 scopus 로고
    • 13C labeling pattern of glutamate by gas chromatography-mass spectrometry
    • 13C labeling pattern of glutamate by gas chromatography-mass spectrometry. Anal Biochem 212: 532-536
    • (1993) Anal Biochem , vol.212 , pp. 532-536
    • Beylot, M.1    David, F.2    Brunengraber, H.3
  • 28
    • 0026581005 scopus 로고
    • 13C isotopic analysis of carbon dioxide in breath: Evaluation of on-line gas chromatography-isotope ratio mass spectrometry
    • 13C isotopic analysis of carbon dioxide in breath: evaluation of on-line gas chromatography-isotope ratio mass spectrometry. Anal Chim Acta 259: 193-202
    • (1992) Anal Chim Acta , vol.259 , pp. 193-202
    • Guilluy, R.1    Billion-Rey, F.2    Pachiaudi, C.3
  • 29
    • 0028939904 scopus 로고
    • Stable isotope determination of plasma lactate conversion into glucose in fasting infants
    • Bougneres PF, Rocchiccioli F, Nurjhan N, Zeller J (1995) Stable isotope determination of plasma lactate conversion into glucose in fasting infants. Am J Physiol 268: E652-E659
    • (1995) Am J Physiol , vol.268
    • Bougneres, P.F.1    Rocchiccioli, F.2    Nurjhan, N.3    Zeller, J.4
  • 30
    • 0021873259 scopus 로고
    • 14C labeled substrates
    • 14C labeled substrates. Am J Physiol 248: R391-R399
    • (1985) Am J Physiol , vol.248
    • Katz, J.1
  • 31
    • 4243408699 scopus 로고
    • Insulin inhibition of overnight glucose production and gluconeogenesis from lactate
    • Yki-Jarvinen H, Helve E, Sane T, Nurjhan N, Taskinen MR (1989) Insulin inhibition of overnight glucose production and gluconeogenesis from lactate. Am J Physiol. 256: E732-E739
    • (1989) Am J Physiol. , vol.256
    • Yki-Jarvinen, H.1    Helve, E.2    Sane, T.3    Nurjhan, N.4    Taskinen, M.R.5
  • 32
    • 0015363978 scopus 로고
    • Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus
    • Wahren J, Felig P, Cerasi E, Luft R (1972) Splanchnic and peripheral glucose and amino acid metabolism in diabetes mellitus. J Clin Invest 51: 1870-1872
    • (1972) J Clin Invest , vol.51 , pp. 1870-1872
    • Wahren, J.1    Felig, P.2    Cerasi, E.3    Luft, R.4
  • 33
    • 0028289935 scopus 로고
    • Glycogen: Its mode of formation and contribution to hepatic glucose output in postabsorptive humans
    • Pimenta W, Nurjhan N, Jansson PA, Stumvoll M, Gerich JE, Korytkowski M (1994) Glycogen: its mode of formation and contribution to hepatic glucose output in postabsorptive humans. Diabetologia 37: 697-702
    • (1994) Diabetologia , vol.37 , pp. 697-702
    • Pimenta, W.1    Nurjhan, N.2    Jansson, P.A.3    Stumvoll, M.4    Gerich, J.E.5    Korytkowski, M.6
  • 35
    • 0030021321 scopus 로고    scopus 로고
    • Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period
    • Petersen KF, Price T, Cline GW, Rothman DG, Shulman GI (1996) Contribution of net hepatic glycogenolysis to glucose production during the early postprandial period. Am J Physiol 270: E186-E191
    • (1996) Am J Physiol , vol.270
    • Petersen, K.F.1    Price, T.2    Cline, G.W.3    Rothman, D.G.4    Shulman, G.I.5
  • 37
    • 0030023775 scopus 로고    scopus 로고
    • The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans
    • Roden R, Perseghin G, Petersen KF et al. (1996) The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest 97: 642-648
    • (1996) J Clin Invest , vol.97 , pp. 642-648
    • Roden, R.1    Perseghin, G.2    Petersen, K.F.3
  • 38
    • 0028347241 scopus 로고
    • A non-invasive assessment of hepatic glycogen kinetics and post-absorptive gluconeogenesis in man
    • Gay LJ, Schneiter PH, Schutz Y, Di Vetta V, Jéquier E, Tappy L (1994) A non-invasive assessment of hepatic glycogen kinetics and post-absorptive gluconeogenesis in man. Diabetologia 37: 517-523
    • (1994) Diabetologia , vol.37 , pp. 517-523
    • Gay, L.J.1    Schneiter, P.H.2    Schutz, Y.3    Di Vetta, V.4    Jéquier, E.5    Tappy, L.6
  • 40
    • 0030988702 scopus 로고    scopus 로고
    • Evidence of increased systemic glucose production and gluconeogenesis in an early stage of NIDDM
    • Periello G, Pampanelli S, Del Sindaco P et al. (1996) Evidence of increased systemic glucose production and gluconeogenesis in an early stage of NIDDM. Diabetes 46: 1010-1016
    • (1996) Diabetes , vol.46 , pp. 1010-1016
    • Periello, G.1    Pampanelli, S.2    Del Sindaco, P.3
  • 42
    • 0017176862 scopus 로고
    • Glutamine synthetase and glutamyltransferase in the kidney of man, dog and rat
    • Lemieux G, Baverel G, Vinay P, Wadoux P (1976) Glutamine synthetase and glutamyltransferase in the kidney of man, dog and rat. Am J Physiol 231: 1068-1073
    • (1976) Am J Physiol , vol.231 , pp. 1068-1073
    • Lemieux, G.1    Baverel, G.2    Vinay, P.3    Wadoux, P.4
  • 43
    • 0016583677 scopus 로고
    • Splanchnic and leg exchange of glucose, amino acids and free fatty acids during exercise in diabetes mellitus
    • Wahren J, Hagenfeldt L, Felig P (1975) Splanchnic and leg exchange of glucose, amino acids and free fatty acids during exercise in diabetes mellitus. J Clin Invest 55: 1303-1309
    • (1975) J Clin Invest , vol.55 , pp. 1303-1309
    • Wahren, J.1    Hagenfeldt, L.2    Felig, P.3


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